Immunotherapy of Gram-negative Septic Shock

A Controlled Clinical Trial of High-Dose Methylprednisolone in the Treatment of Severe Sepsis and Septic Shock

1987 • 1,434 citations

Gram-negative bacteremia

1980 • 1,341 citations

Treatment of Gram-Negative Bacteremia and Shock with Human Antiserum to a MutantEscherichia coli

1982 • 1,062 citations

Effect of High-Dose Glucocorticoid Therapy on Mortality in Patients with Clinical Signs of Systemic Sepsis

1987 • 687 citations

PREVENTION OF GRAM-NEGATIVE SHOCK AND DEATH IN SURGICAL PATIENTS BY ANTIBODY TO ENDOTOXIN CORE GLYCOLIPID

1985 • 381 citations

Analysis of 1,186 Episodes of Gram-Negative Bacteremia in Non-University Hospitals: The Effects of Antimicrobial Therapy

1983 • 369 citations

Protection against gram-negative bacteremia and endotoxemia with human monoclonal IgM antibodies.

1985 • 316 citations

Treatment of Gram-Negative Septic Shock with Human IgG Antibody to Escherichia coli J5: A Prospective, Double-Blind, Randomized Trial

1988 • 266 citations

Structural Studies on the Hexose Region of the Core in Lipopolysaccharides from Enterobacteriaceae

2005 • 265 citations

Treatment of E. Coli and Klebsiella Bacteremia in Agranulocytic Animals with Antiserum to a UDP-GAL Epimerase-Deficient Mutant

1973 • 216 citations

Type-Specific and Cross-Reactive Antibodies in Gram-Negative Bacteremia

1972 • 214 citations

Immunization with R mutants of S. Minnesota. I. Protection against challenge with heterologous gram-negative bacilli.

1972 • 197 citations

A Proposed Mechanism for Natural Immunity to Enterobacterial Pathogens

1968 • 188 citations

Functional role of antibody against "core" glycolipid of Enterobacteriaceae.

1975 • 156 citations

Passive Immunization against the Local Shwartzman Reaction

1972 • 142 citations

Monoclonal antibodies specific for Escherichia coli J5 lipopolysaccharide: cross-reaction with other gram-negative bacterial species

1984 • 126 citations

Immunization with Rough Mutants of Salmonella minnesota. IV. Protection by Antisera to O and Rough Antigens Against Endotoxin

1983 • 112 citations

Immunization with Rough Mutants of Salmonella minnesota: Protective Activity of IgM and IgG Antibody to the R595 (Re Chemotype) Mutant

1988 • 104 citations

Enhanced survival in Pseudomonas aeruginosa septicemia associated with high levels of circulating antibody to Escherichia coli endotoxin core.

1983 • 104 citations

Prevention of lethal pseudomonas bacteremia with epimerase-deficient E. coli antiserum.

1975 • 90 citations

Immunization with R Mutants of S. Minnesota

1972 • 90 citations

Relationship of Structure to Function in Bacterial Endotoxins: Serologically Cross-reactive Components and their Effect on Protection of Mice against some Gram-negative Infections

1976 • 80 citations

Cross-Reactivity of Rabbit Antibodies to Lipopolysaccharides of Escherichia coli J5 and Other Gram-Negative Bacteria

1985 • 80 citations

Human monoclonal antibodies that recognize conserved epitopes in the core-lipid A region of lipopolysaccharides.

1987 • 79 citations

Specificity and Cross-Reactivity of Monoclonal Antibodies Reactive with the Core and Lipid A Regions of Bacterial Lipopolysaccharide

1989 • 75 citations

Experimental Gram-Negative Bacterial Sepsis: Reevaluation of the Ability of Rough Mutant Antisera to Protect Mice

1978 • 70 citations

Mouse monoclonal antibodies reactive with J5 lipopolysaccharide exhibit extensive serological cross-reactivity with a variety of gram-negative bacteria

1984 • 68 citations

Failure of Monoclonal Antibodies to Core Glycolipid to Bind Intact Smooth Strains of Escherichia coli

1985 • 67 citations

Characterization of murine monoclonal antibodies to Escherichia coli J5

1986 • 64 citations

Failure of Antisera to J5 and R595 Rough Mutants to Reduce Endotoxemic Lethality

1988 • 60 citations

Efficacy of type-specific and cross-reactive murine monoclonal antibodies directed against endotoxin during experimental sepsis.

1985 • 53 citations

Type-Specific vs. Cross-Protective Vaccination for Gram-Negative Bacterial Pneumonia

1981 • 51 citations

Controversies in the Use of Passive Immunotherapy for Bacterial Infections in the Critically Ill Patient

1987 • 51 citations

Cross-Reactive Immunoprotective Antibodies to Escherichia coli 0111 Rough Mutant J5

1985 • 46 citations

Lipopolysaccharide (LPS)-Reactive Monoclonal Antibodies Fail To Inhibit LPS-Induced Tumor Necrosis Factor Secretion by Mouse-Derived Macrophages

1989 • 38 citations

Implications of Endotoxin Contamination in the Evaluation of Antibodies to Lipopolysaccharides in a Murine Model of Gram-Negative Sepsis

1987 • 38 citations

Antiserum gegen Escherichia coli J5: Erneute Beurteilung seiner In vitro- und In-vivo-Aktivität gegen heterologe gramnegative Bakterien

1985 • 35 citations

Demonstration of Cross-Reactive Antibodies to Smooth Gram-Negative Bacteria in Antiserum to Escherichia coli J5

1987 • 33 citations

Antibody specific for Escherichia coli J5 cross-reacts to various degrees with an Escherichia coli clinical isolate grown for different lengths of time

1987 • 32 citations

Carumonam enhances reactivity of Escherichia coli with mono- and polyclonal antisera to rough Escherichia coli J5

1987 • 29 citations

"Core" Glycolipid of Enterobacteriaceae: Immunofluorescent Detection of Antigen and Antibody

1975 • 29 citations

Resistance to meningococcemia apparently conferred by anti-H.8 monoclonal antibody is due to contaminating endotoxin and not to specific immunoprotection

1987 • 29 citations

The Biosynthesis of Cell Wall Lipopolysaccharide in Escherichia coli

1973 • 29 citations

Limited protective effect of rough mutant antisera in murine Escherichia coli bacteremia

1982 • 28 citations

Effect of active and passive immunizations with lipid A and salmonella minnesota Re 595 on gram-negative infections in mice

1976 • 25 citations

Reactivity of Antibodies to Core Glycolipid with Gram-Negative Bacteria

1987 • 17 citations

Impact of molecular biology on Pseudomonas aeruginosa immunization

1988 • 14 citations

Immunochemical Specificity of Human Antibodies to Lipopolysaccharide from the J5 Rough Mutant of Escherichia coli O111:B4

1989 • 13 citations

Detection by Immunofluorescence of Common Antigenic Determinants in Unrelated Gram-Negative Bacteria and Their Lipopolysaccharides

1977 • 12 citations