Evolutionary approach to the question of immunoglobulin heavy chain switching: evidence from cloned human and mouse genes.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

The isolation of structural genes from libraries of eucaryotic DNA

1978 • 1,877 citations

Charon Phages: Safer Derivatives of Bacteriophage Lambda for DNA Cloning

1977 • 951 citations

Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways

1980 • 880 citations

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH

1980 • 872 citations

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

1979 • 859 citations

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

1980 • 803 citations

Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions.

1976 • 726 citations

A complete immunoglobulin gene is created by somatic recombination.

1978 • 610 citations

Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.

1979 • 472 citations

THE ORGANIZATION, EXPRESSION, AND EVOLUTION OF ANTIBODY GENES AND OTHER MULTIGENE FAMILIES

1975 • 446 citations

The molecular basis of antibody formation: a paradox.

1965 • 394 citations

Packaging recombinant DNA molecules into bacteriophage particles in vitro.

1977 • 343 citations

The evolution and sequence comparison of two recently diverged mouse chromosomal β-globin genes

1979 • 337 citations

An immunoglobulin heavy-chain gene is formed by at least two recombinational events

1980 • 306 citations

Organization of immunoglobulin heavy chain genes and allelic deletion model.

1978 • 297 citations

A κ-immunoglobulin gene is formed by site-specific recombination without further somatic mutation

1979 • 283 citations

The arrangement and rearrangement of antibody genes

1978 • 277 citations

Antibody Diversity

1978 • 240 citations

[60] Computer analysis of nucleic acids and proteins

1980 • 238 citations

Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.

1980 • 213 citations

Deletions are associated with somatic rearrangement of immunoglobulin heavy chain genes

1980 • 159 citations

Exon shuffling generates an immunoglobulin heavy chain gene.

1980 • 146 citations

A comparison of two cloned mouse β-globin genes and their surrounding and intervening sequences

1978 • 142 citations

High capacity gel preparative electrophoresis for purification of fragments of genomic DNA

1978 • 128 citations

Rearrangement of immunoglobulin heavy chain genes during B-lymphocyte development as revealed by studies of mouse plasmacytoma cells

1980 • 120 citations

Deletions in the constant region locus can account for switches in immunoglobulin heavy chain expression

1980 • 106 citations

Variation in the crossover point of kappa immunoglobulin gene V-J recombination: Evidence from a cryptic gene

1980 • 97 citations

Mouse Cμ heavy chain immunoglobulin gene segment contains three intervening sequences separating domains

1980 • 65 citations

Intervening sequences divide the gene for the constant region of mouse immunoglobulin mu chains into segments, each encoding a domain.

1980 • 59 citations

Immunoglobulin γ1 heavy chain gene: Structural gene sequences cloned in a bacterial plasmid

1980 • 22 citations