Putative Role of Neutrophil Elastase in the Pathogenesis of Emphysema^a

Neutrophils in Human Diseases

1987 • 852 citations

Animal Models of Emphysema^1–3

1986 • 439 citations

MECHANISMS OF LYSOSOMAL ENZYME RELEASE FROM LEUKOCYTES EXPOSED TO IMMUNE COMPLEXES AND OTHER PARTICLES

1971 • 439 citations

Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters.

1988 • 436 citations

The Centrilobular Form of Hypertrophic Emphysema and its Relation to Chronic Bronchitis

1957 • 346 citations

The Induction of Pulmonary Emphysema with Human Leukocyte Elastase^1–3

1977 • 335 citations

Experimental emphysema induced with purified human neutrophil elastase: tissue localization of the instilled protease.

1977 • 284 citations

Neutrophils degrade subendothelial matrices in the presence of alpha-1-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites.

1984 • 253 citations

Proteolysis by Neutrophils

1982 • 244 citations

CONTRIBUTION OF CIGARETTE SMOKING TO CADMIUM ACCUMULATION IN MAN

1972 • 219 citations

Loss of alveolar attachments in smokers. A morphometric correlate of lung function impairment.

1985 • 187 citations

Immunolocalization of elastase in human emphysematous lungs.

1986 • 185 citations

Lung Fibrosis and Emphysema: Divergent Responses to a Common Injury?

1982 • 142 citations

Levels of Elastase Activity in Bronchoalveolar Lavage Fluids of Healthy Smokers and Nonsmokers^1–3

1983 • 131 citations

Pericellular proteolysis by neutrophils in the presence of proteinase inhibitors: effects of substrate opsonization.

1988 • 128 citations

Emphysema-like changes in the lungs of starved rats.

1981 • 124 citations

Emphysema and bronchial secretory cell metaplasia induced in hamsters by human neutrophil products.

1984 • 123 citations

Elastin Degradation by Human Alveolar Macrophages: A Prominent Role of Metalloproteinase Activity

1989 • 122 citations

Human neutrophils contain an intracellular pool of putative receptors for the chemoattractant N-formyl-methionyl-leucyl-phenylalanine

1983 • 118 citations

Centrilobular emphysema experimentally induced by cadmium chloride aerosol.

1973 • 103 citations

Morphometric and morphologic evaluation of pulmonary lesions in beagle dogs chronically exposed to high ambient levels of air pollutants.

1978 • 103 citations

Role of Plasminogen Activator in Degradation of Extracellular Matrix Protein by Live Human Alveolar Macrophages

1988 • 94 citations

Desmosine Radioimmunoassay for Measuring Elastin DegradationIn Vivo^1–3

1980 • 93 citations

Effects of starvation and refeeding on lung mechanics and morphometry.

1979 • 84 citations

Effect of combined human neutrophil cathepsin G and elastase on induction of secretory cell metaplasia and emphysema in hamsters, with in vitro observations on elastolysis by these enzymes.

1985 • 79 citations

Cadmium-Chloride-induced Air-Space Enlargement with Interstitial Pulmonary Fibrosis Is Not Associated with Destruction of Lung Elastin: Implications for the Pathogenesis of Human Emphysema

1988 • 74 citations

Elastic properties of the centrilobular emphysematous space

1969 • 74 citations

Induction of Experimental Emphysema^1,2

1972 • 74 citations

Nutritional Emphysema in the Rat

1985 • 73 citations

Effects of starvation on lung mechanics and biochemistry in young and old rats

1985 • 69 citations

A comparison of starvation and elastase models of emphysema in the rat.

1984 • 62 citations

Pathogenesis of the nitrogen dioxide-induced lesion in the rat lung: a review and presentation of new observations.

1968 • 62 citations

An enzyme-linked immunosorbent assay to quantitate the elastin crosslink desmosine in tissue and urine samples

1985 • 59 citations

Fatal Emphysema in Two Men Making a Copper Cadmium Alloy

1954 • 58 citations

Prevention of Collagen Deposition Following Pulmonary Oxygen Toxicity in the Rat by Cis-4-Hydroxy-l-Proline

1980 • 57 citations

An 18-Month Study of the Effects on Hamster Lungs of Intratracheally Administered Human Neutrophil Elastase

1988 • 47 citations

Chronic Toxicity of Nitrogen Dioxide

1969 • 47 citations

Elevated cadmium concentration in emphysematous lungs.

1973 • 45 citations

Experimental Pulmonary Emphysema: The Effect of Intratracheal Injection of Cadmium Chloride Solution in the Guinea Pig.

1963 • 44 citations

Urine Desmosine is Unrelated to Cigarette Smoking or to Spirometric Function

1983 • 44 citations

Utilization of a peroxidase antiperoxidase complex in an enzyme-linked immunosorbent assay of elastin-derived peptides in human plasma.

1985 • 42 citations

Neutrophil recruitment and degranulation during induction of emphysema in the rat by nitrogen dioxide.

1987 • 42 citations

Cigarette Smoke Inhalation Potentiates Elastase-induced Emphysema in Hamsters^1–3

1983 • 41 citations

Urinary excretion of desmosine (elastin cross-links) in subjects with PiZZ alpha-1-antitrypsin deficiency, a phenotype associated with hereditary predisposition to pulmonary emphysema.

1985 • 40 citations

Pulmonary intravascular leukocyte sequestration. A potential mechanism of lung injury.

1974 • 37 citations

Quantitation of elastin in human urine and rat pleural mesothelial cell matrix by a sensitive avidin-biotin ELISA for desmosine

1988 • 36 citations

Effects of Nitrogen Dioxide on Elastin and Collagen Contents of Lung

1979 • 36 citations

Effects of starvation and refeeding on lung biochemistry in rats.

1982 • 35 citations

Neutrophil lysosomal elastase activity in normal subjects and in patients with chronic obstructive pulmonary disease.

1979 • 35 citations

Lung mechanics and connective tissue levels in starvation-induced emphysema in hamsters

1986 • 33 citations

Morphologic alterations induced by short-term cigarette smoking.

1983 • 33 citations

Emphysema associated with intravascular leukocyte sequestration. Comparison with papain-induced emphysema.

1981 • 30 citations

Demonstration of a free elastolytic metalloenzyme in human lung lavage fluid and its relationship to alpha 1-antiprotease.

1984 • 29 citations

Relationship of leukocyte elastase concentration to severity of emphysema in homozygous alpha1-antitrypsin-deficient persons.

1977 • 27 citations

Nitrogen dioxide-induced emphysema in rabbits.

1967 • 26 citations

THE TISSUE RESPONSE TO EXOGENOUS ELASTASE

1981 • 26 citations

Defenses of the Hamster Lung against Human Neutrophil and Porcine Pancreatic Elastase

1988 • 25 citations

A matched-pair study of the leukocyte elastase-like activity in normal persons and in emphysematous patients with and without alpha 1-antitrypsin deficiency.

1980 • 25 citations

Is neutrophil elastase associated with elastic tissue in emphysema?

1988 • 25 citations

Comparison of the elastolytic effects of human leukocyte elastase and porcine pancreatic elastase

1976 • 24 citations

Interactions of neutrophil elastase, serum trypsin inhibitory activity, and smoking history as risk factors for chronic obstructive pulmonary disease in patients with MM, MZ, and ZZ phenotypes for alpha-antitrypsin.

1977 • 24 citations

Emphysema Induced by Intravenously Administered Endotoxin in an Alpha₁-Antitrypsin-Deficient Rat Model

1984 • 19 citations

Effect of low-level NO2 chronic exposure on elastase-induced emphysema

1987 • 19 citations

Neutrophil elastase and pulmonary function in subjects with intermediate alpha1-antitrypsin deficiency (MZ phenotype).

1979 • 18 citations

Long-term sequelae of bronchiolitis induced by nitrogen dioxide in hamsters.

1983 • 17 citations

Interrelationships between neutrophil elastase, serum alpha, -antitrypsin, lung function and chest radiography in patients with chronic airflow obstruction.

1979 • 15 citations

Ultrastructural changes in hamster lung 15 min to 3 hr after exposure to pancreatic elastase

1986 • 15 citations

The role of neutrophils in the development of cadmium chloride-induced emphysema in lathyrogen-fed hamsters.

1985 • 14 citations

Serum studies of leucocyte elastase in acute and chronic lung diseases.

1982 • 14 citations

Nitrogen Dioxide - Induced Emphysema in Rabbits

1968 • 14 citations

Nitrogen-Dioxide-induced Emphysema in Rats: Lack of Worsening by Beta-Aminopropionitrile Treatment

1988 • 13 citations

Elastolytic activity in rabbit leukocyte extracts. Effects of the whole leukocyte homogenate on the rabbit lung

1979 • 12 citations

Direct Cleavage of Soluble Collagen by Ozone or Hydroxyl Radicals

1984 • 11 citations

Serum Antielastase and Neutrophil Elastase Levels in PiM Phenotype Cigarette Smokers with Airflow Obstruction

1985 • 6 citations