Integrins in Development

Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator

1991 • 3,314 citations

Role of cell shape in growth control

1978 • 2,434 citations

Developmental mechanisms that generate precise patterns of neuronal connectivity

1993 • 1,435 citations

Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin

1993 • 1,279 citations

Regulation of development and differentiation by the extracellular matrix

1993 • 1,216 citations

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.

1989 • 1,073 citations

Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons

1992 • 895 citations

Embryonic mesodermal defects in α5 integrin-deficient mice

1993 • 694 citations

Distribution patterns of extracellular matrix components and adhesion receptors are intricately modulated during first trimester cytotrophoblast differentiation along the invasive pathway, in vivo.

1992 • 669 citations

Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity.

1991 • 659 citations

Vinculin: A cytoskeletal target of the transforming protein of rous sarcoma virus

1981 • 591 citations

Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes.

1988 • 534 citations

Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information

1992 • 532 citations

Responses of embryonic xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm

1992 • 486 citations

CELLULAR MOVEMENT AND CONTACT IN SEA URCHIN MORPHOGENESIS

1967 • 484 citations

Ligands “activate” integrin αIIbβ3 (platelet GPIIb-IIIa)

1991 • 481 citations

Biologically active synthetic peptides as probes of embryonic development: a competitive peptide inhibitor of fibronectin function inhibits gastrulation in amphibian embryos and neural crest cell migration in avian embryos.

1984 • 429 citations

Occupation of the extracellular matrix receptor, integrin, is a control point for myogenic differentiation

1987 • 419 citations

Fibronectin in early avian embryos: Synthesis and distribution along the migration pathways of neural crest cells

1980 • 417 citations

Roles for the integrin VLA-4 and its counter receptor VCAM-1 in myogenesis

1992 • 404 citations

Protein synthesis requires cell-surface contact while nuclear events respond to cell shape in anchorage-dependent fibroblasts

1980 • 399 citations

Recognition of osteopontin and related peptides by an alpha v beta 3 integrin stimulates immediate cell signals in osteoclasts.

1991 • 387 citations

Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape.

1991 • 368 citations

N-cadherin, NCAM, and integrins promote retinal neurite outgrowth on astrocytes in vitro.

1988 • 326 citations

Alterations in neural crest migration by a monoclonal antibody that affects cell adhesion.

1985 • 322 citations

Developmental regulation of integrin expression at the time of implantation in the mouse embryo

1993 • 321 citations

A monoclonal antibody detaches embryonic skeletal muscle from extracellular matrices.

1982 • 310 citations

Cell adhesion and migration in the early vertebrate embryo: location and possible role of the putative fibronectin receptor complex

1986 • 309 citations

An antibody to a receptor for fibronectin and laminin perturbs cranial neural crest development in vivo

1986 • 304 citations

The activation dependent adhesion of macrophages to laminin involves cytoskeletal anchoring and phosphorylation of the alpha 6 beta 1 integrin.

1990 • 288 citations

Interaction of mouse mammary epithelial cells with collagen substrata: regulation of casein gene expression and secretion.

1985 • 279 citations

Alpha 2 beta 1 integrins from different cell types show different binding specificities.

1990 • 274 citations

Mesoderm induction and mesoderm-inducing factors in early amphibian development

1989 • 274 citations

The Drosophila PS2 antigen is an invertebrate integrin that, like the fibronectin receptor, becomes localized to muscle attachments

1987 • 263 citations

The alpha 1-alpha 6 subunits of integrins are characteristically expressed in distinct segments of developing and adult human nephron.

1990 • 261 citations

Extracellular matrix regulates expression of the TGF-beta 1 gene.

1993 • 260 citations

Multiple elevations of cytosolic-free Ca2+ in human neutrophils: initiation by adherence receptors of the integrin family.

1991 • 259 citations

Cells into organs (the forces that shape the embryo)

1985 • 256 citations

Embryonic neural retinal cell response to extracellular matrix proteins: developmental changes and effects of the cell substratum attachment antibody (CSAT).

1987 • 249 citations

Transmembrane molecular assemblies in cell-extracellular matrix interactions

1991 • 244 citations

Recognition of the laminin E8 cell-binding site by an integrin possessing the alpha 6 subunit is essential for epithelial polarization in developing kidney tubules.

1990 • 243 citations

Control of intracellular pH and growth by fibronectin in capillary endothelial cells.

1990 • 241 citations

Distinct molecular interactions mediate neuronal process outgrowth on non-neuronal cell surfaces and extracellular matrices.

1986 • 240 citations

Expression of collagen binding integrins during cardiac development and hypertrophy.

1991 • 240 citations

H36-alpha 7 is a novel integrin alpha chain that is developmentally regulated during skeletal myogenesis [published erratum appears in J Cell Biol 1992 Jul;118(1):213]

1992 • 236 citations

Prevention of gastrulation but not neurulation by antibodies to fibronectin in amphibian embryos

1984 • 235 citations

The lethal myospheroid gene of Drosophila encodes a membrane protein homologous to vertebrate integrin beta subunits.

1988 • 235 citations

Temporal and spatial regulation of fibronectin in early Xenopus development

1984 • 232 citations

The function and mechanism of convergent extension during gastrulation of Xenopus laevis

1985 • 231 citations

The participation of a putative cell surface receptor for laminin and fibronectin in peripheral neurite extension

1986 • 223 citations

Monoclonal Antibodies Which Alter the Morphology of Cultured Chick Myogenic Cells

1982 • 212 citations

Distribution of a putative cell surface receptor for fibronectin and laminin in the avian embryo.

1986 • 203 citations

Integrin expression during human epidermal development in vivo and in vitro

1991 • 203 citations

The distribution of PS integrins, laminin A and F-actin during key stages in Drosophila wing development

1993 • 195 citations

Regulation of in vitro capillary tube formation by anti-integrin antibodies.

1993 • 194 citations

Adhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK

1993 • 192 citations

Cell-surface regulation of β1-integrin activity on developing retinal neurons

1991 • 191 citations

A novel transcriptional enhancer is involved in the prolactin- and extracellular matrix-dependent regulation of beta-casein gene expression.

1992 • 187 citations

Regulation of expression of fibronectin and its receptor, α5β1, during development and regeneration of peripheral nerve

1992 • 184 citations

The influence of tissue microenvironment (stroma and extracellular matrix) on the development and function of mammary epithelium.

1993 • 183 citations

Characterization of a 140-kD avian cell surface antigen as a fibronectin-binding molecule.

1986 • 180 citations

Distribution of laminin and collagens during avian neural crest development

1987 • 171 citations

Multiple integrins share the ability to induce elevation of intracellular pH*1

1991 • 161 citations

Characterization of the integrin alpha 8 subunit: a new integrin beta 1-associated subunit, which is prominently expressed on axons and on cells in contact with basal laminae in chick embryos.

1991 • 161 citations

Laminin receptors in the retina: sequence analysis of the chick integrin alpha 6 subunit. Evidence for transcriptional and posttranslational regulation.

1991 • 160 citations

Integrin (the CSAT antigen): functionality requires oligomeric integrity.

1986 • 160 citations

Integrin heterodimer and receptor complexity in avian and mammalian cells.

1989 • 156 citations

Adhesion-dependent protein tyrosine phosphorylation in neutrophils treated with tumor necrosis factor.

1993 • 155 citations

Integrin-mediated neurite outgrowth in neuroblastoma cells depends on the activation of potassium channels

1993 • 153 citations

Retrovirally introduced antisense integrin RNA inhibits neuroblast migration in vivo

1992 • 151 citations

Tumor necrosis factor and CD11/CD18 (beta 2) integrins act synergistically to lower cAMP in human neutrophils.

1990 • 151 citations

Signaling by integrins: implications for tumorigenesis.

1993 • 150 citations

Requirement for integrins during Drosophila wing development

1989 • 149 citations

Human smooth muscle VLA-1 integrin: purification, substrate specificity, localization in aorta, and expression during development.

1990 • 148 citations

Distribution and function of tenascin during cranial neural crest development in the chick

1988 • 141 citations

Tyrosine phosphorylation of the focal adhesion kinase pp125FAK during development: relation to paxillin

1993 • 139 citations

The NC1 domain of type IV collagen promotes axonal growth in sympathetic neurons through interaction with the alpha 1 beta 1 integrin.

1991 • 136 citations

Calcium signaling capacity of the integrin on human neutrophils

1991 • 135 citations

Fibronectin in early amphibian embryos

1983 • 134 citations

Regulation of vertebrate left–right asymmetries by extracellular matrix

1992 • 132 citations

Xenopus laevis integrins. Structural conservation and evolutionary divergence of integrin beta subunits.

1988 • 126 citations

Antibodies to β₁‐integrins cause alterations of aortic vasculogenesis, in vivo

1992 • 126 citations

Expression of α1 integrin, a laminin-collagen receptor, during myogenesis and neurogenesis in the avian embryo

1992 • 124 citations

Appearance and distribution of fibronectin during chick embryo gastrulation and neurulation

1982 • 123 citations

N-cadherin localization in early heart development and polar expression of Na+, K+-ATPase, and integrin during pericardial coelom formation and epithelialization of the differentiating myocardium

1992 • 123 citations

Paxillin is a major phosphotyrosine-containing protein during embryonic development.

1991 • 119 citations

Mesoderm induction and the control of gastrulation in Xenopus laevis: the roles of fibronectin and integrins

1990 • 116 citations

Developmentally regulated expression ofα6 integrin in avian embryos

1992 • 113 citations

Mesoderm-inducing factors and the control of gastrulation

1992 • 111 citations

The 140-kDa fibronectin receptor complex is required for mesodermal cell adhesion during gastrulation in the amphibian Pleurodeles waltlii

1988 • 110 citations

Expression of Fibronectin, the Integrin α5, and α-Smooth Muscle Actin in Heart and Lung Development

1992 • 108 citations

Inhibition of Neural Crest Cell Attachment by Integrin Antisense Oligonucleotides

1993 • 107 citations

Requirements for integrins during Drosophila development

1990 • 107 citations

β-integrin is a maternal protein that is inserted into all newly formed plasma membranes during early Xenopus embryogenesis

1992 • 104 citations

In Vitro and in Vivo Expression α7 Integrin and Desmin Define the Primary and Secondary Myogenic Lineages

1993 • 102 citations

Gastrulation : movements, patterns, and molecules

1991 • 97 citations

Integrin expression profiles during erythroid differentiation

1992 • 95 citations

A histological and ultrastructural analysis of developmental defects produced by the mutation, lethal(1)myospheroid, in Drosophila melanogaster

1981 • 95 citations

Mechanism of skin morphogenesis. I. Analyses with antibodies to adhesion molecules tenascin, N-CAM, and integrin

1992 • 95 citations

Signal transduction by the platelet integrin alpha IIb beta 3: induction of calcium oscillations required for protein-tyrosine phosphorylation and ligand-induced spreading of stably transfected cells.

1992 • 95 citations

PS2 Integrin Requirements in Drosophila Embryo and Wing Morphogenesis

1993 • 95 citations

Potential role of RGD-binding integrins in mammalian lung branching morphogenesis

1991 • 92 citations

Tyrosine phosphorylated proteins in different tissues during chick embryo development.

1988 • 85 citations

Phosphotyrosine-modified proteins are concentrated at the membranes of epithelial and endothelial cells during tissue development in chick embryos.

1988 • 84 citations

Down-regulation of the chicken α5β1 integrin fibronectin receptor during development

1991 • 81 citations

Specificity of cell adhesion in development: the cadherin superfamily

1992 • 79 citations

The α5β1 integrin associates with a dystrophin-containing lattice during muscle development

1992 • 73 citations

Differential effects of laminin and merosin on neurite outgrowth by developing retinal ganglion cells

1991 • 72 citations

Integrin α subunit mRNAs are differentially expressed in early Xenopus embryos

1993 • 68 citations

Identification of integrin cell‐substratum adhesion receptors on cultured rat bone cells

1992 • 67 citations

Cranial and trunk neural crest cells use different mechanisms for attachment to extracellular matrices

1992 • 66 citations

Basement membranes during development of human nerve: Schwann cells and perineurial cells display marked changes in their expression profiles for laminin subunits and ?1 and ?4 integrins

1993 • 66 citations

The Drosophila position-specific antigens are a family of cell surface glycoprotein complexes.

1984 • 65 citations

Temporal changes in the expression and distribution of adhesion molecules during liver development and regeneration.

1992 • 60 citations

Xenopus gastrulation without a blastocoel roof

1992 • 60 citations

Alpha 1 beta 1 integrin on neural crest cells recognizes some laminin substrata in a Ca(2+)-independent manner.

1992 • 59 citations

Adhesion of rat glomerular epithelial cells to extracellular matrices: Role of β1 integrins

1992 • 59 citations

Developmental analysis of Drosophila position-specific antigens

1985 • 57 citations

Developmentally regulated expression of the beta 4 integrin on immature mouse thymocytes.

1992 • 56 citations

Integrin Expression in Early Amphibian Embryos: cDNA Cloning and Characterization of Xenopus β1, β2, β3, and β6 Subunits

1993 • 56 citations

Perturbation of β1 integrin-mediated adhesions results in altered somite cell shape and behavior

1992 • 52 citations

Cell surface proteins of chicken hematopoietic progenitors, thrombocytes and eosinophils detected by novel monoclonal antibodies.

1992 • 48 citations

α5 Integrin Is a Critical Component of Adhesion Plaques in Myogenesis

1993 • 48 citations

Differential expression of integrin alpha chains by renal epithelial cells

1992 • 44 citations

Integrins : biological problems

1994 • 40 citations

Molecular Mechanisms of Human Melanocyte Attachment to Fibronectin

1992 • 39 citations

Growth cone migration across extracellular matrix components depends on integrin, but migration across glioma cells does not

1988 • 39 citations

Distribution of integrins and their ligands in the trunk of Xenopus laevis during neural crest cell migration

1990 • 39 citations

Modulation of integrin expression during mast cell differentiation

1992 • 36 citations

Maturation induced internalization of β1-integrin by Xenopus oocytes and formation of the maternal integrin pool

1993 • 34 citations

An abundant chick gizzard integrin is the avian α1β1 integrin heterodimer and functions as a divalent cation-dependent collagen IV receptor

1991 • 32 citations

Changes in the gene expression of collagens, fibronectin, integrin and proteoglycans during matrix-induced bone morphogenesis

1991 • 30 citations

Are β1 integrins involved in Xenopus gastrulation?

1992 • 30 citations

Adhesion receptors are differentially expressed on developing thymocytes and epithelium in human thymus.

1992 • 29 citations

3 Role of the Extracellular Matrix in Amphibian Gastrulation

1992 • 29 citations

Identification and characterization of a dimeric chicken fibronectin receptor. Subunit-specific monoclonal antibodies to the putative chicken alpha 5 beta 1 integrin.

1990 • 25 citations

Identification of cytoskeletal, focal adhesion, and cell adhesion proteins in growth cone particles isolated from developing chick brain

1991 • 25 citations

Transforming Growth Factor-β Up-Regulates the Expression of the Genes for β4 Integrin and Bullous Pemphigoid Antigens (BPAG1 and BPAG2) in Normal and Transformed Human Keratinocytes

1992 • 24 citations

Reagents That Inhibit Fibronectin Matrix Assembly of Cultured Cells Also Inhibit Lung Branching Morphogenesis in Vitro

1991 • 23 citations

Functions of the cytoplasmic domain of the βPS integrin subunit during Drosophila development

1994 • 23 citations

α5 Integrin subunit expression changes during myogenesis

1992 • 18 citations

Adhesion of a chicken myeloblast cell line to fibrinogen and vitronectin through a beta 1-class integrin.

1992 • 17 citations

The Expression of Fibronectins and Integrins During Mesodermal Induction and Gastrulation in Xenopus

1991 • 8 citations

Reagents that inhibit fibronectin matrix assembly of cultured cells also inhibit lung branching morphogenesis in vitro. Implications for lung development, injury, and repair

1991 • 7 citations