Metabolism of Endogenous Estrogens

Functional role of estrogen metabolism in target cells: review and perspectives

1998 • 965 citations

The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth

1994 • 743 citations

Increased 2-Hydroxylation of Estradiol as a Possible Mechanism for the Anti-Estrogenic Effect of Cigarette Smoking

1986 • 665 citations

Molecular Mechanisms of Estrogen Carcinogenesis

1996 • 659 citations

The Brain as a Target for Steroid Hormone Action

1979 • 520 citations

Placental Estrogen Biosynthesis During Human Pregnancy1

1966 • 478 citations

Estrogen Excretion Patterns and Plasma Levels in Vegetarian and Omnivorous Women

1982 • 477 citations

P450 enzymes of estrogen metabolism

1993 • 395 citations

[Estrogens in the environment].

1986 • 328 citations

SMOKING AND ESTROGEN-RELATED DISEASE

1984 • 285 citations

The relationship between estrogen levels and diets of Caucasian American and Oriental immigrant women

1986 • 262 citations

Abnormal oxidative metabolism of estradiol in women with breast cancer.

1982 • 256 citations

Estrogen Metabolism and Excretion in Oriental and Caucasian Women

1994 • 255 citations

Estrogens in the Environment

1997 • 242 citations

INFLUENCE OF BODY WEIGHT ON ESTRADIOL METABOLISM IN YOUNG WOMEN

1975 • 231 citations

Alterations of estrogen metabolism in systemic lupus erythematosus

1979 • 224 citations

Biological Properties of 16α-Hydroxyestrone: Implications in Estrogen Physiology and Pathophysiology*

1980 • 216 citations

Urinary estrogen metabolites and breast cancer: a case-control study.

1997 • 214 citations

Estradiol 16 alpha-hydroxylation in the mouse correlates with mammary tumor incidence and presence of murine mammary tumor virus: a possible model for the hormonal etiology of breast cancer in humans.

1985 • 210 citations

Increased 16α-Hydroxylation of Estradiol in Systemic Lupus Erythematosus*

1981 • 208 citations

Steroid sulfotransferases and steroid sulfate sulfatases: characteristics and biological roles

1985 • 200 citations

Effects of dietary fat and fiber on plasma and urine androgens and estrogens in men: a controlled feeding study

1996 • 187 citations

2-hydroxyestrone: the 'good' estrogen.

1996 • 184 citations

Induction of Estradiol Metabolism by Dietary Indole-3-carbinol in Humans

1990 • 180 citations

Effects of pesticides on the ratio of 16 alpha/2-hydroxyestrone: a biologic marker of breast cancer risk.

1995 • 177 citations

Intestinal Metabolism of Estrogens1

1976 • 166 citations

Altered estrogen metabolism and excretion in humans following consumption of indole‐3‐carbinol

1991 • 155 citations

Increased estrogen-16α-hydroxylase activity in women with breast and endometrial cancer

1984 • 154 citations

Preliminary Results of the Use of Indole‐3‐Carbinol for Recurrent Respiratory Papillomatosis

1998 • 153 citations

Catecholoestrogens (2-and 4-hydroxyoestrogens): chemistry, biogenesis, metabolism, occurrence and physiological significance.

1980 • 152 citations

Effects of dietary broccoli on human in vivo drug metabolizing enzymes: evaluation of caffeine, oestrone and chlorzoxazone metabolism

1996 • 150 citations

Upregulation of Estradiol C16 -hydroxylation in Human Breast Tissue: a Potential Biomarker of Breast Cancer Risk

1993 • 149 citations

Changes in Levels of Urinary Estrogen Metabolites After Oral Indole-3-Carbinol Treatment in Humans

1997 • 146 citations

The Role of Estrogen in Mammary Carcinogenesis^a

1995 • 140 citations

Selective Responsiveness of Human Breast Cancer Cells to Indole-3-carbinol, a Chemopreventive Agent

1994 • 136 citations

Urinary estrogen profile determination in young finnish vegetarian and omnivorous women

1986 • 136 citations

Effects of Obesity on Estradiol Metabolism: Decreased Formation of Nonuterotropic Metabolites*

1983 • 134 citations

Effect of dietary indole-3-carbinol on intestinal and hepatic monooxygenase, glutathione S-transferase and epoxide hydrolase activities in the rat

1984 • 130 citations

Long-term responses of women to indole-3-carbinol or a high fiber diet.

1994 • 125 citations

Oxidative Metabolism of Estradiol

1960 • 115 citations

DNA single-strand breaks in kidneys of Syrian hamsters treated with steroidal estrogens: hormone-induced free radical damage preceding renal malignancy

1994 • 114 citations

The Effect of a Low Fat Diet on Estrogen Metabolism*

1987 • 114 citations

The Influence of Dietary Protein and Carbohydrate on the Principal Oxidative Biotransformations of Estradiol in Normal Subjects*

1984 • 112 citations

Increased urinary catechol estrogen excretion in female smokers

1988 • 103 citations

Formation of 2- and 4-Hydroxyestrogens by Brain, Pituitary, and Liver of the Human Fetus*

1978 • 96 citations

Diet and the excretion and enterohepatic cycling of estrogens

1987 • 93 citations

Effect of Thyroid on Hydroxylation of Estrogen in Man

1965 • 93 citations

The interaction between HPV infection and estrogen metabolism in cervical carcinogenesis

1991 • 91 citations

Radiometric analysis of biological oxidations in man: sex differences in estradiol metabolism.

1980 • 91 citations

Estrogen, progesterone, and testosterone: Can they be used to treat autoimmune diseases?

1994 • 90 citations

Estrogen 2-Hydroxylase Oxidation and Menstrual Function among Elite Oarswomen*

1989 • 89 citations

The connective tissue diseases and the overall influence of gender.

1996 • 86 citations

Estrogen metabolism and human papillomavirus-induced tumors of the larynx: chemo-prophylaxis with indole-3-carbinol.

1993 • 85 citations

Indole‐3‐carbinol

1995 • 83 citations

The Effects of Cimetidine on the Oxidative Metabolism of Estradiol

1989 • 81 citations

Bioactivation of Estrone and Its Catechol Metabolites to Quinoid−Glutathione Conjugates in Rat Liver Microsomes

1996 • 80 citations

STEROID METABOLISM IN THE HUMAN FOETO-PLACENTAL UNIT

1969 • 80 citations

Reduced maternal plasma and urinary estriol during ampicillin treatment

1971 • 79 citations

Estradiol metabolism in cirrhosis

1968 • 78 citations

THE AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY

1991 • 74 citations

Omega-3 Fatty Acids: Modulation of Estrogen Metabolism and Potential for Breast Cancer Prevention

1988 • 69 citations

Estradiol Transformation in Men with Breast Cancer

1966 • 68 citations

Assay of estrogens in human feces

1982 • 64 citations

Estrogen Metabolism in Normal and Pregnant Women

1962 • 62 citations

Influence of Thyroid Hormone on Estrogen Metabolism in Man

1962 • 61 citations

TESTOSTERONE-ESTRADIOL BINDING GLOBULIN BINDS TO 2-METHOXYESTRADIOL WITH GREATER AFFINITY THAN TO TESTOSTERONE1

1980 • 56 citations

Abnormal estrogen and androgen metabolism in the human with systemic lupus erythematosus.

1982 • 56 citations

Treatment of recurrent respiratory papillomatosis with indole-3-carbinol

1997 • 55 citations

CATECHOLOESTROGENS (2-AND 4-HYDROXYOESTROGENS):

1980 • 54 citations

Adipose tissue as a source of hormones

1987 • 52 citations

EFFECT OF AMPICILLIN ADMINISTRATION ON THE EXCRETION OF TWELVE OESTROGENS IN PREGNANCY URINE

1975 • 50 citations

Influence of Age and Sex on Normal Estradiol Metabolism

1968 • 49 citations

Altered Hydroxylation of Estrogen in Patients with Postmenopausal Osteopenia

1997 • 49 citations

Purification of urine for quantification of the complete estrogen profile

1980 • 48 citations

RAPID METABOLIC CLEARANCE OF THE CATECHOL ESTROGEN 2-HYDROXYESTRONE

1980 • 48 citations

Inhibition of the Catechol-O-Methyltransferase-Catalyzed O-Methylation of 2- and 4-Hydroxyestradiol by Catecholamines: Implications for the Mechanism of Estrogen-Induced Carcinogenesis

1993 • 47 citations

OESTROGEN IN HUMAN PREGNANCY FAECES

1976 • 47 citations

Steroid and lipid metabolism.1 The hypocholesteremic effect of estrogen metabolites

1964 • 46 citations

Association of low unconjugated estriol in the second trimester and adverse pregnancy outcome

1998 • 46 citations

Serum concentration and urinary excretion of “classical” estrogens, catecholestrogens and 2-methoxyestrogens in normal human pregnancy

1992 • 46 citations

The excretion of five different 2-hydroxyoestrogen monomethyl ethers in human pregnancy urine

1976 • 45 citations

Urinary markers of estrogen metabolism 2- and 16α-hydroxylation in premenopausal women

1996 • 43 citations

Reduction of maternal estrogen excretion by neomycin

1973 • 40 citations

Endometrial cancer: How does cigarette smoking influence the risk of women under age 55 years having this tumor?

1985 • 40 citations

Radioimmunoassay and Metabolism of the Catechol Estrogen 2-Hydroxyestradiol

1982 • 40 citations

Cigarette smoking alters hepatic estrogen metabolism in men: Implications for atherosclerosis

1989 • 40 citations

Estrogen Metabolite Ratios and Risk Assessment of Hormone‐related Cancers

1995 • 38 citations

Metabolism of exogenous 4- and 2-hydroxyestradiol in the human male

1987 • 36 citations

Identification and determination of oestrogens in various biological materials in pregnancy.

1970 • 35 citations

Regulation and Inhibition of Steroid Sulfatase Activity in Breast Cancer^a

1996 • 33 citations

Estradiol Metabolism During Oral and Transdermal Estradiol Replacement Therapy in Postmenopausal Women

1998 • 33 citations

Estrogen binding sites on membranes from human laryngeal papilloma

1984 • 30 citations

METABOLISM OF CATECHOL ESTROGEN BY HUMAN ERYTHROCYTES

1977 • 30 citations

4-hydroxycatecholestrogen metabolism responses to exercise and training: Possible implications for menstrual cycle irregularities and breast cancer

1997 • 30 citations

Female sex hormones and the immune system.

1996 • 29 citations

Determination of 16 alpha‐hydroxyestrone by radioimmunoassay in systemic lupus erythematosus

1985 • 28 citations

Excretion of 2-Hydroxyestrone in Urine Throughout Human Pregnancies1

1975 • 28 citations

GAS CHROMATOGRAPHIC AND MASS SPECTROMETRIC STUDIES ON OESTROGENS IN BILE: PART I. PREGNANT WOMEN

1973 • 27 citations

Metabolic Clearance Rate and Conversion Ratios of [3H]2-Hydroxyestrone in Normal Men*

1982 • 26 citations

Cimetidine inhibits catechol estrogen metabolism in women

1991 • 25 citations

Laryngeal papillomas

1985 • 24 citations

Multiple Estrogen Function in Human Prostate Cancer Cells^a

1996 • 24 citations

Catechol Estrogen Formation in Placental and Fetal Tissues of Humans, Macaques, Rats and Rabbits

1981 • 24 citations

Estrogen Content and Metabolism in Human Breast Tumor Tissues and Cells

1996 • 23 citations

Effects of exogenous thyroxine on C-2 and C-16a hydroxylations of estradiol in humans

1990 • 23 citations

The Psychotropic Properties of Estrogens

1978 • 22 citations

Plasma 2-hydroxycatecholestrogen responses to acute submaximal and maximal exercise in untrained women

1997 • 20 citations

Effects of a training program on resting plasma 2-hydroxycatecholestrogen levels in eumenorrheic women

1997 • 20 citations

Metabolism of 2-Methoxyestrone in Normal Men*

1983 • 20 citations

Immunomodulatory Mechanisms Mediated by Sex Hormones in Rheumatoid Arthritis^a

1996 • 20 citations

Metabolism of 2-methoxy- and 4-methoxyoestrone in man in vivo

1977 • 19 citations

Estradiol Metabolism in Total Extrahepatic Biliary Obstruction

1970 • 19 citations

Measurement of urinary estrogen metabolites using a monoclonal enzyme-linked immunoassay kit: assay performance and feasibility for epidemiological studies.

1996 • 19 citations

Non-genomic effects of catecholestrogens in the in vitro rat uterine contraction

1995 • 19 citations

Identification of 2-hydroxyoestradiol and the pattern of catechol oestrogens in human pregnancy urine

1975 • 18 citations

Estrogen Biosynthesis in Adipose

1996 • 17 citations

Identification of 4-Hydroxyestriol in Pregnancy Urine*

1980 • 14 citations

Antioxidation Potential of Indole Compounds — Structure Activity Studies

1991 • 12 citations

Omeprazole Fails to Alter the Cytochrome P450-Dependent 2-Hydroxylation of Estradiol in Male Volunteers

1993 • 12 citations

Estrogen hydroxylase activity in the human placenta at term

1988 • 11 citations

Effect of serum albumin on estrogen metabolism in human cancer cell lines

1995 • 10 citations

The System Estradiol→Estrone; A Sex Difference in Oxidation of Estradiol in Man

1972 • 10 citations

Formation and metabolism of catecholestrogens in depressed patients

1990 • 9 citations

Do catechol estrogens participate in the initiation of labor?

1991 • 9 citations

Reversible Reproduction of the Abnormal Estradiol Metabolism of Biliary Obstruction by Administration of Norethandrolone¹

1970 • 7 citations

Gynäkologische Endokrinologie & [und] steriles Paar

1989 • 6 citations

Metabolism of 3H-estradiol in men with prostate cancer

1980 • 4 citations