Cimetidine inhibits catechol estrogen metabolism in women

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

1986 • 734 citations

Increased 2-Hydroxylation of Estradiol as a Possible Mechanism for the Anti-Estrogenic Effect of Cigarette Smoking

1986 • 665 citations

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

1989 • 643 citations

Hip Fracture and the Use of Estrogens in Postmenopausal Women

1988 • 627 citations

Does Calcium Supplementation Prevent Postmenopausal Bone Loss?

1987 • 528 citations

Biologic effects of transdermal estradiol

1987 • 467 citations

Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes.

1983 • 436 citations

Human liver microsomal steroid metabolism: Identification of the major microsomal steroid hormone 6β-hydroxylase cytochrome P-450 enzyme

1988 • 413 citations

The increase in urinary excretion of 6 beta‐hydroxycortisol as a marker of human hepatic cytochrome P450IIIA induction.

1989 • 334 citations

Antiestrogen action of 2-hydroxyestrone on MCF-7 human breast cancer cells.

1984 • 248 citations

A nomograph method for assessing body weight

1976 • 222 citations

Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons.

1989 • 221 citations

Cigarette Smoking and Levels of Adrenal Androgens in Postmenopausal Women

1988 • 211 citations

Pathophysiological Mechanisms of Estrogen Effect on Bone Metabolism. Dose-Response Relationships in Early Postmenopausal Women*

1982 • 208 citations

On the regulation of sex-hormone-binding globulin—A challenge of an old dogma and outlines of an alternative mechanism

1989 • 167 citations

Serum and Urinary Markers of Bone Remodeling: Assessment of Bone Turnover

1988 • 158 citations

Impact of Continuously Administered Catechol Estrogens on Uterine Growth and Luteinizing Hormone Secretion*

1979 • 146 citations

Effects of a Short Course of Estrogen on Mineral Metabolism in Postmenopausal Women*

1985 • 141 citations

Effects of Obesity on Estradiol Metabolism: Decreased Formation of Nonuterotropic Metabolites*

1983 • 134 citations

Imidazole derivatives—A new class of microsomal enzyme inhibitors

1972 • 130 citations

Alteration of Theophylline Clearance and Half-life by Cimetidine in Normal Volunteers

1981 • 123 citations

Aromatic Hydroxylation of Estrogens

1983 • 114 citations

Aging and drug interactions. II. Effect of phenytoin and smoking on the oxidation of theophylline and cortisol in healthy men.

1988 • 101 citations

Radiometric analysis of biological oxidations in man: sex differences in estradiol metabolism.

1980 • 91 citations

Obese young men have elevated plasma estrogen levels but obese premenopausal women do not

1981 • 86 citations

Effect of ketoconazole on hepatic oxidative drug metabolism

1985 • 86 citations

The Effects of Cimetidine on the Oxidative Metabolism of Estradiol

1989 • 81 citations

Opposite effects of estrogen and catecholestrogen on hormone-sensitive breast cancer cell growth and differentiation

1989 • 81 citations

Gynaecomastia associated with cimetidine.

1979 • 72 citations

Effects of cimetidine on caffeine disposition in smokers and nonsmokers

1982 • 70 citations

Sex hormone binding globulin and risk factors for breast cancer in a population of normal women who had never used exogenous sex hormones

1987 • 67 citations

Cancer occurrence in a cohort of patients treated with cimetidine.

1989 • 63 citations

Dose-dependent effect of cimetidine on phenytoin kinetics

1983 • 50 citations

The effects of H2-receptor antagonists and imidazole on testosterone hydroxylations in mouse liver microsomes.

1984 • 12 citations

The oxidative metabolism of estradiol: inhibition by cimetidine.

1989 • 5 citations

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