Acetyllysine-binding and function of bromodomain-containing proteins in chromatin

The language of covalent histone modifications

2000 • 8,260 citations

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

2001 • 2,768 citations

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

2001 • 2,746 citations

ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS

1964 • 2,410 citations

Phosphorylated CREB binds specifically to the nuclear protein CBP

1993 • 2,039 citations

Histone acetylation and transcriptional regulatory mechanisms

1998 • 1,793 citations

The CBP co-activator is a histone acetyltransferase

1996 • 1,773 citations

Acetylation of Histones and Transcription-Related Factors

2000 • 1,702 citations

Structure and ligand of a histone acetyltransferase bromodomain

1999 • 1,625 citations

Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation

1996 • 1,567 citations

Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300

1997 • 1,472 citations

2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

1994 • 1,472 citations

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

1996 • 1,457 citations

Nuclear protein CBP is a coactivator for the transcription factor CREB

1994 • 1,447 citations

Regulation of transcription by MAP kinase cascades

1996 • 1,330 citations

Steroid receptor coactivator-1 is a histone acetyltransferase

1997 • 1,245 citations

Roles of histone acetyltransferases and deacetylases in gene regulation

1998 • 1,207 citations

Histone acetylation and an epigenetic code

2000 • 1,164 citations

ALTERATION OF NUCLEOSOME STRUCTURE AS A MECHANISM OF TRANSCRIPTIONAL REGULATION

1998 • 1,124 citations

brahma: A regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2SWI2

1992 • 951 citations

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

1992 • 944 citations

Prediction of the Coding Sequences of Unidentified Human Genes. IX. The Complete Sequences of 100 New cDNA Clones from Brain Which Can Code for Large Proteins in vitro

1998 • 848 citations

Ordered Recruitment of Transcription and Chromatin Remodeling Factors to a Cell Cycle– and Developmentally Regulated Promoter

1999 • 703 citations

BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription

1993 • 668 citations

The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18.

1995 • 627 citations

A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor.

1993 • 598 citations

Chromatin disruption and modification

1999 • 537 citations

The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5p

2000 • 508 citations

Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2α subunit of NuRD

2001 • 504 citations

Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation

2000 • 415 citations

Histone Acetyltransferase Complexes Stabilize SWI/SNF Binding to Promoter Nucleosomes

2001 • 359 citations

CBP-induced stimulation of c-Fos activity is abrogated by E1A.

1995 • 342 citations

The many HATs of transcription coactivators

2000 • 342 citations

ACF consists of two subunits, Acf1 and ISWI, that function cooperatively in the ATP-dependent catalysis of chromatin assembly

1999 • 331 citations

MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)

1997 • 323 citations

The yeast SNF2/SWI2 protein has DNA-stimulated ATPase activity required for transcriptional activation.

1993 • 299 citations

Transcriptional Repression by RING Finger Protein TIF1 That Interacts with the KRAB Repressor Domain of KOX1

1996 • 277 citations

Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors.

1994 • 276 citations

An activity gel assay detects a single, catalytically active histone acetyltransferase subunit in Tetrahymena macronuclei.

1995 • 275 citations

Cell cycle-regulated histone acetylation required for expression of the yeast HO gene

1999 • 275 citations

ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation

2000 • 271 citations

MAP kinase-mediated signalling to nucleosomes and immediate-early gene induction

1999 • 226 citations

Chromatin-related properties of CBP fused to MLL generate a myelodysplastic-like syndrome that evolves into myeloid leukemia

2000 • 201 citations

Bromodomain factor 1 corresponds to a missing piece of yeast TFIID

2000 • 200 citations

The Gcn5 bromodomain co-ordinates nucleosome remodelling

2000 • 194 citations

The p250 subunit of native TATA box-binding factor TFIID is the cell-cycle regulatory protein CCG1

1993 • 185 citations

An essential Saccharomyces cerevisiae gene homologous to SNF2 encodes a helicase-related protein in a new family.

1992 • 173 citations

The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas

1999 • 170 citations

A Novel Human Gene,WSTF,Is Deleted in Williams Syndrome

1998 • 161 citations

TIF1γ, a novel member of the transcriptional intermediary factor 1 family

1999 • 161 citations

Transcription: Gene control by targeted histone acetylation

1998 • 153 citations

Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain

2000 • 152 citations

Regulation of gene expression by transcription factor acetylation

2000 • 147 citations

A Novel Family of Bromodomain Genes

2000 • 140 citations

Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases.

1993 • 139 citations

c-Myb acetylation at the carboxyl-terminal conserved domain by transcriptional co-activator p300

2000 • 127 citations

Histone acetylation: A possible mechanism for the inheritance of cell memory at mitosis

1997 • 121 citations

Repression of GCN5 Histone Acetyltransferase Activity via Bromodomain-Mediated Binding and Phosphorylation by the Ku–DNA-Dependent Protein Kinase Complex

1998 • 120 citations

Regulation of the c-fos promoter by the ternary complex factor Sap-1a and its coactivator CBP.

1996 • 120 citations

Histone H4 acetylation in Drosophila Frequency of acetylation at different sites defined by immunolabelling with site‐specific antibodies

1991 • 119 citations

Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex

1994 • 117 citations

The bromodomain of Gcn5p interacts in vitro with specific residues in the N terminus of histone H4 1 1Edited by T. Richmond

1999 • 110 citations

Differential Interaction of Nuclear Receptors with the Putative Human Transcriptional Coactivator hTIF1

1997 • 107 citations

Identification and Characterization of BRDT: A Testis-Specific Gene Related to the Bromodomain Genes RING3 andDrosophila fsh

1997 • 105 citations

brg1: A Putative Murine Homologue of the Drosophila brahma Gene, a Homeotic Gene Regulator

1994 • 104 citations

Histone acetylation and an epigenetic code

2000 • 104 citations

Drosophila 230-kD TFIID subunit, a functional homolog of the human cell cycle gene product, negatively regulates DNA binding of the TATA box-binding subunit of TFIID.

1993 • 97 citations

Histone H4 acetylation in human cells Frequency of acetylation at different sites defined by immunolabeling with site‐specific antibodies

1989 • 91 citations

A homologue of the Drosophila female sterile homeotic (fsh) gene in the class II region of the human MHC

1992 • 87 citations

The yeast BDF1 gene encodes a transcription factor involved in the expression of a broad class of genes including snRNAs

1994 • 85 citations

The Saccharomyces cerevisiae NPS1 gene, a novel CDC gene which encodes a 160 kDa nuclear protein involved in G2 phase control.

1992 • 75 citations

Preparation of Site-Specific Antibodies to Acetylated Histones

1999 • 70 citations

Identification and Characterization of BPTF, a Novel Bromodomain Transcription Factor

2000 • 62 citations

Induction-independent Recruitment of CREB-binding Protein to the c-fos Serum Response Element through Interactions between the Bromodomain and Elk-1

2001 • 54 citations

Molecular cloning of polybromo, a nuclear protein containing multiple domains including five bromodomains, a truncated HMG-box, and two repeats of a novel domain

1996 • 52 citations

BR140, a Novel Zinc-Finger Protein with Homology to the TAF250 Subunit of TFIID

1994 • 49 citations

Molecular characterization of Celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2

2000 • 41 citations

Phylogeny and structure of theRING3 gene

1996 • 39 citations

Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene

1997 • 36 citations

A Bromodomain Protein, MCAP, Associates with Mitotic Chromosomes and Affects G2-to-M Transition

2000 • 36 citations

A Novel Mutation Lacking the Bromodomain of the Transcriptional Coactivator p300 in the SiHa Cervical Carcinoma Cell Line

2001 • 34 citations

Isolation of cDNAs encoding chicken homologues of the yeast SNF2 and Drosophila Brahma proteins

1997 • 26 citations

Cloning and sequencing of a human cDNA encoding a putative transcription factor containing a bromodomain

1996 • 9 citations

XI. Yeast sequencing reports. DNA sequencing and analysis of a 24·7 kb segment encompassing centromereCEN11 ofSaccharomyces cerevisiae reveals nine previously unknown open reading frames

1992 • 9 citations

Phylogeny and structure of the RING3 gene

1996 • 3 citations