Encrypted morphogens of skeletogenesis

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Bone: Formation by Autoinduction

1965 • 5,498 citations

Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

1997 • 4,191 citations

Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

1997 • 4,168 citations

Novel Regulators of Bone Formation: Molecular Clones and Activities

1988 • 3,919 citations

Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member

1997 • 3,802 citations

Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development

1997 • 2,784 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.

1995 • 1,782 citations

The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4

1996 • 1,604 citations

Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia

1997 • 1,463 citations

Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage [published erratum appears in J Cell Biol 1995 Feb;128(4):following 713]

1994 • 1,442 citations

HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse Embryo

1995 • 1,380 citations

Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4

1996 • 1,126 citations

A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.

1995 • 1,118 citations

Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes

1994 • 1,114 citations

BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.

1995 • 1,021 citations

Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development

1993 • 908 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

Limb alterations in brachypodism mice due to mutations in a new member of the TGFβ-superfamily

1994 • 855 citations

Biochemical evidence that Patched is the Hedgehog receptor

1996 • 852 citations

Alternative Neural Crest Cell Fates Are Instructively Promoted by TGFβ Superfamily Members

1996 • 785 citations

Induction of epidermis and inhibition of neural fate by Bmp-4

1995 • 782 citations

Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus

1995 • 731 citations

MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

1996 • 710 citations

Bone morphogenetic proteins in development

2004 • 678 citations

A human Mad protein acting as a BMP-regulated transcriptional activator

1996 • 674 citations

THE HEALING OF SEGMENTAL BONE DEFECTS, INDUCED BY RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN (rhBMP-2): A RADIOGRAPHIC, HISTOLOGICAL, AND BIOMECHANICAL STUDY IN RATS

1993 • 653 citations

Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse

1991 • 646 citations

Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing

1996 • 629 citations

Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for Bone Morphogenetic Protein-2A (BMP-2A)

1990 • 616 citations

Human Type II Receptor for Bone Morphogenic Proteins (BMPs): Extension of the Two-Kinase Receptor Model to the BMPs

1995 • 602 citations

The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog Signal

1996 • 591 citations

Requirement for BMP Signaling in Interdigital Apoptosis and Scale Formation

1996 • 552 citations

Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing

1995 • 489 citations

The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGFβ superfamily

1992 • 483 citations

Evidence from normal expression and targeted misexpression that Bone Morphogenetic Protein-4 (Bmp-4) plays a role in mouse embryonic lung morphogenesis

1996 • 480 citations

Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb

1994 • 465 citations

Evidence for Involvement of Activin A and Bone Morphogenetic Protein 4 in Mammalian Mesoderm and Hematopoietic Development

1995 • 464 citations

Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo

1994 • 463 citations

Oocyte-specific expression of growth/differentiation factor-9.

1995 • 447 citations

Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development.

1989 • 440 citations

Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily

1996 • 432 citations

A human chondrodysplasia due to a mutation in a TGF-β superfamily member

1996 • 412 citations

Effect of recombinant human osteogenic protein-1 on healing of segmental defects in non-human primates.

1995 • 411 citations

Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern

1995 • 390 citations

The effect of recombinant human osteogenic protein-1 on healing of large segmental bone defects.

1994 • 384 citations

Immunolocalization and expression of bone morphogenetic proteins 2 and 4 in fracture healing

1995 • 374 citations

Fibrodysplasia ossificans progressiva. The clinical features and natural history of 34 patients

1982 • 362 citations

Overexpression of an Osteogenic Morphogen in Fibrodysplasia Ossificans Progressiva

1996 • 360 citations

Recombinant Human Bone Morphogenetic Protein-7 Induces Healing in a Canine Long-Bone Segmental Defect Model

1994 • 340 citations

The natural history of heterotopic ossification in patients who have fibrodysplasia ossificans progressiva. A study of forty-four patients.

1993 • 330 citations

Transient and localized expression of bone morphogenetic protein 4 messenger RNA during fracture healing

1994 • 329 citations

Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis.

1995 • 326 citations

Experimental spinal fusion with recombinant human bone morphogenetic protein-2.

1995 • 322 citations

GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines.

1993 • 318 citations

Characterization and relationship of dpp receptors encoded by the saxophone and thick veins genes in Drosophila

1994 • 317 citations

An absolute requirement for both the type II and type I receptors, punt and thick veins, for Dpp signaling in vivo

1995 • 312 citations

Bone Morphogenetic Protein-2

1996 • 311 citations

What do BMPs do in mammals? Clues from the mouse short-ear mutation

1994 • 300 citations

The Pericyte as a Possible Osteoblast Progenitor Cell

1992 • 295 citations

Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embryo.

1993 • 283 citations

The expression of cytokine activity by fracture callus

1995 • 282 citations

Experimental Spinal Fusion With Recombinant Human Bone Morphogenetic Protein-2

1995 • 276 citations

Drosophila Dpp signaling is mediated by the punt gene product: A dual ligand-binding type II receptor of the TGFβ receptor family

1995 • 275 citations

The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse.

1996 • 274 citations

Oocyte-specific expression of growth/differentiation factor-9

1995 • 273 citations

Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis.

1992 • 265 citations

The Xenopus Dorsalizing Factor noggin Ventralizes Drosophila Embryos by Preventing DPP from Activating Its Receptor

1996 • 242 citations

The histopathology of fibrodysplasia ossificans progressiva. An endochondral process.

1993 • 239 citations

Identification of a Human Type II Receptor for Bone Morphogenetic Protein-4 That Forms Differential Heteromeric Complexes with Bone Morphogenetic Protein Type I Receptors

1995 • 238 citations

Drosophila transforming growth factor beta superfamily proteins induce endochondral bone formation in mammals.

1993 • 227 citations

Use of Bone Morphogenetic Protein-2 in the Rabbit Ulnar Nonunion Model

1996 • 226 citations

Embryonic Patterning: To BMP or Not to BMP, That Is the Question

1997 • 221 citations

Journal of Bone and Mineral Research

1993 • 206 citations

Osteogenic Protein-1

1996 • 184 citations

Bone morphogenetic protein-9 binds to liver cells and stimulates proliferation.

1995 • 176 citations

Enhanced expression of type I receptors for bone morphogenetic proteins during bone formation

1995 • 174 citations

Bone Morphogenetic Protein: The Molecularization of Skeletal System Development

1997 • 170 citations

Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure.

1991 • 163 citations

Competition between noggin and bone morphogenetic protein 4 activities may regulate dorsalization during Xenopus development.

1995 • 161 citations

Animal studies of application of rhBMP-2 in maxillofacial reconstruction

1996 • 149 citations

On the Origin of Cells in Heterotopic Bone Formation

1975 • 149 citations

Anti-Dorsalizing Morphogenetic Protein is a novel TGF-β homolog expressed in the Spemann organizer

1995 • 145 citations

Identification of mammalian noggin and its expression in the adult nervous system

1995 • 135 citations

Genetic transmission of fibrodysplasia ossificans progressiva. Report of a family.

1993 • 127 citations

Genetic aspects of fibrodysplasia ossificans progressiva.

1982 • 123 citations

Evaluation of Human Bone Morphogenetic Protein 2 in a Canine Spinal Fusion Model

1994 • 119 citations

Bone morphogenetic protein in early fibromatous lesions of fibrodysplasia ossificans progressiva

1997 • 117 citations

Age- and Joint-Specific Risk of Initial Heterotopic Ossification in Patients Who Have Fibrodysplasia Ossificans Progressiva

1994 • 116 citations

Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6).

1993 • 115 citations

Fibrodysplasia ossificans progressiva: A clue from the fly?

1990 • 115 citations

Permanent heterotopic ossification at the injection site after diphtheria-tetanus-pertussis immunizations in children who have fibrodysplasia ossificans progressiva

1995 • 115 citations

A three generation family with fibrodysplasia ossificans progressiva.

1993 • 76 citations

Bone Morphogenetic Protein-12 and -13 Inhibit Terminal Differentiation of Myoblasts, but Do Not Induce Their Differentiation into Osteoblasts

1996 • 66 citations

Spinal deformity in patients who have fibrodysplasia ossificans progressiva.

1994 • 66 citations

Involvement of Ras/Raf/AP-1 in BMP-4 signaling during Xenopus embryonic development.

1996 • 63 citations

Expression of bone morphogenetic protein-6 messenger RNA in bovine growth plate chondrocytes of different size

1995 • 51 citations

cDNA Cloning and Genomic Structure of Human Bone Morphogenetic Protein-3b (BMP-3b)

1996 • 44 citations

Fibrodysplasia Ossificans Progressiva (FOP)

1997 • 32 citations

Transfilter Bone Induction by Chinese Hamster Ovary (CHO) Cells Transfected by DNA Encoding Bone Morphogenetic Protein-4

1994 • 31 citations

Periosteal and Intratumorous Bone Formation in Athymic Nude Mice by Chinese Hamster Ovary Tumors Expressing Murine Bone Morphogenetic Protein-4

1994 • 25 citations

Protein Builds Second Skeleton

1996 • 24 citations

Chromosomal Localization, Embryonic Expression, and Imprinting Tests for Bmp7 on Distal Mouse Chromosome 2

1995 • 16 citations

Abstracts From The Second International Symposium on Fibrodysplasia Ossificans Progressiva

1996 • 1 citations