From first to second generation antipsychotics

Negative Symptoms in Schizophrenia

1982 • 2,228 citations

Positron Emission Tomographic Analysis of Central D1 and D2 Dopamine Receptor Occupancy in Patients Treated With Classical Neuroleptics and Clozapine

1992 • 1,420 citations

Risperidone in the treatment of schizophrenia

1994 • 1,205 citations

Determinants of Medication Compliance in Schizophrenia: Empirical and Clinical Findings

1997 • 985 citations

Translating Research Into Practice: The Schizophrenia Patient Outcomes Research Team (PORT) Treatment Recommendations

1998 • 937 citations

EPPIC: An Evolving System of Early Detection and Optimal Management

1996 • 921 citations

Duration of psychosis and outcome in first-episode schizophrenia

1992 • 878 citations

Neuroleptics and the Natural Course of Schizophrenia

1991 • 777 citations

Multiple fixed doses of “Seroquel” (quetiapine) in patients with acute exacerbation of schizophrenia: A comparison with haloperidol and placebo

1997 • 756 citations

Patterns of Usual Care for Schizophrenia: Initial Results From the Schizophrenia Patient Outcomes Research Team (PORT) Client Survey

1998 • 628 citations

Neuroleptic sensitivity in patients with senile dementia of Lewy body type.

1992 • 609 citations

Significance of Neuroleptic Dose and Plasma Level in the Pharmacological Treatment of Psychoses

1988 • 554 citations

Neuroleptic Withdrawal in Schizophrenic Patients

1995 • 436 citations

Early Detection and Intervention With Schizophrenia: Rationale

1996 • 421 citations

Comparative Doses and Costs of Antipsychotic Medication

1976 • 417 citations

Optimal Dose of Neuroleptic in Acute Schizophrenia

1991 • 384 citations

Mechanisms of action of atypical antipsychotic drugs: a critical analysis

1996 • 315 citations

Controlled, dose-response study of sertindole and haloperidol in the treatment of schizophrenia. Sertindole Study Group

1997 • 311 citations

Relapse and Rehospitalization During Maintenance Treatment of Schizophrenia

1997 • 303 citations

Negative symptoms: a path analytic approach to a double-blind, placebo- and haloperidol-controlled clinical trial with olanzapine

1997 • 302 citations

Subjective Response to Neuroleptics in Schizophrenia

1993 • 280 citations

Mortality in schizophrenia

1998 • 270 citations

Schizophrenia

1996 • 270 citations

Quality of life measurement in schizophrenia: reconciling the quest for subjectivity with the question of reliability

1998 • 266 citations

Dopamine blockade and clinical response: evidence for two biological subgroups of schizophrenia

1989 • 261 citations

High levels of dopamine D2 receptor occupancy with low-dose haloperidol treatment: a PET study

1996 • 257 citations

Clinical Risk Following Abrupt and Gradual Withdrawal of Maintenance Neuroleptic Treatment

1997 • 245 citations

Evaluation of Treatment-Resistant Schizophrenia

1997 • 241 citations

Costs of schizophrenia

1997 • 220 citations

Neuroleptic Withdrawal in Schizophrenic Patients

1995 • 200 citations

Continuous versus targeted medication in schizophrenic outpatients: outcome results [published erratum appears in Am J Psychiatry 1991 Jun;148(6):819]

1990 • 197 citations

A Controlled Dose Comparison of Haloperidol in Newly Admitted Schizophrenic Patients

1990 • 187 citations

THE NORTHWICK PARK "FUNCTIONAL" PSYCHOSIS STUDY: DIAGNOSIS AND TREATMENT RESPONSE

1988 • 186 citations

Conventional Antipsychotic Medications for Schizophrenia

1995 • 185 citations

Trial of brief intermittent neuroleptic prophylaxis for selected schizophrenic outpatients: clinical and social outcome at two years.

1990 • 174 citations

Time course of D2-dopamine receptor occupancy examined by PET after single oral doses of haloperidol

1992 • 160 citations

Course of treatment response in first-episode and chronic schizophrenia

1996 • 155 citations

Haloperidol plasma levels and clinical response: a therapeutic window relationship

1992 • 150 citations

D2 dopamine receptor occupancy during low-dose treatment with haloperidol decanoate

1995 • 148 citations

Treatment of schizophrenia: A clinical and preclinical evaluation of neuroleptic drugs

1993 • 132 citations

Electrocardiographic changes in patients receiving neuroleptic medication

1996 • 130 citations

Cognitive Function in Schizophrenia— Do Neuroleptics Make a Difference?

1997 • 128 citations

Treatment of neuroleptic-resistant schizophrenic relapse.

1993 • 127 citations

The relationship between D 2 receptor occupancy and plasma levels on low dose oral haloperidol: a PET study

1997 • 126 citations

Binding of Antipsychotic Drugs to Cortical 5-HT_2A Receptors: A PET Study of Chlorpromazine, Clozapine, and Amisulpride in Schizophrenic Patients

1998 • 125 citations

Olanzapine Versus Placebo and Haloperidol: Quality of Life and Efficacy Results of the North American Double-Blind Trial

1998 • 120 citations

Haloperidol Blood Levels and Clinical Effects

1992 • 112 citations

Dosage of Haloperidol for Schizophrenia

1991 • 110 citations

Psychopathology, executive (frontal) and general cognitive impairment in relation to duration of initially untreated versus subsequently treated psychosis in chronic schizophrenia

1997 • 108 citations

Long-term morbidity associated with delayed treatment of first admission schizophrenic patients: a re-analysis of the Camarillo State Hospital data

1997 • 107 citations

The Evaluation and Treatment of First-episode Psychosis

1997 • 104 citations

Antipsychotic medication effects on neuropsychological functions.

1992 • 102 citations

Fluphenazine Dose, Clinical Response, and Extrapyramidal Symptoms During Acute Treatment

1990 • 99 citations

PET Evidence That Loxapine Is an Equipotent Blocker of 5-HT₂and D₂Receptors: Implications for the Therapeutics of Schizophrenia

1997 • 96 citations

Drug treatment of the negative symptoms of schizophrenia

1998 • 93 citations

Increased morbidity and mortality related to asthma among asthmatic patients who use major tranquillisers

1996 • 85 citations

High central D2-dopamine receptor occupancy as assessed with positron emission tomography in medicated but therapy-resistant schizophrenic patients

1991 • 77 citations

Bodyweight Gain Induced by Psychotropic Drugs

1998 • 77 citations

Post-Mortem Antipsychotic Drug Concentrations and Unexplained Deaths

1994 • 75 citations

Neuroleptic Intolerance

1997 • 75 citations

Negative symptoms in schizophrenia: considerations for clinical trials

1994 • 74 citations

A comparison of patients' and prescribers' beliefs about neuroleptic side‐effects: prevalence, distress and causation

1998 • 69 citations

Evaluating outcomes of treatments for persons with psychotic disorders.

1996 • 65 citations

Time course of antipsychotic effects of neuroleptic drugs

1989 • 64 citations

Advances in the neurobiology of schizophrenia

1995 • 62 citations

Hospital use of antipsychotic agents in 1989 and 1993: stable dosing with decreased length of stay

1995 • 60 citations

New Antipsychotics

1996 • 58 citations

Plasma Haloperidol Levels and Clinical Effects in Schizophrenia and Schizoaffective Disorder

1995 • 55 citations

Review of Adverse Effects of Psychotropic Drugs.

1995 • 53 citations

Further evidence of a dose-response threshold for haloperidol in psychosis

1995 • 52 citations

Delayed Normalization of Central D2 Dopamine Receptor Availability After Discontinuation of Haloperidol Decanoate

1997 • 50 citations

Haloperidol Plasma Levels and Dose Optimization

1998 • 47 citations

Pharmacokinetics of long-acting injectable neuroleptic drugs: clinical implications

1989 • 46 citations

Advances in the neurobiology of schizophrenia

1996 • 45 citations

The new antipsychotics, and their potential for early intervention in schizophrenia

1997 • 42 citations

Optimal drug and behavior therapy for treatment-refractory schizophrenic patients

1994 • 40 citations

Early antipsychotic response to resumption of neuroleptics in drug-free chronic schizophrenic patients

1992 • 38 citations

What Makes an Antipsychotic ‘Atypical’?

1997 • 37 citations

Early response to haloperidol treatment in chronic schizophrenia

1993 • 37 citations

Antipsychotic-Induced Extrapyramidal Symptoms

1996 • 35 citations

Drug treatment of schizophrenia: myths and realities

1994 • 32 citations

Cognitive Functioning in Schizophrenia

1996 • 31 citations

The Australian multicentre double‐blind comparative study of remoxipride and thioridazine in schizophrenia

1994 • 29 citations

Schizophrenia: problems in clinical practice

1993 • 20 citations

Adverse Effects of Psychotropic Drugs

1994 • 15 citations

What Makes an Antipsychotic ‘Atypical’?

1997 • 15 citations

Statistical differentiation between direct and indirect effects of neuroleptics on negative symptoms

1997 • 14 citations

Effect of varying haloperidol plasma levels on negative symptoms in schizophrenia and schizoaffective disorder.

1996 • 13 citations

Drug-responsive symptoms during early neuroleptic treatment

1992 • 13 citations

Duration of initially untreated psychosis predicts selectively the ‘psychomotor poverty’ factor in schizophrenia

1998 • 3 citations

Deleted Work

1955 • 0 citations