Use of Radioligands in the Identification, Classification, and Study of Adenosine Receptors

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY

1963 • 10,322 citations

Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity

1962 • 6,970 citations

Handbook of Psychopharmacology

1988 • 2,778 citations

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS

1979 • 1,370 citations

Subclasses of external adenosine receptors.

1980 • 1,087 citations

Handbook of Psychopharmacology

1978 • 1,034 citations

The effect of adenosine and adenine nucleotides on the cyclic adenosine 3', 5'-phosphate content of guinea pig cerebral cortex slices.

1970 • 860 citations

A new method for receptor autoradiography: [3H]Opioid receptors in rat brain

1979 • 797 citations

Two distinct adenosine-sensitive sites on adenylate cyclase.

1977 • 574 citations

Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes.

1982 • 573 citations

Quantitative analysis of drug-receptor interactions: I. Determination of kinetic and equilibrium properties

1981 • 557 citations

Adenosine receptors in brain membranes: binding of N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthine.

1980 • 554 citations

A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data.

1980 • 545 citations

Insulin Receptors in the Liver: Specific Binding of [ ¹²⁵ I]Insulin to the Plasma Membrane and Its Relation to Insulin Bioactivity

1971 • 494 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 473 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 469 citations

Regulatory Function of Adenosine

1983 • 454 citations

Insulin-Receptor Interactions in Adipose Tissue Cells: Direct Measurement and Properties

1971 • 443 citations

Are methylxanthine effects due to antagonism of endogenous adenosine?

1979 • 419 citations

Simultaneous determination of beta-1 and beta-2-adrenergic receptors in tissues containing both receptor subtypes.

1979 • 418 citations

Autoradiographic localization of adenosine receptors in rat brain using [3H]cyclohexyladenosine

1982 • 417 citations

PREPARATION AND CHARACTERIZATION OF A PLASMA MEMBRANE FRACTION FROM ISOLATED FAT CELLS

1970 • 402 citations

ACTH Receptors in the Adrenal: Specific Binding of ACTH- ¹²⁵ I and Its Relation to Adenyl Cyclase

1970 • 303 citations

Characterization of adenosine receptors in rat brain by (?)[3H]N6-phenylisopropyladenosine

1980 • 296 citations

Adenosine analogs inhibit adipocyte adenylate cyclase by a GTP-dependent process: basis for actions of adenosine and methylxanthines on cyclic AMP production and lipolysis.

1978 • 253 citations

Receptor Binding Studies in Adrenergic Pharmacology

1978 • 240 citations

Xanthine derivatives as adenosine receptor antagonists

1982 • 239 citations

Quantitative resolution of beta-adrenergic receptor subtypes by selective ligand binding: application of a computerized model fitting technique.

1979 • 220 citations

Adipose Tissue. Regulation and Metabolic Functions.

1971 • 217 citations

The Synaptosome

1969 • 197 citations

Guanine nucleotide and cation regulation of the binding of [3H]cyclohexyladenosine and [3H]diethylphenylxanthine to adenosine A1 receptors in brain membranes.

1982 • 169 citations

Receptor binding studies in adrenergic pharmacology

1979 • 169 citations

Effects of adenosine on levels of adenosine cyclic 3',5'-monophosphate in human blood platelets in relation to adenosine incorporation and platelet aggregation.

1975 • 168 citations

Estimation of hormone receptor affinity by competitive displacement of labeled ligand: Effect of concentration of receptor and of labeled ligand

1975 • 166 citations

Adipocyte beta-adrenergic receptors. Identification and subcellular localization by (-)-[3H]dihydroalprenolol binding.

1976 • 164 citations

Adenosine receptor binding: structure-activity analysis generates extremely potent xanthine antagonists.

1983 • 164 citations

Two affinity states of Ri adenosine receptors in brain membranes. Analysis of guanine nucleotide and temperature effects on radioligand binding.

1984 • 164 citations

Agonist-specific effects of guanine nucleotides on alpha-adrenergic receptors in human platelets.

1979 • 155 citations

Biochemical characterization of putative central purinergic receptors by using 2-chloro[3H]adenosine, a stable analog of adenosine.

1980 • 155 citations

Coexistence of beta1 and beta2 adrenoceptors in mammalian lung: evidence from direct binding studies.

1978 • 153 citations

Adenosine antagonism by purines, pteridines and benzopteridines in human fibroblasts

1981 • 137 citations

Activation and inhibition of blood platelet adenylate cyclase by adenosine or by 2-chloroadenosine

1972 • 127 citations

Agonist and antagonist affinities for inhibitory adenosine receptors are reciprocally affected by 5'-guanylylimidodiphosphate or N-ethylmaleimide.

1983 • 119 citations

Adenosine receptors in fat cells. Identification by (-)-N6-[3H]phenylisopropyladenosine binding.

1981 • 118 citations

Autoradiographic visualization of rat brain adenosine receptors using N6-cyclohexyl [3H]adenosine

1981 • 118 citations

Heterogeneity of adenosine A1 receptor binding in brain tissue.

1982 • 115 citations

Membrane Receptors for Polypeptide Hormones

1975 • 114 citations

The dextro and levorotatory isomers of N-phenylisopropyladenosine: Stereospecific effects on cyclic AMP-formation and evoked synaptic responses in brain slices

1979 • 106 citations

Ra Adenosine receptors in human platelets

1984 • 102 citations

Opiate Receptor Mechanisms

1975 • 102 citations

Stereospecificity in some central and circulatory effects of phenylisopropyl-adenosine (PIA).

1975 • 99 citations

Fluorescence histochemistry indicates damage of striatal dopamine nerve terminals in rats after multiple doses of methamphetamine

1981 • 94 citations

Characterization of adenosine receptors in brain using N6 cyclohexyl [3H]adenosine

1982 • 91 citations

Solubilized Adenosine Receptors in the Brain: Regulation of Guanine Nucleotides

1982 • 89 citations

Blood Platelet Receptors for ADP and for Adenosine

1981 • 74 citations

Specific binding of 2-[³H]chloroadenosine to rat brain cortical membranes

1980 • 69 citations

Adenosine as a Regulator of Adenylate Cyclase

1981 • 61 citations

Characterization of [3H]adenosine binding to fat cell membranes.

1978 • 60 citations

Specific binding of 3H-adenosine to rat brain membranes

1979 • 57 citations

Functional identification of adenylate cyclase-coupled adenosine receptors in rat brain microvessels

1982 • 57 citations

Adenosine receptors in rat testes: Labeling with 3Hcyclohexyladenosine

1981 • 52 citations

Adenosine receptor agonists: Binding and adenylate cyclase stimulation in rat liver plasma membranes

1982 • 50 citations

[125I] N6-p-hydroxyphenylisopropyladenosine, a new ligand for Ri adenosine receptors

1982 • 45 citations

Guanine nucleotide and cation regulation of radioligand binding to R i adenosine receptors of rat fat cells

1984 • 44 citations

Evidence against adenylate cyclase-coupled adenosine receptors in the guinea pig heart

1981 • 43 citations

Effects of N-ethylmaleimide on adenosine receptors of rat fat cells and human platelets

1984 • 42 citations

The binding of [3H]adenosine to synaptosomal and other preparations from the mammalian brain

1981 • 39 citations

Binding characteristics of an adenosine receptor in human placenta.

1983 • 35 citations

Adenosine receptors in rat brain membranes: Characterization of high affinity binding of [3H]-2-chloroadenosine

1982 • 28 citations

High affinity binding of 2-chloroadenosine to rat brain synaptic membranes

1980 • 27 citations

Methods in membrane biology, vol. 6

1976 • 23 citations

Labelling of Ri adenosine receptors in rat fat cell membranes with (?)-[125iodo]N6-hydroxyphenylisopropyladenosine

1984 • 22 citations

General Aspects of Binding of Ligands to Adenosine Receptors

1983 • 21 citations

Binding of 2′,5′-dideoxyadenosine to brain membranes

1982 • 19 citations

Radioiodination of p-hydroxyphenylisopropyladenosine: development of a new ligand for adenosine receptors

1982 • 19 citations

Interaction of the benzodiazepine antagonists, CGS 8216 and Ro 15-1788, with central adenosine A-1 receptors.

1982 • 16 citations

Inhibitors of lipolysis: potency and mode of action of - and -adrenolytics, methoxamine derivatives, prostaglandin E 1 and phenylisopropyl adenosine.

1970 • 16 citations

Application of the miniature ultracentrifuge in receptor-binding assays

1979 • 14 citations

Autoradiographic demonstration of peripheral adenosine binding sites using [3H]NECA

1983 • 13 citations

Characterization of [<sup>3</sup>H]-Adenosine Binding to Media Membranes of Hog Carotid Arteries

1982 • 13 citations

A simple and rapid assay for measuring radiolabeled ligand binding to purified plasma membranes

1983 • 12 citations

[Inhibition of induced thrombocyte aggregation by adenosine and adenosine derivatives. 2. Correlation between inhibition of aggregation and peripheral vasodilatation].

1970 • 5 citations

GABA dehydrogenase activity in rat brain

1982 • 1 citations

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