Risk for subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep-vein thrombosis

Mutation in blood coagulation factor V associated with resistance to activated protein C

1994 • 3,871 citations

A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis

1996 • 3,124 citations

The Long-Term Clinical Course of Acute Deep Venous Thrombosis

1996 • 2,090 citations

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.

1993 • 1,997 citations

The Management of Thrombosis in the Antiphospholipid-Antibody Syndrome

1995 • 1,467 citations

Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study

1993 • 1,283 citations

Resistance to Activated Protein C as a Basis for Venous Thrombosis

1994 • 1,148 citations

A Comparison of Three Months of Anticoagulation with Extended Anticoagulation for a First Episode of Idiopathic Venous Thromboembolism

1999 • 1,076 citations

A Comparison of Six Weeks with Six Months of Oral Anticoagulant Therapy after a First Episode of Venous Thromboembolism

1995 • 950 citations

Accuracy of clinical assessment of deep-vein thrombosis

1995 • 762 citations

The Duration of Oral Anticoagulant Therapy after a Second Episode of Venous Thromboembolism

1997 • 618 citations

Inherited Thrombophilia: Part 1

1996 • 600 citations

Comparison of subcutaneous low-molecular-weight heparin with intravenous standard heparin in proximal deep-vein thrombosis

1992 • 599 citations

Anticardiolipin Antibodies Predict Early Recurrence of Thromboembolism and Death Among Patients with Venous Thromboembolism Following Anticoagulant Therapy

1998 • 510 citations

The Risk of Recurrent Deep Venous Thrombosis among Heterozygous Carriers of Both Factor V Leiden and the G20210A Prothrombin Mutation

1999 • 483 citations

Inherited thrombophilia: pathogenesis, clinical syndromes, and management [see comments]

1996 • 438 citations

Anticoagulant protein C pathway defective in majority of thrombophilic patients [see comments]

1993 • 411 citations

The Risk of Recurrent Venous Thromboembolism in Patients with an Arg⁵⁰⁶→Gln Mutation in the Gene for Factor V (Factor V Leiden)

1997 • 380 citations

Is hyperhomocysteinaemia a risk factor for recurrent venous thrombosis?

1995 • 374 citations

Anticoagulant protein C pathway defective in majority of thrombophilic patients [see comments]

1993 • 337 citations

Distribution of Thrombosis in Patients With Symptomatic Deep Vein Thrombosis

1993 • 304 citations

Inherited Thrombophilia*: Part 2

1996 • 293 citations

G20210A Mutation in Prothrombin Gene and Risk of Myocardial Infarction, Stroke, and Venous Thrombosis in a Large Cohort of US Men

1999 • 259 citations

The 20210 A Allele of the Prothrombin Gene Is a Common Risk Factor among Swedish Outpatients with Verified Deep Venous Thrombosis

1997 • 255 citations

Factor V Leiden and Risks of Recurrent Idiopathic Venous Thromboembolism

1995 • 251 citations

Increased Risk for Venous Thrombosis in Carriers of the Prothrombin G→A^20210 Gene Variant

1998 • 240 citations

Hyperhomocysteinemia is a risk factor of recurrent venous thromboembolism.

1998 • 225 citations

Deep-vein thrombosis

1999 • 220 citations

The Risk of Recurrent Venous Thromboembolism in Carriers and Non-carriers of the G1691A Allele in the Coagulation Factor V Gene and the G20210A Allele in the Prothrombin Gene

1999 • 217 citations

The Risk of Recurrent Venous Thromboembolism in Patients with and without Factor V Leiden

1997 • 206 citations

Co-inheritance of the 20210A Allele of the Prothrombin Gene Increases the Risk of Thrombosis in Subjects with Familial Thrombophilia

1997 • 177 citations

Prevalence of the Prothrombin Gene Variant (nt20210A) in Venous Thrombosis and Arterial Disease

1997 • 175 citations

Risk of venous thromboembolism associated with a G to A transition at position 20210 in the 3′‐untranslated region of the prothrombin gene

1997 • 160 citations

Prevalence of 20210 A Allele of the Prothrombin Gene in Venous Thromboembolism Patients

1998 • 136 citations

The Risk of Early Recurrent Venous Thromboembolism after Oral Anticoagulant Therapy in Patients with the G20210A Transition in the Prothrombin Gene

1999 • 135 citations

Recurrence of venous thromboembolism in patients with familial thrombophilia

1997 • 134 citations

Coexistence of Factor V Leiden and Factor II A20210 Mutations and Recurrent Venous Thromboembolism

1999 • 118 citations

Probability of Recurrence of Thrombosis in Patients with and without Factor V Leiden

1996 • 92 citations

Recurrence of Venous Thromboembolism in Patients With Familial Thrombophilia

1997 • 82 citations

Is the Prevalence of the Factor V Leiden Mutation in Patients with Pulmonary Embolism and Deep Vein Thrombosis Really Different?

1999 • 46 citations

Recurrent Deep Vein Thrombosis and Two Coagulation Factor Gene Mutations: Quo Vadis?

1999 • 25 citations