Antigen- and ionophore-induced signal transduction in rat basophilic leukemia cells involves protein tyrosine phosphorylation.

Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

1977 • 5,640 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

The Receptor with High Affinity for Immunoglobulin E

1986 • 540 citations

Tyrphostins Inhibit Epidermal Growth Factor (EGF)-Receptor Tyrosine Kinase Activity in Living Cells and EGF-Stimulated Cell Proliferation

1989 • 286 citations

Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release.

1990 • 234 citations

The calcium signal and phosphatidylinositol breakdown in 2H3 cells.

1984 • 214 citations

Protein kinase C regulation of the receptor-coupled calcium signal in histamine-secreting rat basophilic leukaemia cells

1985 • 186 citations

Synergistic action of protein kinase C and calcium for histamine release from rat peritoneal mast cells

1984 • 179 citations

Direct demonstration of increased intracellular concentration of free calcium as measured by quin-2 in stimulated rat peritoneal mast cell.

1984 • 118 citations

Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells

1991 • 117 citations

Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products.

1988 • 113 citations

A combination of hydrogen peroxide and vanadate concomitantly stimulates protein tyrosine phosphorylation and polyphosphoinositide breakdown in different cell lines

1990 • 106 citations

Effects of ADP-ribosylation of GTP-binding protein by pertussis toxin on immunoglobulin E-dependent and -independent histamine release from mast cells and basophils.

1987 • 104 citations

Membrane Phosphoinositide-Activated Signals in Mast Cells and Basophils1

2015 • 91 citations

Synergistic signals in the mechanism of antigen-induced exocytosis in 2H3 cells: evidence for an unidentified signal required for histamine release.

1987 • 90 citations

The kinetics of phosphoinositide hydrolysis in rat basophilic leukemia (RBL-2H3) cells varies with the type of IgE receptor cross-linking agent used.

1987 • 79 citations

Studies of protein kinase C in the rat basophilic leukemia (RBL-2H3) cell reveal that antigen-induced signals are not mimicked by the actions of phorbol myristate acetate and Ca2+ ionophore.

1989 • 71 citations

Translocation of protein kinase C in rat basophilic leukemic cells induced by phorbol ester or by aggregation of IgE receptors.

1988 • 69 citations

Release of histamine from human leukocytes stimulated with the tumor-promoting phorbol diesters. II. Interaction with other stimuli.

1982 • 58 citations

The rise in concentration of free Ca2+ and of pH provides sequential, synergistic signals for secretion in antigen-stimulated rat basophilic leukemia (RBL-2H3) cells.

1989 • 50 citations

The receptor for immunoglobulin E: Examination for kinase activity and as a substrate for kinases

1986 • 39 citations