Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate.

A Comparative Study of the Peroxidase-antiperoxidase Method and an Avidin-Biotin Complex Method for Studying Polypeptide Hormones with Radioimmunoassay Antibodies

1981 • 1,664 citations

Transferrin receptor on endothelium of brain capillaries

1984 • 1,008 citations

Receptor‐mediated transcytosis of transferrin across the blood‐brain barrier

1987 • 523 citations

Capillary Depletion Method for Quantification of Blood–Brain Barrier Transport of Circulating Peptides and Plasma Proteins

1990 • 454 citations

Human Blood—Brain Barrier Insulin Receptor

1985 • 386 citations

Anti-transferrin receptor antibody and antibody-drug conjugates cross the blood-brain barrier.

1991 • 385 citations

Blood-brain barrier transcytosis of insulin in developing rabbits

1987 • 348 citations

Human blood-brain barrier transferrin receptor

1987 • 347 citations

Macromolecular permeability across the blood-nerve and blood-brain barriers.

1994 • 343 citations

Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo.

1991 • 323 citations

Blood-Brain Barrier Penetration and in Vivo Activity of an NGF Conjugate

1993 • 316 citations

Absorptive-mediated endocytosis of cationized albumin and a beta-endorphin-cationized albumin chimeric peptide by isolated brain capillaries. Model system of blood-brain barrier transport.

1987 • 314 citations

Peptide Drug Delivery to the Brain

1992 • 309 citations

Morphology of blood-brain interfaces

1977 • 300 citations

Relationship between plasma and cerebrospinal fluid insulin levels of dogs.

1977 • 216 citations

Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor

1986 • 203 citations

Pharmacologic effects in vivo in brain by vector-mediated peptide drug delivery.

1993 • 153 citations

Analysis of lymphopoietic stem cells with a monoclonal antibody to the rat transferrin receptor.

1985 • 121 citations

Quantitative Autoradiographic Evidence for Insulin Receptors in the Choroid Plexus of the Rat Brain

1986 • 98 citations

Cross-linking of a B25 azidophenylalanine insulin derivative to the carboxyl-terminal region of the alpha-subunit of the insulin receptor. Identification of a new insulin-binding domain in the insulin receptor.

1994 • 90 citations

Biotin delivery to brain with a covalent conjugate of avidin and a monoclonal antibody to the transferrin receptor.

1992 • 79 citations

Identification of epitopes on the human insulin receptor reacting with rabbit polyclonal antisera and mouse monoclonal antibodies.

1990 • 78 citations

THE RHESUS MONKEY

1982 • 67 citations

Monoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts.

1989 • 63 citations

Use of neutral avidin improves pharmacokinetics and brain delivery of biotin bound to an avidin-monoclonal antibody conjugate.

1994 • 57 citations

Internalization of the human insulin receptor. The insulin-independent pathway.

1992 • 54 citations

Human brain microvascular DR‐antigen

1989 • 48 citations

Pharmacokinetics and saturable blood-brain barrier transport of biotin bound to a conjugate of avidin and a monoclonal antibody to the transferrin receptor.

1994 • 41 citations

QUANTITATIVE ANATOMY OF THE CEREBRAL VASCULAR BED WITH ESPECIAL EMPHASIS ON HOMOGENEITY AND INHOMOGENEITY IN SMALL PARTS OF THE GRAY AND WHITE MATTER

2009 • 40 citations

Transport of recombinant CD4 through the rat blood-brain barrier in vivo.

1992 • 22 citations

Deletion of residues 485-599 from the human insulin receptor abolishes antireceptor antibody binding and influences tyrosine kinase activation.

1994 • 11 citations

Ultrastructural study on the interaction of insulinalbumin-gold complex with mouse brain microvascular endothelial cells

1994 • 7 citations