Changes in Human Mucosal γδ T Cell Repertoire and Function Associated with the Disease Process in Inflammatory Bowel Disease

Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5.

1996 • 1,227 citations

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

1994 • 1,129 citations

Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)

1995 • 965 citations

Gamma/Delta Cells

1993 • 819 citations

Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice

1993 • 732 citations

Modulation of Epithelial Cell Growth by Intraepithelial γδ T Cells

1994 • 644 citations

Cytokines in intestinal inflammation: Pathophysiological and clinical considerations

1994 • 607 citations

Specificity and function of T cells bearing γδ receptors

1988 • 570 citations

Human lymphocytes bearing T cell receptor gamma/delta are phenotypically diverse and evenly distributed throughout the lymphoid system.

1989 • 547 citations

Human γδ+ T cells respond to mycobacterial heat-shock protein

1989 • 417 citations

Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine.

1988 • 404 citations

Isolation and functional characterization of human intestinal mucosal lymphoid cells.

1977 • 403 citations

A protective role of gamma/delta T cells in primary infection with Listeria monocytogenes in mice.

1992 • 393 citations

Roles of alphabeta and gammadelta T Cell Subsets in Viral Immunity

1992 • 350 citations

Collagen content and types in the intestinal strictures of Crohn's disease

1988 • 321 citations

Intraepithelial T Cells of the TcRγ/δ⁺CD8⁻ and Vδ1/Jδ1⁺ Phenotypes are Increased in Coeliac Disease

1989 • 311 citations

Intestinal lymphocyte subpopulations in inflammatory bowel disease: an analysis by immunohistological and cell isolation techniques.

1984 • 273 citations

A major fraction of human intraepithelial lymphocytes simultaneously expresses the γ/δ T cell receptor, the CD8 accessory molecule and preferentially uses the V_δ1 gene segment

1991 • 261 citations

Interferon gamma inhibits apoptotic cell death in B cell chronic lymphocytic leukemia.

1993 • 258 citations

Expression of disulfide‐linked and non‐disulfide‐linked forms of the T cell receptor γ/δ heterodimer in human intestinal intraepithelial lymphocytes

1989 • 248 citations

T lymphocytes from healthy individuals with specificity to self-epitopes shared by the mycobacterial and human 65-kilodalton heat shock protein.

1989 • 237 citations

Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis

1992 • 220 citations

Gamma delta T cells contribute to immunity against the liver stages of malaria in alpha beta T-cell-deficient mice.

1994 • 207 citations

Chronic intestinal inflammation: An unexpected outcome in cytokine or T cell receptor mutant mice

1993 • 193 citations

Increased collagen type III synthesis by fibroblasts isolated from strictures of patients with Crohn's disease

1992 • 190 citations

Biology of the Human γ T‐Cell Receptor

1991 • 185 citations

Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway.

1995 • 182 citations

Spontaneous release of interferon gamma by intestinal lamina propria lymphocytes in Crohn's disease. Kinetics of in vitro response to interferon gamma inducers.

1991 • 171 citations

Increased concentrations of interleukin 1 beta, interleukin-2, and soluble interleukin-2 receptors in endoscopical mucosal biopsy specimens with active inflammatory bowel disease.

1992 • 169 citations

Distinct molecular forms of human T cell receptor gamma/delta detected on viable T cells by a monoclonal antibody.

1988 • 161 citations

Activation of cytokine genes in T cells during primary and secondary murine influenza pneumonia.

1993 • 150 citations

Triggered human mucosal T cells release tumour necrosis factor-alpha and interferon-gamma which kill human colonic epithelial cells

1991 • 149 citations

Induction of murine peritoneal gamma/delta T cells and their role in resistance to bacterial infection.

1993 • 144 citations

Disease-specific changes in gammadelta T cell repertoire and function in patients with pulmonary tuberculosis.

1996 • 140 citations

The immunologic basis of inflammatory bowel disease

1986 • 140 citations

Proliferative responses of human intraepithelial lymphocytes to various T-cell stimuli

1989 • 138 citations

Gamma/delta T cells and the diagnosis of coeliac disease

1991 • 133 citations

Inflammatory bowel disease: From bench to bedside

1994 • 124 citations

CDR3-independent gamma delta V delta 1+ T cell expansion in the peripheral blood of HIV-infected persons.

1995 • 120 citations

A role for gamma delta + T cells during experimental infection of mice with Leishmania major.

1993 • 104 citations

Characteristics of isolated intestinal mucosal lymphoid cells in inflammatory bowel disease

1979 • 104 citations

Activation and signaling status of human lamina propria T lymphocytes

1991 • 102 citations

The V delta 1 T cell receptor repertoire in human small intestine and colon.

1994 • 101 citations

Developmentally regulated fetal thymic and extrathymic T-cell receptor gamma delta gene expression.

1990 • 99 citations

Differential responsiveness to CD3‐Ti vs. CD2‐dependent activation of human intestinal T lymphocytes

1990 • 97 citations

Extrathymic origin of human gamma delta T cells during fetal development.

1996 • 97 citations

Gamma delta T cell receptor-positive cells of the human gastrointestinal mucosa: occurrence and V region gene expression in Heliobacter pylori-associated gastritis, coeliac disease and inflammatory bowel disease.

1991 • 92 citations

Regulated expression and structure of T cell receptor gamma/delta transcripts in human thymic ontogeny.

1991 • 82 citations

Immunohistochemical characterization, distribution, and ultrastructure of lymphocytes bearing T-cell receptor γ/δ in inflammatory bowel disease

1991 • 79 citations

Continuous in vivo activation and transient hyporesponsiveness to TcR/CD3 triggering of human gut lamina propria lymphocytes

1993 • 78 citations

Fibroblasts mediate T cell survival: a proposed mechanism for retention of primed T cells.

1990 • 76 citations

Tγδ Cells in Juvenile Rheumatoid Arthritis and Rheumatoid Arthritis

1990 • 68 citations

Tγδ Cells and their Subsets in Blood and Synovial Tissue from Rheumatoid Arthritis Patients

1990 • 68 citations

Mucosal immunology: new frontiers

1996 • 58 citations

Clonal expansion of lung V delta 1+ T cells in pulmonary sarcoidosis.

1993 • 58 citations

Tissue distribution of human gamma delta T cells: no evidence for general epithelial tropism.

1991 • 53 citations

A hierarchy for integrin expression and adhesiveness among T cell subsets that is linked to TCR gene usage and emphasizes V delta 1+ gamma delta T cell adherence and tissue retention.

1995 • 50 citations

Synovial Cells Responding to a 65‐kDa Mycobacterial Heat Shock Protein have a High Proportion of a TcRγδ Subtype Uncommon in Peripheral Blood

1990 • 48 citations

T cell receptor diversity and activation markers in the V_δ1 subset of rheumatoid synovial fluid and peripheral blood T lymphocytes

1992 • 47 citations

The Vδ Gene Usage by Freshly Isolated T Lymphocytes from Synovial Fluids in Rheumatoid Synovitis: a Preliminary Report

1990 • 41 citations

Phenotypic characterization of CD4-/alpha beta TCR+ and gamma delta TCR+ T cells with a transendothelial migratory capacity.

1994 • 37 citations

Clinical Gastroenterology

1994 • 36 citations

Effects of fibronectin and group B streptococci on tumour necrosis factor-alpha production by human culture-derived macrophages.

1995 • 29 citations

Preferential adherence of human gamma delta, CD8+, and memory T cells to fibroblasts.

1994 • 23 citations

Escherichia coli and Pseudomonas aeruginosa induce expansion of V delta 2 cells in adult peripheral blood, but of V delta 1 cells in cord blood.

1996 • 22 citations

Characterization of γ/δ T cell clones isolated from human fetal liverand thymus

1990 • 19 citations

Adhesion and costimulation of proliferative responses of human γδ T cells by interaction of VLA-4 and VLA-5 with fibronectin

1993 • 17 citations

Immunology of Inflammatory Bowel Disease

1989 • 13 citations

γδ T cells in coeliac disease

1990 • 6 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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