Immunology of Inflammatory Bowel Disease

A Progress Report on the Treatment of 157 Patients with Advanced Cancer Using Lymphokine-Activated Killer Cells and Interleukin-2 or High-Dose Interleukin-2 Alone

1987 • 2,769 citations

Treatment of Crohn's Disease with 6-Mercaptopurine

1980 • 1,055 citations

Enhanced Synthesis of Leukotriene B4 by Colonic Mucosa in Inflammatory Bowel Disease

1984 • 749 citations

Dissection of the lymphokine-activated killer phenomenon. Relative contribution of peripheral blood natural killer cells and T lymphocytes to cytolysis.

1986 • 698 citations

The Role of the T3/Antigen Receptor Complex in T-Cell Activation

1986 • 627 citations

H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structures coded for in H-2K or H-2D;.

1975 • 623 citations

AUTOANTIBODIES IN HUMAN ULCERATIVE COLITIS

1959 • 422 citations

Recent Developments in Nonspecific Inflammatory Bowel Disease

1982 • 341 citations

DOUBLE-BLIND WITHDRAWAL TRIAL OF AZATHIOPRINE AS MAINTENANCE TREATMENT FOR CROHN'S DISEASE

1978 • 341 citations

Antigen presentation by epithelial cells of the rat small intestine. I. Kinetics, antigen specificity and blocking by anti-Ia antisera.

1986 • 289 citations

Intestinal lymphocyte subpopulations in inflammatory bowel disease: an analysis by immunohistological and cell isolation techniques.

1984 • 273 citations

Intraepithelial lymphocytes modulate Ia expression by intestinal epithelial cells.

1984 • 272 citations

Expression of HLA-DR antigens by colonic epithelium in inflammatory bowel disease.

1983 • 264 citations

Leu-11+ lymphocytes with natural killer (NK) activity are precursors of recombinant interleukin 2 (rIL 2)-induced activated killer (AK) cells.

1985 • 263 citations

Antigen presentation by epithelial cells of the rat small intestine. II. Selective induction of suppressor T cells.

1986 • 252 citations

IN VITRO STUDIES OF ULCERATIVE COLITIS

1963 • 237 citations

HLA‐DR‐like Antigens in the Epithelium of the Human Small Intestine

1980 • 206 citations

Immunohistochemical Characterization of Local Immunoglobulin Formation in Ulcerative Colitis

1974 • 196 citations

Recent Developments in Nonspecific Inflammatory Bowel Disease

1982 • 195 citations

A working hypothesis for the etiology and pathogenesis of nonspecific inflammatory bowel disease

1972 • 179 citations

Effect of antibiotics on the immune response

1982 • 168 citations

Comparative mapping of the local distribution of immunoglobulin-containing cells in ulcerative colitis and Crohn's disease of the colon.

1975 • 167 citations

Isolation and characterization of a colonic autoantigen specifically recognized by colon tissue-bound immunoglobulin G from idiopathic ulcerative colitis.

1985 • 164 citations

Lectin-dependent and anti-CD3 induced cytotoxicity are preferentially mediated by peripheral blood cytotoxic T lymphocytes expressing Leu-7 antigen.

1986 • 164 citations

Arachidonic acid metabolites and their role in inflammatory bowel disease

1985 • 161 citations

Quantitative Fecal Indium 111-Labeled Leukocyte Excretion in the Assessment of Disease in Crohn's Disease

1983 • 158 citations

Alterations of IgM, IgG, and IgA Synthesis and Secretion by Peripheral Blood and Intestinal Mononuclear Cells from Patients with Ulcerative Colitis and Crohn's Disease

1981 • 157 citations

Mucosal subclass distribution of immunoglobulin G-producing cells is different in ulcerative colitis and Crohn's disease of the colon

1987 • 155 citations

The Human T-Cell Receptor

1985 • 152 citations

Chemotactic activity in inflammatory bowel disease

1987 • 148 citations

Immunohistological characterization of intraepithelial and lamina propria lymphocytes in control ileum and colon and in inflammatory bowel disease

1986 • 143 citations

Spontaneous secretion of IgG subclasses by intestinal mononuclear cells: differences between ulcerative colitis, Crohn's disease, and controls.

1986 • 143 citations

The immunologic basis of inflammatory bowel disease

1986 • 140 citations

IN VITRO STUDIES OF ULCERATIVE COLITIS

1963 • 138 citations

Decreased suppressor cell activity in inflammatory bowel disease.

1978 • 133 citations

Gut mucosal lymphocytes in inflammatory bowel disease

1979 • 132 citations

Interleukin 2 Activity of Human Intestinal Mucosa Mononuclear Cells

1984 • 128 citations

Mast cells and immunoglobulin E in inflammatory bowel disease.

1975 • 121 citations

Effect of lymphocytes from patients with ulcerative colitis on human adult colon epithelial cells.

1966 • 120 citations

Human intestinal mononuclear cells. I. Investigation of antibody-dependent, lectin-induced, and spontaneous cell-mediated cytotoxic capabilities.

1980 • 118 citations

The production and characterization of monoclonal antibodies to a human colonic antigen associated with ulcerative colitis: cellular localization of the antigen by using the monoclonal antibody.

1987 • 116 citations

Characterization of Spontaneous Colitis in Cotton-Top Tamarins (Saguinus oedipus) and Its Response to Sulfasalazine

1985 • 110 citations

Disodium cromoglycate in the treatment of chronic proctitis.

1975 • 108 citations

The “Early” Ulcerative Lesion of Crohnʼs Disease

1980 • 107 citations

Immunoglobulin containing cells in inflammatory bowel disease of the colon: a morphometric and immunohistochemical study.

1980 • 107 citations

Effect of Lymphocytes from Patients with Ulcerative Colitis on Human Adult Colon Epithelial Cells

1966 • 105 citations

Macrophage turnover in Crohn's disease and ulcerative colitis

1978 • 104 citations

In Vitro Studies of Inflammatory Bowel Disease

1976 • 100 citations

Immunoelectron microscopic localization of HLA-DR antigen in control small intestine and colon and in inflammatory bowel disease

1986 • 95 citations

Intestinal immunity and inflammation: Recent progress

1986 • 94 citations

Covert suppressor T cells in Crohn's disease

1981 • 92 citations

Altered patterns of secretion of monomeric IgA and IgA subclass 1 by intestinal mononuclear cells in inflammatory bowel disease

1986 • 92 citations

Inhibition of leucocyte motility by drugs used in ulcerative colitis.

1981 • 91 citations

Neuroendocrine modulation of the immune system

1988 • 91 citations

Human intestinal mononuclear cells

1980 • 88 citations

Immunological studies in ulcerative colitis. 3. Incidence of antibodies to colon-antigen in ulcerative colitis and other gastro-intestinal diseases.

1966 • 87 citations

Auto-immune reactions in ulcerative colitis.

1966 • 86 citations

Human intestinal mucosal mononuclear cells exhibit lymphokine-activated killer cell activity

1985 • 85 citations

Animal models of inflammatory bowel disease?An overview

1985 • 85 citations

Immunologic Mechanisms in Intestinal Diseases

1987 • 82 citations

Recent Advances in Crohn’s Disease

1981 • 82 citations

Rectal Biopsy in Patients With Crohn's Disease

1977 • 81 citations

Further Studies of in Vitro Cytotoxicity of Lymphocytes from Patients with Ulcerative and Granulomatous Colitis for Allogeneic Colonic Epithelial Cells, Including the Effects of Colectomy

1969 • 79 citations

Cytotoxicity of mononuclear cells for autologous colonic epithelial cells in colonic diseases

1984 • 78 citations

Sensitization to epithelial antigens in chronic mucosal inflammatory disease. Characterization of human intestinal mucosa-derived mononuclear cells reactive with purified epithelial cell-associated components in vitro.

1985 • 76 citations

Immunoregulatory Function of Lamina Propria T Cells in Crohn's Disease

1985 • 74 citations

Human colonic intraepithelial and lamina proprial lymphocytes: cytotoxicity in vitro and the potential effects of the isolation method on their functional properties.

1981 • 74 citations

Correlation of histopathologic evidence of disease activity with the presence of immunoglobulin-containing cells in the colons of patients with inflammatory bowel disease

1984 • 74 citations

Isolation and characterization of colonic tissue-bound antibodies from patients with idiopathic ulcerative colitis

1978 • 73 citations

Suppression of Immunoglobulin Synthesis by Lymphocyte Subpopulations in Patients With Crohn's Disease

1984 • 72 citations

Impaired natural killer cell activity in patients with inflammatory bowel disease: Evidence for a qualitative defect

1983 • 72 citations

Effects of Preliminary Incubation of Lymphocytes with Serum on their Cytotoxicity for Colonic Epithelial Cells

1970 • 71 citations

Macrophages of the mammalian small intestine: a review.

1979 • 71 citations

Macrophage activation, chronic inflammation and gastrointestinal disease.

1984 • 70 citations

Immune status in Crohn's disease. V. Decreased in vitro natural killer cell activity in peripheral blood.

1980 • 68 citations

Isolation and purification of human large bowel mucosal lymphoid cells: effect of separation technique on functional characteristics.

1979 • 66 citations

Functional Studies of Fc Receptor-Bearing Human Lymphocytes: Effect of Treatment with Proteolytic Enzymes

1979 • 66 citations

Reduced suppressor cell activity in intestinal lymphocytes from patients with Crohn's disease.

1982 • 63 citations

Inhibition of humoral and cell-mediated immune responses in man by distinct suppressor cell systems.

1979 • 62 citations

IgG SUBCLASS DEFICIENCIES

1987 • 61 citations

Rectal mucosal plasma cells in inflammatory bowel disease.

1983 • 61 citations

Lymphokine-activated and natural killer cell activity in human intestinal mucosa.

1985 • 60 citations

Deficient cell-mediated cytotoxicity and hyporesponsiveness to interferon and mitogenic lectin activation by inflammatory bowel disease peripheral blood and intestinal mononuclear cells

1986 • 57 citations

Immunoregulatory function of human intestinal mucosa lymphoid cells: evidence for enhanced suppressor cell activity in inflammatory bowel disease.

1983 • 55 citations

Further Studies of in Vitro Cytotoxicity of Lymphocytes for Colonic Epithelial Cells

1969 • 53 citations

Modification of in Vitro Cytotoxicity of Lymphocytes from Patients with Chronic Ulcerative Colitis or Granulomatous Colitis for Allogenic Colonic Epithelial Cells

1970 • 52 citations

Mast cell heterogeneity

1984 • 52 citations

Inflammatory bowel disease

1971 • 51 citations

Isolation of spontaneous and interferon inducible natural killer like cells from human colonic mucosa: lysis of lymphoid and autologous epithelial target cells.

1983 • 49 citations

Human mucosal cytotoxic effector cells

1987 • 48 citations

Immune Status in Crohn's Disease. VI. Immunoregulation Evaluated by Multiple, Distinct T-Suppressor Cell Assays of Lymphocyte Proliferation, and by Enumeration of Immunoregulatory T-Lymphocyte Subsets

1984 • 48 citations

Immunosuppressant Therapy of Inflammatory Bowel Disease

1987 • 47 citations

Inflammatory bowel disease: study of cell mediated cytotoxicity for isolated human colonic epithelial cells.

1980 • 46 citations

T cell-B cell regulation in the intestinal lamina propria in Crohn's disease

1985 • 45 citations

Absence of K cells in human gut mucosa.

1978 • 44 citations

Immunosuppression in the treatment of inflammatory bowel disease. II. The effects of azathioprine on lymphoid cell populations in a double blind trial in ulcerative colitis.

1976 • 44 citations

Aetiological Theories of Inflammatory Bowel Disease

1980 • 43 citations

Local immune mechanisms in inflammatory bowel disease and colorectal carcinoma

1986 • 42 citations

Reduced suppressor cell activity in intestinal lymphocytes from patients with Crohn's disease

1982 • 42 citations

Human mucosal T-cell cytotoxicity

1988 • 41 citations

Immune Interventions in Disease

1987 • 40 citations

Anti-colon antibody and lymphocytophilic antibody in ulcerative colitis.

1982 • 40 citations

Sensitization to epithelial antigens in chronic mucosal inflammatory disease. I. Purification, characterization, and immune reactivity of murine epithelial cell-associated components (ECAC).

1983 • 38 citations

Development of IgA and IgG2 subclass deficiency after sulfasalazine therapy

1986 • 37 citations

Intestinal fine structure in crohn's disease

1981 • 36 citations

Human colonic mononuclear cells: studies of cytotoxic function.

1981 • 36 citations

Detection of colonic antigen(s) in tissues from ulcerative colitis using purified colitis colon tissue-bound IgG (CCA-IgG)

1981 • 36 citations

Defective autologous mixed-lymphocyte reaction and suppressor cell generation in patients with inflammatory bowel disease.

1982 • 36 citations

The effect of 6-mercaptopurine on natural killer-cell activities in Crohn's disease

1985 • 35 citations

Antibody-dependent cell-mediated cytotoxicity in serum samples from patients with ulcerative colitis

1984 • 35 citations

Ultrastructure of the Ileum in Crohn's Disease

1972 • 34 citations

Mast cells as a component of the granuloma in crohn's disease

1973 • 33 citations

K-cell activity in Lamina proprial lymphocytes from the human colon

1979 • 32 citations

Granulocyte migration in ulcerative colitis

1985 • 32 citations

Crohn's disease

1987 • 32 citations

Nutrition and immune responses

1983 • 32 citations

Isolation of intestinal mononuclear cells: factors released which affect lymphocyte viability and function.

1985 • 32 citations

Defective Autologous Mixed-Lymphocite Reaction and Suppressor Cell Generation in Patients with Inflammatory Bower Disease

1982 • 30 citations

Inhibition of cytotoxicity by sulfasalazine. I. Sulfasalazine inhibits spontaneous cell-mediated cytotoxicity by peripheral blood and intestinal mononuclear cells from control and inflammatory bowel disease patients

1986 • 28 citations

Peripheral, mucosal, and tumour-infiltrating components of cellular immunity in cancer of the large bowel.

1981 • 28 citations

Hypogammaglobulinemia Due to Abnormal Suppressor T-Cell Activity in Crohn's Disease

1984 • 28 citations

Cell-mediated immunity in gastrointestinal disease

1986 • 27 citations

Enhanced peripheral blood T-cell cytotoxicity in inflammatory bowel disease

1989 • 26 citations

Progress in Gastroenterology

1969 • 26 citations

Demonstration of an assay for specific cytolytic antibody in sera from patients with ulcerative colitis

1981 • 26 citations

Inhibition of cytotoxicity by sulfasalazine. II. Sulfasalazine and sulfapyridine inhibit different stages of the NK and NKCF lytic processes

1986 • 25 citations

Functional suppressor T cell activity in Crohn's disease and the effects of sulphasalazine.

1982 • 24 citations

Cytotoxic lymphocytes and intestinal disease

1986 • 23 citations

Development of a monoclonal antibody specifically reactive to gastrointestinal goblet cells.

1987 • 20 citations

The Mononuclear Cells of Human Mesenteric Blood, Intestinal Mucosa, and Mesenteric Lymph Nodes: Compartmentalization of NK Cells

1984 • 19 citations

The immunology of idiopathic inflammatory bowel disease.

1986 • 19 citations

Immunoregulatory Mechanisms in Nonspecific Inflammatory Bowel Disease

1983 • 18 citations

Histological Studies on the Formal Pathogenesis of the Epithelioid Cell Granuloma in Crohn’s Disease

1981 • 14 citations

Mast cells in human disease

1983 • 14 citations

In vitro cellular cytotoxicity for a human colon cancer cell line by mucosal mononuclear cells of patients with colon cancer and other disorders

1985 • 14 citations

Nonpathogenicity of antiintestinal antibody in the rabbit.

1976 • 14 citations

Depressed spontaneous cell-mediated cytotoxicity in Crohn's disease.

1983 • 13 citations

Immune regulation in inflammatory bowel disease: absence of a serum inhibitor of suppressor cell function.

1980 • 9 citations

K562 killing by K, IL 2-responsive NK, and T cells involves different effector cell post-binding trigger mechanisms.

1986 • 8 citations

Developments in Digestive Diseases

1980 • 7 citations

Mucosal Ulcerative Colitis

1987 • 6 citations

Cellular cytotoxicity and gastrointestinal inflammation in inbred rats: induction with gut organ-specific antigens.

1981 • 4 citations

Role of Natural Effector Cells in Human Gastrointestinal Disease

1989 • 1 citations