The Thioester Bond of C3

Family study of the major histocompatibility complex in patients with systemic lupus erythematosus: importance of null alleles of C4A and C4B in determining disease susceptibility.

1983 • 456 citations

Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3.

1981 • 426 citations

Evidence for presence of an internal thiolester bond in third component of human complement.

1980 • 368 citations

Interaction between the third complement protein and cell surface macromolecules.

1977 • 345 citations

Evidence for an Ester Linkage between the Labile Binding Site of C3b and Receptive Surfaces

1979 • 297 citations

A comparison of the properties of two classes, C4A and C4B, of the human complement component C4.

1984 • 296 citations

Two HLA-linked loci controlling the fourth component of human complement.

1978 • 291 citations

Complement in health and disease

2011 • 256 citations

Structural basis of the polymorphism of human complement components C4A and C4B: gene size, reactivity and antigenicity.

1986 • 220 citations

Nucleophilic modification of human complement protein C3: correlation of conformational changes with acquisition of C3b-like functional properties

1981 • 184 citations

Covalent binding and hemolytic activity of complement proteins.

1980 • 183 citations

LYSIS OF ERYTHROCYTES BY COMPLEMENT IN THE ABSENCE OF ANTIBODY

1970 • 181 citations

Mechanism of Action of Glutathione‐Dependent Enzymes

1987 • 166 citations

COMPLEMENT AND COMPLEMENT-LIKE ACTIVITY IN LOWER VERTEBRATES AND INVERTEBRATES

1970 • 137 citations

Polymorphism of human complement component C4

1985 • 136 citations

Reactive site in human alpha 2-macroglobulin: circumstantial evidence for a thiolester.

1981 • 131 citations

C5 convertase of the alternative complement pathway: covalent linkage between two C3b molecules within the trimolecular complex enzyme.

1988 • 105 citations

Fourth component of human complement: studies of an amine-sensitive site comprised of a thiol component

1981 • 104 citations

Binding reaction between the third human complement protein and small molecules

1981 • 102 citations

DEFICIENCY OF C4A IS A GENETIC DETERMINANT OF SYSTEMIC LUPUS ERYTHEMATOSUS IN THREE ETHNIC GROUPS

1987 • 102 citations

Phylogeny and Function of the Complement System

1971 • 97 citations

Null alleles of the fourth component of complement and HLA haplotypes in familial systemic lupus erythematosus

1985 • 96 citations

Covalent association of C3b with C4b within C5 convertase of the classical complement pathway.

1987 • 90 citations

Sequence determination of the thiolester site of the fourth component of human complement.

1981 • 89 citations

Sequence location of the reactive thiol ester in human α₂‐macroglobulin

1981 • 87 citations

Third component of human complement: Localization of the internal thiolester bond

1982 • 80 citations

Interaction of C3 with antigen-antibody complexes in the process of solubilization of immune precipitates.

1984 • 72 citations

Structural Basis of the Binding Specificity of the Thioester-Containing Proteins, C4, C3 and Alpha-2-Macroglobulin

1988 • 47 citations

Complete cDNA sequence of the fourth component of murine complement.

1985 • 47 citations

Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.

1985 • 46 citations

Abnormality of glycophorin-alpha on paroxysmal nocturnal hemoglobinuria erythrocytes.

1984 • 46 citations

Conservation of structural and functional domains in complement component C3 of Xenopus and mammals.

1989 • 45 citations

Quantitative analyses of the relationship between C3 consumption, C3b capture, and immune adherence of complement-fixing antibody/DNA immune complexes.

1988 • 45 citations

The Purification and properties of some less common allotypes of the fourth component of human complement

1986 • 43 citations

Serum complement systems of ectothermic vertebrates

1987 • 43 citations

Covalent binding efficiency of the third and fourth complement proteins in relation to pH, nucleophilicity, and availability of hydroxyl groups

1984 • 40 citations

Non-enzymic activation of the covalent binding reaction of the complement protein C3

1983 • 33 citations

AUTOLYTIC FRAGMENTATION OF COMPLEMENT COMPONENTS C3 AND C4 AND ITS RELATIONSHIP TO COVALENT BINDING ACTIVITY

1983 • 29 citations

The fluid-phase binding of human C4 and its genetic variants, C4A3 and C4B1, to immunoglobulins

1988 • 28 citations

A HIGH FREQUENCY OF INHERITED DEFICIENCY OF COMPLEMENT COMPONENT C4 IN DARWIN ABORIGINES

1987 • 22 citations

Interaction between erythrocyte membrane proteins and complement components

1974 • 16 citations

Biosynthesis of the Internal Thioester Bond of the Third Component of Complement1

1984 • 16 citations

The low C5 convertase activity of the C4A6 allotype of human complement component C4

1989 • 16 citations

The esterase-like activity of covalently bound human third complement protein

1988 • 16 citations

Spin-label and fluorescence labeling studies of the thioester bonds in human .alpha.2-macroglobulin

1988 • 15 citations

INTERACTIONS BETWEEN C3b AND CELL‐SURFACE MACROMOLECULES^a

1983 • 9 citations