Two defective forms of reverse transcriptase can complement to restore retroviral infectivity.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Selective extraction of polyoma DNA from infected mouse cell cultures

1967 • 5,357 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor

1992 • 1,887 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

A detailed model of reverse transcription and tests of crucial aspects

1979 • 621 citations

Retroviral Recombination and Reverse Transcription

1990 • 596 citations

Origins and Evolutionary Relationships of Retroviruses

1989 • 581 citations

Mechanism and fidelity of HIV reverse transcriptase.

1992 • 484 citations

Genetic consequences of packaging two RNA genomes in one retroviral particle: pseudodiploidy and high rate of genetic recombination.

1990 • 477 citations

Structure of Ribonuclease H Phased at 2 Å Resolution by MAD Analysis of the Selenomethionyl Protein

1990 • 475 citations

Isolation and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptase

1981 • 439 citations

Mechanism of DNA Strand Transfer Reactions Catalyzed by HIV-1 Reverse Transcriptase

1992 • 330 citations

Construction and analysis of deletion mutations in the pol gene of moloney murine leukemia virus: A new viral function required for productive infection

1984 • 244 citations

Sequence and spacing requirements of a retrovirus integration site

1988 • 215 citations

Retroviral reverse transcriptase: synthesis, structure, and function.

1990 • 212 citations

Subunit-selective mutagenesis indicates minimal polymerase activity in heterodimer-associated p51 HIV-1 reverse transcriptase.

1991 • 208 citations

Domain structure of the Moloney murine leukemia virus reverse transcriptase: mutational analysis and separate expression of the DNA polymerase and RNase H activities.

1988 • 206 citations

Template switching by reverse transcriptase during DNA synthesis

1990 • 202 citations

Two dominant-acting selectable markers for gene transfer studies in mammalian cells.

1988 • 184 citations

Identification of the amino acid residues involved in an active site of Escherichia coli ribonuclease H by site-directed mutagenesis.

1990 • 176 citations

HIV-1 RT-associated ribonuclease H displays both endonuclease and 3′----5′ exonuclease activity.

1990 • 154 citations

Polymerization and RNase H activities of the reverse transcriptases from avian myeloblastosis, human immunodeficiency, and Moloney murine leukemia viruses are functionally uncoupled.

1991 • 150 citations

Reconstitution in vitro of RNase H activity by using purified N-terminal and C-terminal domains of human immunodeficiency virus type 1 reverse transcriptase.

1991 • 119 citations

Reverse transcriptase of human immunodeficiency virus type 1: functionality of subunits of the heterodimer in DNA synthesis

1992 • 96 citations

RNase H domain mutations affect the interaction between Moloney murine leukemia virus reverse transcriptase and its primer-template.

1993 • 95 citations

Intrinsic properties of reverse transcriptase in reverse transcription

1989 • 90 citations

Abortive reverse transcription by mutants of Moloney murine leukemia virus deficient in the reverse transcriptase-associated RNase H function

1991 • 79 citations

Inhibition of RNase H activity and viral replication by single mutations in the 3' region of Moloney murine leukemia virus reverse transcriptase

1989 • 74 citations

Mutational analysis of two conserved sequence motifs in HIV‐1 reverse transcriptase

1991 • 74 citations

Defects in Moloney murine leukemia virus replication caused by a reverse transcriptase mutation modeled on the structure of Escherichia coli RNase H

1992 • 55 citations

Analysis of mutations in the integration function of Moloney murine leukemia virus: effects on DNA binding and cutting

1990 • 52 citations

Murine leukemia virus pol gene products: analysis with antisera generated against reverse transcriptase and endonuclease fusion proteins expressed in Escherichia coli

1986 • 50 citations

Analysis of mutations in the envelope gene of moloney murine leukemia virus: Separation of infectivity from superinfection resistance

1991 • 42 citations

Reverse transcriptase

2015 • 20 citations