Tumor Antigens Discovery: Perspectives for Cancer Therapy

Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray

1995 • 9,575 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

1991 • 3,493 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC ^−/− Colon Carcinoma

1997 • 3,234 citations

Use of Tumor-Infiltrating Lymphocytes and Interleukin-2 in the Immunotherapy of Patients with Metastatic Melanoma

1988 • 2,196 citations

Use of a cDNA microarray to analyse gene expression patterns in human cancer

1996 • 2,002 citations

A New Approach to the Adoptive Immunotherapy of Cancer with Tumor-Infiltrating Lymphocytes

1986 • 1,787 citations

MHC ligands and peptide motifs: first listing

1995 • 1,674 citations

Accessing Genetic Information with High-Density DNA Arrays

1996 • 1,511 citations

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1995 • 1,500 citations

A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening

1997 • 1,235 citations

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

1997 • 1,215 citations

A p16 ^INK4a -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma

1995 • 1,147 citations

Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor.

1994 • 1,108 citations

The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1993 • 986 citations

A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1994 • 934 citations

Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection.

1994 • 921 citations

Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes.

1994 • 850 citations

Identification of a Peptide Recognized by Five Melanoma-Specific Human Cytotoxic T Cell Lines

1994 • 841 citations

E-cadherin gene mutations provide clues to diffuse type gastric carcinomas.

1994 • 772 citations

Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.

1994 • 771 citations

Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor.

1994 • 712 citations

A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E.

1992 • 694 citations

Adoptive T Cell Therapy of Tumors: Mechanisms Operative in the Recognition and Elimination of Tumor Cells

1991 • 619 citations

BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes

1995 • 598 citations

A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma.

1995 • 591 citations

Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes.

1994 • 584 citations

Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in vivo tumor regression.

1995 • 552 citations

A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes.

1996 • 542 citations

Identification of an immunodominant peptide of HER-2/neu protooncogene recognized by ovarian tumor-specific cytotoxic T lymphocyte lines.

1995 • 542 citations

Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer.

1994 • 467 citations

Breast and ovarian cancer-specific cytotoxic T lymphocytes recognize the same HER2/neu-derived peptide.

1995 • 446 citations

Immunotherapy of patients with advanced cancer using tumor-infiltrating lymphocytes and recombinant interleukin-2: a pilot study.

1988 • 432 citations

Two tyrosinase nonapeptides recognized on HLA‐A2 melanomas by autologous cytolytic T lymphocytes

1994 • 421 citations

A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma.

1995 • 416 citations

An HLA-A2-restricted tyrosinase antigen on melanoma cells results from posttranslational modification and suggests a novel pathway for processing of membrane proteins.

1996 • 416 citations

Identification of Tyrosinase-related Protein 2 as a Tumor Rejection Antigen for the B16 Melanoma

1997 • 405 citations

Karnofsky Memorial Lecture. The immunotherapy and gene therapy of cancer.

1992 • 394 citations

A peptide encoded by human gene MAGE‐3 and presented by HLA‐A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE‐3

1994 • 379 citations

Induction of anti-tumor cytotoxic T lymphocytes in normal humans using primary cultures and synthetic peptide epitopes.

1994 • 316 citations

Targeting p53 as a general tumor antigen.

1995 • 315 citations

Eradication of adenovirus E1-induced tumors by E1A-specific cytotoxic T lymphocytes

1989 • 300 citations

Vitiligo in patients with metastatic melanoma: A good prognostic sign

1983 • 292 citations

The structural and functional analysis of cadherin calcium-dependent cell adhesion molecules

1993 • 291 citations

Human CD4+ T cells specifically recognize a shared melanoma-associated antigen encoded by the tyrosinase gene.

1994 • 287 citations

Identification of a gene encoding a melanoma tumor antigen recognized by HLA-A31-restricted tumor-infiltrating lymphocytes.

1995 • 282 citations

A new enzymatic function in the melanogenic pathway. The 5,6-dihydroxyindole-2-carboxylic acid oxidase activity of tyrosinase-related protein-1 (TRP1).

1994 • 275 citations

Identification of TRP-2 as a Human Tumor Antigen Recognized by Cytotoxic T Lymphocytes

1996 • 272 citations

In vitro induction of human cytotoxic T lymphocyte responses against peptides of mutant and wild‐type p53

1993 • 267 citations

MUC‐1 Epithelial Tumor Mucin‐Based Immunity and Cancer Vaccines

1995 • 267 citations

Practical, biochemical and evolutionary implications of the discovery of HLA class I supermotifs

1996 • 263 citations

Utilization of an alternative open reading frame of a normal gene in generating a novel human cancer antigen.

1996 • 261 citations

Melanoma-specific CD4+ T cells recognize nonmutated HLA-DR-restricted tyrosinase epitopes.

1996 • 259 citations

Sequential chemoimmunotherapy in the treatment of metastatic melanoma.

1992 • 258 citations

CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma

1994 • 254 citations

Recognition of tyrosinase by tumor-infiltrating lymphocytes from a patient responding to immunotherapy.

1994 • 247 citations

Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases.

1996 • 245 citations

Autologous cytolytic T lymphocytes recognize a MAGE‐1 nonapeptide on melanomas expressing HLA‐Cw* 1601

1994 • 233 citations

Loss of E-Cadherin-Dependent Cell-Cell Adhesion due to Mutation of the β-Catenin Gene in a Human Cancer Cell Line, HSC-39

1995 • 225 citations

Retroviral transduction of human dendritic cells with a tumor-associated antigen gene.

1996 • 218 citations

Cytotoxic T cells from ovarian malignant tumors can recognize polymorphic epithelial mucin core peptides.

1993 • 213 citations

Human T lymphocytes recognize a peptide of single point-mutated, oncogenic ras proteins.

1991 • 208 citations

Induction of anti-self-immunity to cure cancer

1995 • 207 citations

Implicating a role for immune recognition of self in tumor rejection: passive immunization against the brown locus protein.

1995 • 186 citations

Induction of pigmentation in mouse fibroblasts by expression of human tyrosinase cDNA.

1989 • 186 citations

Immunity to Oncogenic Proteins

1995 • 180 citations

Prognostic significance of hypopigmentation in malignant melanoma

1987 • 176 citations

Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24-restricted tumor-infiltrating lymphocytes.

1995 • 145 citations

A mutated HLA-A2 molecule recognized by autologous cytotoxic T lymphocytes on a human renal cell carcinoma.

1996 • 142 citations

A tyrosinase nonapeptide presented by HLA‐B44 is recognized on a human melanoma by autologous cytolytic T lymphocytes

1996 • 135 citations

A previously unrecognized influenza B virus glycoprotein from a bicistronic mRNA that also encodes the viral neuraminidase.

1983 • 131 citations

Identification of a novel peptide derived from the melanocyte‐specific gp100 antigen as the dominant epitope recognized by an HLA‐A2.1‐restricted anti‐melanoma CTL line

1995 • 128 citations

CTL specific for the tyrosinase autoantigen can be induced from healthy donor blood to lyse melanoma cells.

1995 • 124 citations

Tumor-specific and HLA-A2-restricted cytolysis by tumor-associated lymphocytes in human metastatic breast cancer.

1995 • 122 citations

Human dendritic cells genetically engineered to express high levels of the human epithelial tumor antigen mucin (MUC-1).

1996 • 121 citations

The intronic region of an incompletely spliced gp100 gene transcript encodes an epitope recognized by melanoma-reactive tumor-infiltrating lymphocytes.

1997 • 121 citations

Mechanism of translation of monocistronic and multicistronic human immunodeficiency virus type 1 mRNAs.

1992 • 121 citations

IL-2 enhances the function of recombinant poxvirus-based vaccines in the treatment of established pulmonary metastases.

1995 • 117 citations

Pigmentation-Associated Glycoprotein of Human Melanomas and Melanocytes: Definition with a Mouse Monoclonal Antibody

1985 • 115 citations

A small highly basic protein is encoded in overlapping frame within the P gene of vesicular stomatitis virus

1993 • 113 citations

Shared epitopes for HLA-A3-restricted melanoma-reactive human CTL include a naturally processed epitope from Pmel-17/gp100.

1996 • 106 citations

Cytotoxic T-lymphocyte clones from different patients display limited T-cell-receptor variable-region gene usage in HLA-A2-restricted recognition of the melanoma antigen Melan-A/MART-1.

1995 • 104 citations

Recognition of an Antigenic Peptide Derived from Tyrosinase-Related Protein-2 by CTL in the Context of HLA-A31 and -A33

1998 • 103 citations

Melanocyte lineage-specific antigens recognized by monoclonal antibodies NKI-beteb, HMB-50, and HMB-45 are encoded by a single cDNA.

1993 • 103 citations

A pigmentation‐associated, differentiation antigen of human melanoma defined by a precipitating antibody in human serum

1983 • 95 citations

Differentiation Antigens of Melanocytes and Melanoma: Analysis of Melanosome and Cell Surface Markers of Human Pigmented Cells With Monoclonal Antibodies

1988 • 90 citations

p53, a potential target for tumor-directed T cells

1994 • 88 citations

Peptide motifs of HLA-A1,-A11,-A31, and-A33 molecules

1994 • 88 citations

Melanoma‐specific CD4+ T lymphocytes recognize human melanoma antigens processed and presented by epstein‐barr virus‐transformed B cells

1994 • 86 citations

Induction and characterization of cytotoxic T‐lymphocytes recognizing a mutated p21ras peptide presented by HLA‐A*0201

1995 • 84 citations

Identification of two cytotoxic T lymphocyte-recognized epitopes in the Ras protein.

1993 • 83 citations

Association of HER2/neu expression with sensitivity to tumor-specific CTL in human ovarian cancer.

1994 • 76 citations

A rare cryptic translation product is presented by Kb major histocompatibility complex class I molecule to alloreactive T cells.

1995 • 70 citations

Use of combinatorial peptide libraries to construct functional mimics of tumor epitopes recognized by MHC class I-restricted cytolytic T lymphocytes.

1996 • 59 citations

CD4+ T lymphocytes infiltrating human breast cancer recognise autologous tumor in an MHC-class-II restricted fashion

1995 • 59 citations

Characterization of Cytotoxic T Lymphocyte Epitopes of a Self-Protein, p53, and a Non-Self-Protein, Influenza Matrix

1993 • 57 citations

Reactivity of autologous CD4+ T lymphocytes against human melanoma. Evidence for a shared melanoma antigen presented by HLA-DR15.

1995 • 57 citations

Mechanism of Translation of Monocistronic and Multicistronic Human Immunodeficiency Virus Type 1 mRNAs

1992 • 52 citations

Specific and Effective T‐Cell Recognition of Cells Transfected with a Truncated Human Mucin cDNA

1993 • 34 citations

Cytotoxic T‐Cell Clones Isolated from Ovarian Tumour Infiltrating Lymphocytes Recognize Common Determinants on Non‐Ovarian Tumour Clones

1993 • 33 citations

Analysis of Cytokine Secretion by Melanoma-Specific CD4⁺T Lymphocytes

1995 • 14 citations