Genetic Findings in Anorexia and Bulimia Nervosa

Diagnostic and Statistical Manual of Mental Disorders

2009 • 11,002 citations

The Future of Genetic Studies of Complex Human Diseases

1996 • 5,355 citations

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

1995 • 5,291 citations

A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

2007 • 4,239 citations

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

1993 • 3,693 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

Personal genomes: The case of the missing heritability

2008 • 1,714 citations

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

2008 • 1,696 citations

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

2008 • 1,356 citations

Eating disorders

2003 • 1,325 citations

Comorbidity of Anxiety Disorders With Anorexia and Bulimia Nervosa

2004 • 1,094 citations

The endocannabinoid system and its therapeutic exploitation

2004 • 1,045 citations

The long-term course of severe anorexia nervosa in adolescents: Survival analysis of recovery, relapse, and outcome predictors over 10-15 years in a prospective study

1997 • 911 citations

Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

2000 • 896 citations

Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor

2003 • 858 citations

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

2000 • 795 citations

New insights into symptoms and neurocircuit function of anorexia nervosa

2009 • 764 citations

The Structure of the Genetic and Environmental Risk Factors for Six Major Psychiatric Disorders in Women

1995 • 684 citations

The genetic epidemiology of bulimia nervosa

1991 • 642 citations

Risk Factors for Anorexia Nervosa

1999 • 610 citations

Controlled Family Study of Anorexia Nervosa and Bulimia Nervosa: Evidence of Shared Liability and Transmission of Partial Syndromes

2000 • 545 citations

Genome Wide Association (GWA) Study for Early Onset Extreme Obesity Supports the Role of Fat Mass and Obesity Associated Gene (FTO) Variants

2007 • 511 citations

Diagnostic Crossover in Anorexia Nervosa and Bulimia Nervosa: Implications for DSM-V

2008 • 487 citations

Several Mutations in the Melanocortin-4 Receptor Gene Including a Nonsense and a Frameshift Mutation Associated with Dominantly Inherited Obesity in Humans

1999 • 439 citations

Genomewide Association Studies: History, Rationale, and Prospects for Psychiatric Disorders

2009 • 433 citations

Serum leptin levels in women with anorexia nervosa.

1996 • 400 citations

Twelve‐year course and outcome predictors of anorexia nervosa

2005 • 397 citations

Postremission Predictors of Relapse in Women With Eating Disorders

2005 • 395 citations

A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10

1998 • 385 citations

Ten-year follow-up of anorexia nervosa: clinical course and outcome

1995 • 380 citations

Anorexia Nervosa and Major Depression: Shared Genetic and Environmental Risk Factors

2000 • 371 citations

Binge Eating as a Major Phenotype of Melanocortin 4 Receptor Gene Mutations

2003 • 371 citations

Anorexia nervosa and anorexic-like syndromes in a population-based female twin sample

1995 • 344 citations

Twin studies of eating disorders: A review

2000 • 335 citations

Altered Reward Processing in Women Recovered From Anorexia Nervosa

2007 • 327 citations

Instability of eating disorder diagnoses: prospective study

2005 • 307 citations

Symptom Fluctuation in Eating Disorders: Correlates of Diagnostic Crossover

2005 • 298 citations

Altered Serotonin Activity in Anorexia Nervosa After Long-term Weight Restoration

1991 • 275 citations

Genetic and environmental influences on anorexia nervosa syndromes in a population–based twin sample

2001 • 257 citations

Heritability of binge-eating and broadly defined bulimia nervosa

1998 • 252 citations

From monogenic to polygenic obesity: recent advances

2010 • 234 citations

Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations

2004 • 228 citations

Anorexia nervosa: Evidence for a genetic basis

1988 • 228 citations

Evidence for a Susceptibility Gene for Anorexia Nervosa on Chromosome 1

2002 • 224 citations

Leptin levels in patients with anorexia nervosa are reduced in the acute stage and elevated upon short-term weight restoration

1997 • 222 citations

Melanocortin-4 Receptor Gene Variant I103 Is Negatively Associated with Obesity

2004 • 218 citations

Low Serotonin and Dopamine Metabolite Concentrations in Cerebrospinal Fluid From Bulimic Patients With Frequent Binge Episodes

1992 • 217 citations

Melanocortin-4 Receptor Gene: Case-Control Study and Transmission Disequilibrium Test Confirm that Functionally Relevant Mutations Are Compatible with a Major Gene Effect for Extreme Obesity

2003 • 212 citations

Alterations in Serotonin Activity and Psychiatric Symptoms After Recovery From Bulimia Nervosa

1998 • 210 citations

Prevalence, Spectrum, and Functional Characterization of Melanocortin-4 Receptor Gene Mutations in a Representative Population-Based Sample and Obese Adults from Germany

2006 • 210 citations

Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type

2003 • 202 citations

The role of leptin in anorexia nervosa: clinical implications

2006 • 195 citations

Gene–environment interactions for complex traits: definitions, methodological requirements and challenges

2008 • 193 citations

Anorexia and Bulimia Nervosa

2000 • 190 citations

Altered Dopamine Activity after Recovery from Restricting-Type Anorexia Nervosa

1999 • 183 citations

Separate systems for serotonin and leptin in appetite control

2000 • 179 citations

Anorexia Nervosa: A Study of 34 Twin Pairs and One Set of Triplets

1984 • 172 citations

Association between an agouti-related protein gene polymorphism and anorexia nervosa

2001 • 168 citations

Linkage analysis of anorexia nervosa incorporating behavioral covariates

2002 • 166 citations

Predictors of the Development of Bulimia Nervosa in Women with Anorexia Nervosa

1997 • 160 citations

GAD2 on Chromosome 10p12 Is a Candidate Gene for Human Obesity

2003 • 159 citations

Candidate genes for anorexia nervosa in the 1p33–36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa

2003 • 150 citations

Decreased levels of serum brain-derived neurotrophic factor in female patients with eating disorders

2003 • 149 citations

Mutation screen of the brain derived neurotrophic factor gene (BDNF): Identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention‐deficit/hyperactivity disorder

2004 • 146 citations

The Genetics of Anorexia Nervosa

2007 • 145 citations

Systematic Mutation Screening of the Estrogen Receptor Beta Gene in Probands of Different Weight Extremes: Identification of Several Genetic Variants

1998 • 144 citations

Significant Linkage on Chromosome 10p in Families with Bulimia Nervosa

2003 • 142 citations

Understanding the Relation Between Anorexia Nervosa and Bulimia Nervosa in a Swedish National Twin Sample

2009 • 142 citations

Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations

2004 • 141 citations

Long-term stability of eating disorder diagnoses

2007 • 141 citations

Association of Multiple DRD2 Polymorphisms with Anorexia Nervosa

2005 • 133 citations

A preliminary population-based twin study of self-reported eating disorder

2001 • 132 citations

Individual-specific risk factors for anorexia nervosa: a pilot study using a discordant sister-pair design

2001 • 132 citations

The human genetics of anorexia nervosa

2003 • 131 citations

On the role of dopamine in the pathophysiology of anorexia nervosa

1976 • 128 citations

Frequency of binge eating episodes in bulimia nervosa and binge eating disorder: Diagnostic considerations

2009 • 125 citations

Serotonin, Eating Behavior, and Fat Intake

1995 • 125 citations

From nature versus nurture, via nature and nurture, to gene × environment interaction in mental disorders

2009 • 124 citations

Family trios analysis of common polymorphisms in the obestatin/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: Association with subtype, body-mass index, severity and age of onset

2007 • 122 citations

Lifetime course of eating disorders: design and validity testing of a new strategy to define the eating disorders phenotype

2008 • 117 citations

Serotonin transporter gene-linked polymorphic region: Allele distributions in relationship to body weight and in anorexia nervosa

1997 • 117 citations

A search for susceptibility loci for anorexia nervosa: methods and sample description

2000 • 117 citations

Opposite Changes in the Serum Brain-Derived Neurotrophic Factor in Anorexia Nervosa and Obesity

2004 • 108 citations

Association of anorexia nervosa with the high activity allele of the COMT gene: a family-based study in Israeli patients

2001 • 107 citations

Circulating brain-derived neurotrophic factor is decreased in women with anorexia and bulimia nervosa but not in women with binge-eating disorder: relationships to co-morbid depression, psychopathology and hormonal variables

2004 • 107 citations

Environmental and Genetic Risk Factors for Eating Disorders: What the Clinician Needs to Know

2008 • 103 citations

Association study of cannabinoid receptor gene (CNR1) alleles and anorexia nervosa: Differences between restricting and bingeing/purging subtypes

2003 • 103 citations

The dopamine-4 receptor gene associated with binge eating and weight gain in women with seasonal affective disorder: An evolutionary perspective

2004 • 102 citations

5-HT2A receptor gene polymorphisms in anorexia nervosa and bulimia nervosa

1999 • 102 citations

Leptin and body weight regulation in patients with anorexia nervosa before and during weight recovery1–2

2005 • 100 citations

Binge-eating episodes are not characteristic of carriers of melanocortin-4 receptor gene mutations

2004 • 99 citations

Gene variants and binge eating as predictors of comorbidity and outcome of treatment in severe obesity

2004 • 99 citations

Systematic Mutation Screening of the Pro-Opiomelanocortin Gene: Identification of Several Genetic Variants Including Three Different Insertions, One Nonsense and Two Missense Point Mutations in Probands of Different Weight Extremes

1998 • 98 citations

Anorexia Nervosa Outcome: Six-Year Controlled Longitudinal Study of 51 Cases Including a Population Cohort

1994 • 97 citations

THE EVOLVING GENETIC FOUNDATIONS OF EATING DISORDERS

2001 • 96 citations

Interacting Genetic Loci on Chromosomes 20 and 10 Influence Extreme Human Obesity

2003 • 96 citations

Does environment matter? A review of nonshared environment and eating disorders

2002 • 94 citations

The 5-HT2A −1438G/A polymorphism in anorexia nervosa: a combined analysis of 316 trios from six European centres

2002 • 94 citations

Association between 5HT2A receptor gene promoter region polymorphism and eating disorders in Japanese patients

2001 • 90 citations

Altered striatal response to reward in bulimia nervosa after recovery

2009 • 90 citations

Leptin, neuropeptide Y, and peptide YY in long-term recovered eating disorder patients

1999 • 89 citations

The 5‐HTTLPR polymorphism and eating disorders: A meta‐analysis

2010 • 89 citations

No coding variant of the tryptophan hydroxylase gene detected in seasonal affective disorder, obsessive–compulsive disorder, anorexia nervosa, and alcoholism

1999 • 89 citations

Further Evidence of Association of OPRD1 & HTR1D Polymorphisms with Susceptibility to Anorexia Nervosa

2006 • 87 citations

Studies of serotonin function in anorexia nervosa

1996 • 87 citations

Physical similarity and twin resemblance for eating attitudes and behaviors: a test of the equal environments assumption.

2000 • 86 citations

5-HT2A receptor gene polymorphism and eating disorders

2002 • 84 citations

The need to revise the diagnostic criteria for anorexia nervosa

2004 • 84 citations

Eating disorders: the current status of molecular genetic research

2009 • 83 citations

Theoretical perspective on anorexia nervosa: The conflict of reward

2009 • 82 citations

Clarifying criteria for cognitive signs and symptoms for eating disorders in DSM‐V

2009 • 79 citations

A DRD4/BDNF gene–gene interaction associated with maximum BMI in women with bulimia nervosa

2007 • 79 citations

β3-adrenergic-receptor allele distributions in children, adolescents and young adults with obesity, underweight or anorexia nervosa

1997 • 77 citations

Association of the MC4R V103I Polymorphism With Obesity: A Chinese Case–control Study and Meta‐analysis in 55,195 Individuals

2009 • 75 citations

D2 dopamine receptor (DRD2) gene Taq1A polymorphism and the eatingrelated psychological traits in eating disorders (anorexia nervosa and bulimia) and obesity

2007 • 75 citations

Association between serotonin transporter gene polymorphism and eating disorders: A meta‐analytic study

2009 • 74 citations

Candidate gene polymorphisms in eating disorders

2000 • 74 citations

Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects

2009 • 73 citations

Anorexia nervosa viewed as an extreme weight condition: genetic implications

1995 • 73 citations

A locus affecting obesity in human chromosome region 10p12

2001 • 73 citations

Anorexia nervosa, perfectionism, and dopamine D4 receptor (DRD4)

2007 • 72 citations

Further lack of association between the 5-HT2A gene promoter polymorphism and susceptibility to eating disorders and a meta-analysis pertaining to anorexia nervosa

1999 • 71 citations

Serum leptin levels in patients with anorexia nervosa before and after partial refeeding, relationships to serum lipids and biochemical nutritional parameters.

1999 • 70 citations

Analysis of the serotonin transporter gene linked polymorphism (5-HTTLPR) in anorexia nervosa

2000 • 70 citations

Eating Disorders, Serotonin Transporter Polymorphisms and Potential Treatment Response

2004 • 69 citations

Independent Confirmation of a Major Locus for Obesity on Chromosome 10

2000 • 67 citations

No evidence for involvement of the leptin gene in anorexia nervosa, bulimia nervosa, underweight or early onset extreme obesity: identification of two novel mutations in the coding sequence and a novel polymorphism in the leptin gene linked upstream region

1998 • 64 citations

Genetic factors in anorexia nervosa

1999 • 63 citations

No evidence for involvement of polymorphisms of the dopamine D4 receptor gene in anorexia nervosa, underweight, and obesity

1999 • 60 citations

Contribution of NTRK2 to the genetic susceptibility to anorexia nervosa, Harm avoidance and minimum body mass index

2005 • 60 citations

Brain Serotonin, Carbohydrate-Craving, Obesity and Depression

1996 • 60 citations

Reproductive function during weight gain in anorexia nervosa. Leptin represents a metabolic gate to gonadotropin secretion

2003 • 59 citations

Amenorrhea in anorexia nervosa neuroendocrine control of hypothalamic dysfunction

1994 • 56 citations

Screening for mutations in the neuropeptide Y Y5 receptor gene in cohorts belonging to different weight extremes

1998 • 56 citations

Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders

2008 • 55 citations

The 5-HT2A –1438 A/G and 5-HTTLPR Polymorphisms and Personality Dimensions in Adolescent Anorexia Nervosa: Association Study

2006 • 52 citations

Association between anorexia nervosa and the hsKCa3 gene: a family-based and case control study

2002 • 52 citations

Lack of Support for the Association between GAD2 Polymorphisms and Severe Human Obesity

2005 • 52 citations

Serotonin transporter regulatory region polymorphism is associated with anorexia nervosa

2004 • 52 citations

The relationship between premorbid body weight, weight loss, and weight at referral in adolescent patients with anorexia nervosa

1999 • 52 citations

Lack of Association between Anorexia Nervosa and D3 Dopamine Receptor Gene

1998 • 51 citations

Genetic predisposition to obesity in bulimia nervosa: a mutation screen of the melanocortin-4 receptor gene

2002 • 50 citations

Association of trait-defined, eating-disorder sub-phenotypes with (biallelic and triallelic) 5HTTLPR variations

2009 • 50 citations

Combined family trio and case‐control analysis of the COMT Val158Met polymorphism in European patients with anorexia nervosa

2003 • 49 citations

Serum brain-derived neurotrophic factor and peripheral indicators of the serotonin system in underweight and weight-recovered adolescent girls and women with anorexia nervosa.

2009 • 47 citations

Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa

2008 • 47 citations

The validity and utility of subtyping bulimia nervosa

2009 • 45 citations

The association of catechol-O-methyltransferase genotype with the phenotype of women with eating disorders

2009 • 41 citations

Allelic variation of the 5-HT2C receptor (HTR2C) in bulimia nervosa and binge eating disorder

1999 • 40 citations

No change between the serum brain-derived neurotrophic factor in female patients with anorexia nervosa before and after partial weight recovery

2006 • 39 citations

Functional variants of the serotonin receptor type 3A and B gene are associated with eating disorders

2009 • 39 citations

Brain derived neurotrophic factor gene Val66Met and -270C/T polymorphisms and personality traits predisposing to anorexia nervosa.

2007 • 37 citations

Association of Eating Disorders with Catechol-<i>O</i>-Methyltransferase Gene Functional Polymorphism

2006 • 37 citations

Investigation of Epistasis Between the Serotonin Transporter and Norepinephrine Transporter Genes in Anorexia Nervosa

2003 • 37 citations

Polymorphisms within the promoter and the intron 2 of the serotonin transporter gene in a population of bulimic patients

2003 • 36 citations

Polymorphisms in Serotonin-Related Genes in Anorexia Nervosa. The First Study in Czech Population and Meta-analyses with Previously Performed Studies

2009 • 36 citations

No evidence for an involvement of alleles of polymorphisms in the serotonin1Dβ and 7 receptor genes in obesity, underweight or anorexia nervosa

1999 • 35 citations

5-HT2A promoter polymorphism is not associated with anorexia nervosa in Japanese patients

2001 • 33 citations

A four‐year prospective follow‐up study of 49 eating‐disordered adolescents: differences in course of illness

1994 • 33 citations

Psychological and weight-related characteristics of patients with anorexia nervosa-restricting type who later develop bulimia nervosa

2008 • 33 citations

Reduced body fat in long-term followed-up female patients with anorexia nervosa

2000 • 31 citations

Single nucleotide polymorphisms in the leptin receptor gene: studies in anorexia nervosa

2004 • 29 citations

Child and adolescent psychiatric genetics

2010 • 27 citations

Serotonin-System Polymorphisms (5-HTTLPR and -1438G/A) and Responses of Patients With Bulimic Syndromes to Multimodal Treatments

2008 • 27 citations

Haplotype analysis of the COMT‐ARVCF gene region in Israeli anorexia nervosa family trios

2005 • 23 citations

Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?

2009 • 22 citations

Bulimia nervosa with history of anorexia nervosa: Could the clinical subtype of anorexia have implications for clinical status and treatment response?

2010 • 17 citations

Tumor necrosis factor alpha-308 gene polymorphism in patients with anorexia nervosa.

2008 • 14 citations

An Association Study of the A218C Polymorphism of the Tryptophan Hydroxylase 1 Gene with Eating Disorders in a Korean Population: A Pilot Study

2009 • 7 citations