Genomewide Association Studies: History, Rationale, and Prospects for Psychiatric Disorders

PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses

2007 • 29,581 citations

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

Principal components analysis corrects for stratification in genome-wide association studies

2006 • 9,771 citations

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

2007 • 9,332 citations

Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

1980 • 8,270 citations

Genetics of Food Intake Self-Regulation in Childhood: Literature Review and Research Opportunities

2013 • 7,434 citations

The International HapMap Project

2003 • 5,951 citations

Impact of Informing Overweight Individuals about the Role of Genetics in Obesity: An Online Experimental Study

2013 • 5,797 citations

The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions

2003 • 5,516 citations

The Future of Genetic Studies of Complex Human Diseases

1996 • 5,355 citations

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

2007 • 5,117 citations

A second generation human haplotype map of over 3.1 million SNPs

2007 • 4,436 citations

Complement Factor H Polymorphism in Age-Related Macular Degeneration

2005 • 4,314 citations

A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

2007 • 4,239 citations

Global variation in copy number in the human genome

2006 • 4,228 citations

Prevalence and Development of Psychiatric Disorders in Childhood and Adolescence

2003 • 3,922 citations

Genetic Epidemiology of Major Depression: Review and Meta-Analysis

2000 • 3,230 citations

A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

2006 • 2,903 citations

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

2008 • 2,860 citations

Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels

2007 • 2,820 citations

Strong Association of De Novo Copy Number Mutations with Autism

2007 • 2,782 citations

A new multipoint method for genome-wide association studies by imputation of genotypes

2007 • 2,593 citations

A polymorphic DNA marker genetically linked to Huntington's disease

1983 • 2,329 citations

Molecular Genetics of Attention-Deficit/Hyperactivity Disorder

2005 • 2,305 citations

Schizophrenia as a Complex Trait

2003 • 2,253 citations

Cross-National Epidemiology of Major Depression and Bipolar Disorder

1996 • 2,176 citations

Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits

2002 • 2,077 citations

A Systematic Review of the Prevalence of Schizophrenia

2005 • 2,017 citations

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

2008 • 1,838 citations

Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia

2008 • 1,788 citations

Structural Variation of Chromosomes in Autism Spectrum Disorder

2008 • 1,781 citations

Large recurrent microdeletions associated with schizophrenia

2008 • 1,752 citations

Epidemiology of Major Depressive Disorder

2005 • 1,620 citations

Association between Microdeletion and Microduplication at 16p11.2 and Autism

2008 • 1,557 citations

Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease

2003 • 1,522 citations

Rare chromosomal deletions and duplications increase risk of schizophrenia

2008 • 1,456 citations

Common variants near MC4R are associated with fat mass, weight and risk of obesity

2008 • 1,313 citations

General hospital psychiatry: the Italian experience.

2003 • 1,301 citations

Are Rare Variants Responsible for Susceptibility to Complex Diseases?

2001 • 1,224 citations

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

2008 • 1,211 citations

The Heritability of Bipolar Affective Disorder and the Genetic Relationship to Unipolar Depression

2003 • 1,188 citations

The New Genomics: Global Views of Biology

1996 • 1,174 citations

Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part II: Schizophrenia

2003 • 1,160 citations

Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol

2004 • 1,131 citations

Identification of loci associated with schizophrenia by genome-wide association and follow-up

2008 • 1,055 citations

Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database

2008 • 1,045 citations

High Rates of Schizophrenia in Adults With Velo-Cardio-Facial Syndrome

1999 • 1,013 citations

Functional SNPs in the lymphotoxin-α gene that are associated with susceptibility to myocardial infarction

2002 • 942 citations

A genetic linkage map of the human genome

1987 • 913 citations

Genome-wide strategies for detecting multiple loci that influence complex diseases

2005 • 897 citations

Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor

2003 • 887 citations

A HapMap harvest of insights into the genetics of common disease

2008 • 887 citations

Strong association of de novo copy number mutations with sporadic schizophrenia

2008 • 822 citations

Rare independent mutations in renal salt handling genes contribute to blood pressure variation

2008 • 797 citations

Estimation of the multiple testing burden for genomewide association studies of nearly all common variants

2008 • 779 citations

Whole-genome association study of bipolar disorder

2008 • 703 citations

A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder

2007 • 699 citations

Recurrent 16p11.2 microdeletions in autism

2007 • 687 citations

Assessing the Evolutionary Impact of Amino Acid Mutations in the Human Genome

2008 • 684 citations

Estimation of significance thresholds for genomewide association scans

2008 • 670 citations

Association Between Microdeletion and Microduplication at 16p11.2 and Autism

2008 • 666 citations

The genetics of autistic disorders and its clinical relevance: a review of the literature

2006 • 634 citations

Genome–wide association studies provide new insights into type 2 diabetes aetiology

2007 • 580 citations

Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease

2005 • 459 citations

Incidence of autism spectrum disorders: Changes over time and their meaning*

2005 • 444 citations

Bayes factors for genome‐wide association studies: comparison with P‐values

2008 • 397 citations

Physicochemical constraint violation by missense substitutions mediates impairment of protein function and disease severity

2005 • 395 citations

A Hospital-Based Twin Register of the Heritability of DSM-IV Unipolar Depression

1996 • 379 citations

Genomewide association for schizophrenia in the CATIE study: results of stage 1

2008 • 356 citations

CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration

2006 • 340 citations

Genome-Wide Association Identifies a Common Variant in the Reelin Gene That Increases the Risk of Schizophrenia Only in Women

2008 • 340 citations

Multiple Loci With Different Cancer Specificities Within the 8q24 Gene Desert

2008 • 331 citations

The Lifetime History of Major Depression in Women

1993 • 325 citations

Incidence of autism spectrum disorders: Changes over time and their meaning*

2005 • 310 citations

Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI

2008 • 307 citations

Novel Submicroscopic Chromosomal Abnormalities Detected in Autism Spectrum Disorder

2008 • 300 citations

Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia

2002 • 280 citations

Genetic linkage studies

2005 • 265 citations

The road to genome-wide association studies

2008 • 253 citations

Combined Analysis from Eleven Linkage Studies of Bipolar Disorder Provides Strong Evidence of Susceptibility Loci on Chromosomes 6q and 8q

2005 • 246 citations

Genome‐wide significance for dense SNP and resequencing data

2008 • 207 citations

A Twin Study of Depressive Symptoms in Childhood

1994 • 200 citations

Statistical false positive or true disease pathway?

2006 • 182 citations

False Discovery Rate in Linkage and Association Genome Screens for Complex Disorders

2003 • 169 citations

Epigenetics and Complex Disease: From Etiology to New Therapeutics

2007 • 167 citations

Fine-Scale Genetic Mapping Based on Linkage Disequilibrium: Theory and Applications

1997 • 159 citations

A genome-wide association study in 574 schizophrenia trios using DNA pooling

2008 • 159 citations

An update on the genetics of schizophrenia

2006 • 150 citations

A heterogeneity-based genome search meta-analysis for autism-spectrum disorders

2005 • 140 citations

A genome-wide search for genes predisposing to manic-depression, assuming autosomal dominant inheritance.

1993 • 87 citations

Meta-analysis in psychiatric genetics

2005 • 53 citations

The Structure of Common Genetic Variation in United States Populations

2007 • 53 citations

Biases and Reconciliation in Estimates of Linkage Disequilibrium in the Human Genome

2006 • 42 citations

The expanding universe of inflammatory bowel disease genetics

2008 • 26 citations

Collaborative genome-wide association analysis of 10,596 individuals supports a role for Ankyrin-G (ANK3) and the alpha-1C subunit of the L-type voltage-gated calcium channel (CACNA1C) in bipolar disorder

2008 • 15 citations

The FTO (fat mass and obesity-associated) gene: big in adipocyte lipolysis?

2008 • 5 citations