The molecular characterization of PRP6 and PRP9 yeast genes reveals a new cysteine/histidine motif common to several splicing factors.

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector

1987 • 1,181 citations

DNA sequence required for efficient transcription termination in yeast

1982 • 1,014 citations

‘DNA Strider’: a ‘C’ program for the fast analysis of DNA and protein sequences on the Apple Macintosh family of computers

1988 • 1,010 citations

Evidence That the Leucine Zipper Is a Coiled Coil

1989 • 869 citations

RNA-binding proteins as developmental regulators.

1989 • 679 citations

PRE-mRNA SPLICING

1986 • 673 citations

The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing

1987 • 594 citations

A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly

1988 • 535 citations

Loops in Globular Proteins: A Novel Category of Secondary Structure

1986 • 533 citations

Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences

1985 • 524 citations

Electrophoretic separation of complexes involved in the splicing of precursors to mRNAs

1986 • 490 citations

The "Spliceosome": Yeast Pre-Messenger RNA Associates with a 40 S Complex in a Splicing-Dependent Reaction

1985 • 421 citations

Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm

1989 • 417 citations

Spliceosome assembly in yeast.

1987 • 402 citations

Identification of functional U1 snRNA-pre-mRNA complexes committed to spliceosome assembly and splicing

1989 • 391 citations

Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor.

1989 • 375 citations

Each of three "TATA elements" specifies a subset of the transcription initiation sites at the CYC-1 promoter of Saccharomyces cerevisiae.

1985 • 342 citations

Isolation and characterization of pre-mRNA splicing mutants of Saccharomyces cerevisiae.

1989 • 340 citations

Helix-turn-helix, zinc-finger, and leucine-zipper motifs for eukaryotic transcriptional regulatory proteins

1989 • 306 citations

Electrophoresis of ribonucleoproteins reveals an ordered assembly pathway of yeast splicing complexes

1986 • 283 citations

An Early Hierarchic Role of U1 Small Nuclear Ribonucleoprotein in Spliceosome Assembly

1988 • 271 citations

The effect of temperature-sensitive RNA mutants on the transcription products from cloned ribosomal protein genes of yeast

1981 • 206 citations

Gel electrophoretic isolation of splicing complexes containing U1 small nuclear ribonucleoprotein particles.

1988 • 183 citations

Identification of ten genes that control ribosome formation in yeast

1970 • 182 citations

Identification of a yeast snRNP protein and detection of snRNP-snRNP interactions

1987 • 180 citations

Nuclear pre‐mRNA splicing in yeast

1989 • 156 citations

Sequences responsible for transcription termination on a gene segment in Saccharomyces cerevisiae.

1984 • 154 citations

Early commitment of yeast pre-mRNA to the spliceosome pathway.

1988 • 143 citations

The yeast RNA gene products are essential for mRNA splicing in vitro

1986 • 138 citations

U1-Specific Protein C needed for Efficient Complex Formation of U1 snRNP with a 5′ Splice Site

1990 • 135 citations

S. cerevisiae U1 RNA is large and has limited primary sequence homology to metazoan U1 snRNA

1987 • 131 citations

RNA11 protein is associated with the yeast spliceosome and is localized in the periphery of the cell nucleus.

1988 • 102 citations

Conservation between yeast and man of a protein associated with U5 small nuclear ribonucleoprotein

1989 • 101 citations

Gel Electrophoretic Isolation of Splicing Complexes Containing U1 Small Nuclear Ribonucleoprotein Particles

1988 • 95 citations

Human Ul snRNP-specificC protein: complete cDNA and protein sequence and identification of a multigene family in mammals

1988 • 90 citations

Early Commitment of Yeast Pre-mRNA to the Spliceosome Pathway

1988 • 75 citations

The mammalian analogue of the yeast PRP8 splicing protein is present in the U4/5/6 small nuclear ribonucleoprotein particle and the spliceosome.

1989 • 74 citations

PRP18, a protein required for the second reaction in pre-mRNA splicing.

1990 • 73 citations

TFIIIA and homologous gens. The ‘finger’ protiens

1986 • 66 citations

Affinity purification of spliceosomes reveals that the precursor RNA processing protein PRP8, a protein in the U5 small nuclear ribonucleoprotein particle, is a component of yeast spliceosomes.

1990 • 59 citations

RNA11 Protein is Associated with the Yeast Spliceosome and is Localized in the Periphery of the Cell Nucleus

1988 • 45 citations

Sequences Responsible for Transcription Termination on a Gene Segment in Saccharomyces cerevisiae

1984 • 42 citations

PRP18, a Protein Required for the Second Reaction in Pre-mRNA Splicing

1990 • 31 citations