Chapter 5. Drugs Acting at Central 5-Hydroxytryptamine Receptors

Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors

1985 • 1,855 citations

Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol.

1979 • 1,321 citations

[3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role.

1982 • 1,049 citations

8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site

1983 • 869 citations

Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors

1985 • 803 citations

Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT

1983 • 759 citations

Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites

1986 • 686 citations

The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-Propylamino) tetralin in the rat

1984 • 678 citations

Two Distinct Central Serotonin Receptors with Different Physiological Functions

1981 • 640 citations

Discrimination of Multiple [³H]5‐Hydroxytryptamine Binding Sites by the Neuroleptic Spiperone in Rat Brain

1981 • 629 citations

Serotonergic component of neuroleptic receptors

1978 • 621 citations

The binding of serotonergic ligands to the porcine choroid plexus: Characterization of a new type of serotonin recognition site

1984 • 598 citations

Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents

1984 • 597 citations

Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: Radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (−)[125I]iodocyanopindolol, [3H]mesulergine and [3H]Ketanserin

1985 • 581 citations

8-hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT, a potent and selective simplified ergot congener with central 5-HT-receptor stimulating activity

1982 • 517 citations

Serotonergic facilitation of facial motoneuron excitation

1979 • 440 citations

Presynaptic 5-HT autoreceptors on serotonergic cell bodies and/or dendrites but not terminals are of the 5-HT1A subtype

1985 • 383 citations

Selective interaction of novel anxiolytics with 5-hydroxytryptamine1A receptors

1985 • 367 citations

Effects of a new type of 5-HT receptor agonist on male rat sexual behavior

1981 • 327 citations

Determination of selective and nonselective compounds for the 5-HT 1A and 5-HT 1B receptor subtypes in rat frontal cortex.

1984 • 324 citations

Low doses of the putative serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicit feeding in the rat

1985 • 323 citations

Characterization of the 5-HTIB recognition site in rat brain: Binding studies with (−)[125I]Iodocyanopindolol

1985 • 281 citations

Neuropharmacology of Serotonin

1986 • 251 citations

Hypothermia in the rat induced by the potent serotoninergic agent 8-OH-DPAT

1985 • 241 citations

The Influence of Ritanserin, a Serotonin Antagonist, in Anxiety Disorders: A Double-blind Placebo-controlled Study versus Lorazepam

1985 • 223 citations

Biology of serotonergic transmission

1983 • 214 citations

Stereoselective blockade at [3H]5-HT binding sites and at the 5-HT autoreceptor by propranolol

1984 • 206 citations

Mechanism of the Hypotensive Effect of Ketanserin

1982 • 183 citations

3H-TVX Q 7821: identification of 5-HT1 binding sites as target for a novel putative anxiolytic

1985 • 174 citations

Biochemical evidence for the 5-HT agonist properties of PAT (8-hydroxy-2-(di-n-propylamino)tetralin) in the rat brain

1984 • 168 citations

Inhibition of 5-hydroxytryptamine-mediated behaviour by the putative 5-HT2 antagonist pirenperone

1983 • 163 citations

Calcium antagonist subgroups

1985 • 160 citations

Mesulergine, a selective serotonin-2 ligand in the rat cortex, does not label these receptors in porcine and human cortex: Evidence for species differences in brain serotonin-2 receptors

1984 • 141 citations

Buspirone: Effects on central monoaminergic transmission - possible relevance to animal experimental and clinical findings

1982 • 139 citations

Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat

1985 • 139 citations

Brain serotonin receptors as a target for the putative anxiolytic TVX Q 7821

1984 • 138 citations

[3H]Mianserin: differential labeling of serotonin and histamine receptors in rat brain.

1981 • 137 citations

8-Hydroxy-2-(di-n-propylamino) tetralin is devoid of activity at the 5-hydroxytryptamine autoreceptor in rat brain. Implications for the proposed link between the autoreceptor and the [3H] 5-HT recognition site

1984 • 132 citations

Buspirone: Action on serotonin receptors in calf hippocampus

1983 • 127 citations

The head-twitch response to intraperitoneal injection of 5-hydroxytryptophan in the rat: Antagonist effects of purported 5-hydroxytryptamine antagonists and of pirenperone, an LSD antagonist

1983 • 123 citations

5-HT2 receptor blockade to study serotonin-induced pathology

1983 • 119 citations

Pharmacology of Potent and Selective S2-Serotonergic Antagonists

1985 • 116 citations

5HT-receptor antagonist properties of SCH 23390 in vascular smooth muscle and brain

1984 • 105 citations

The putative 5-HT1 receptor agonist, RU 24969, inhibits the efflux of 5-hydroxytryptamine from rat frontal cortex slices by stimulation of the 5-HT autoreceptor

1985 • 104 citations

Two 5-HT receptors linked to adenylate cyclase in guinea pig hippocampus are discriminated by 5-carboxamidotryptamine and spiperone

1985 • 102 citations

Serotonergic excitation of sympathetic preganglionic neurons: a microiontophoretic study

1983 • 97 citations

Citalopram antagonizes the stimulation by lysergic acid diethylamide of presynaptic inhibitory serotonin autoreceptors in the rat hypothalamus.

1982 • 95 citations

Pharmacological analysis of muscarinic receptors coupled to oxyntic cell secretion in the mouse stomach

1985 • 91 citations

Blockade of the central 5-HT autoreceptor by β-adrenoceptor antagonists

1986 • 90 citations

Biochemical assessment of the central 5-HT agonist activity of RU 24969 (a piperidinyl indole)

1980 • 85 citations

Pharmacological characterization of serotonin receptors in the facial motor nucleus: A microiontophoretic study

1980 • 84 citations

Serotonin: Current aspects of neurochemistry and function

1982 • 84 citations

Clozapine—A serotonin antagonist?

1984 • 81 citations

5-HT-la and 5-HT-lb selectivity of two phenylpiperazine derivatives: Evidence for 5-HT-lb heterogeneity

1985 • 78 citations

Acute administration of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), a selective 5-HT-receptor agonist, causes a biphasic blood pressure response and a bradycardia in the normotensive Sprague-Dawley rat and in the spontaneously hypertensive rat

1985 • 75 citations

Interaction between tricyclic and nontricyclic 5-hydroxytryptamine uptake inhibitors and the presynaptic 5-hydroxytryptamine inhibitory autoreceptors in the rat hypothalamus.

1985 • 73 citations

Comparative neuropharmacology of buspirone and MJ-13805, a potential anti-anxiety drug

1983 • 71 citations

[3H]Mesulergine, a selective ligand for serotonin-2 receptors

1983 • 70 citations

The Citalopram/5‐HTP‐induced Head Shake Syndrome is Correlated to 5‐HT₂ Receptor Affinity and also Influenced by other Transmitters

1984 • 68 citations

Evidence that blood pressure reduction by serotonin antagonists is related to alpha receptor blockade in spontaneously hypertensive rats.

1983 • 66 citations

Spiperone differentiates multiple 5-hydroxytryptamine responses in rat hippocampal slices in vitro

1985 • 66 citations

Dissociation constants of serotonin agonists in the canine basilar artery correlate to Ki values at the 5-HT1A binding site.

1986 • 66 citations

2-[125Iodo]LSD, a new ligand for the characterisation and localisation of 5-HT2 receptors

1984 • 65 citations

Buspirone: A potential atypical neuroleptic

1983 • 61 citations

8-Hydroxy-2-(alkylamino)tetralins and related compounds as central 5-hydroxytryptamine receptor agonists

1984 • 59 citations

[³H]Metergoline: A New Ligand of Serotonin Receptors in the Rat Brain

1981 • 54 citations

Raphe origin of serotonin-containing neurons within choroid plexus of the rat

1979 • 53 citations

Serotonin receptor changes after chronic antidepressant treatments: Ligand binding, electrophysiological, and behavioral studies

1983 • 53 citations

[³H]1‐[2‐(4‐Aminophenyl)Ethyl]‐4‐(3‐Trifluoromethylphenyl)Piperazine: A Selective Radioligand for 5‐HT_1A Receptors in Rat Brain

1986 • 52 citations

Noninvasive assessment of the cardiovascular effects of psychotropic drugs.

1982 • 50 citations

Interactions of trazodone with serotonin neurons and receptors

1984 • 48 citations

(−)-Pindolol stereospecifically inhibits rat brain serotonin (5-HT) synthesis

1985 • 43 citations

Cyanopindolol is a highly potent and selective antagonist at the presynaptic serotonin autoreceptor in the rat brain cortex

1985 • 42 citations

Verapamil, an antagonist at 5-Hydroxytryptamine receptors of human blood platelets

1985 • 40 citations

Chapter 1. Biochemical Models for Serotonin Receptors

1982 • 39 citations

The Interaction of Indole Derivatives with the Serotonin Receptor and Non-Dopaminergic Circling Behaviour

1981 • 38 citations

Functional correlates of 5-HT1 recognition sites

1983 • 38 citations

[3H]WB4101 labels S1 serotonin receptors in rat cerebral cortex

1984 • 38 citations

Characteristics of d-lysergic acid diethylamide binding to subcellular fractions derived from rat brain

1973 • 36 citations

Aetiology of cerebral arterial spasm following subarachnoid haemorrhage: evidence against a major involvement of 5‐hydroxy‐ tryptamine in the production of acute spasm.

1978 • 36 citations

Redistribution of carotid artery blood flow by 5-HT: Effects of the 5-HT2 receptor antagonists ketanserin and Wal 1307

1984 • 36 citations

Enhancement by the putative 5-HT receptor agonist 8-OH-2-(di-n-propylamino)tetralin of the acoustic startle response in the rat

1983 • 35 citations

Monophenolic octahydrobenzo[f]quinolines: central dopamine- and serotonin-receptor stimulating activity

1982 • 33 citations

In vitro and in vivo disposition of 3H-methiothepin in brain tissues

1979 • 33 citations

Inhibition of [3H]spiperone binding to 5-HT2 receptors of rat cerebral cortex by the calcium antagonists verapamil and D600

1984 • 28 citations

Buspirone analogs. 1. Structure-activity relationships in a series of N-aryl- and heteroarylpiperazine derivatives

1983 • 28 citations

Receptor specificity of the 5HT₂ receptor antagonist, LY53857

1985 • 28 citations

N-(3-acetylaminophenyl)piperazine hydrochloride (BEA 1654), a putative 5-HT1 agonist, causes constriction of arteriovenous anastomoses and dilatation of arterioles

1985 • 26 citations

Blockade of a 5-hydroxytryptophan-induced animal model of depression with a potent and selective 5-HT2 receptor antagonist (LY53857)

1985 • 24 citations

Irreversible blockade of central 5-HT binding sites by 8-methoxy-2′-chloro-PAT

1985 • 21 citations

[125I]LSD binding to serotonin and dopamine receptors in bovine caudate membranes

1985 • 17 citations

A Trifluoromethylphenyl Piperazine Derivative with High Affinity for 5‐Hydroxytryptamine‐1A Sites in Rat Brain

1985 • 13 citations

N1-methyl-2-[125I]LSD([125I]MIL), a preferred ligand for serotonin 5-HT2 receptors

1985 • 13 citations

Differential photoaffinity labelling of serotonin‐S2 receptors and histamine‐H₁ receptors using 7‐azidoketanserin

1985 • 9 citations

The mode of action of ketanserin

1983 • 7 citations

The characterization of 5-HT receptors Introduction

1984 • 6 citations

Photoaffinity labelling of serotonin-S2 receptors with 7-azidoketanserin

1985 • 4 citations

Presynaptic receptors: Mechanisms and functions

1983 • 3 citations