Molecular Interactions of Organophosphates (OPs), Oximes and Carbamates at Nicotinic Receptors

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Single-channel currents recorded from membrane of denervated frog muscle fibres

1976 • 2,456 citations

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

1957 • 1,457 citations

Voltage clamp analysis of acetylcholine produced end‐plate current fluctuations at frog neuromuscular junction

1973 • 992 citations

Local anaesthetics transiently block currents through single acetylcholine‐receptor channels.

1978 • 864 citations

A quantitative description of end‐plate currents

1972 • 625 citations

Acetylcholine Receptor: An Allosteric Protein

1984 • 620 citations

Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist

1980 • 608 citations

Chemistry and Pharmacology of Polypeptide Toxins in Snake Venoms

1972 • 479 citations

Cloning and sequence analysis of calf cDNA and human genomic DNA encoding α-subunit precursor of muscle acetylcholine receptor

1983 • 433 citations

Structural and Functional Properties of the Acetylcholine Receptor Protein in its Purified and Membrane-Bound States

1978 • 399 citations

The Cell surface and neuronal function

1980 • 379 citations

Fluctuations in the microsecond time range of the current through single acetylcholine receptor ion channels

1981 • 366 citations

Role of acetylcholine receptor subunits in gating of the channel

1985 • 272 citations

Desensitization at the frog neuromuscular junction: a biphasic process

1982 • 211 citations

Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica

1977 • 183 citations

The characteristics of ‘end‐plate noise’ produced by different depolarizing drugs

1973 • 171 citations

A quantitative analysis of local anaesthetic alteration of miniature end‐plate currents and end‐plate current fluctuations.

1977 • 169 citations

Toxicology and pharmacology of bispyridinium oximes insight into the mechanism of action vs Soman poisoning in vivo

1981 • 147 citations

Anatoxin-a: a novel, potent agonist at the nicotinic receptor.

1980 • 133 citations

The reversible cholinesterase inhibitor physostigmine has channel-blocking and agonist effects on the acetylcholine receptor-ion channel complex.

1985 • 130 citations

A Kinetic Model for the Action of Xylocaine on Receptors for Acetylcholine

1968 • 96 citations

A study of the irreversible cholinesterase inhibitor, diisopropylfluorophosphate, on time course of end-plate currents in frog sartorius muscle.

1974 • 94 citations

Interaction of a fluorescent agonist with the membrane-bound acetylcholine receptor from Torpedomarmorata in the millisecond time range: Resolution of an “intermediate” conformational transition and evidence for positive cooperative effects

1980 • 90 citations

Molecular mechanisms of the potent and stereospecific nicotinic receptor agonist (+)-anatoxin-a.

1986 • 87 citations

Effect of histrionicotoxin on the ionic conductance modulator of the cholinergic receptor: a quantitative analysis of the end-plate current.

1974 • 80 citations

Protease effects on the structure of acetylcholine receptor membranes from Torpedo californica.

1980 • 74 citations

Multiple actions of anticholinesterase agents on chemosensitive synapses: Molecular basis for prophylaxis and treatment of organophosphate poisoning*1

1985 • 74 citations

Kinetic analysis of end plate currents altered by atropine and scopolamine.

1978 • 70 citations

Effectiveness of physostigmine as a pretreatment drug for protection of rats from organophosphate poisoning

1986 • 61 citations

Progress in Cholinergic Biology: Model Cholinergic Synapses

1983 • 61 citations

Acetylcholinesterase reactivators modify the functional properties of the nicotinic acetylcholine receptor ion channel.

1988 • 56 citations

An electrophysiological study of the effects of d-tubocurarine, atropine, and α-bungarotoxin on the cholinergic receptor in innervated and chronically denervated mammalian skeletal muscles

1974 • 50 citations

Comparison of the ultrastructural myopathy induced by anticholinesterase agents at the end plates of rat soleus and extensor muscles

1985 • 44 citations

Medical protection against chemical-warfare agents

1976 • 43 citations

Interactions of bupivacaine with ionic channels of the nicotinic receptor. Analysis of single-channel currents.

1984 • 41 citations

Structure-activity relationship of reversible cholinesterase inhibitors: activation, channel blockade and stereospecificity of the nicotinic acetylcholine receptor-ion channel complex.

1988 • 39 citations

Neurobiology of Acetylcholine

1987 • 39 citations

Noncompetitive blockade of the nicotinic acetylcholine receptor-ion channel complex by an irreversible cholinesterase inhibitor.

1987 • 36 citations

Myasthenia gravis: biology and treatment.

1987 • 32 citations

Enantiomer (+)physostigmine prevents organophosphate‐induced subjunctional damage at the neuromuscular synapse by a mechanism not related to cholinesterase carbamylation

1988 • 32 citations

Macromolecular Sites for Specific Neurotoxins and Drugs on Chemosensitive Synapses and Electrical Excitation in Biological Membranes

1988 • 29 citations

[Pyridinium and imidazolium salts as antidotes for soman and paraoxon poisoning in mice].

1970 • 27 citations

Interactions of bupivacaine with ionic channels of the nicotinic receptor. Electrophysiological and biochemical studies.

1984 • 27 citations

The Molecular Basis of Anticholinesterase Actions on Nicotinic and Glutamatergic Synapses^a

1987 • 25 citations

Desensitization of the nicotinic acetylcholine receptor by diisopropylfluorophosphate

1988 • 22 citations

Voltage- and time-dependent effects of phencyclidines on the endplate current arise from open and closed channel blockade.

1986 • 21 citations

Organophosphate and carbamate compounds have pre- and postjunctional effects at the insect glutamatergic synapse.

1986 • 20 citations

Activation and Blockade of the Nicotinic and Glutamatergic Synapses by Reversible and Irreversible Cholinesterase Inhibitors

1987 • 18 citations

The frog interosseal muscle fiber as a new model for patch clamp studies of chemosensitive- and voltage-sensitive ion channels: actions of acetylcholine and batrachotoxin.

1984 • 17 citations

The ionic channel of the nicotinic acetylcholine receptor is unable to differentiate between the optical antipodes of perhydrohistrionicotoxin

1983 • 9 citations

The reversible carbamate, (−)physostigmine, reduces the size of synaptic end plate lesions induced by sarin, an irreversible organophosphate

1989 • 9 citations