Thioredoxin and Glutaredoxin Isoforms

Physiological functions of thioredoxin and thioredoxin reductase

2000 • 2,440 citations

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1

1998 • 2,360 citations

THIOREDOXIN

1985 • 1,885 citations

Thioredoxin and Glutaredoxin Systems

1989 • 1,778 citations

REDOX REGULATION OF CELLULAR ACTIVATION

1997 • 1,121 citations

Thioredoxin —a fold for all reasons

1995 • 799 citations

Molecular and Cellular Aspects of Thiol–Disulfide Exchange

1990 • 763 citations

Identification, Characterization, and Crystal Structure of the Omega Class Glutathione Transferases

2000 • 712 citations

Distinct effects of thioredoxin and antioxidants onthe activation of transcription factors NF-kappa B and AP-1.

1994 • 694 citations

Mammalian Peroxiredoxin Isoforms Can Reduce Hydrogen Peroxide Generated in Response to Growth Factors and Tumor Necrosis Factor-α

1998 • 672 citations

Distinct Roles of Thioredoxin in the Cytoplasm and in the Nucleus

1999 • 597 citations

Crystal structure of thioredoxin from Escherichia coli at 1.68 Å resolution

1990 • 568 citations

Structure and mechanism of mammalian thioredoxin reductase: The active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence

2000 • 498 citations

Recent Trends in Glutathione Biochemistry—Glutathione–Protein Interactions: A Molecular Link between Oxidative Stress and Cell Proliferation?

1998 • 482 citations

Hydrogen donor system for Escherichia coli ribonucleoside-diphosphate reductase dependent upon glutathione.

1976 • 474 citations

YAP1 dependent activation of TRX2 is essential for the response of Saccharomyces cerevisiae to oxidative stress by hydroperoxides.

1994 • 472 citations

Three-dimensional structure of Escherichia coli thioredoxin-S2 to 2.8 A resolution.

1975 • 435 citations

Cloning and Expression of a Novel Mammalian Thioredoxin

1997 • 391 citations

Thioredoxin, a Redox Enzyme Released in Infection and Inflammation, Is a Unique Chemoattractant for Neutrophils, Monocytes, and T Cells

1999 • 340 citations

Thioredoxin reductase

2000 • 335 citations

Cloning and Expression of a Novel Human Glutaredoxin (Grx2) with Mitochondrial and Nuclear Isoforms

2001 • 326 citations

Reduction of disulfides by thioredoxin. Exceptional reactivity of insulin and suggested functions of thioredoxin in mechanism of hormone action.

1979 • 324 citations

Preparation and assay of mammalian thioredoxin and thioredoxin reductase

1999 • 316 citations

Thioltransferase is a specific glutathionyl mixed-disulfide oxidoreductase

1993 • 305 citations

Grx5 Glutaredoxin Plays a Central Role in Protection against Protein Oxidative Damage in Saccharomyces cerevisiae

1999 • 294 citations

The Skn7 response regulator controls gene expression in the oxidative stress response of the budding yeast Saccharomyces cerevisiae

1997 • 284 citations

[29] Glutaredoxin

1995 • 284 citations

The Glutathione Transferase Structural Family Includes a Nuclear Chloride Channel and a Ryanodine Receptor Calcium Release Channel Modulator

2001 • 279 citations

Rat and Calf Thioredoxin Reductase Are Homologous to Glutathione Reductase with a Carboxyl-terminal Elongation Containing a Conserved Catalytically Active Penultimate Selenocysteine Residue

1998 • 261 citations

High-resolution solution structures of oxidized and reduced Escherichia coli thioredoxin

1994 • 261 citations

The YeastSaccharomyces cerevisiaeContains Two Glutaredoxin Genes That Are Required for Protection against Reactive Oxygen Species

1998 • 230 citations

Structural and functional characterization of the mutant Escherichia coli glutaredoxin (C14.fwdarw.S) and its mixed disulfide with glutathione

1992 • 228 citations

Thioredoxin deficiency in yeast prolongs S phase and shortens the G1 interval of the cell cycle

1991 • 209 citations

Mitochondria of Saccharomyces cerevisiae Contain One-conserved Cysteine Type Peroxiredoxin with Thioredoxin Peroxidase Activity

2000 • 197 citations

Two additional glutaredoxins exist in Escherichia coli: glutaredoxin 3 is a hydrogen donor for ribonucleotide reductase in a thioredoxin/glutaredoxin 1 double mutant.

1994 • 195 citations

Mutagenesis of structural half-cystine residues in human thioredoxin and effects on the regulation of activity by selenodiglutathione

1993 • 162 citations

Reactivity of Glutaredoxins 1, 2, and 3 fromEscherichia coli Shows That Glutaredoxin 2 Is the Primary Hydrogen Donor to ArsC-catalyzed Arsenate Reduction

1999 • 157 citations

Thioredoxin 2 Is Involved in the Oxidative Stress Response inEscherichia coli

2000 • 156 citations

Encyclopedia of Molecular Biology

2002 • 152 citations

New Thioredoxins and Glutaredoxins as Electron Donors of 3′-Phosphoadenylylsulfate Reductase

1999 • 151 citations

Cloning, Expression, and Characterization of a NovelEscherichia coli Thioredoxin

1997 • 148 citations

Enzymatic reduction-oxidation of protein disulfides by thioredoxin

1984 • 145 citations

The Nuclear Magnetic Resonance Solution Structure of the Mixed Disulfide between Escherichia coli Glutaredoxin(C14S) and Glutathione

1994 • 140 citations

Transcriptional Regulation of Glutaredoxin and Thioredoxin Pathways and Related Enzymes in Response to Oxidative Stress

2000 • 138 citations

NMR structure of Escherichia coli glutaredoxin 3-glutathione mixed disulfide complex: implications for the enzymatic mechanism 1 1Edited by P. E. Wright

1999 • 136 citations

The Cloning and Characterization of a New Stress Response Protein

1999 • 103 citations

Yeast thioredoxin genes

1991 • 102 citations

Cloning, Overexpression, and Characterization of Glutaredoxin 2, An Atypical Glutaredoxin from Escherichia coli

1997 • 97 citations

Neuroprotection by glial cells through adult T cell leukemia-derived factor/human thioredoxin (ADF/TRX)

1994 • 93 citations

The NMR solution structure of human glutaredoxin in the fully reduced form

1998 • 92 citations

Thiotransferase in human red blood cells: kinetics and equilibrium

1991 • 89 citations

Purification from Placenta, Amino Acid Sequence, Structure Comparisons and cDNA Cloning of Human Glutaredoxin

1995 • 82 citations

A single glutaredoxin or thioredoxin gene is essential for viability in the yeast Saccharomyces cerevisiae

2000 • 81 citations

Solution structure of Escherichia coli glutaredoxin-2 shows similarity to mammalian glutathione-S-transferases

2001 • 80 citations

Structure of oxidized bacteriophage T4 glutaredoxin (thioredoxin)

1992 • 78 citations

[68] Glutaredoxin from Escherichia coli and calf thymus

1985 • 43 citations

Deoxyribonucleotides are maintained at normal levels in a yeast thioredoxin mutant defective in DNA synthesis.

1994 • 42 citations

Reactivity of glutaredoxins 1, 2 and 3 from Escherichia coli and protein disulfide isomerase towards glutathionyl‐mixed disulfides in ribonuclease A

1999 • 34 citations

Growth-phase regulation of the Escherichia coli thioredoxin gene

2000 • 22 citations

[27] Thioredoxin genetics

1995 • 14 citations