Effects of novel retinoid X receptor-selective ligands on myeloid leukemia differentiation and proliferation in vitro

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Proposed Revised Criteria for the Classification of Acute Myeloid Leukemia

1985 • 2,981 citations

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

1988 • 2,380 citations

A human retinoic acid receptor which belongs to the family of nuclear receptors

1987 • 2,245 citations

Identification of a receptor for the morphogen retinoic acid

1987 • 2,007 citations

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

1992 • 1,790 citations

Nuclear receptor that identifies a novel retinoic acid response pathway

1990 • 1,529 citations

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

1992 • 1,514 citations

The induction of differentiation in teratocarcinoma stem cells by retinoic acid

1978 • 1,459 citations

Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)

1991 • 1,298 citations

9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

1992 • 1,252 citations

RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements

1991 • 1,241 citations

All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results [see comments]

1990 • 1,224 citations

Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells

1980 • 1,094 citations

Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors

1992 • 966 citations

Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications

1983 • 585 citations

Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid

1992 • 583 citations

H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes.

1992 • 480 citations

RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors.

1992 • 446 citations

A clinical and experimental study on all-trans retinoic acid-treated acute promyelocytic leukemia patients

1991 • 412 citations

Synthesis and Structure-Activity Relationships of Novel Retinoid X Receptor-Selective Retinoids

1994 • 367 citations

Retinoids Selective for Retinoid X Receptor Response Pathways

1992 • 342 citations

Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha).

1990 • 330 citations

A new class of retinoids with selective inhibition of AP-1 inhibits proliferation

1994 • 318 citations

A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects.

1992 • 256 citations

Retinoic acid. Inhibition of the clonal growth of human myeloid leukemia cells.

1982 • 224 citations

Vitamin D compounds. Effect on clonal proliferation and differentiation of human myeloid cells.

1986 • 193 citations

Retinoic acid-resistant HL-60R cells harbor a point mutation in the retinoic acid receptor ligand-binding domain that confers dominant negative activity

1992 • 190 citations

RAR gamma 2 expression is regulated through a retinoic acid response element embedded in Sp1 sites.

1992 • 115 citations

9-cis-retinoic acid: effects on normal and leukemic hematopoiesis in vitro

1993 • 111 citations

A Functional Retinoic Acid Receptor Encoded by the Gene on Human Chromosome 12

1990 • 99 citations

Effects of novel retinoic acid compound, 9-cis-retinoic acid, on proliferation, differentiation, and expression of retinoic acid receptor-alpha and retinoid X receptor-alpha RNA by HL-60 cells

1993 • 92 citations

Conformational Effects on Retinoid Receptor Selectivity. 2. Effects of Retinoid Bridging Group on Retinoid X Receptor Activity and Selectivity

1995 • 81 citations

Antibodies specific to the retinoic acid human nuclear receptors alpha and beta.

1989 • 70 citations

Nuclear receptors for retinoids: mediators of retinoid effects on normal and malignant cells

1991 • 68 citations

Retinoic acid-resistant HL-60 cells exclusively contain mutant retinoic acid receptor-alpha

1994 • 55 citations

Myeloid differentiation mediated through retinoic acid receptor/retinoic X receptor (RXR) not RXR/RXR pathway

1994 • 53 citations

The Retinoic Acid Receptors α and β are Expressed in the Human Promyelocytic Leukemia Cell Line HL-60

1989 • 50 citations

Novel retinoic acid, 9-cis retinoic acid, in combination with all-trans retinoic acid is an effective inducer of differentiation of retinoic acid-resistant HL-60 cells

1994 • 39 citations

Induction of Differentiation and Covalent Binding to Proteins by the Synthetic Retinoids Ch55 and Am80

1994 • 10 citations