Thrombin-induced phosphoinositide hydrolysis in platelets. Receptor occupancy and desensitization

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Turnover of Inositol Phospholipids and Signal Transduction

1984 • 1,629 citations

Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase

1985 • 960 citations

Protein kinase C phosphorylates the inhibitory guanine‐nucleotide‐binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase

1985 • 736 citations

Platelets in Biology and Pathology

1981 • 644 citations

The polyphosphoinositide phosphodiesterase of erythrocyte membranes

1981 • 614 citations

5-Hydroxytryptamine stimulates inositol phosphate production in a cell-free system from blowfly salivary glands. Evidence for a role of GTP in coupling receptor activation to phosphoinositide breakdown.

1985 • 429 citations

Hormone-stimulated polyphosphoinositide breakdown in rat liver plasma membranes. Roles of guanine nucleotides and calcium.

1986 • 378 citations

Interrelations of Platelet Aggregation and Secretion

1977 • 350 citations

Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.

1985 • 332 citations

Mass changes in myoinositol trisphosphate in human platelets stimulated by thrombin. Inhibitory effects of phorbol ester.

1985 • 292 citations

Platelet aggregation: Part II Some results from a new method of study

1962 • 259 citations

Phorbol diesters promote β-adrenergic receptor phosphorylation and adenylate cyclase desensitization in duck erythrocytes

1984 • 238 citations

1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis.

1985 • 222 citations

Biochemistry of Platelets

1986 • 194 citations

Phorbol myristate acetate inhibits thrombin-stimulated Ca2+ mobilization and phosphatidylinositol 4,5-bisphosphate hydrolysis in human platelets.

1985 • 179 citations

Tumour‐promoting phorbol esters inhibit agonist‐induced phosphatidate formation and Ca²⁺ flux in human platelets

1985 • 173 citations

Thyrotropin-releasing hormone and GTP activate inositol trisphosphate formation in membranes isolated from rat pituitary cells.

1986 • 169 citations

Kinetics of the thrombin-induced release of calcium(II) by platelets

1973 • 164 citations

Activation of human platelet phospholipase C by ionophore A23187 is totally dependent upon cyclo-oxygenase products and ADP

1984 • 162 citations

Equilibrium binding of thrombin to platelets

1976 • 154 citations

Desensitization of turkey erythrocyte adenylate cyclase. Beta-adrenergic receptor phosphorylation is correlated with attenuation of adenylate cyclase activity.

1984 • 154 citations

Platelet Sequestration in Man. II. Immunological and Clinical Studies*

1964 • 127 citations

Collagen stimulates [3H]inositol trisphosphate formation in indomethacin-treated human platelets

1985 • 122 citations

Kinetics of the thrombin-induced release of adenosine triphosphate by platelets. Comparison with release of calcium

1973 • 118 citations

Effect of Repeated Treatment of Rabbit Platelets with Low Concentrations of Thrombin on their Function, Metabolism and Survival

1973 • 105 citations

Thrombin-induced platelet responses differ in requirement for receptor occupancy. Evidence for tight coupling of occupancy and compartmentalized phosphatidic acid formation.

1981 • 101 citations

Modified platelet responses to thrombin. Evidence for two types of receptors or coupling mechanisms.

1986 • 94 citations

Tight coupling of thrombin-induced acid hydrolase secretion and phosphatidate synthesis to receptor occupancy in human platelets

1984 • 85 citations

Platelet thrombin receptors. Binding of alpha-thrombin is coupled to signal generation by a chymotrypsin-sensitive mechanism.

1980 • 82 citations

Dissociation of thrombin from platelets by hirudin. Evidence for receptor processing.

1979 • 66 citations

ADP‐Induced Refractory State of Platelets in vitro

1975 • 59 citations

The effects of lithium on platelet phosphoinositide metabolism

1986 • 50 citations

Reassessment of the evidence for the role of secreted ADP in biphasic platelet aggregation. Mechanism of inhibition by creatine phosphate plus creatine phosphokinase.

1980 • 44 citations

Binding of thrombin to human platelet plasma membranes

1978 • 43 citations

Thrombin-Induced Platelet Secretion

1979 • 42 citations

Desensitization and antagonism of vasopressin-induced phosphoinositide metabolism and elevation of cytosolic free calcium concentration in human platelets

1986 • 39 citations

Mechanisms of Stimulus—Response Coupling in Platelets

1986 • 36 citations

Desensitisation in Human and Rabbit Blood Platelets

1982 • 27 citations

Further evidence against the validity of using an ADP-removing enzyme system (CP/CPK) for demonstrating the role of secreted ADP in platelet activaticn

1983 • 17 citations

Characterization of the thrombin-induced desensitization of platelet activation by thrombin

1983 • 14 citations

Lack of inhibition of thrombin‐induced rise in intracellular Ca²⁺ levels and 5‐hydroxytryptamine secretion by 1‐oleoyl‐2‐acetylglycerol in human platelets

1986 • 14 citations