Chemotherapy and Pelvic Hypofractionated Radiation Followed by Brachytherapy for Cervical Cancer

NCT04070976

NAINTERVENTIONAL

National Institute of Cancerología

82 participants

Started 2019-07-01 · Completed 2024-12-30

Status: Unknown (as of 12-23-2025)

Conditions

Cervical Cancer

Interventions

RADIATION: Hypofractionated therapy RADIATION: Standard therapy

Linked Papers (from SciSciNet-V2)

Total Papers19

Background

4

Result

0

Derived

0

Unknown

15

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

The main goal of this trial is to assess the safety and response rate to concomitant chemotherapy and external hypofractionated radiotherapy followed by brachytherapy in patients with clinical stage III cervical cancer. The trial will take place in the National Cancer Institute (INCan). Patients will be randomized into two groups: chemotherapy with external standard fractionated radiotherapy (45 Gy in 25 fractions) followed by brachytherapy or chemotherapy with external hypofractionated radiotherapy (37.5 Gy in 15 fractions) followed by brachytherapy.

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Background Papers8

Management and Care of Women With Invasive Cervical Cancer: American Society of Clinical Oncology Resource-Stratified Clinical Practice Guideline

Management and Care of Women With Invasive Cervical Cancer: American Society of Clinical Oncology Resource-Stratified Clinical Practice Guideline

An assessment of GLOBOCAN methods for deriving national estimates of cancer incidence

An assessment of GLOBOCAN methods for deriving national estimates of cancer incidence

Twenty-first century cervical cancer management: A historical perspective of the gynecologic oncology group/NRG oncology over the past twenty years

Twenty-first century cervical cancer management: A historical perspective of the gynecologic oncology group/NRG oncology over the past twenty years

Cost Implications of an Evidence-Based Approach to Radiation Treatment After Lumpectomy for Early-Stage Breast Cancer

Cost Implications of an Evidence-Based Approach to Radiation Treatment After Lumpectomy for Early-Stage Breast Cancer

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers15

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

74,955 citations

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

26,824 citations

Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

6,648 citations

Pelvic Radiation with Concurrent Chemotherapy Compared with Pelvic and Para-Aortic Radiation for High-Risk Cervical Cancer

2,214 citations

Cervical Cancer, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology

Cancer of the cervix uteri

Phase III, Open-Label, Randomized Study Comparing Concurrent Gemcitabine Plus Cisplatin and Radiation Followed by Adjuvant Gemcitabine and Cisplatin Versus Concurrent Cisplatin and Radiation in Patients With Stage IIB to IVA Carcinoma of the Cervix

A systematic review of acute and late toxicity of concomitant chemoradiation for cervical cancer

Risk of Late Toxicity in Men Receiving Dose-Escalated Hypofractionated Intensity Modulated Prostate Radiation Therapy: Results From a Randomized Trial

NCCN Framework for Resource Stratification: A Framework for Providing and Improving Global Quality Oncology Care

Fractionated Grid Therapy in Treating Cervical Cancers: Conventional Fractionation or Hypofractionation?

Long‐term follow‐up of the risk for cervical intraepithelial neoplasia grade 2 or worse in HPV‐negative women after conization

Hypofractionated radiotherapy in carcinoma cervix IIIB: Tata Memorial Hospital experience.

Disparities in Standard of Care Treatment and Associated Survival Decrement in Patients With Locally Advanced Cervical Cancer

Low-dose fractionated radiation and chemotherapy prior to definitive chemoradiation in locally advanced carcinoma of the uterine cervix: Results of a prospective phase II clinical trial