Cervical Cancer, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology

Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium

2009 • 2,700 citations

Concurrent Cisplatin-Based Radiotherapy and Chemotherapy for Locally Advanced Cervical Cancer

1999 • 2,474 citations

Pelvic Radiation with Concurrent Chemotherapy Compared with Pelvic and Para-Aortic Radiation for High-Risk Cervical Cancer

1999 • 2,214 citations

Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer

1997 • 1,599 citations

Minimally Invasive versus Abdominal Radical Hysterectomy for Cervical Cancer

2018 • 1,530 citations

Randomized Comparison of Fluorouracil Plus Cisplatin Versus Hydroxyurea as an Adjunct to Radiation Therapy in Stage IIB-IVA Carcinoma of the Cervix With Negative Para-Aortic Lymph Nodes: A Gynecologic Oncology Group and Southwest Oncology Group Study

1999 • 1,470 citations

Improved Survival with Bevacizumab in Advanced Cervical Cancer

2014 • 1,284 citations

A Randomized Trial of Pelvic Radiation Therapy versus No Further Therapy in Selected Patients with Stage IB Carcinoma of the Cervix after Radical Hysterectomy and Pelvic Lymphadenectomy: A Gynecologic Oncology Group Study

1999 • 1,177 citations

FIVE CLASSES OF EXTENDED HYSTERECTOMY FOR WOMEN WITH CERVICAL CANCER

1975 • 783 citations

Revised FIGO staging for carcinoma of the cervix

2009 • 695 citations

Classification of radical hysterectomy

2008 • 609 citations

Phase III Study of Cisplatin With or Without Paclitaxel in Stage IVB, Recurrent, or Persistent Squamous Cell Carcinoma of the Cervix: A Gynecologic Oncology Group Study

2004 • 603 citations

Survival after Minimally Invasive Radical Hysterectomy for Early-Stage Cervical Cancer

2018 • 581 citations

Phase III, Open-Label, Randomized Study Comparing Concurrent Gemcitabine Plus Cisplatin and Radiation Followed by Adjuvant Gemcitabine and Cisplatin Versus Concurrent Cisplatin and Radiation in Patients With Stage IIB to IVA Carcinoma of the Cervix

2011 • 441 citations

Bilateral Negative Sentinel Nodes Accurately Predict Absence of Lymph Node Metastasis in Early Cervical Cancer: Results of the SENTICOL Study

2011 • 398 citations

Class II versus Class III Radical Hysterectomy in Stage IB–IIA Cervical Cancer: A Prospective Randomized Study

2001 • 387 citations

Incidence and distribution pattern of pelvic and paraaortic lymph node metastasis in patients with stages IB, IIA, and IIB cervical carcinoma treated with radical hysterectomy

1999 • 351 citations

Paclitaxel Plus Carboplatin Versus Paclitaxel Plus Cisplatin in Metastatic or Recurrent Cervical Cancer: The Open-Label Randomized Phase III Trial JCOG0505

2015 • 344 citations

Impact of Radiotherapy on Fertility, Pregnancy, and Neonatal Outcomes in Female Cancer Patients

2009 • 321 citations

Early Invasive Cervical Cancer: Tumor Delineation by Magnetic Resonance Imaging, Computed Tomography, and Clinical Examination, Verified by Pathologic Results, in the ACRIN 6651/GOG 183 Intergroup Study

2006 • 289 citations

Multicenter Validation Study of the Sentinel Lymph Node Concept in Cervical Cancer: AGO Study Group

2008 • 286 citations

Radiation therapy with and without extrafascial hysterectomy for bulky stage IB cervical carcinoma: a randomized trial of the Gynecologic Oncology Group☆

2003 • 262 citations

Endocervical adenocarcinoma and its variants: their morphology and differential diagnosis

2002 • 252 citations

Multimodality Therapy for Locally Advanced Cervical Carcinoma: State of the Art and Future Directions

2007 • 250 citations

Laparoscopic versus open radical hysterectomy in early-stage cervical cancer: long-term survival outcomes in a matched cohort study

2011 • 244 citations

Oncological outcomes after fertility-sparing surgery for cervical cancer: a systematic review

2016 • 238 citations

Small cell neuroendocrine carcinoma of the cervix: outcome and patterns of recurrence

2004 • 232 citations

Ovarian transposition for patients with cervical carcinoma treated by radiosurgical combination

2000 • 227 citations

Paclitaxel has moderate activity in squamous cervix cancer. A Gynecologic Oncology Group study.

1996 • 220 citations

Rethinking the use of radiation and chemotherapy after radical hysterectomy: a clinical–pathologic analysis of a Gynecologic Oncology Group/Southwest Oncology Group/Radiation Therapy Oncology Group trial

2004 • 203 citations

Prognostic significance of low volume sentinel lymph node disease in early-stage cervical cancer

2011 • 200 citations

Management of low-risk early-stage cervical cancer: Should conization, simple trachelectomy, or simple hysterectomy replace radical surgery as the new standard of care?

2013 • 198 citations

Radical vaginal trachelectomy as a fertility‐sparing procedure in women with early‐stage cervical cancer—cumulative pregnancy rate in a series of 123 women

2006 • 194 citations

Oncologic outcome of fertility-sparing radical trachelectomy versus radical hysterectomy for stage IB1 cervical carcinoma

2008 • 193 citations

Pregnancy outcomes in patients after radical trachelectomy

2003 • 191 citations

Prospective Multicenter Study Evaluating the Survival of Patients With Locally Advanced Cervical Cancer Undergoing Laparoscopic Para-Aortic Lymphadenectomy Before Chemoradiotherapy in the Era of Positron Emission Tomography Imaging

2013 • 176 citations

Robotic radical hysterectomy in early stage cervical cancer: A systematic review and meta-analysis

2015 • 172 citations

Early Invasive Cervical Cancer: CT and MR Imaging in Preoperative Evaluation—ACRIN/GOG Comparative Study of Diagnostic Performance and Interobserver Variability

2007 • 169 citations

Sentinel lymph node detection in early stage uterine cervix carcinoma: A systematic review

2007 • 167 citations

Establishing a sentinel lymph node mapping algorithm for the treatment of early cervical cancer

2011 • 163 citations

Comparison of the validity of magnetic resonance imaging and positron emission tomography/computed tomography in the preoperative evaluation of patients with uterine corpus cancer

2008 • 161 citations

Sentinel Node Mapping in Cervical and Endometrial Cancer: Indocyanine Green Versus Other Conventional Dyes—A Meta-Analysis

2016 • 159 citations

Microinvasive carcinoma of the cervix

1992 • 158 citations

Treatment of (“bulky”) stage IB cervical cancer with or without neoadjuvant vincristine and cisplatin prior to radical hysterectomy and pelvic/para-aortic lymphadenectomy: A phase III trial of the gynecologic oncology group

2007 • 157 citations

Robotic radical hysterectomy versus total laparoscopic radical hysterectomy with pelvic lymphadenectomy for treatment of early cervical cancer.

2008 • 157 citations

Surgical, oncological, and obstetrical outcomes after abdominal radical trachelectomy — A systematic literature review

2013 • 154 citations

Pregnancy after radical trachelectomy: A real option?

2005 • 153 citations

Fertility-sparing radical abdominal trachelectomy for cervical carcinoma: Technique and review of the literature

2006 • 151 citations

Clinical significance of lympho vascular space involvement and lymph node micrometastases in early-stage cervical cancer: A retrospective case-control surgico-pathological study

2005 • 146 citations

Concurrent mitomycin C, 5-fluorouracil, and radiotherapy in the treatment of locally advanced carcinoma of the cervix: a randomized trial

2003 • 145 citations

Screening and adenocarcinoma of the cervix

2009 • 144 citations

Efficacy of neoadjuvant chemotherapy in patients with FIGO stage IB1 to IIA cervical cancer: An international collaborative meta-analysis

2012 • 144 citations

Robot-assisted versus open radical hysterectomy: A multi-institutional experience for early-stage cervical cancer

2016 • 143 citations

Chemoradiation and Adjuvant Chemotherapy in Cervical Cancer

1999 • 141 citations

Bilateral ultrastaging of sentinel lymph node in cervical cancer: Lowering the false-negative rate and improving the detection of micrometastasis

2012 • 138 citations

The Sentinel Node Technique Detects Unexpected Drainage Pathways and Allows Nodal Ultrastaging in Early Cervical Cancer: Insights from the Multicenter Prospective SENTICOL Study

2012 • 135 citations

Surgery Insight: radical vaginal trachelectomy as a method of fertility preservation for cervical cancer

2007 • 133 citations

Sentinel node biopsy for lymph nodal staging of uterine cervix cancer: A systematic review and meta-analysis of the pertinent literature

2014 • 132 citations

New classification system of radical hysterectomy: Emphasis on a three-dimensional anatomic template for parametrial resection

2011 • 127 citations

A review of hypofractionated palliative radiotherapy

2007 • 124 citations

Survival rate comparisons amongst cervical cancer patients treated with an open, robotic-assisted or laparoscopic radical hysterectomy: A five year experience

2015 • 117 citations

Radical vaginal versus abdominal trachelectomy for stage IB1 cervical cancer: A comparison of surgical and pathologic outcomes

2008 • 113 citations

An International Series on Abdominal Radical Trachelectomy: 101 Patients and 28 Pregnancies

2012 • 109 citations

Clinical examination versus magnetic resonance imaging in the pretreatment staging of cervical carcinoma: systematic review and meta-analysis

2013 • 105 citations

Diagnostic value of intraoperative examination of sentinel lymph node in early cervical cancer: A prospective, multicenter study

2011 • 102 citations

Surgical and clinical safety and effectiveness of robot-assisted laparoscopic hysterectomy compared to conventional laparoscopy and laparotomy for cervical cancer: A systematic review and meta-analysis

2016 • 102 citations

Comparison of clinical outcomes of adenocarcinoma and adenosquamous carcinoma in uterine cervical cancer patients receiving surgical resection followed by radiotherapy: A multicenter retrospective study (KROG 13-10)

2014 • 100 citations

Concurrent Chemotherapy and Pelvic Radiation Therapy Compared With Pelvic Radiation Therapy Alone as Adjuvant Therapy After Radical Surgery in High-Risk Early-Stage Cancer of the Cervix

2023 • 98 citations

Sentinel lymph node biopsy in early-stage cervical cancer: Utility of intraoperative versus postoperative assessment

2008 • 97 citations

Outcomes after radical hysterectomy in patients with early-stage adenocarcinoma of uterine cervix

2010 • 96 citations

High false negative rate of frozen section examination of sentinel lymph nodes in patients with cervical cancer

2013 • 95 citations

Curative pelvic exenteration for recurrent cervical carcinoma in the era of concurrent chemotherapy and radiation therapy. A systematic review

2015 • 89 citations

Intermediate-risk grouping of cervical cancer patients treated with radical hysterectomy: a Korean Gynecologic Oncology Group study

2013 • 89 citations

Comparisons of vaginal and abdominal radical trachelectomy for early-stage cervical cancer: preliminary results of a multi-center research in China

2013 • 88 citations

The sentinel node concept in early cervical cancer performs well in tumors smaller than 2 cm

2010 • 88 citations

The Outcome of Laparoscopic Radical Hysterectomy and Lymphadenectomy for Cervical Cancer: A Prospective Analysis of 295 Patients

2008 • 87 citations

Close Vaginal Margins as a Prognostic Factor after Radical Hysterectomy

1998 • 87 citations

Identification of Distant Metastatic Disease in Uterine Cervical and Endometrial Cancers with FDG PET/CT: Analysis from the ACRIN 6671/GOG 0233 Multicenter Trial

2017 • 85 citations

A comparison of cisplatin/paclitaxel and carboplatin/paclitaxel in stage IVB, recurrent or persistent cervical cancer

2007 • 85 citations

Clinical tumor diameter and prognosis of patients with FIGO stage IB1 cervical cancer (JCOG0806-A)

2015 • 84 citations

Ovarian metastases in early-stage cervical cancer (IA2-IIA): a multicenter retrospective study of 1965 patients (a Cooperative Task Force study)

2007 • 83 citations

Stage IB1 Cervical Cancer: Role of Preoperative MR Imaging in Selection of Patients for Fertility-Sparing Radical Trachelectomy

2013 • 82 citations

Morbidity After Pelvic Exenteration for Gynecological Malignancies: A Retrospective Multicentric Study of 230 Patients

2013 • 80 citations

Lymphadenectomy in Locally Advanced Cervical Cancer Study (LiLACS): Phase III Clinical Trial Comparing Surgical With Radiologic Staging in Patients With Stages IB2–IVA Cervical Cancer

2013 • 80 citations

New pattern-based personalized risk stratification system for endocervical adenocarcinoma with important clinical implications and surgical outcome

2016 • 79 citations

Radical Vaginal Trachelectomy After Laparoscopic Staging and Neoadjuvant Chemotherapy in Women With Early-Stage Cervical Cancer Over 2 cm: Oncologic, Fertility, and Neonatal Outcome in a Series of 20 Patients

2014 • 78 citations

Brachytherapy versus radical hysterectomy after external beam chemoradiation with gemcitabine plus cisplatin: a randomized, phase III study in IB2–IIB cervical cancer patients

2013 • 77 citations

Imaging of endometrial and cervical cancer

2010 • 73 citations

Use of Abdominal Radical Trachelectomy to Treat Cervical Cancer Greater Than 2 cm in Diameter

2013 • 73 citations

Is there a role for postoperative treatment in patients with stage Ib2–IIb cervical cancer treated with neo-adjuvant chemotherapy and radical surgery? An Italian multicenter retrospective study

2013 • 73 citations

Laparoscopic ovarian transposition in patients with early cervical cancer

2007 • 70 citations

Abdominal radical trachelectomy: Is it safe for IB1 cervical cancer with tumors ≥2cm?

2013 • 69 citations

Gynecologic Oncology Group Surgical Procedures Manual

2009 • 69 citations

A Comparison between Loop Electrosurgical Excision Procedure and Cold Knife Conization for Treatment of Cervical Dysplasia: Residual Disease in a Subsequent Hysterectomy Specimen

1999 • 68 citations

Impact of Adoption of Chemoradiotherapy on the Outcome of Cervical Cancer in Ontario: Results of a Population-Based Cohort Study

2007 • 67 citations

A phase II trial of carboplatin for recurrent or metastatic squamous carcinoma of the uterine cervix: A Southwest Oncology Group Study

1990 • 67 citations

Total laparoscopic radical hysterectomy for locally advanced cervical carcinoma (stages IIB, IIA and bulky stages IB) after concurrent chemoradiation therapy: Surgical morbidity and oncological results

2009 • 66 citations

ACR Appropriateness Criteria® on Advanced Cervical Cancer Expert Panel on Radiation Oncology—Gynecology

2011 • 66 citations

Fertility-Sparing Surgery for Early Cervical Cancer—Approach to Less Radical Surgery

2012 • 64 citations

Long-term Survival and Late Toxicity after Chemoradiotherapy for Cervical Cancer — The Addenbrooke's Experience

2008 • 61 citations

Perioperative morbidity and rate of upstaging after laparoscopic staging for patients with locally advanced cervical cancer: results of a prospective randomized trial

2015 • 59 citations

Impact of the Human Papilloma Vaccine on Cervical Cancer

2007 • 58 citations

Influence of quantity of lymph vascular space invasion on time to recurrence in women with early-stage squamous cancer of the cervix

2005 • 58 citations

Cisplatin, Radiation, and Adjuvant Hysterectomy Compared with Radiation and Adjuvant Hysterectomy for Bulky Stage IB Cervical Carcinoma

1999 • 58 citations

Prognostic Value of Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography or PET-Computed Tomography in Cervical Cancer: A Meta-Analysis

2013 • 57 citations

Carboplatin and paclitaxel for advanced and recurrent cervical carcinoma: the British Columbia Cancer Agency experience

2005 • 56 citations

Fertility-Sparing Surgery in Early-Stage Cervical Cancer: Indications and Applications

2010 • 54 citations

Pattern-based classification of invasive endocervical adenocarcinoma, depth of invasion measurement and distinction from adenocarcinoma in situ: interobserver variation among gynecologic pathologists

2016 • 52 citations

Pattern classification of endocervical adenocarcinoma: reproducibility and review of criteria

2016 • 52 citations

Sentinel lymph node mapping in cervical cancer: the future?

2011 • 49 citations

ACR Appropriateness Criteria® Pretreatment Planning of Invasive Cancer of the Cervix

2012 • 49 citations

Radical abdominal trachelectomy for stage IB1 cervical cancer at 15-week gestation

2009 • 49 citations

Radical trachelectomy: The first step of fertility preservation in young women with cervical cancer (Review)

2013 • 46 citations

Predictors of residual carcinoma or carcinoma-in-situ at hysterectomy following cervical conization with positive margins

2013 • 45 citations

Concurrent carboplatin with pelvic radiation therapy in the primary treatment of cervix cancer

2003 • 44 citations

Reproductive outcomes after laparoscopic radical trachelectomy for early-stage cervical cancer

2014 • 44 citations

Contribution of lymphoscintigraphy to intraoperative sentinel lymph node detection in early cervical cancer: Analysis of the prospective multicenter SENTICOL cohort

2015 • 44 citations

Preoperative Concurrent Radiation Therapy and Chemotherapy for Bulky Stage IB2, IIA, and IIB Carcinoma of the Uterine Cervix With Proximal Parametrial Invasion

2008 • 43 citations

Clinical evaluation of neoadjuvant chemotherapy followed by radical surgery in the management of stage IB2–IIB cervical cancer

2012 • 41 citations

Role of MRI in detecting involvement of the uterine internal os in uterine cervical cancer: Systematic review of diagnostic test accuracy

2013 • 39 citations

Sentinel lymph node biopsy in cervical cancer: A meta-analysis

2013 • 38 citations

Improved Survival After Concurrent Weekly Cisplatin and Radiotherapy for Cervical Carcinoma with Assessment of Acute and Late Side-effects

2005 • 37 citations

Do FIGO Stage IA and Small (≤2 cm) IB1 Cervical Adenocarcinomas Have a Good Prognosis and Warrant Less Radical Surgery?

2011 • 36 citations

A phase III randomized trial of postoperative pelvic irradiation in stage IB cervical carcinoma with poor prognostic features: Follow-up of a Gynecologic Oncology Group study

2007 • 35 citations

Metastasis to deep obturator and para-aortic lymph nodes in 649 patients with cervical carcinoma

2011 • 34 citations

Conservative Therapy for Microinvasive Carcinoma of the Uterine Cervix

1994 • 34 citations

Randomized Phase III Trial of Cisplatin With or Without Topotecan in Carcinoma of the Uterine Cervix: A Gynecologic Oncology Group Study

2006 • 34 citations

Cervical conization of adenocarcinoma in situ: a predicting model of residual disease

2013 • 31 citations

Surgical Treatment of Microinvasive Cervical Cancer: Analysis of Pathologic Features With Implications on Radicality

2015 • 30 citations

Outcomes and costs of open, robotic, and laparoscopic radical hysterectomy for stage IB1 cervical cancer.

2018 • 30 citations

The vaginal radical trachelectomy: An update of a series of 125 cases and 106 pregnancies

2011 • 28 citations

Concurrent chemoradiation with carboplatin for elderly, diabetic and hypertensive patients with locally advanced cervical cancer.

2008 • 28 citations

Postoperative Chemoradiation Therapy in High-Risk Cervical Cancer: Re-evaluating the Findings of Gynecologic Oncology Group Study 109 in a Large, Population-Based Cohort

2015 • 26 citations

A phase III trial of adjuvant chemotherapy following chemoradiation as primary treatment for locally advanced cervical cancer compared to chemoradiation alone: Outback (ANZGOG0902/GOG0274/RTOG1174).

2014 • 25 citations

PET/CT in Gynecologic Cancer: Present Applications and Future Prospects—A Clinician’s Perspective

2011 • 25 citations

Combined chemoradiation of cisplatin versus carboplatin in cervical carcinoma: a single institution experience from Thailand

2016 • 24 citations

Preoperative imaging in patients undergoing trachelectomy for cervical cancer: Validation of a combined T2- and diffusion-weighted endovaginal MRI technique at 3.0T

2014 • 24 citations

Influencing surgical management in patients with carcinoma of the cervix using a T2- and ZOOM-diffusion-weighted endovaginal MRI technique

2013 • 23 citations

Primary surgery versus primary radiation therapy with or without chemotherapy for early adenocarcinoma of the uterine cervix

2010 • 22 citations

Cold knife conization vs. LEEP. Are they the same procedure?

2002 • 21 citations

Phase III randomised controlled trial of neoadjuvant chemotherapy plus radical surgery vs radical surgery alone for stages IB2, IIA2, and IIB cervical cancer: a Japan Clinical Oncology Group trial (JCOG 0102)

2013 • 21 citations

Evaluating cervical neoplasia. LEEP as an alternative to cold knife conization.

1998 • 20 citations

Phase III Trial of Four Cisplatin-Containing Doublet Combinations in Stage IVB, Recurrent, or Persistent Cervical Carcinoma: A Gynecologic Oncology Group Study

2010 • 19 citations

Population-Based Study of Microinvasive Adenocarcinoma of the Uterine Cervix

2001 • 19 citations

Loop Electrosurgical Excision Procedure Findings for Identification of Patients With Early-Stage Cervical Cancer Suitable for Less Radical Surgery

2012 • 17 citations

Compliance After Loop Electrosurgical Excision Procedure or Cold Knife Cone Biopsy

2007 • 17 citations

ACR Appropriateness Criteria® Definitive Therapy for Early-Stage Cervical Cancer

2012 • 16 citations

Long-Term Follow-Up of a Randomized Trial Comparing Concurrent Single Agent Cisplatin, Cisplatin-Based Combination Chemotherapy, or Hydroxyurea During Pelvic Irradiation for Locally Advanced Cervical Cancer: A Gynecologic Oncology Group Study

2008 • 16 citations

Oncological safety of laparoscopic-assisted vaginal radical trachelectomy (LARVT or Dargent’s operation): A comparative study with laparoscopic-assisted vaginal radical hysterectomy (LARVH)

2007 • 16 citations

The Role of Pretreatment FDG-PET in Treating Cervical Cancer Patients With Enlarged Pelvic Lymph Node(s) Shown on MRI: A Phase 3 Randomized Trial With Long-Term Follow-Up

2015 • 15 citations

Early stage cervical cancer: role of magnetic resonance imaging after conization in determining residual tumor

2015 • 11 citations

Which clinical/pathologic factors matter in the era of chemoradiation as treatment for locally advanced cervical carcinoma? Analysis of two Gynecologic Oncology Group (GOG) trials

2008 • 10 citations

Interpretability of Excisional Biopsies of the Cervix: Cone Biopsy and Loop Excision

2009 • 9 citations

Vaginal Radical Trachelectomy: A Valuable Fertility-Preserving Option in the Management of Early-Stage Cervical Cancer, a Series of 50 Pregnancies and Review of the Literature

2005 • 8 citations

Cervical conization and sentinel lymph node mapping in the treatment of stage I cervical cancer: Is less enough?

2013 • 7 citations

Survival outcomes for women undergoing type III robotic radical hysterectomy for cervical cancer: A 3-year experience

2010 • 7 citations

Evaluation of concurrent and adjuvant carboplatin with radiation therapy for locally advanced cervical cancer

2004 • 5 citations

Nonradical surgery for small early-stage cervical cancer: Is it time?

2014 • 5 citations

Ovarian Metastasis in Carcinoma of the Uterine Cervix

2006 • 2 citations