Feasibility of Polychromatic Light Emitting Diode System to Reduce Pain

NCT03246282

EARLY_PHASE1INTERVENTIONAL

John W. Reeves, MD

150 participants

Started 2017-02-08 · Completed 2018-12-31

Status: Suspended (as of 12-23-2025)

Conditions

Pain

Interventions

DEVICE: UVL1000 Treatment Station DRUG: Normal Saline 0.9% Infusion Solution Bag DEVICE: Peripheral Catheterization

Linked Papers (from SciSciNet-V2)

Total Papers62

Background

10

Result

0

Derived

0

Unknown

52

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

This study uses a prospective non-randomized, non-controlled design. One Hundred Fifty (150) subjects presenting with pain will be enrolled into a single treatment group The purpose of the study is to evaluate the feasibility of PLEDS for PIV catheter light delivery for pain reduction, through change between baseline average pain and final average VAS score. The absence of a control group is based on the following reason: The purpose of this investigation is to further the understanding of the feasibility of PLEDS for PIV catheter light delivery for pain management. Further, the results of this investigation will be used (internally only) to determine if subject-perceived reductions in pain warrant proceeding with more controlled, targeted and possibly randomized studies.

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Background Papers20

Cytokines, Inflammation, and Pain

2,548 citations

Cytokines, Inflammation, and Pain

2,548 citations

Biphasic Dose Response in Low Level Light Therapy

1,004 citations

Biphasic Dose Response in Low Level Light Therapy

1,004 citations

Low-Level Laser Therapy Activates NF-kB via Generation of Reactive Oxygen Species in Mouse Embryonic Fibroblasts

Low-Level Laser Therapy Activates NF-kB via Generation of Reactive Oxygen Species in Mouse Embryonic Fibroblasts

A randomised, placebo controlled trial of low level laser therapy for activated Achilles tendinitis with microdialysis measurement of peritendinous prostaglandin E₂concentrations

A randomised, placebo controlled trial of low level laser therapy for activated Achilles tendinitis with microdialysis measurement of peritendinous prostaglandin E₂concentrations

The Effect of Low-Level Laser in Knee Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Trial

The Effect of Low-Level Laser in Knee Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Trial

Effect of low-level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation

Effect of low-level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation

NADPH Oxidase 1 and Its Derived Reactive Oxygen Species Mediated Tissue Injury and Repair

NADPH Oxidase 1 and Its Derived Reactive Oxygen Species Mediated Tissue Injury and Repair

532 nm Low-Power Laser Irradiation Recovers γ-Secretase Inhibitor-Mediated Cell Growth Suppression and Promotes Cell Proliferation via Akt Signaling

532 nm Low-Power Laser Irradiation Recovers γ-Secretase Inhibitor-Mediated Cell Growth Suppression and Promotes Cell Proliferation via Akt Signaling

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers52

Primary and secondary mechanisms of action of visible to near-IR radiation on cells

1,314 citations

Enzyme-Catalyzed Phosphoryl Transfer Reactions

1,120 citations

Photobiology of Low-power Laser Effects

A systematic review of low level laser therapy with location-specific doses for pain from chronic joint disorders

Photobiomodulation Directly Benefits Primary Neurons Functionally Inactivated by Toxins

Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase

Low-Level Laser Therapy in Acute Pain: A Systematic Review of Possible Mechanisms of Action and Clinical Effects in Randomized Placebo-Controlled Trials

Increase of proton electrochemical potential and ATP synthesis in rat liver mitochondria irradiated in vitro by helium‐neon laser

Mitochondrial Signaling in Mammalian Cells Activated by Red and Near‐IR Radiation

Effect of NASA Light-Emitting Diode Irradiation on Wound Healing

Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy

Effect of low‐power laser irradiation on cell growth and procollagen synthesis of cultured fibroblasts

Influence of low level laser therapy on wound healing and its biological action upon myofibroblasts

Effects of photostimulation on wound healing in diabetic mice

780 nm low power diode laser irradiation stimulates proliferation of keratinocyte cultures: Involvement of reactive oxygen species

Thermoregulation during Exercise in the Heat

Low-Level Laser Therapy Induces Dose-Dependent Reduction of TNFα Levels in Acute Inflammation

Specific helium-neon laser sensitivity of the purified cytochrome c oxidase

Effect of phototherapy (low-level laser therapy and light-emitting diode therapy) on exercise performance and markers of exercise recovery: a systematic review with meta-analysis

Low Energy Visible Light Induces Reactive Oxygen Species Generation and Stimulates an Increase of Intracellular Calcium Concentration in Cardiac Cells

Nox1-Based NADPH Oxidase Is the Major Source of UVA-Induced Reactive Oxygen Species in Human Keratinocytes

Light-emitting diode treatment reverses the effect of TTX on cytochrome oxidase in neurons

Human fibroblast alterations induced by low power laser irradiation at the single cell level using confocal microscopy

Analgesic Effect of He-Ne (632.8 nm) Low-Level Laser Therapy on Acute Inflammatory Pain

Mitochondrial ROS – radical detoxification, mediated by protein kinase D

A Clinical Study on Serum Prostaglandin E₂ with Low-Level Laser Therapy

Analysis of the Systemic Effect of Red and Infrared Laser Therapy on Wound Repair

Cytochrome oxidase, ligands and electrons

Cyclooxygenase-2 and vascular endothelial growth factor expression in 5-fluorouracil-induced oral mucositis in hamsters: evaluation of two low-intensity laser protocols

Anti-Inflammatory Effect of Low-Level Laser and Light-Emitting Diode in Zymosan-Induced Arthritis

Effects of low‐level laser therapy on collagen expression and neutrophil infiltrate in 5‐fluorouracil‐induced oral mucositis in hamsters

Green Light Emitting Diode Irradiation Enhances Fibroblast Growth Impaired by High Glucose Level

Pro- and Anti-inflammatory Cytokine Content in Human Peripheral Blood after Its Transcutaneous (in Vivo) and Direct (in Vitro) Irradiation with Polychromatic Visible and Infrared Light

Relaxation of Mammalian Smooth Muscles by Visible and Ultraviolet Radiation

Ação da terapia com laser de baixa potência nas fases iniciais do reparo tecidual: princípios básicos

A comparative study of 632.8 and 532 nm laser irradiation on some rheological factors in human blood in vitro

Very low level laser therapy attenuates edema and pain in experimental models.

Low Level Light Therapy Modulates Inflammatory Mediators Secreted by Human Annulus Fibrosus Cells during Intervertebral Disc Degeneration In Vitro

Hydration, Hydration, Hydration

Anti‐inflammatory effect of 635 nm irradiations on in vitro direct/indirect irradiation model

Low-level laser therapy in IL-1β, COX-2, and PGE2 modulation in partially injured Achilles tendon

The response of Na+/K+-ATPase of human erythrocytes to green laser light treatment

Mitochondrial alterations induced by 532 nm laser irradiation.

Characterization of pulsed‐dye laser‐mediated vasodilatation in a rabbit femoral artery model of vasoconstriction

The use of light-emitting diodes to stimulate mitochondrial function and liver regeneration of partially hepatectomized rats

Intravenous -artemether formulation (ARM NLC) as a superior alternative to commercial artesunate formulation

Performing peripheral intravenous cannulation.

Study on the selection of laser wavelengths in the intravascular low-level laser irradiation therapy

Cardiodynamics and pumping function of the heart during hyperthermia

Immediate recovery of an "ischemic stroke" following treatment with intravenous thiamine (vitamin B1).

Blue Light Mediated Photoreduction of the Flavoprotein NADPH-Cytochrome P450 Reductase. A Förster-Type Energy Transfer