A Study to Evaluate the Effects of a Turmeric and Black Cumin Seed Formulation on Cholesterol Levels

NCT03175757

NAINTERVENTIONAL

Supplement Formulators, Inc.

33 participants

Started 2017-05-12 · Completed 2018-08-16

Status: Completed (as of 12-23-2025)

Conditions

Cholesterol Health

Interventions

DIETARY_SUPPLEMENT: Turmeric and Black Cumin Seed DIETARY_SUPPLEMENT: Placebo

Linked Papers (from SciSciNet-V2)

Total Papers41

Background

9

Result

0

Derived

0

Unknown

32

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

The purpose of this study is to assess the effects of a turmeric and black cumin seed formulation on cholesterol levels.

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Background Papers18

Phase IIa Clinical Trial of Curcumin for the Prevention of Colorectal Neoplasia

Phase IIa Clinical Trial of Curcumin for the Prevention of Colorectal Neoplasia

Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study

Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study

Favorable impact of Nigella sativa seeds on lipid profile in type 2 diabetic patients

Favorable impact of Nigella sativa seeds on lipid profile in type 2 diabetic patients

Antiatherogenic Potential ofNigella sativaSeeds and Oil in Diet-Induced Hypercholesterolemia in Rabbits

Protective Effects of Nigella sativa on Metabolic Syndrome in Menopausal Women.

Protective Effects of Nigella sativa on Metabolic Syndrome in Menopausal Women.

Antiatherogenic Potential ofNigella sativaSeeds and Oil in Diet-Induced Hypercholesterolemia in Rabbits

Toxicity effect of nigella sativa on the liver function of rats.

Toxicity effect of nigella sativa on the liver function of rats.

Nigella sativa: A Potential Antiosteoporotic Agent

Nigella sativa: A Potential Antiosteoporotic Agent

Attenuation of the development of hypercholesterolemic atherosclerosis by thymoquinone

Attenuation of the development of hypercholesterolemic atherosclerosis by thymoquinone

Curcumin Supplementation Decreases Intestinal Adiposity Accumulation, Serum Cholesterol Alterations, and Oxidative Stress in Ovariectomized Rats

Curcumin Supplementation Decreases Intestinal Adiposity Accumulation, Serum Cholesterol Alterations, and Oxidative Stress in Ovariectomized Rats

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers32

Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.

2,024 citations

Pharmacological and toxicological properties of Nigella sativa

1,092 citations

Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer.

Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus

Curcumin Lowers Serum Lipids and Uric Acid in Subjects With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial

Efficacy and Safety of Curcumin in Major Depressive Disorder: A Randomized Controlled Trial

Lipid‐Lowering Effects of Curcumin in Patients with Metabolic Syndrome: A Randomized, Double‐Blind, Placebo‐Controlled Trial

Effects of Nigella sativa fixed oil on blood homeostasis in rat

Molecular mechanisms of hypolipidemic effects of curcumin

Curcumin induces changes in expression of genes involved in cholesterol homeostasis

Molecular mechanism of curcumin on the suppression of cholesterol accumulation in macrophage foam cells and atherosclerosis

Clinical efficacy of the co-administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome – A double blind randomized controlled trial – TAK-MetS trial

Hypolipidemic and antioxidant activities of thymoquinone and limonene in atherogenic suspension fed rats

Curcumin enhances cell‐surface LDLR level and promotes LDL uptake through downregulation of PCSK9 gene expression in HepG2 cells

Effects of black seed (Nigella sativa) on metabolic parameters in diabetes mellitus: A systematic review

Effects of supplementation with curcumin on serum adipokine concentrations: A randomized controlled trial

Cardio-protective and anti-cancer therapeutic potential of Nigella sativa.

Curcumin Enhanced Cholesterol Efflux by Upregulating ABCA1 Expression Through AMPK-SIRT1-LXRα Signaling in THP-1 Macrophage-Derived Foam Cells

The effect of thymoquinone on blood lipids in rats.

Curcumin retunes cholesterol transport homeostasis and inflammation response in M1 macrophage to prevent atherosclerosis

Nigella sativa (black seed) effects on plasma lipid concentrations in humans: A systematic review and meta-analysis of randomized placebo-controlled trials

The Effect of Curcumin on some of Traditional and Non-traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-blind, Placebo-controlled Trial.

Curcumin promotes cholesterol efflux from adipocytes related to PPARgamma–LXRalpha–ABCA1 passway

Ameliorative effects of Nigella sativa on dyslipidemia

Curcumin inhibits monocyte chemoattractant protein-1 expression and enhances cholesterol efflux by suppressing the c-Jun N-terminal kinase pathway in macrophage

Curcuma oil ameliorates hyperlipidaemia and associated deleterious effects in golden Syrian hamsters

Effect of Nigella sativa (kalonji) on serum cholesterol of albino rats.

Curcuma oil attenuates accelerated atherosclerosis and macrophage foam-cell formation by modulating genes involved in plaque stability, lipid homeostasis and inflammation

The Effect of Nutritional Supplements on Serum High-Density Lipoprotein Cholesterol and Apolipoprotein A-I

Coadministration of Black Seeds and Turmeric Shows Enhanced Efficacy in Preventing Metabolic Syndrome in Fructose-fed Rats

Regulation of LDL receptor expression by the effect of curcumin on sterol regulatory element pathway.

Induction of apolipoprotein A-I gene expression by black seed (Nigella sativa) extracts