Effect of Dietary Sodium Intake on Vascular Endothelium

NCT01550315

NAINTERVENTIONAL

Vanderbilt University Medical Center

27 participants

Started 2012-04 · Completed 2021-09

Status: Completed (as of 12-23-2025)

Conditions

Postural Tachycardia Syndrome (POTS)

Interventions

PROCEDURE: Pulsitile Arterial Tonometry (PAT) Protocol DEVICE: Calf Blood Flow in Reactive Hyperemia (CBF-RH)DEVICE: Evaluation of Forearm-Mediated Dilation

Linked Papers (from SciSciNet-V2)

Total Papers24

Background

3

Result

0

Derived

0

Unknown

21

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

The investigators will test the hypothesis that markers of vascular endothelial dysfunction will be exaggerated acutely with an extreme high sodium diet compared to an extreme low-sodium diet. The investigators will compare patients with postural orthostatic tachycardia (POTS) to healthy control subjects.

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Background Papers6

Assessment of flow-mediated dilation in humans: a methodological and physiological guideline

1,311 citations

Assessment of flow-mediated dilation in humans: a methodological and physiological guideline

1,311 citations

Nitric oxide activity in the human coronary circulation. Impact of risk factors for coronary atherosclerosis.

Nitric oxide activity in the human coronary circulation. Impact of risk factors for coronary atherosclerosis.

Local inhibition of nitric oxide generation in man reduces blood flow in finger pulp but not in hand dorsum skin.

Local inhibition of nitric oxide generation in man reduces blood flow in finger pulp but not in hand dorsum skin.

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers21

Asymmetric Dimethylarginine (ADMA): A Novel Risk Factor for Endothelial Dysfunction

1,182 citations

Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia

Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude

Links Between Dietary Salt Intake, Renal Salt Handling, Blood Pressure, and Cardiovascular Diseases

Endothelial function and dysfunction. Part I

Nitric Oxide Regulates Local Arterial Distensibility In Vivo

Role of nitric oxide in the regulation of digital pulse volume amplitude in humans

The Importance of Population-Wide Sodium Reduction as a Means to Prevent Cardiovascular Disease and Stroke

Postischemic vasodilation in human forearm is dependent on endothelium-derived nitric oxide

Obesity is independently associated with coronary endothelial dysfunction in patients with normal or mildly diseased coronary arteries

Endothelium-Dependent Dilatation Is Impaired in Young Healthy Subjects With a Family History of Premature Coronary Disease

Vascular Extracellular Superoxide Dismutase Activity in Patients With Coronary Artery Disease

Study on the Relationship Between Plasma Nitrite and Nitrate Level and Salt Sensitivity in Human Hypertension

Effect of Native and Oxidized Low-Density Lipoprotein on Endothelial Nitric Oxide and Superoxide Production

Experimental epidemiology of chronic sodium chloride toxicity and the protective effect of potassium chloride

POTASSIUM INTAKE, STROKE, AND CARDIOVASCULAR DISEASE: A META-ANALYSIS OF PROSPECTIVE STUDIES

Contribution of Nitric Oxide to Reactive Hyperemia

Effects of lysolipids and oxidatively modified low density lipoprotein on endothelium-dependent relaxation of rabbit aorta.

A noninvasive measurement of reactive hyperemia that can be used to assess resistance artery endothelial function in humans

Peripheral Arterial Responses to Treadmill Exercise Among Healthy Subjects and Atherosclerotic Patients

Nitric oxide production decreases after salt loading but is not related to blood pressure changes or nitric oxide-mediated vascular responses