Enteral Glutamine in Critical Illness

NCT00318331

PHASE2|PHASE3INTERVENTIONAL

Christiana Care Health Services

20 participants

Started 2006-05 · Completed 2007-09

Status: Terminated (as of 12-23-2025)

Conditions

Critical IllnessSepsisRespiratory Insufficiency

Interventions

DRUG: Glutamine

Linked Papers (from SciSciNet-V2)

Total Papers56

Background

1

Result

0

Derived

0

Unknown

55

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

Glutamine is an amino acid which is rapidly depleted in critical illness. It is used as energy by cells that line the gut, vital for immune system function, and works as an anti-oxidant. Glutamine supplementation has been shown to improve outcomes in ICU patients. We hypothesize that critically ill patients given extra glutamine will have less of an inflammatory response and therefore better outcomes than patients not given extra glutamine. Our study randomizes patients to tube feeding with OR without extra glutamine to see if it affects patient outcomes as well as markers of inflammation.

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Background Papers2

Gut origin of sepsis: a prospective study investigating associations between bacterial translocation, gastric microflora, and septic morbidity

Gut origin of sepsis: a prospective study investigating associations between bacterial translocation, gastric microflora, and septic morbidity

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers55

Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients

1,500 citations

Should Immunonutrition Become Routine in Critically Ill Patients?

Clinical and Metabolic Efficacy of Glutamine-supplemented Parenteral Nutrition after Bone Marrow Transplantation

Glutamine supplementation in serious illness: A systematic review of the evidence*

Six-month outcome of critically ill patients given glutamine-supplemented parenteral nutrition

Glutamine Metabolism by the Intestinal Tract

Immunonutrition in the critically ill: A systematic review of clinical outcome

C-Reactive Protein Levels Correlate With Mortality and Organ Failure in Critically Ill Patientsa

Glutamine administration reduces Gram-negative bacteremia in severely burned patients: A prospective, randomized, double-blind trial versus isonitrogenous control

Plasma glutamine depletion and patient outcome in acute ICU admissions

Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: A prospective, controlled, randomized clinical trial*

Parenteral l-alanyl-l-glutamine improves 6-month outcome in critically ill patients*

Intestinal permeability and systemic infections in critically ill patients: Effect of glutamine*

Randomized clinical outcome study of critically ill patients given glutamine-supplemented enteral nutrition

Glutamine attenuates lung injury and improves survival after sepsis: Role of enhanced heat shock protein expression*

A descriptive study of skeletal muscle metabolism in critically ill patients

Sensitivity and specificity of various markers of inflammation for the prediction of tumor necrosis factor-α and interleukin-6 in patients with sepsis

Glutamine attenuates tumor necrosis factor-α release and enhances heat shock protein 72 in human peripheral blood mononuclear cells

Effect of a glutamine-enriched enteral diet on intestinal permeability and infectious morbidity at 28 days in critically ill patients with Systemic Inflammatory Response Syndrome

A prospective randomized trial of enteral glutamine in critical illness

Glutamine: essential for immune nutrition in the critically ill

Clinical evidence for enteral nutritional support with glutamine:

A double-blind, prospective, randomized study of glutamine-enriched compared with standard peptide-based feeding in critically ill patients

The metabolic consequences of critical illness: acute effects on glutamine and protein metabolism

Role of L-glutamine in critical illness: new insights

Regulative capacity of glutamine

Glutamine depletion impairs cellular stress response in human leucocytes

Effects of albumin supplementation on microvascular permeability in septic patients

The Role of Glutamine in Intensive Care Unit Patients: Mechanisms of Action and Clinical Outcome

Clinical Applications of <scp>l</scp>‐Glutamine: Past, Present, and Future

Accelerated Glutamine Synthesis in Critically III Patients Cannot Maintain Normal Intramuscular Free Glutamine Concentration

Total parenteral nutrition enriched with arginine and glutamate generates glutamine and limits protein catabolism in surgical patients hospitalized in intensive care units

Glutamine: An Essential Amino Acid for the Gut

Pilot study with a glutamine-supplemented enteral formula in critically ill infants

Glutamine as an Immunoenhancing Nutrient

Outcome of critically ill patients after supplementation with glutamine

Glutamine Supplementation in Catabolic Patients

Controversy of immunonutrition for surgical critical-illness patients

Practical Recommendations for Immune-Enhancing Diets

The evidence for glutamine use in the critically-ill

Nutritional support in critical care

Glutamine and acute illness

Role of Glutamine in the Immune Response in Critical Illness

Influence of polymeric enteral nutrition supplemented with different doses of glutamine on gut permeability in critically ill patients

Immunonutrition: Fact, fantasy, and future

Correlation of blood volume values and pulmonary artery catheter measurements.

Enteral nutritional supplementation prevents mesenteric lymph node T-cell suppression in burn injury

Intravascular volume in cirrhosis

Regulation of the Cellular and Physiological Effects of Glutamine

Influence of perfusate oncotic pressure on the transcapillary clearance of albumin in maximally vasodilated rat skeletal muscle

Glutamine-enhanced nutrition in the critically ill patient