Accumulation of PtdIns(3,4)P2 and PtdIns(3,4,5)P3 in thrombin-stimulated platelets. Different sensitivities to Ca2+ or functional integrin

The platelet membrane glycoprotein IIb-IIIa complex

1988 • 1,031 citations

Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils

1991 • 488 citations

Phosphoinositide kinases

1990 • 331 citations

Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets.

1989 • 276 citations

Tyrosine-specific protein phosphorylation is regulated by glycoprotein IIb-IIIa in platelets.

1989 • 250 citations

Role of platelet membrane glycoprotein IIb-IIIa in agonist-induced tyrosine phosphorylation of platelet proteins.

1990 • 237 citations

Platelet tyrosine-specific protein phosphorylation is regulated by thrombin.

1988 • 229 citations

Human platelets form 3-phosphorylated phosphoinositides in response to alpha-thrombin, U46619, or GTP gamma S.

1990 • 204 citations

Activated phosphoinositide 3-kinase associates with membrane skeleton in thrombin-exposed platelets.

1992 • 186 citations

Calcium regulation of the platelet membrane glycoprotein IIb-IIIa complex.

1985 • 178 citations

Phosphoinositide 3-kinase: A new effector in signal transduction?

1991 • 166 citations

Is there a relationship between phosphatidylinositol trisphosphate and F-actin polymerization in human neutrophils?

1990 • 153 citations

“Thrombin” receptor-directed ligand accounts for activation by thrombin of platelet phospholipase C and accumulation of 3-phosphorylated phosphoinositides.

1991 • 119 citations

Thrombin stimulates the production of a novel polyphosphoinositide in human platelets.

1990 • 107 citations

Involvement of platelet glycoprotein IIb-IIIa (alpha IIb-beta 3 integrin) in thrombin-induced synthesis of phosphatidylinositol 3‘,4‘-bisphosphate.

1991 • 91 citations

Elevated cytosolic Ca2+ activates phospholipase D in human platelets

1991 • 90 citations

Pathway for the formation of D-3 phosphate containing inositol phospholipids in intact human platelets.

1990 • 66 citations

The novel inositol lipid phosphatidylinositol 3,4-bisphosphate is produced by human blood platelets upon thrombin stimulation

1990 • 61 citations

Platelet Tyrosine-Specific Protein Phosphorylation Is Regulated by Thrombin

1988 • 50 citations

Ca²⁺ influx mediated through the GPIIb/IIIa complex during platelet activation

1987 • 50 citations

Protein kinase C regulates the stimulated accumulation of 3-phosphorylated phosphoinositides in platelets

1991 • 44 citations

Platelet glycoproteins IIb and IIIa as a calcium channel in liposomes

1988 • 44 citations

Ionophore A23187-induced protein-tyrosine phosphorylation of human platelets: Possible synergism between Ca2+ mobilization and protein kinase C activation

1991 • 41 citations

Ligand Inhibition of the Platelet Glycoprotein IIb-IIIa Complex Function as a Calcium Channel in Liposomes

1989 • 37 citations

Effect of GPIIb-IIIa complex ligands on calciumion movement and cytoskeleton organization in activated platelets

1988 • 35 citations

Familial bleeding disorder associated with deficiencies in platelet signal processing and glycoproteins.

1987 • 18 citations

Functional Ca2+ Channel Produced by Purified Platelet Membrane Glycoprotein IIb-IIIa Complex Incorporated into Planar Phospholipid Bilayer

1991 • 16 citations