Segregation analysis indicates a major gene in the control of interleukine-5 production in humans infected with Schistosoma mansoni.

Predominant T_H2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

1992 • 2,802 citations

Strategies for multilocus linkage analysis in humans.

1984 • 2,600 citations

Linkage Analysis of IL4 and Other Chromosome 5q31.1 Markers and Total Serum Immunoglobulin E Concentrations

1994 • 1,025 citations

Recombinant human interleukin 5 is a selective activator of human eosinophil function.

1988 • 976 citations

Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma.

1991 • 841 citations

Genetic Susceptibility to Asthma — Bronchial Hyperresponsiveness Coinherited with a Major Gene for Atopy

1995 • 774 citations

Antibody to Interleukin-5 Inhibits Helminth-Induced Eosinophilia in Mice

1989 • 635 citations

Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. IL-5 as an eosinophil chemotactic factor.

1988 • 619 citations

Cytotoxic Properties of the Eosinophil Major Basic Protein

1979 • 595 citations

Eosinophilia in transgenic mice expressing interleukin 5.

1990 • 579 citations

Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors.

1988 • 528 citations

Evidence for a Locus Regulating Total Serum IgE Levels Mapping to Chromosome 5

1994 • 395 citations

Transforming growth factor beta induces IgA production and acts additively with interleukin 5 for IgA production.

1989 • 394 citations

Eosinophils as mediators of antibody-dependent damage to schistosomula

1975 • 369 citations

Eosinophils express interleukin 5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics.

1992 • 364 citations

CD4⁺T-Lymphocytes and Interleukin-5 Mediate Antigen-induced Eosinophil Infiltration into the Mouse Trachea

1992 • 353 citations

Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5).

1987 • 322 citations

Recombinant human interleukin 5 is a selective eosinophil chemoattractant

1989 • 319 citations

Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production.

1991 • 303 citations

Identification of a lymphokine that stimulates eosinophil differentiation in vitro. Its relationship to interleukin 3, and functional properties of eosinophils produced in cultures.

1985 • 296 citations

Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression.

1987 • 259 citations

On the statistical determination of major gene mechanisms in continuous human traits: Regressive models

1984 • 254 citations

Effect of Anti-IL-5 and IL-5 on Airway Hyperreactivity and Eosinophils in Guinea Pigs

1993 • 245 citations

The role of IL-5 in IgA B cell differentiation.

1988 • 240 citations

Molecular organization of the cytokine gene cluster, involving the human IL-3, IL-4, IL-5, and GM-CSF genes, on human chromosome 5

1989 • 229 citations

Interleukin-5 selectively enhances the chemotactic response of eosinophils obtained from normal but not eosinophilic subjects

1992 • 226 citations

Inhibitory Effect of the TRFK-5 Anti-IL-5 Antibody in a Guinea Pig Model of Asthma

1993 • 226 citations

Elevated serum levels of the eosinophil granule major basic protein in patients with eosinophilia.

1981 • 213 citations

Resistance to Schistosoma mansoni in Humans: Influence of the IgE/IgG4 Balance and IgG2 in Immunity to Reinfection after Chemotherapy

1993 • 181 citations

MOLECULAR MECHANISMS OF IMMUNOGLOBULIN A DEFENSE

1989 • 162 citations

Evidence for the segregation of a major gene in human susceptibility/resistance to infection by Schistosoma mansoni.

1991 • 159 citations

Immunity after treatment of human schistosomiasis: association between cellular responses and resistance to reinfection

1993 • 149 citations

The Eosinophil and its Role in Immunity to Helminth Infection

1977 • 141 citations

Antibody-dependent cell-mediated damage to schistosomula in vitro

1974 • 138 citations

IL-4- and IL-5-dependent protective immunity to Onchocerca volvulus infective larvae in BALB/cBYJ mice.

1994 • 130 citations

The role of interleukin-5 in protective immunity to Strongyloides venezuelensis infection in mice.

1991 • 126 citations

Human eosinophil hematopoiesis studied in vitro by means of murine eosinophil differentiation factor (IL5): production of functionally active eosinophils from normal human bone marrow

1988 • 120 citations

Studies on blood eosinophils. II. Patients with Löffler's cardiomyopathy.

1976 • 119 citations

Ablation of eosinophils with anti‐IL‐5 antibody enhances the survival of intracranial worms of Angiostrongylus cantonensis in the mouse

1993 • 118 citations

Anti-IL-5 monoclonal antibody inhibits allergic late phase bronchial eosinophilia in guinea pigs: a therapeutic approach

1992 • 112 citations

Combined linkage and segregation analysis using regressive models.

1988 • 108 citations

Synthesis of interleukin-5 by activated eosinophils in patients with eosinophilic heart diseases

1993 • 99 citations

Analysis of Cytokine Transcripts in the Bronchoalveolar Lavage Cells of Patients with Asthma

1993 • 92 citations

Equivalence of the mixed and regressive models for genetic analysis. I. Continuous traits

1989 • 75 citations

Enhancement of human blood eosinophil cytotoxicity by semi-purified eosinophil colony-stimulating factor(s).

1982 • 75 citations

Schistosoma-specific helper T cell clones from subjects resistant to infection bySchistosoma mansoni are Th0/2

1995 • 71 citations

Modulation of eosinophil cytotoxicity by blood mononuclear cells from healthy subjects and patients with chronic Schistosomiasis mansoni

1984 • 54 citations

Activation of guinea pig eosinophils by human recombinant IL-5. Selective priming to platelet-activating factor-acether and interference of its antagonists.

1991 • 53 citations

Search for faster methods of fitting the regressive models to quantitative traits

1990 • 49 citations

The Role of the Eosinophil Granulocyte in the Inflammatory Reaction

1979 • 35 citations

Alterations in blood eosinophil morphology, binding capacity for complexed IgG and kinetics in patients with tropical (filarial) eosinophilia

1981 • 23 citations

Modulation of the cytotoxicity of human blood eosinophils by factors secreted by monocytes and T lymphocytes.

1983 • 18 citations

Esophagitis cystica.

1973 • 2 citations