Transport of Antibiotics into Bacteria

The Journal of General Microbiology

1985 • 2,446 citations

The Molecular Basis of Antibiotic Action

1981 • 1,237 citations

Linkage map of Escherichia coli K-12, edition 6

1980 • 785 citations

THE MECHANISM OF ACTION OF FOSFOMYCIN (PHOSPHONOMYCIN)

1974 • 765 citations

The Outer Membrane of Gram-negative Bacteria

1980 • 588 citations

Periplasmic space in Salmonella typhimurium and Escherichia coli.

1977 • 563 citations

GLYCEROL DISSIMILATION AND ITS REGULATION IN BACTERIA

1976 • 530 citations

Molecular Mechanisms of Protein Biosynthesis

1977 • 472 citations

The Outer Membrane Proteins of Gram-Negative Bacteria: Biosynthesis, Assembly, and Functions

1978 • 457 citations

Plasmid-Determined Resistance to Antimicrobial Agents

1978 • 437 citations

Structure and function of the cell envelope of gram-negative bacteria

1974 • 431 citations

Structure and Function in Biological Membranes

1965 • 427 citations

The Mechanism of the Irreversible Antimicrobial Effects of Penicillins: How the Beta-Lactam Antibiotics Kill and Lyse Bacteria

1979 • 427 citations

Molecular Sieving by theBacillus megateriumCell Wall and Protoplast

1971 • 398 citations

Outer membrane of Salmonella typhimurium

1976 • 379 citations

Specific labeling and partial purification of the M protein, a component of the beta-galactoside transport system of Escherichia coli.

1965 • 374 citations

Microorganisms and nitrogen sources.

1980 • 374 citations

Bacterial Assimilation of iron

1973 • 365 citations

The Collected Papers of Paul Ehrlich

2013 • 363 citations

Linkage map of Escherichia coli K-12, edition 6.

1980 • 362 citations

Membrane proteins in energy transduction

1979 • 356 citations

Function of the Outer Membrane of Escherichia coli as a Permeability Barrier to Beta-Lactam Antibiotics

1977 • 321 citations

Substrate specificity and transport properties of the glycerol facilitator of Escherichia coli

1980 • 321 citations

Biochemistry of Antimicrobial Action

1989 • 319 citations

The Molecular Basis of Antibiotic Action

1973 • 298 citations

The electrochemical gradient of protons and its relationship to active transport in Escherichia coli membrane vesicles.

1976 • 296 citations

Bacterial Exopolysaccharides

1972 • 295 citations

Bacterial respiration.

1977 • 290 citations

Proteins of the Outer Membrane of Gram-Negative Bacteria

1980 • 282 citations

Structure and Function of Biological Membranes

1971 • 281 citations

Carbohydrate transport in bacteria

1980 • 276 citations

Effects of Membrane-Energy Mutations and Cations on Streptomycin and Gentamicin Accumulation by Bacteria: a Model for Entry of Streptomycin and Gentamicin in Susceptible and Resistant Bacteria

1977 • 276 citations

Microbial polysaccharides and polysaccharases

1979 • 273 citations

Active Transport of l-α-Glycerophosphate in Escherichia coli

1964 • 265 citations

THE BACTERIA: A TREATISE ON STRUCTURE AND FUNCTION

1990 • 246 citations

Bacterial membranes and walls

1973 • 243 citations

THE JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

1975 • 233 citations

Involvement of the outer membrane in gentamicin and streptomycin uptake and killing in Pseudomonas aeruginosa

1981 • 223 citations

Structure and function of the cell envelope of gram-negative bacteria.

1974 • 220 citations

Nature of the energy requirement for the irreversible adsorption of bacteriophages T1 and phi80 to Escherichia coli

1976 • 216 citations

Membrane Adenosine Triphosphatases of Prokaryotic Cells

1979 • 216 citations

Protonic conductance across phospholipid bilayer membranes induced by uncoupling agents for oxidative phosphorylation.

1968 • 213 citations

The Energetics of Bacterial Active Transport

1975 • 208 citations

Inhibition of Membrane-bound Adenosine Triphosphatase and of Cation Transport in Streptococcus faecalis by N,N′-Dicyclohexylcarbodiimide

1969 • 204 citations

Relation Between Lipophilicity and Pharmacological Behavior of Minocycline, Doxycycline, Tetracycline, and Oxytetracycline in Dogs

1975 • 203 citations

Aminoglycoside uptake and mode of action—with special reference to streptomycin and gentamicin

1981 • 201 citations

Bacterial phosphoenolpyruvate: sugar phosphotransferase systems: structural, functional, and evolutionary interrelationships

1977 • 190 citations

Iron Uptake in Salmonella typhimurium : Utilization of Exogenous Siderochromes as Iron Carriers

1972 • 180 citations

The chemistry of the tetracycline antibiotics

1978 • 180 citations

Mutants of Escherichia coli That Are Resistant to Certain Beta-Lactam Compounds Lack the ompF Porin

1981 • 178 citations

Asymmetrical Distribution and Artifactual Reorientation of Lipopolysaccharide in the Outer Membrane Bilayer of Salmonella typhimurium

1975 • 175 citations

Magnesium Transport in Escherichia coli

1971 • 175 citations

A common receptor protein for phage T5 and colicin M in the outer membrane of Escherichia coli B

1973 • 172 citations

Properties of the large ion-permeable pores formed from protein F of Pseudomonas aeruginosa in lipid bilayer membranes

1981 • 168 citations

Control of amino sugar metabolism in Escherichia coli and isolation of mutants unable to degrade amino sugars

1968 • 168 citations

On the importance of being ionized

1958 • 161 citations

The role of Na+ in transport processes of bacterial membranes

1979 • 161 citations

The Specificity and Action of Animal, Bacterial and Plant Toxins

1977 • 160 citations

Streptomycin Accumulation in Susceptible and Resistant Strains of Escherichia coli and Pseudomonas aeruginosa

1976 • 157 citations

pH-Partition Behavior of Tetracyclines

1969 • 157 citations

Differential inhibitory effects of antibiotics on the biosynthesis of envelope proteins of Escherichia coli

1973 • 155 citations

Effect of arsenate on inorganic phosphate transport in Escherichia coli

1980 • 143 citations

Cephalosporins and Penicillins

1972 • 142 citations

Penicillin-binding proteins in bacteria

1980 • 139 citations

Fuctional organization of the outer membrane of escherichia coli: Phage and colicin receptors as components of iron uptake systems

1976 • 137 citations

The Uptake of C₄‐Dicarboxylic Acids by Escherichia coli

1971 • 131 citations

Carbohydrate transport in bacteria.

1980 • 131 citations

Energy Coupling in Membrane Vesicles of Escherichia coli

1974 • 130 citations

Outer Membrane Proteins of Escherichia coli VII. Evidence That Bacteriophage-Directed Protein 2 Functions as a Pore

1978 • 129 citations

Energy coupling in secondary active transport

1980 • 128 citations

The role of the bacterial cell envelope in antibiotic resistance

1975 • 126 citations

Biochemistry of Bacterial Membranes

1973 • 124 citations

Biochemistry of Bacterial Cell Envelopes

1974 • 123 citations

The Mode of Action of Bacilysin and Anticapsin and Biochemical Properties of Bacilysin-resistant Mutants

1976 • 123 citations

The sequence of some effects of streptomycin in Escherichia coli

1963 • 117 citations

Antimicrobial Activities and Antagonists of Bacilysin and Anticapsin

1976 • 117 citations

Plasmid-mediated tetracycline resistance in escherichia coli involves increased efflux of the antibiotic

1980 • 113 citations

Extrachromosomally Determined Antibiotic Production

1978 • 109 citations

Effect of Streptomycin on Escherichia Coli: Uptake of Streptomycin by Escherichia coli

1960 • 102 citations

Relationship between the tonB locus and iron transport in Escherichia coli

1975 • 101 citations

Uptake and Conversion of the Antibiotic Albomycin by Escherichia coli K‐12

1979 • 97 citations

Mutants in three genes affecting transport of magnesium in Escherichia coli: genetics and physiology

1976 • 95 citations

Pores in the outer membrane of Escherichia coli K12

1978 • 91 citations

Penetration of beta-lactam antibiotics into their target enzymes in Pseudomonas aeruginosa: comparison of a highly sensitive mutant with its parent strain

1980 • 90 citations

New major outer membrane proteins found in an Escherichia coli tolF mutant resistant to bacteriophage TuIb

1978 • 90 citations

Asymmetric localization of lipopolysaccharides on the outer membrane of Salmonella typhimurium

1980 • 87 citations

Transport Systems for Alanine, Serine, and Glycine in Escherichia coli K-12

1973 • 85 citations

Ribosome-tetracycline interactions

1977 • 83 citations

Outer Penetration Barrier of Escherichia coli K-12: Kinetics of the Uptake of Gentian Violet by Wild Type and Envelope Mutants

1973 • 78 citations

Bacterial resistance to the tetracyclines

1978 • 78 citations

Transport of Magnesium by a Repressible and a Nonrepressible System in Escherichia coli

1972 • 77 citations

Interrelationships between the utilization of magnesium and the uptake of other bivalent cations by bacteria

1970 • 77 citations

Cation Transport Alteration Associated with Plasmid-Determined Resistance to Cadmium in Staphylococcus aureus

1978 • 76 citations

Haematin-dependent Oxidative Phosphorylation in Streptococcus faecalis

1969 • 76 citations

BACTERIAL MEMBRANE STRUCTURE

1976 • 75 citations

Mechanism of <scp>d</scp> -Cycloserine Action: Transport Mutants for <scp>d</scp> -Alanine, <scp>d</scp> -Cycloserine, and Glycine

1971 • 75 citations

Bacterial phosphoenolpyruvate: sugar phosphotransferase systems: structural, functional, and evolutionary interrelationships.

1977 • 68 citations

Streptomycin Uptake via an Inducible Polyamine Transport System in Escherichia coli

1978 • 67 citations

On the Transport of Tripeptide Antibiotics in Bacteria

1976 • 64 citations

Biochemistry of Antimicrobial Action

1975 • 64 citations

Two Transport Systems for Tetracycline in Sensitive Escherichia coli : Critical Role for an Initial Rapid Uptake System Insensitive to Energy Inhibitors

1978 • 61 citations

Effect of Enzymatic Adenylylation on Dihydrostreptomycin Accumulation in Escherichia coli Carrying an R-Factor: Model Explaining Aminoglycoside Resistance by Inactivating Mechanisms

1978 • 59 citations

Induction of an active transport system for glucose 6-phosphate in Escherichia coli

1966 • 58 citations

Interaction Between Aminoglycoside Uptake and Ribosomal Resistance Mutations

1980 • 55 citations

Aminoglycoside-Resistant Mutation of Pseudomonas aeruginosa Defective in Cytochrome c ₅₅₂ and Nitrate Reductase

1980 • 54 citations

PEPTIDOGLYCANS (MUCOPEPTIDES): STRUCTURE, FUNCTION, AND VARIATIONS

1974 • 53 citations

Accumulation of thallous ions (Tl⁺) as a measure of the electrical potential difference across the cytoplasmic membrane of bacteria

1978 • 53 citations

Ribosomal function and its inhibition by antibiotics in prokaryotes

1980 • 52 citations

The Beta-Lactam Antibiotics

1981 • 51 citations

Diffusion of tetracycline across the outer membrane of Escherichia coli K-12: Involvement of protein Ia

1978 • 49 citations

Bacterial resistance to the tetracyclines.

1978 • 49 citations

Identification of the Escherichia coli tonB gene product in minicells containing tonB hybrid plasmids

1979 • 48 citations

How partially inhibitory concentrations of chloramphenicol affect the growth of Escherichia coli

1980 • 46 citations

Characterisation of mutants of Escherichia coli K12, selected by resistance to streptozotocin

1980 • 46 citations

Mode of Action of Streptozotocin

1971 • 45 citations

Relation of aerobiosis and ionic strength to the uptake of dihydrostreptomycin in Escherichia coli

1980 • 45 citations

The molecular mechanism of dicarboxylic acid transport in escherichia coli K 12

1977 • 43 citations

Proton movements coupled to lactate and alanine transport in Escherichia coli: isolation of mutants with altered stoichiometry in alanine transport

1976 • 43 citations

Comparison of the polypeptide composition of Escherichia coli outer membranes prepared by two methods

1980 • 41 citations

Purification and characterization of the inactive Ca2+, Mg2+-activated adenosine triphosphatase of the unc A− mutant Escherichia coli AN120

1977 • 40 citations

Identification of an Escherichia coli inner membrane polypeptide specified by a λ-tonB transducing bacteriophage

1979 • 40 citations

The bacterial outer-membrane permeability of .BETA.-lactam antibiotics.

1979 • 39 citations

Involvement of inner and outer membrane components in the transport of iron and in colicin B action in Escherichia coli

1978 • 38 citations

Antibiotic Transport in Bacteria

1973 • 37 citations

Energy coupling in the uptake of hexose phosphates by Escherichia coli.

1975 • 37 citations

A showdomycin-resistant mutant of Escherichia coli K-12 with altered nucleoside transport character

1972 • 37 citations

Active uptake of tetracycline by membrane vesicles from susceptible Escherichia coli

1981 • 37 citations

ENZYMES THAT INACTIVATE ANTIBIOTICS IN TRANSIT TO THEIR TARGETS*

1974 • 35 citations

Evidence for More Than One Mechanism of Plasmid-determined Tetracycline Resistance in Escherichia coli

1980 • 33 citations

Role of ribosome recycling in uptake of dihydrostreptomycin by sensitive and resistant Escherichia coli

1981 • 32 citations

Metabolic products of microorganisms. 176. On the transport of small peptide antibiotics in bacteria.

1979 • 32 citations

Two kinds of mutants defective in multiple carbohydrate utilization isolated from in vitro fosfomycin-resistant strains of Escherichia coli K-12.

1978 • 32 citations

Induction of Streptomycin Uptake in Resistant Strains of Escherichia coli

1979 • 32 citations

'Don't talk to me about permeability': The Tenth Marjory Stephenson Memorial Lecture

1971 • 31 citations

Porin activity in the osmotic shock fluid of Escherichia coli

1978 • 31 citations

Pores in the outer membrane of Escherichia coli K12. Involvement of proteins b and c in the permeation of cephaloridine and ampicillin

1978 • 31 citations

R-Factors: Their Properties and Possible Control

1977 • 31 citations

Deoxycytidine uptake by isolated membrain vesicles from Escherichia coli K 12

1973 • 29 citations

Characterization of the active transport of chlorotetracycline in Staphylococcus aureus by a florescence technique

1974 • 28 citations

Mapping of a genetic locus that affects glycerol 3-phosphate transport in Bacillus subtilis

1978 • 25 citations

The Porosity of the Cell Wall of Candida albicans

1980 • 25 citations

THE BACTERIA: A TREATISE ON STRUCTURE AND FUNCTION

1960 • 25 citations

Antibiotic therapy and cystic fibrosis: increased resistance of mucoid Pseudomonas aeruginosa to carbenicillin

1976 • 24 citations

The effect of lipid a on the fluidity and permeability propertes of phospholipid dispersions

1978 • 24 citations

Physiology of Neisseria gonorrhoeae

1980 • 23 citations

Accumulation of tetracyclines by Escherichia coli K-12

1977 • 22 citations

Metabolic fate of 3,4-dihydroxybutyl-1-phosphonate in Escherichia coli.

1976 • 22 citations

Tetracycline transport in Bacteroides fragilis

1980 • 22 citations

Transport of tetracyclines through the bacterial cell membrane assayed by fluorescence: a study with susceptible and resistant strains of Staphylococcus aureus and Escherichia coli.

1978 • 19 citations

Purification and Properties of a Periplasmic Protein

1977 • 19 citations

Reaction of cyanide with cytochrome d in respiratory particles from exponential phase Escherichia coli

1975 • 18 citations

Tetracycline resistance genes from Bacillus plasmid pAB124 confer decreased accumulation of the antibiotic in Bacillus subtilis but not in Escherichia coli

1981 • 18 citations

Biochimica et biophysica acta

1980 • 18 citations

Membrane phase transitions and the transport of chlortetracycline

1975 • 17 citations

Encyclopaedia of Antibiotics.

1977 • 17 citations

Functions in outer and inner membranes of Escherichia coli for ferrichrome transport

1981 • 17 citations

tonB-independent ferrichrome-mediated iron transport in Escherichia coli spheroplasts

1980 • 17 citations

Preferential sensitivity of syntheses of exported proteins to translation inhibitors of low polarity in Escherichia coli

1978 • 16 citations

Membrane lateral phase separations and chlortetracycline transport by Bacillus megaterium

1978 • 16 citations

Measurement of Binding of Chloramphenicol by Intact Cells

1967 • 15 citations

A novel method for evaluating the outer membrane permeability to .BETA.-lactamase-stable .BETA.-lactam antibiotics.

1980 • 15 citations

Light-induced, carrier-mediated transport of tetracycline by Rhodopseudomonas sphaeroides

1979 • 15 citations

Transport of the iron ionophore ferrichrome inEscherichia coliK-12 andSalmonella typhimuriumLT2

1981 • 15 citations

Characterization of a periplasmic protein related to sn-glycerol-3-phosphate transport in escherichia coli

1977 • 13 citations

Transport of 3,4-dihydroxybutyl-1-phosphonate, an analogue of sn-glycerol 3-phosphate

1977 • 12 citations

Lysozyme-promoted association of protein I molecules in the outer membrane of Escherichia coli

1977 • 12 citations

Beta-Lactam Antibiotics

1979 • 11 citations

Phosphorylation of streptozotocin during uptake via the phosphoenolpyruvate: sugar phosphotransferase system in Escherichia coli

1979 • 11 citations

Resolution of glpA and glpT loci into separate operons in Escherichia coli K-12 strains

1979 • 11 citations

Antibiotic interactions

1980 • 10 citations

Light‐Induced tetracycline accumulation by rhodopseudomonas sphaeroides

1976 • 10 citations

Chloramphenicol-resistant variants of Pseudomonas aeruginosa defective in amino acid transport

1980 • 9 citations

The specificity and action of animal, bacterial and plant toxins

1977 • 9 citations

Glycerol 3-phosphate analogues as metabolic inhibitors in Escherichia coli 3-hydroxy-4-oxobutyl-1-phosphonate, a drug that interferes with normal phosphoglyceride metabolism

1979 • 6 citations

Susceptibility of Protein Synthesis in Escherichia coli to Tetracycline and Minocycline

1981 • 6 citations

Incorporation of 3,4-dihydroxybutyl-1-phosphonate, a glycerol 3-phosphate analogue, into the cell wall of Bacillus subtilis

1977 • 5 citations

BACTERIAL WALLS AND MEMBRANES

1971 • 2 citations