Beta-Lactam Antibiotics

CP-45,899, a Beta-Lactamase Inhibitor That Extends the Antibacterial Spectrum of Beta-Lactams: Initial Bacteriological Characterization

1978 • 399 citations

Structure and absolute configuration of thienamycin

1978 • 297 citations

On the process of cellular division in Escherichia coli: a series of mutants of E. coli altered in the penicillin-binding proteins.

1978 • 278 citations

Risk of 45,X karyotype in offspring of turner's syndrome patients. [Letters to the editor]

1977 • 189 citations

Structure-activity relationships among the semisynthetic antibiotics

1977 • 184 citations

Piperacillin, a new penicillin active against many bacteria resistant to other penicillins

1978 • 173 citations

Total synthesis of (.+-.)-thienamycin

1978 • 124 citations

Beta-Lactamase Stability of HR 756, a Novel Cephalosporin, Compared to That of Cefuroxime and Cefoxitin

1978 • 123 citations

In vitro study of clavulanic acid in combination with penicillin, amoxycillin, and carbenicillin

1978 • 114 citations

6-beta-bromopenicillanic acid, a potent beta-lactamase inhibitor.

1978 • 105 citations

Cefotaxime (HR 756) a new cephalosporin with exceptional broad-spectrum activity in vitro

1978 • 103 citations

Azlocillin and Mezlocillin: New Ureido Penicillins

1978 • 101 citations

Cefuroxime, a Beta-Lactamase-Resistant Cephalosporin with a Broad Spectrum of Gram-Positive and -Negative Activity

1978 • 89 citations

Combined Activity of Clavulanic Acid and Ticarcillin Against Ticarcillin-Resistant, Gram-Negative Bacilli

1978 • 81 citations

Isolation of a mutant of Escherichia coli lacking penicillin-sensitive D-alanine carboxypeptidase IA.

1978 • 81 citations

In vitro activity of piperacillin, a new semisynthetic penicillin with an unusually broad spectrum of activity

1978 • 75 citations

Cefaclor: In Vitro Spectrum of Activity and Beta-Lactamase Stability

1978 • 73 citations

In Vitro Activity of Thienamycin

1978 • 72 citations

Genetics of antibiotic production.

1977 • 72 citations

Activity of HR 756 against Haemophilus influenzae, Barteroides fragilis and Gram-negative rods

1978 • 69 citations

SCE-129, Antipseudomonal Cephalosporin: In Vitro and In Vivo Antibacterial Activities

1978 • 68 citations

A sulfone .BETA.-lactam compound which acts as a .BETA.-lactamase inhibitor.

1978 • 68 citations

Cell-free ring expansion of penicillin N to deacetoxycephalosporin C by Cephalosporium acremonium CW-19 and its mutants.

1978 • 65 citations

SK&F 75073, New Parenteral Broad-Spectrum Cephalosporin with High and Prolonged Serum Levels

1978 • 61 citations

SCE-963, a New Broad-Spectrum Cephalosporin: In Vitro and In Vivo Antibacterial Activities

1978 • 60 citations

Studies on the biosynthesis of clavulanic acid. I. Incorporation of 13C-labelled precursors.

1978 • 60 citations

PS-5, A new .BETA.-lactam antibiotic from Streptomyces.

1978 • 56 citations

Effect of Clavulanic Acid on Anaerobic Bacteria Resistant to Beta-Lactam Antibiotics

1978 • 51 citations

HR 756, the syn Isomer of a New Methoxyimino Cephalosporin with Unusual Antibacterial Activity

1978 • 50 citations

Piperacillin: In Vitro Evaluation

1978 • 49 citations

Stability and Blood Level Determinations of Cefaclor, a New Oral Cephalosporin Antibiotic

1978 • 46 citations

Identification of the binding protein which may be the target of penicillin action in Bacillus megaterium

1978 • 46 citations

Pharmacokinetics of Cephalosporin Antibiotics: Protein-Binding Considerations

1978 • 38 citations

Clavulanic acid inhibition of .BETA.-lactamase I from Bacillus cereus 569/H.

1978 • 36 citations

Preparation of the 7-oxo-4-oxa-1-azabicyclo[3.2.0]hept-2-ene system and the reversible cleavage of its oxazoline ring

1978 • 33 citations

In vitro activity of HR 756, a new cephalosporin compound.

1978 • 32 citations

Secretion of Cell Wall Polymers into the Growth Medium of Lysis-Defective Pneumococci During Treatment with Penicillin and Other Inhibitors of Cell Wall Synthesis

1978 • 31 citations

Comparison of the In Vitro Activity of Bay k 4999 and Piperacillin, Two New Antipseudomonal Broad-Spectrum Penicillins, with Other β-Lactam Drugs

1978 • 29 citations

Inhibition of Cell Division of Escherichia coli by a New Synthetic Penicillin, Piperacillin

1978 • 28 citations

Development and Evaluation of a Potency Index Screen for Detecting Mutants of Penicillium chrysogenum Having Increased Penicillin Yield

1978 • 28 citations

Susceptibility of the Anaerobic Bacteria, Group D Streptococci, Enterobacteriaceae , and Pseudomonas to Semisynthetic Penicillins: Carbenicillin, Piperacillin, and Ticarcillin

1978 • 27 citations

In vitro and in vivo activity of piperacillin, a new broad-spectrum semisynthetic penicillin.

1978 • 26 citations

A new cephalosporin. SCE-963: 7-[2-(2-aminothiazol-4-yl)-acetamido]-3-[[[1-(2-dimethylaminoethyl)-1H-tetrazol-5-yl]-thio]methyl]ceph-3-em-4-carboxylic acid. Chemistry and structure-activity relationships.

1978 • 26 citations

Effect of carbon sources on β-lactam antibiotic formation by Cephalosporium acremonium

1978 • 25 citations

Nuclear analogs of .beta.-lactam antibiotics. 4. Total synthesis of bisnorisopenicillins from antibacterially active monocyclic .beta.-lactam precursors

1978 • 25 citations

Comparative in vitro activities of SCE-129, sulbenicillin, gentamicin, and dibekacin against Pseudomonas

1978 • 24 citations

Substrate specificity of penicillin acylase of E. coli.

1978 • 24 citations

Piperacillin, a new penicillin with high anti-pseudomonal activity

1978 • 23 citations

In Vitro Activity and Beta-Lactamase Stability of BL-S786 Compared with Those of Other Cephalosporins

1978 • 23 citations

Comparison of BL-S786 with cephalothin, cefamandole and cefoxitin in vitro and in treatment of experimental infections in mice.

1978 • 21 citations

In vitro and in vivo studies with BL-S786, cefoxitin, and cefamandole

1978 • 20 citations

Development of the Agar Disk Method for the Rapid Selection of Cephalosporin Producers with Improved Yields

1978 • 19 citations

Irreversible Effects of Serum Proteins on Beta-Lactam Antibiotics

1978 • 19 citations

The stereochemistry of β-lactam formation in cephalosporin biosynthesis

1978 • 17 citations

Sodium Clavulanate Potentiation of Cephalosporin Activity Against Clinical Isolates of Cephalothin-Resistant Klebsiella pneumoniae

1978 • 16 citations

Metabolic fate of SCE-963, a new broad-spectrum cephalosporin, after parenteral administration in rats and dogs.

1978 • 16 citations

High performance liquid chromatography of natural products. II. Direct biological correlation of components in the fermentation broth.

1978 • 15 citations

In Vitro Activity of Cefaclor Against Aerobic and Anaerobic Bacteria

1978 • 15 citations

Diastereomeric 7-ureidoacetyl cephalosporins. I. Superiority of 7.ALPHA.-H-L-isomers over D-isomers.

1978 • 14 citations

Day services for mentally handicapped adults.

1977 • 14 citations

Interaction of Cephalosporins with Human and Canine Serum Proteins

1978 • 13 citations

Production of 3-aminonocardicinic acid from nocardicin C by microbial enzymes.

1978 • 13 citations

Hetacillin (R)- and (S)-sulfoxides. Synthesis and structure-activity relationships

1978 • 13 citations

Metabolic Fate of SCE-129, a New Antipseudomonal Cephalosporin, After Parenteral Administration in Rats and Dogs

1978 • 13 citations

Reactions of sulphur nucleophiles with activated derivatives of clavulanic acid

1978 • 12 citations

Cefamandole--A Status Report Based on the Symposium on Cefamandole

1978 • 11 citations

Genetic recombination in Streptomyces griseus

1978 • 9 citations

Membrane-bound penicillin-binding proteins of Escherichia coli. Comparison of a strain carrying an R-factor and the parent strain.

1978 • 9 citations

Susceptibility of Staphylococcus aureus to Cefaclor and Cephalothin: Laboratory and Clinical Studies

1978 • 8 citations

Diastereomeric 7-ureidoacetyl cephalosporins. II. 7.BETA.[[[(Aminocarbonyl) amino]-2-thienylacetyl] amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl) thio] methyl]-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-carboxylic acid.

1978 • 8 citations

Cephamycin derivatives: Comparison of the in vitro and in vivo antibacterial activities of SQ 14,359, CS-1170, and cefoxitin.

1978 • 8 citations

Semisynthetic cephalosporins with antifungal activity: Laboratory studies on 2-pyridinethiol 1-oxide cephalosporins.

1978 • 7 citations

Diastereomeric 7-ureidoacetyl cephalosporins. III. Contribution of D- and L-isomers to the growth inhibiting activities of 7.ALPHA.-H and 7.ALPHA.-OCH3 derivatives for gram-positive and gram-negative bacteria.

1978 • 7 citations

Bactericidal activity of cefoxitin and cefuroxime

1978 • 7 citations

Effect of β-Lactam Antibiotics on In Vitro Peptidoglycan Cross-Linking by a Particulate Fraction from Escherichia coli K-12 and Bacillus megaterium KM

1978 • 6 citations

Absorption, distribution and excretion of cefsulodin, an antipseudomonal cephalosporin, in mice, rats and dogs.

1978 • 5 citations

Cefoxitin: microbiology, pharmacology and clinical use.

1978 • 5 citations

In vitro activity against Escherichia coli of CGP 9000, a new oral cephalosporin.

1978 • 5 citations