Haemophilia A: Mutation Type Determines Risk of Inhibitor Formation

Attachment of a 40-base-pair G + C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes.

1989 • 1,295 citations

[31] Detection and localization of single base changes by denaturing gradient gel electrophoresis

1987 • 944 citations

Reactivity of cytosine and thymine in single-base-pair mismatches with hydroxylamine and osmium tetroxide and its application to the study of mutations.

1988 • 636 citations

Incidence of development of factor VIII and factor IX inhibitors in haemophiliacs

1992 • 613 citations

A More Uniform Measurement of Factor VIII Inhibitors

1975 • 498 citations

[30] Computational simulation of DNA melting and its application to denaturing gradient gel electrophoresis

1987 • 491 citations

Recombinant Factor VIII for the Treatment of Previously Untreated Patients with Hemophilia A -- Safety, Efficacy, and Development of Inhibitors

1993 • 482 citations

The factor VIII complex: structure and function

1981 • 408 citations

A multicenter study of recombinant factor VIII (recombinate): safety, efficacy, and inhibitor risk in previously untreated patients with hemophilia A. The Recombinate Study Group.

1994 • 352 citations

Gene deletions in patients with haemophilia B and anti-factor IX antibodies

1983 • 207 citations

The natural history of factor VIII:C inhibitors in patients with hemophilia A: a national cooperative study. II. Observations on the initial development of factor VIII:C inhibitors

1988 • 171 citations

Haemophilia A: database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene, second edition

1994 • 156 citations

Molecular etiology of factor VIII deficiency in hemophilia A

1995 • 131 citations

The molecular basis of α1-antichymotrypsin deficiency in a heterozygote with liver and lung disease

1993 • 94 citations

Inhibitors in hemophilia patients: Current status and management

1994 • 84 citations

Characterization of mutations within the factor VIII gene of 73 unrelated mild and moderate haemophiliacs

1995 • 62 citations

Factor VIII gene rearrangements in patients with severe haemophilia A

1994 • 59 citations

The molecular genetic analysis of haemophilia A; characterization of six partial deletions in the factor VIII gene

1990 • 42 citations

WHY DO SO MANY HAEMOPHILIA A PATIENTS DEVELOP AN INHIBITOR?

1995 • 38 citations

Relationship of Major Histocompatibility Complex Class II Genes to Inhibitor Antibody Formation in Hemophilia A

1990 • 37 citations

Analysis of the essential sequences of the factor VIII gene in twelve haemophilia A patients by single-stranded conformation polymorphism

1994 • 35 citations

HLA antigens and factor VIII antibody in classic hemophilia. European study group of factor VIII antibody.

1981 • 29 citations

Possible Linkage between the Major Histocompatibility Complex and the Immune Response to Factor VIII in Classic Haemophilia

1977 • 21 citations

Risk of gastrointestinal bleeding from dexamethasone in children with bacterial meningitis

1994 • 12 citations