Na+/H+ antiporters, molecular devices that couple the Na+ and H+ circulation in cells

Coupling of Phosphorylation to Electron and Hydrogen Transfer by a Chemi-Osmotic type of Mechanism

1961 • 4,416 citations

Regulation of cytoplasmic pH in bacteria

1985 • 1,034 citations

Transcriptional Regulator of Oxidative Stress-Inducible Genes: Direct Activation by Oxidation

1990 • 869 citations

Molecular cloning, primary structure, and expression of the human growth factor-activatable antiporter

1989 • 774 citations

Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation

1989 • 749 citations

Modifier role of internal H+ in activating the Na+–H+ exchanger in renal microvillus membrane vesicles

1982 • 681 citations

Kinetic Properties of the Plasma Membrane Na+ -H+ Exchanger

1985 • 670 citations

Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins.

1992 • 585 citations

A large family of bacterial activator proteins.

1988 • 559 citations

A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH.

1984 • 544 citations

Effects of Growth Factors on Intracellular pH Regulation

1986 • 498 citations

Respiration-driven proton translocation in rat liver mitochondria

1967 • 463 citations

Growth Factors Induce Phosphorylation of the Na ⁺ /H ⁺ Antiporter, a Glycoprotein of 110 kD

1990 • 452 citations

pH homesstasis in bacteria

1981 • 427 citations

OxyR, a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins.

1989 • 415 citations

The heat shock response of E. coli is regulated by changes in the concentration of σ32

1987 • 414 citations

The Proton Electrochemical Gradient in Escherichia coli Cells

1976 • 391 citations

Gene regulation of plasmid- and chromosome-determined inorganic ion transport in bacteria

1992 • 369 citations

A novel P‐type ATPase from yeast involved in sodium transport

1991 • 362 citations

Cloning and sequencing of a rabbit cDNA encoding an intestinal and kidney-specific Na+/H+ exchanger isoform (NHE-3).

1992 • 347 citations

PROTON TRANSFER IN REACTION CENTERS FROM PHOTOSYNTHETIC BACTERIA

1992 • 344 citations

Na⁺/H⁺ Antiport in Isolated Tonoplast Vesicles from Storage Tissue of Beta vulgaris

1985 • 342 citations

pH homeostasis in Escherichia coli: measurement by 31P nuclear magnetic resonance of methylphosphonate and phosphate.

1981 • 323 citations

Tonoplast energization: Two H⁺ pumps, one membrane

1987 • 317 citations

The Na+/H+ antiporter cytoplasmic domain mediates growth factor signals and controls "H(+)-sensing".

1992 • 291 citations

Na+/H+ antiport in Swiss 3T3 cells: mitogenic stimulation leads to cytoplasmic alkalinization.

1982 • 282 citations

Proton/sodium ion antiport in Escherichia coli

1974 • 268 citations

Overproduction and purification of a functional Na+/H+ antiporter coded by nhaA (ant) from Escherichia coli

1991 • 260 citations

Na+/H+ antiporters

1983 • 241 citations

Bacterial periplasmic permeases belong to a family of transport proteins operating from to human: Traffic ATPases

1990 • 230 citations

Influence of pH on bacterial gene expression

1993 • 227 citations

Activation of the Na+/H+ antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism.

1992 • 223 citations

Escherichia coli intracellular pH, membrane potential, and cell growth

1984 • 223 citations

Sodium ion transport decarboxylases and other aspects of sodium ion cycling in bacteria

1987 • 210 citations

Characterization of a Na+/H+ antiporter gene of Escherichia coli.

1987 • 209 citations

Alkali Cation Transport Systems in Prokaryotes

2024 • 197 citations

Expression cloning in yeast of a cDNA encoding a broad specificity amino acid permease from Arabidopsis thaliana.

1993 • 196 citations

Cloning and characterization of a putative Ca2+/H+ antiporter gene from Escherichia coli upon functional complementation of Na+/H+ antiporter-deficient strains by the overexpressed gene

1993 • 190 citations

Proton electrochemical gradient in Escherichia coli cells and its relation to active transport of lactose

1979 • 190 citations

Alpha-thrombin, epidermal growth factor, and okadaic acid activate the Na+/H+ exchanger, NHE-1, by phosphorylating a set of common sites.

1991 • 189 citations

Characterization of the ATP synthase of Propionigenium modestum as a primary sodium pump

1988 • 188 citations

Deletion of ant in Escherichia coli Reveals Its Function in Adaptation to High Salinity and an Alternative Na+/H+ Antiporter System(s)

1989 • 184 citations

Physiological role of nhaB, a specific Na+/H+ antiporter in Escherichia coli.

1993 • 179 citations

Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger.

1991 • 178 citations

Sodium-proton antiport in isolated membrane vesicles of Escherichia coli

1978 • 176 citations

Cation transport and electrogenesis byStreptococcus faecalis

1972 • 174 citations

Bacterial periplasmic permeases belong to a family of transport proteins operating fromEscherichia colito human: Traffic ATPases

1990 • 174 citations

Gene amplification at a locus encoding a putative Na+/H+ antiporter confers sodium and lithium tolerance in fission yeast.

1992 • 168 citations

The role of Na+ in transport processes of bacterial membranes

1979 • 161 citations

Flagellar motors of alkalophilic bacillus are powered by an electrochemical potential gradient of Na⁺

1981 • 160 citations

A proton-translocating ATPase regulates pH of the bacterial cytoplasm.

1985 • 158 citations

Proton-sodium stoichiometry of NhaA, an electrogenic antiporter from Escherichia coli.

1993 • 156 citations

Electrochemical proton gradient in inverted membrane vesicles from Escherichia coli

1980 • 154 citations

Regulation of intracellular pH in cultured hippocampal neurons by an amiloride-insensitive Na+/H+ exchanger.

1991 • 148 citations

Cloning and expression of a cAMP-activated Na+/H+ exchanger: evidence that the cytoplasmic domain mediates hormonal regulation.

1992 • 142 citations

Sequencing of the gene ant which affects the Na+/H+ antiporter activity in Escherichia coli.

1988 • 142 citations

Cation/proton antiport systems in Escherichiacoli

1978 • 141 citations

Histidine-226 is part of the pH sensor of NhaA, a Na+/H+ antiporter in Escherichia coli.

1993 • 132 citations

Cloning, sequencing, and expression of the nhaB gene, encoding a Na+/H+ antiporter in Escherichia coli.

1992 • 131 citations

ATP-driven sodium pump in Streptococcus faecalis.

1982 • 127 citations

The sodium ion translocating adenosine triphosphatase of Propionigenium modestum pumps protons at low sodium ion concentrations

1989 • 124 citations

pH-regulated anion antiport in nucleated mammalian cells.

1986 • 117 citations

Regulation of the cytoplasmic pH in Streptococcus faecalis.

1982 • 114 citations

Effects of pH and Repellent Tactic Stimuli on Protein Methylation Levels in Escherichia coli

1982 • 114 citations

Tonoplast vesicles as a tool in the study of ion transport at the plant vacuole

1987 • 110 citations

Bioenergetics of alkalophilic bacteria

1986 • 103 citations

Effect of K⁺, its Counter Anion, and pH on Sodium Efflux from Barley Root Tips

1976 • 102 citations

Cloning and disruption of a putative NaH-antiporter gene of Enterococcus hirae.

1992 • 102 citations

Amplification of the Streptococcus faecalis proton-translocating ATPase by a decrease in cytoplasmic pH

1984 • 101 citations

Cation/proton antiport systems in Escherichia coli. Absence of potassium/proton antiporter activity in a pH-sensitive mutant.

1980 • 100 citations

Effects of aerobiosis and nitrogen source on the proton motive force in growing Escherichia coli and Klebsiella pneumoniae cells

1981 • 98 citations

Molecular biology of the plasma membrane of higher plants.

1989 • 97 citations

Expression of a sodium proton antiporter (NhaA) in Escherichia coli is induced by Na+ and Li+ ions.

1991 • 95 citations

Na⁺/H⁺ and K⁺/H⁺ Antiport in Root Membrane Vesicles Isolated from the Halophyte Atriplex and the Glycophyte Cotton

1990 • 94 citations

Cation/proton antiport systems in Escherichia coli: Properties of the sodium/proton antiporter

1979 • 94 citations

Na⁺/H⁺ antiport in isolated plasma membrane vesicles from the halotolerant alga Dunaliella salina

1986 • 93 citations

Structure function of the growth factor-activatable Na+/H+ exchanger (NHE1)

1992 • 92 citations

NhaR, a protein homologous to a family of bacterial regulatory proteins (LysR), regulates nhaA, the sodium proton antiporter gene in Escherichia coli.

1992 • 89 citations

Measurement of intracellular sodium concentration and sodium transport in Escherichia coli by 23Na nuclear magnetic resonance.

1986 • 89 citations

Intracellular pH and membrane potential as regulators in the prokaryotic cell

1987 • 84 citations

pH homeostasis : mechanisms and control

1988 • 83 citations

SITE-DIRECTED MUTAGENESIS AND ION-GRADIENT DRIVEN ACTIVE TRANSPORT: On the Path of the Proton

1988 • 83 citations

Homologous metalloregulatory proteins from both gram-positive and gram-negative bacteria control transcription of mercury resistance operons

1989 • 82 citations

Coupling between the sodium and proton gradients in respiring Escherichia coli cells measured by 23Na and 31P nuclear magnetic resonance.

1986 • 82 citations

The cadC gene product of alkaliphilic Bacillus firmus OF4 partially restores Na+ resistance to an Escherichia coli strain lacking an Na+/H+ antiporter (NhaA)

1992 • 78 citations

A non-alkalophilic mutant of Bacillusalcalophilus lacks the Na+H+ antiporter

1979 • 78 citations

[27] Intracellular pH regulation in bacterial cells

1986 • 76 citations

K+/H+ antiporter functions as a regulator of cytoplasmic pH in a marine bacterium, Vibrio alginolyticus

1984 • 75 citations

Site-specific mutagenesis of histidine residues in the lac permease of Escherichia coli.

1985 • 74 citations

RECENT ADVANCES IN BACTERIAL ION TRANSPORT

1986 • 72 citations

Induction of SOS functions by alkaline intracellular pH in Escherichia coli

1986 • 71 citations

A sodium requirement for growth, solute transport, and pH homeostasis in Bacillus firmus RAB.

1982 • 70 citations

Functional expression of a human Na+/H+ antiporter gene transfected into antiporter-deficient mouse L cells.

1986 • 70 citations

Proton motive force is not obligatory for growth of Escherichia coli

1984 • 69 citations

Molecular cloning and sequencing of a gene from alkaliphilic Bacillus firmus OF4 that functionally complements an Escherichia coli strain carrying a deletion in the nhaA Na+/H+ antiporter gene.

1991 • 68 citations

Altered cation coupling to melibiose transport in mutants of Escherichia coli.

1982 • 67 citations

Isolation and properties of fibroblast mutants overexpressing an altered Na+/H+ antiporter.

1986 • 66 citations

Is sodium proton antiport ubiquitous in plant cells?

1990 • 64 citations

DNA sequences required for the alkalophily of Bacillus sp. strain C-125 are located close together on its chromosomal DNA

1990 • 64 citations

Transcriptional switching by the metalloregulatory MerR protein: initial characterization of DNA and mercury(II) binding activities

1989 • 64 citations

Gene structure of Enterococcus hirae (Streptococcus faecalis) F1F0-ATPase, which functions as a regulator of cytoplasmic pH

1992 • 63 citations

Cation/proton antiport systems in Escherichia coli. Solubilization and reconstitution of delta pH-driven sodium/proton and calcium/proton antiporters.

1986 • 62 citations

Inhibition of Na⁺/H⁺ Antiport Activity in Sugar Beet Tonoplast by Analogs of Amiloride

1987 • 61 citations

Identification of a 170-kDa protein associated with the vacuolar Na+/H+ antiport of Beta vulgaris.

1991 • 57 citations

Presence of a nonmetabolizable solute that is translocated with Na+ enhances Na+-dependent pH homeostasis in an alkalophilic Bacillus.

1985 • 55 citations

Kinetic properties of sodium-proton antiport in Escherichia coli membrane vesicles: effects of imposed electrical potential, proton gradient, and internal pH

1984 • 55 citations

A variable stoichiometry model for pH homeostasis in bacteria

1987 • 53 citations

Alteration in cation specificity of the melibiose transport carrier of Escherichia coli due to replacement of proline 122 with serine

1985 • 51 citations

Molecular analysis of two genes between let-653 and let-56 in the unc 22(IV) region of Caenorhabditis elegans

1993 • 51 citations

Purification of a reconstitutively active K+/H+ antiporter from rat liver mitochondria.

1990 • 50 citations

Alkaline induction of a novel gene locus, alx, in Escherichia coli

1990 • 50 citations

Electrogenic 2 Na+/1 H+ exchange in crustanceans

1990 • 50 citations

Dependence on Na⁺ of control of cytoplasmic pH in a facultative alkalophile

1984 • 49 citations

The electrochemical proton potential ofBacillus alcalophilus

1991 • 49 citations

Sodium/proton antiporter in Streptococcus faecalis

1987 • 48 citations

In Vivo pH Regulation by a Na⁺/H⁺ Antiporter in the Halotolerant Alga Dunaliella salina

1991 • 48 citations

Effect of intracellular pH on the rate of chloride uptake and efflux in different mammalian cell lines

1987 • 48 citations

Generation of a transmembrane gradient of Na+ in Methanosarcina barkeri

1987 • 48 citations

Evidence for a Na⁺/H⁺ Antiporter in Membrane Vesicles Isolated from Roots of the Halophyte Atriplex nummularia

1988 • 48 citations

In vivo 23Na and 31P NMR measurement of a tonoplast Na+/H+ exchange process and its characteristics in two barley cultivars.

1989 • 47 citations

Reconstitution and partial purification of the Na(+)-selective Na+/H+ antiporter of beef heart mitochondria.

1991 • 45 citations

The role of sodium ion transport in Escherichia coli energetics

1991 • 44 citations

Structure of the DNA distal to the gene for ribosomal protein S20 inEscherichia coliK12: presence of a strong terminator and an IS1 element

1986 • 43 citations

Relationship between Na⁺‐dependent cytoplasmic pH homeostasis and Na⁺‐dependent flagellar rotation and amino acid transport in alkalophilic Bacillus

1985 • 43 citations

Characterization of the Na+/H+ antiporter of alkalophilic bacilli in vivo: delta psi-dependent 22Na+ efflux from whole cells

1983 • 43 citations

The Bioenergetics of Alkalophilic Bacilli

1988 • 42 citations

Characterization and reconstitution of the Na+/H+ antiporter from the plasma membrane of the halotolerant alga Dunaliella

1989 • 41 citations

Relationships between the sodium-proton antiport activity and the components of the electrochemical proton gradient in Escherichia coli membrane vesicles

1984 • 41 citations

The mechanism of sodium efflux in yeast

1982 • 40 citations

An NADH:Quinone oxidoreductase of the halotolerant bacterium Ba1 is specifically dependent on sodium ions

1986 • 40 citations

Stoichiometry of the H⁺‐ATPase of Escherichia coli cells during anaerobic growth

1983 • 39 citations

Modulation of Na⁺/H⁺ Antiporter Activity by Extreme pH and Salt in the Halotolerant Alga Dunaliella salina

1992 • 38 citations

Isolation and properties of a mutant of Escherichia coli possessing defective Na+/H+ antiporter.

1987 • 37 citations

Primary structure of the α‐subunit of vacuolar‐type Na⁺‐ATPase inEnterococcus hirae Amplification of a 1000‐bp fragment by polymerase chain reaction

1991 • 37 citations

Sodium efflux from perfused giant algal cells

1987 • 36 citations

Maintenance of a Neutral Cytoplasmic pH Is Not Obligatory for Growth of Escherichia coli and Streptococcus faecalis at an Alkaline pH1

1990 • 36 citations

pH homeostasis and bioenergetic work in alkalophiles

1990 • 35 citations

Proton-coupled bioenergetic processes in extremely alkaliphilic bacteria

1992 • 34 citations

Primary Sodium Pumps and Their Significance in Bacterial Energetics

1990 • 34 citations

Sodium and calcium share the electrogenic 2 Na(+)-1 H+ antiporter in crustacean antennal glands

1990 • 32 citations

Lowering of cytoplasmic pH is essential for growth of Streptococcus faecalis at high pH

1987 • 31 citations

An efflux mechanism determines the low net entry of lithium in yeasts

1977 • 31 citations

The Na(+)-motive respiratory chain of marine bacteria.

1985 • 30 citations

Escherichia coli is able to grow with negligible sodium ion extrusion activity at alkaline pH

1992 • 29 citations

Evidence for a Highly Specific K⁺/H⁺ Antiporter in Membrane Vesicles from Oil-Seed Rape Hypocotyls

1991 • 29 citations

Characterization and mapping of a major Na+/H+ antiporter gene of Escherichia coli

1991 • 28 citations

Photolabeling of Tonoplast from Sugar Beet Cell Suspensions by [³H]5-(N-Methyl-N-Isobutyl)-Amiloride, an Inhibitor of the Vacuolar Na⁺/H⁺ Antiport

1990 • 27 citations

Chemical modifications of the Na⁺– H⁺ antiport in Escherichia coli membrane vesicles

1985 • 27 citations

Energy source for lithium efflux in yeast

1981 • 27 citations

The Na+/pantothenate symporter (PanF) of Escherichia coli is homologous to the Na+/proline symporter (PutP) of E. coli and the Na+/glucose symporters of mammals

1990 • 27 citations

Steady-state measurements of Escherichia coli sodium and proton potentials at alkaline pH support the hypothesis of electrogenic antiport.

1990 • 27 citations

Separation of membrane vesicles from maize roots having different calcium transport activities

1988 • 26 citations

Inhibitory effect of Li+ on cell growth and pyruvate kinase activity of Escherichia coli

1984 • 26 citations

The putative Na⁺/H⁺antiporter (NapA) ofEnterococcus hiraeis homologous to the putative K⁺/H⁺antiporter (KefC) ofEscherichia coli

1992 • 25 citations

Energetics of sodium efflux from Escherichia coli

1984 • 25 citations

Electrogenic 2Na+/H+ Antiport in Echinoderm Gastrointestinal Epithelium

1991 • 25 citations

Cloning, sequencing and expression of the nhaA and nhaR genes from Salmonella entiritidis

1992 • 23 citations

The sodium/proton antiport system in a newly isolated alkalophilic Bacillus sp

1989 • 22 citations

Dependence of the growth of pH-sensitive mutants of a facultatively alkalophilicBacilluson the regulation of cytoplasmic pH

1986 • 22 citations

Assessment of Na+/H+ antiport in ATP-depleted red beet slices and barley roots

1988 • 21 citations

In vivo ^ Na and ^ P NMR measurement of a tonoplast Na^+/H^+ exchange process and its characteristics in two barley cultivars

1989 • 20 citations

Bioenergetics in Extreme Environments

1990 • 20 citations

In vitro protein translocation into inverted membrane vesicles prepared from Vibrio alginolyticus is stimulated by the electrochemical potential of Na⁺ in the presence of Escherichia coli SecA

1990 • 19 citations

Cloning of fragments of lambda dapB2 DNA and identification of the dapB gene product.

1980 • 19 citations

A sodium/proton antiporter in chromaffin-granule membranes

1989 • 16 citations

Kinetic properties of electrogenic Na+/H+ antiport in membrane vesicles from an alkalophilic Bacillus sp

1992 • 16 citations

Respiratory Na+ pump and Na+-dependent energetics inVibrio alginolyticus

1989 • 16 citations

Sodium/proton antiport is required for growth of Escherichia coli at alkaline pH

1989 • 14 citations

Na+-coupled ATP synthesis in Propionigenium modestum

1990 • 13 citations

Sodium ion transport in Neurospora crassa

1986 • 13 citations

Molecular analysis of the role of Na+/H+ antiporters in bacterial cell physiology.

1993 • 12 citations

Cooperative regulation of the -antiporter in Halobacterium halobium by ΔpH and Δφ

1990 • 11 citations

Mechanism of function of dicyclohexylcarbodiimide-sensitive -antiporter in Halobacterium halobium: pH effect

1989 • 11 citations

The Sodium World

1988 • 7 citations

Phosphorylation of the Growth-Factor Activatable Na+/H+ Antiporter: A Mechanism of Regulation

1991 • 6 citations

Δ\̃gmH+Δ\̃gmNa+ exchange ratio in the halobacterial Na+/H+-antiporter determined by a simultaneous measurement of ΔpH, ΔΨ and ΔpNa

1992 • 5 citations

Solubilization and functional reconstitution of the DCCD-sensitive Na+H+-antiporter from Halobacterium halobium

1990 • 4 citations

Inhibition of halobacterial Na+/H(+)-antiporter by carboxyl modifying reagent, EEDQ.

1991 • 1 citations