Human melanocytes and melanoma cells constitutively express the Bcl-2 proto-oncogene in situ and in cell culture.

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

1991 • 1,301 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell death

1991 • 1,195 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

Apoptosis

1993 • 972 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1991 • 876 citations

Programmed cell death: Apoptosis and oncogenesis

1991 • 856 citations

Molecular Analysis of the T(14;18) Chromosomal Translocation in Malignant Lymphomas

1987 • 701 citations

Molecular Cloning of the Chromosomal Breakpoint of B-Cell Lymphomas and Leukemias with the t(11;14) Chromosome Translocation

1984 • 671 citations

Toward an understanding of the molecular mechanisms of physiological cell death.

1993 • 623 citations

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.

1994 • 605 citations

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.

1993 • 488 citations

Activation of cyclin A-dependent protein kinases during apoptosis.

1994 • 352 citations

Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 protein.

1994 • 344 citations

Identification and induction of keratinocyte-derived IL-10.

1992 • 342 citations

Expression of bcl-2 in fetal tissues suggests a role in morphogenesis.

1993 • 320 citations

BCL‐2 expression in adult and embryonic non‐haematopoietic tissues

1993 • 265 citations

Expression of Thy-1 Antigen by Murine Epidermal Cells

1983 • 240 citations

Bcl-2 maintains B cell memory

1991 • 219 citations

Bcl-2: a repressor of lymphocyte death

1992 • 217 citations

c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle.

1994 • 210 citations

bcl-2 Protein Expression and Correlation with the Interchromosomal 14;18 Translocation in Cutaneous Lymphomas and Pseudolymphomas

1994 • 197 citations

Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells.

1994 • 190 citations

Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2 transgenic mice.

1992 • 181 citations

Differential effects of Bcl-2 on T and B cells in transgenic mice.

1992 • 140 citations

Disparate Antioxidant Enzyme Activities in Cultured Human Cutaneous Fibroblasts, Keratinocytes, and Melanocytes

1991 • 135 citations

Cytogenetic analysis of 147 cases of non‐Hodgkin's lymphoma: non‐random chromosomal abnormalities and histological correlations

1990 • 83 citations