Biochemical Pharmacology of Sleep

A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects

1969 • 5,164 citations

Seasonal Affective Disorder

1984 • 2,272 citations

Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat

1972 • 2,054 citations

Timing of human sleep: recovery process gated by a circadian pacemaker

1984 • 1,378 citations

A retinohypothalamic projection in the rat

1972 • 1,255 citations

Sleep Cycle Oscillation: Reciprocal Discharge by Two Brainstem Neuronal Groups

1975 • 1,216 citations

The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle

1972 • 1,091 citations

A CHOLINERGIC-ADRENERGIC HYPOTHESIS OF MANIA AND DEPRESSION

1972 • 1,077 citations

Nucleus basalis and thalamic control of neocortical activity in the freely moving rat

1988 • 1,035 citations

Norepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli.

1981 • 974 citations

The efferent projections from the reticular formation and the locus coeruleus studied by anterograde and retrograde axonal transport in the rat

1985 • 885 citations

Nonrepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli

1981 • 872 citations

Neuronal activities in brain-stem cholinergic nuclei related to tonic activation processes in thalamocortical systems

1990 • 779 citations

AN INHIBITORY MECHANISM IN THE BULBAR RETICULAR FORMATION

1946 • 736 citations

Neuronal excitability modulation over the sleep cycle: a structural and mathematical model

1975 • 636 citations

Network modulation of a slow intrinsic oscillation of cat thalamocortical neurons implicated in sleep delta waves: cortically induced synchronization and brainstem cholinergic suppression

1991 • 479 citations

Sleep-promoting effects of endogenous pyrogen (interleukin-1)

1984 • 450 citations

Acetylcholine released from cerebral cortex in relation to state of activation

1966 • 432 citations

Sleep Suppression after Basal Forebrain Lesions in the Cat

1968 • 430 citations

Acetylcholine Liberation from Cerebral Cortex during Paradoxical (REM) Sleep

1971 • 427 citations

Reticulo-cortical activity and behavior: A critique of the arousal theory and a new synthesis

1981 • 404 citations

Paradoxical sleep and its chemical/structural substrates in the brain

1991 • 402 citations

Mapping of cholinoceptive brainstem structures responsible for the generation of paradoxical sleep in the cat.

1989 • 380 citations

Pharmacology of Histamine Receptors

1982 • 375 citations

Cholinergic Hyperactivity and Negative Schizophrenic Symptoms

1989 • 353 citations

On the effect of melatonin upon human brain. Its possible therapeutic implications

1971 • 320 citations

Brainstem control of wakefulness and sleep

1990 • 311 citations

Lysergic acid diethylamide and serotonin: a comparison of effects on serotonergic neurons and neurons receiving a serotonergic input.

1974 • 311 citations

Limbic cholinergic pathways involved in sleep and emotional behavior

1963 • 307 citations

A re-evaluation of the effects of lesions of the pontine tegmentum and locus coeruleus on phenomena of paradoxical sleep in the cat.

1974 • 286 citations

Recombinant tumor necrosis factor and interleukin 1 enhance slow-wave sleep

1987 • 284 citations

Sleep: Neurotransmitters and neuromodulators

1984 • 282 citations

Regional cerebral glucose metabolic rate in human sleep assessed by positron emission tomography

1989 • 280 citations

Site-specific enhancement and suppression of desynchronized sleep signs following cholinergic stimulation of three brainstem regions

1984 • 267 citations

Neurobiology of Mood Disorders

1985 • 266 citations

Activity of mesencephalic dopamine and non-dopamine neurons across stages of sleep and waking in the rat

1983 • 265 citations

Endogenous sleep-promoting substances and sleep regulation

1989 • 256 citations

The effect of lesions of catecholamine-containing neurons upon monoamine content of the brain and EEG and behavioral waking in the cat

1973 • 250 citations

Cholinergic projections from the laterodorsal and pedunculopontine tegmental nuclei to the pontine gigantocellular tegmental field in the cat

1988 • 245 citations

Adenosine analogs and sleep in rats.

1984 • 239 citations

A quantitative study of morphological changes accompanying the initiation and progress of myelin production in the dorsal funiculus of the rat spinal cord

1971 • 237 citations

The relationship of interleukin-1 and immune functions to sleep in humans.

1986 • 232 citations

5-Hydroxytryptamine-2 antagonist increases human slow wave sleep

1986 • 231 citations

Dose‐related sleep disturbances induced by coffee and caffeine

1976 • 226 citations

Prostaglandin D2, a cerebral sleep-inducing substance in monkeys.

1988 • 225 citations

Effects of melatonin on human mood and performance

1984 • 222 citations

Recovery Sleep Following Sleep Deprivation in Intact and Suprachiasmatic Nuclei-Lesioned Rats

1983 • 218 citations

Sleep-promoting effects of muramyl peptides.

1982 • 216 citations

A neuroanatomical gradient in the pontine tegmentum for the cholinoceptive induction of desynchronized sleep signs

1987 • 215 citations

Suprachiasmatic nuclei lesions eliminate circadian temperature and sleep rhythms in the rat

1984 • 210 citations

Daily fluctuation (circadian and ultradian) in biogenic amines of the rat brain

1968 • 206 citations

The effect of para-chlorophenylalanine on the sleep of cats

1968 • 196 citations

Muramyl peptides: Immunomodulators, sleep factors, and vitamins

1984 • 195 citations

The effects of chronic, small doses of melatonin given in the late afternoon on fatigue in man: A preliminary study

1984 • 176 citations

Enhancement of acetylcholine release during paradoxical sleep in the dorsal tegmental field of the cat brain stem

1990 • 175 citations

Prostaglandin D2 induces sleep when microinjected into the preoptic area of conscious rats

1982 • 173 citations

The effect of amphetamine on the sleep cycle

1964 • 168 citations

The diencephalon and sleep

1991 • 168 citations

Visual Pathways and the Entrainment of Circadian Rhythms^a

1985 • 165 citations

A limit cycle mathematical model of the REM sleep oscillator system

1986 • 164 citations

Cholinergic brainstem mechanisms of REM sleep in the rat

1986 • 163 citations

Cigarette Smoking Associated with Sleep Difficulty

1980 • 159 citations

Interleukin-1 derived from astrocytes enhances slow wave activity in sleep EEG of the rat

1984 • 154 citations

Prostaglandin D2, a cerebral sleep-inducing substance in rats.

1983 • 154 citations

Selective breeding for increased cholinergic function: Development of a new animal model of depression

1986 • 151 citations

Sleep induced by the administration of melatonin (5-methoxy-N-acetyltryptamine) to the hypothalamus in unrestrained cats

1964 • 146 citations

Effect of specific M1, M2 muscarinic receptor agonists on REM sleep generation

1989 • 145 citations

Endogenous peptides and sleep in the rat: III the hypnogenic properties of vasoactive intestinal polypeptide

1982 • 143 citations

Amphetamine Withdrawal: Affective State, Sleep Patterns, and MHPG Excretion

1972 • 139 citations

EFFECTS OF L-TRYPTOPHAN (A NATURAL SEDATIVE) ON HUMAN SLEEP

1970 • 138 citations

Stereotyped and non-stereotyped behaviour in rats induced by various stimulant drugs

1969 • 135 citations

Neurobiological mechanisms of adaptation and behavior

1975 • 133 citations

Central serotonin receptors: effector systems, physiological roles and regulation

1987 • 133 citations

A function for REM sleep: regulation of noradrenergic receptor sensitivity

1988 • 131 citations

Some Effects of Melatonin and the Control of its Secretion in Humans

1985 • 130 citations

Endogenous sleep-substances and sleep regulation.

1986 • 128 citations

Altered Waveform of Plasma Nocturnal Melatonin Secretion in Premenstrual Depression

1990 • 128 citations

Selective breeding for sensitivity to the anticholinesterase DFP

1979 • 127 citations

The Cholinergic Rapid Eye Movement Sleep Induction Test With RS-86

1989 • 127 citations

Dual localization of histamine in an ascending neuronal pathway and in non-neuronal cells evidenced by lesions in the lateral hypothalamic area

1976 • 125 citations

Muscarinic Cholinergic Receptors and the Canine Model of Narcolepsy

1986 • 119 citations

On the effects of melatonin on sleep and behavior in man.

1974 • 118 citations

Electroencephalographic sleep and natural killer activity in depressed patients and control subjects.

1992 • 115 citations

Sleep Patterns of the Monkey and Brain Serotonin Concentration: Effect of p -Chlorophenylalanine

1968 • 114 citations

Peptidoglycans as promoters of slow-wave sleep. I. Structure of the sleep-promoting factor isolated from human urine.

1984 • 113 citations

Characterization of a delta-electroencephalogram (-sleep)-inducing peptide.

1977 • 112 citations

Acetylcholine and the Regulation of REM Sleep: Basic Mechanisms and Clinical Implications for Affective Illness and Narcolepsy

1987 • 110 citations

Slow-wave sleep induced in cats by extremely small amounts of synthetic and pineal vasotocin injected into the third ventricle of the brain

1977 • 110 citations

Cholinergic neurons from the dorsolateral pons project to the medial pons: A WGA-HRP and choline acetyltransferase immunohistochemical study

1988 • 109 citations

Natural and melatonin-induced sleep in young chickens ? A behavioral and electrographic study

1969 • 108 citations

Intracerebroventricular infusion of somatostatin selectively increases paradoxical sleep in rats

1986 • 106 citations

Peptidoglycans as promoters of slow-wave sleep. II. Somnogenic and pyrogenic activities of some naturally occurring muramyl peptides; correlations with mass spectrometric structure determination.

1984 • 105 citations

The carbachol-induced enhancement of desynchronized sleep signs is dose dependent and antagonized by centrally administered atropine

1989 • 100 citations

Differential sleep-promoting effects of five sleep substances nocturnally infused in unrestrained rats.

1984 • 100 citations

N6 (L-Phenylisopropyl)adenosine (L-PIA) increases slow-wave sleep (S2) and decreases wakefulness in rats

1982 • 99 citations

The Cholinergic Rapid Eye Movement Induction Test With Arecoline in Depression

1991 • 97 citations

Muramyl peptides. Variation of somnogenic activity with structure.

1984 • 97 citations

Effects of clonidine and BS 100–141 on the EEG sleep pattern in rats

1975 • 94 citations

The effect of melatonin on normal sleep

1987 • 94 citations

Theoretical view of REM sleep function: Maintenance of catecholamine systems in the central nervous system

1974 • 91 citations

Histaminergic systems and sleep

1985 • 89 citations

The Activating Effect of Histamine On The Central Nervous System

1970 • 89 citations

Increased REM sleep in rats selectively bred for cholinergic hyperactivity

1988 • 89 citations

Genetic linkage of autosomal recessive canine narcolepsy with a mu immunoglobulin heavy-chain switch-like segment.

1991 • 89 citations

Development and use of pharmacological probes of the CNS in man: evidence of cholinergic abnormality in primary affective illness.

1980 • 87 citations

EFFECTS OF MELATONIN ON SLEEP AND NEUROCHEMISTRY IN THE RAT

1982 • 84 citations

Hypothalamic 24-Hour Rhythms in Histamine, Histidine Decarboxylase and Histamine-N-Methyltransferase^*

1975 • 82 citations

Endogenous Sleep Factors

1984 • 80 citations

Dialysis of Sleep and Waking Factors in Blood of the Rabbit

1964 • 80 citations

The effects of chronic ritanserin treatment on sleep and the neuroendocrine response to l-tryptophan

1987 • 79 citations

The effects of scopolamine on sleep and mood in depressed patients with a history of alcoholism and a normal comparison group

1991 • 73 citations

Immunomodulating peptides

1986 • 71 citations

Alterations in the nocturnal sleep cycle resulting from LSD

1966 • 70 citations

Computer graphics analysis of sleep-wakefulness state changes after pontine lesions

1984 • 69 citations

The organization and regulation of sleep

1984 • 68 citations

Immunocytochemical characterization of the suprachiasmatic nucleus and the intergeniculate leaflet in the diurnal ground squirrel, Spermophilus lateralis

1991 • 68 citations

Effects of methoxamine, an alpha‐1 adrenoceptor agonist, and prazosin, an alpha‐1 antagonist, on the stages of the sleep—waking cycle in the cat

1984 • 67 citations

Effect of clonidine on sleep patterns in man

1977 • 66 citations

Increased daytime sleepiness enhances ethanol's sedative effects.

1988 • 66 citations

Hypnotic effects of deoxycorformycin in rats

1983 • 64 citations

Biogenic Amine Concentrations in the Brains of Normal and Narcoleptic Canines: Current Status

1986 • 63 citations

A Benzodiazepine Receptor Antagonist Decreases Sleep and Reverses the Hypnotic Actions of Flurazepam

1983 • 63 citations

Sleep changes during chronic administration of parachlorophenylalanine.

1972 • 63 citations

A comparison of triprolidine and clemastine on histamine antagonism and performance tests in man: Implications for the mechanism of drug induced drowsiness

1975 • 63 citations

Biology of sleep substances

1989 • 61 citations

The delta EEG (sleep)-inducing peptide (DSIP)

1978 • 60 citations

Sleep and the Immune Response

1987 • 60 citations

The molecular biology of serotonin receptors. An overview.

1990 • 59 citations

Cholinergic antagonists and REM sleep generation

1991 • 59 citations

Awaking effect of prostaglandin E2 in freely moving rats

1989 • 58 citations

REM sleep deprivation up-regulates adenosine A1 receptors

1987 • 58 citations

Histamine Receptors in the Brain and Their Possible Functions

1982 • 57 citations

Neuropharmacology of The Sleep-Waking Cycle

1977 • 55 citations

Depletion of brain serotonin following intraventricular 5,7-dihydroxytryptamine fails to disrupt sleep in the rat

1976 • 55 citations

Uridine as an active component of sleep-promoting substance: its effects on nocturnal sleep in rats

1984 • 54 citations

Role of central alpha-1 adrenoceptors in canine narcolepsy.

1988 • 54 citations

Sleep and other behavioural effects induced by acetylcholinic stimulation of basal temporal cortex and striate structures

1967 • 54 citations

EFFECTS ON THE HUMAN CENTRAL NERVOUS SYSTEM OF TWO ISOMERS OF EPHEDRINE AND TRIPROLIDINE, AND THEIR INTERACTION

1974 • 53 citations

The blockage of ponto-geniculo-occipital waves in the cat lateral geniculate nucleus by nicotinic antagonists

1988 • 52 citations

The effect of orally administered cocaine on sleep of depressed patients

1974 • 51 citations

AN EXAMINATION OF THE HYPNOTOXIN THEORY OF SLEEP

1939 • 50 citations

The serotonin-catecholamine-dream bicycle: a clinical study.

1972 • 50 citations

Exacerbation of Human Cataplexy by Prazosin

1989 • 50 citations

Sleep Peptides: Basic and Clinical Approaches

1988 • 49 citations

Awaking effect of PGE2 microinjected into the preoptic area of rats

1988 • 48 citations

Long-term enhancement of REM sleep following cholinergic stimulation

1991 • 48 citations

Monoamine Changes in the Brain of Cats During Slow-Wave Sleep

1976 • 47 citations

Brain dopamine receptors and sleep in the rat: Effects of stimulation and blockade

1976 • 47 citations

Reserpine and sleep

1971 • 45 citations

Effect of sleep deprivation on brain serotonin in the rat

1980 • 43 citations

Pilocarpine, an orally active muscarinic cholinergic agonist, induces REM sleep and reduces delta sleep in normal volunteers

1990 • 43 citations

DSIP in the Treatment of Withdrawal Syndromes from Alcohol and Opiates

1984 • 42 citations

A comparison of the dose response effects of pyrimidine ribonucleosides and adenosine on sleep in rats

1985 • 42 citations

Evidence for tolerance to the central nervous effects of the histamine antagonist, triprolidine, in man

1977 • 41 citations

Characterization of the postsynaptic a‐adrenoceptor in isolated feline cerebral arteries

1981 • 40 citations

Involvement of pre- and postsynaptic receptors in catecholaminergic control of paradoxical sleep in man

1979 • 39 citations

Brain Mechanisms of Sleep

1986 • 39 citations

Paradoxical sleep inhibition by central alpha-adrenoceptor stimulant clonidine antagonized by alpha-receptor blocker yohimbine

1977 • 39 citations

The role of β- and α-adrenoceptors in the regulation of the stages of the sleep-waking cycle in the cat

1983 • 39 citations

Effect of hemicholinium-3 on slow wave and paradoxical sleep of cat

1970 • 38 citations

Modulation of desynchronized sleep through microinjection of ?-adrenergic agonists and antagonists in the dorsal pontine tegmentum of the cat

1989 • 38 citations

Muramyl peptides in mammalian tissues and their effects at the cellular level.

1986 • 38 citations

Humoral transmission of sleep

1972 • 37 citations

Little sleep-promoting effect of three sleep substances diurnally infused in unrestrained rats

1984 • 36 citations

Somatostatin antiserum blocks carbachol-induced increase of paradoxical sleep in the rat

1988 • 35 citations

Brain temperature changes coupled to sleep states persist during interleukin 1-enhanced sleep

1986 • 35 citations

Effects of DSIP in Man

1983 • 35 citations

Microinjections of nicotine in the medial pontine reticular formation elicits REM sleep

1990 • 34 citations

Rapid-eye movement sleep and muscarinic receptor binding in rats are augmented during withdrawal from chronic scopolamine treatment

1986 • 33 citations

Vasoactive intestinal polypeptide (VIP) and cerebrospinal fluid (CSF) of sleep-deprived cats restores REM sleep in insomniac recipients

1986 • 32 citations

Dose dependent inhibition of REM sleep in normal volunteers by biperiden, a muscarinic antagonist

1991 • 32 citations

Pineal vasotocin and sleep: Involvement of serotonin containing neurons

1979 • 32 citations

Effect of delta sleep inducing peptide (DSIP) and arginine vasotocin (AVT) on sleep and motor activity in the rat.

1980 • 32 citations

Suppression of sleep by prostaglandin synthesis inhibitors in unrestrained rats

1988 • 31 citations

Presynaptic alpha2-adrenoceptor function and sleep in man: Studies with clonidine and idazoxan

1991 • 31 citations

Study of sleep-wakefulness states by computer graphics and cluster analysis before and after lesions of the pontine tegmentum in the cat

1984 • 31 citations

Effects of repeated DSIP and DSIP-P administration on the circadian locomotor activity of rats

1981 • 30 citations

Hypnogenic center theory of sleep: no support from metabolic mapping in monkeys

1983 • 29 citations

Electroencephalographic, behavioural and visceral effects of intraventricular infusion of histamine in the rabbit

1973 • 28 citations

Arginine vasotocin and sleep in the rat

1980 • 26 citations

Effects of natural pyrimidines and of certain related compounds on the spontaneous activity of the mouse.

1978 • 25 citations

Intrahypothalamic and intrastriatal dopamine and norepinephrine injections in relation to motor hyperactivity in rats

1972 • 24 citations

Differential effects of cholinergic antagonists on REM sleep components.

1990 • 23 citations

Contribution to serotonin theory of dreaming (LSD infusion).

1968 • 23 citations

Pimozide attentuates d-amphetamine-induced sleep changes in man

1978 • 22 citations

Orcadian Rhythm of Serotonin Binding in Rat Brain—I. Effect of the Light-Dark Cycle

1986 • 22 citations

Chapter 42 Acetylcholine and acetylcholine receptor subtypes in REM sleep generation

1990 • 21 citations

Triazolam fails to induce sleep in suprachiasmatic nucleus-lesioned rats

1991 • 21 citations

Somnogenic Muramyl Peptides

1986 • 20 citations

Circadian Rhythm of Serotonin Binding in Rat Brain—II. Influence of Sleep Deprivation and Imipramine

1986 • 20 citations

The H2-antagonists, cimetidine and ranitidine: Studies on performance

1984 • 19 citations

Increase of paradoxical sleep induced by s-adenosyl-l-homocysteine

1982 • 19 citations

Reversal of desipramine-induced suppression of paradoxical sleep by a long-acting somatostatin analogue (octreotide) in rats

1989 • 19 citations

Differential effects of D- and L-amphetamine on the sleep of depressed patients

1975 • 18 citations

Biperiden administration in normal sleep and after rapid eye movement sleep deprivation in healthy volunteers.

1991 • 17 citations

DSIP/DSIP-P and circadian motor activity of rats under continuous light

1982 • 17 citations

Biphasic effects of pimozide on sleep-wakefulness in dogs

1980 • 16 citations

Scopolamine-induced suppression of paradoxical sleep is reversed by the somatostatin analogue SMS 201–995 in rats

1988 • 15 citations

Sleep Substances: Their Roles And Evolution

2024 • 15 citations

Delta sleep-inducing peptide in spontaneously hypertensive rats

1986 • 15 citations

Factor S and Related Somnogens: An Immune Theory for Slow-Wave Sleep. Appendix I,

1985 • 15 citations

Sleep and other behavioural responses induced by acetylcholinic stimulation of frontal and mesial cortex

1967 • 14 citations

Therapeutic Effects of Delta-Sleep-Inducing Peptide (DSIP) in Patients with Chronic, Pronounced Pain Episodes

1984 • 14 citations

Study of delta sleep-inducing peptide efficacy in improving sleep on short-term administration to chronic insomniacs.

1987 • 12 citations

Effects of biperiden on sleep at baseline and after 72 h of REM sleep deprivation in the cat

1992 • 12 citations

Effects of DSIP on Narcolepsy

1984 • 11 citations

Effects of intracerebroventricular injection of Delta Sleep-Inducing Peptide (DSIP) and an analogue on sleep and brain temperature in rats at night

1985 • 11 citations

Circumstances influencing Otto Loewi's discovery of chemical transmission in the nervous system

1971 • 11 citations

The somatostatin analogue SMS 201-995 promotes paradoxical sleep in aged rats

1989 • 11 citations

DSIP-like immunoreactivity in the developing rat brain

1981 • 10 citations

Circadian variation of dsip-like material in rat plasma

1984 • 9 citations

Effect of apomorphine on human sleep

1978 • 9 citations

Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior.

1981 • 9 citations

Sleep in the Cat: Raphe Dorsalis and Vasotocin

1984 • 9 citations

Current problems and future requirements for 5-hydroxytryptamine receptor classification.

1990 • 7 citations

Rapid eye movement (REM) sleep increases by auditory stimulation reverted with biperiden administration in normal volunteers.

1991 • 7 citations

DSIP in Insomnia

1984 • 7 citations

Efficacy of DSIP to Normalize Sleep in Middle-Aged and Elderly Chronic Insomniacs

1986 • 7 citations

Prostaglandin D2 induces sleep when infused into the cerebral ventricle of conscious monkeys.

1987 • 6 citations

[Liberation of growth hormone and melanocyte-stimulating hormone in natural and melatonin-induced human sleep (author's transl)].

1976 • 6 citations

Central depressant activities of N3-allyluridine and N3-allylthymidine.

1986 • 5 citations

Prostaglandin D2 and sleep.

1989 • 5 citations

A Clinical Trial with DSIP

1984 • 5 citations

Muramyl peptide enhancement of slow-wave sleep.

1986 • 3 citations

Deleted Work

1955 • 0 citations