New Strategies for Chemokine Inhibition and Modulation

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

1996 • 4,184 citations

Identification of a major co-receptor for primary isolates of HIV-1

1996 • 3,649 citations

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

1996 • 3,189 citations

CC CKR5: A RANTES, MIP-1α, MIP-1β Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1

1996 • 2,735 citations

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

1996 • 2,374 citations

Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.

1994 • 2,251 citations

A Dual-Tropic Primary HIV-1 Isolate That Uses Fusin and the β-Chemokine Receptors CKR-5, CKR-3, and CKR-2b as Fusion Cofactors

1996 • 1,868 citations

Properties of the Novel Proinflammatory Supergene "Intercrine" Cytokine Family

1991 • 1,864 citations

lnterleukin-8 and Related Chemotactic Cytokines—CXC and CC Chemokines

1993 • 1,650 citations

The Molecular Biology of Leukocyte Chemoattractant Receptors

1994 • 1,224 citations

Essential involvement of interleukin-8 (IL-8) in acute inflammation

1994 • 982 citations

Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV

1996 • 926 citations

T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-lβ

1993 • 896 citations

Heparan sulphate bound growth factors: a mechanism for stromal cell mediated haemopoiesis

1988 • 845 citations

Heparin Structure and Interactions with Basic Fibroblast Growth Factor

1996 • 789 citations

Signal Sequence Trap: a Cloning Strategy for Secreted Proteins and Type I Membrane Proteins

1993 • 722 citations

Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo.

1995 • 710 citations

Chemokine receptors: Gateways to inflammation and infection

1996 • 659 citations

Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4.

1993 • 542 citations

Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8

1993 • 529 citations

The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation.

1995 • 456 citations

Binding to heparan sulfate or heparin enhances neutrophil responses to interleukin 8.

1993 • 444 citations

Structure-activity relationships of interleukin-8 determined using chemically synthesized analogs. Critical role of NH2-terminal residues and evidence for uncoupling of neutrophil chemotaxis, exocytosis, and receptor binding activities.

1991 • 425 citations

Extension of Recombinant Human RANTES by the Retention of the Initiating Methionine Produces a Potent Antagonist

1996 • 424 citations

Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes

1993 • 412 citations

Scanning mutagenesis of interleukin-8 identifies a cluster of residues required for receptor binding.

1991 • 372 citations

Structure-activity relationships of chemokines

1995 • 367 citations

Crystal structure of interleukin 8: symbiosis of NMR and crystallography.

1991 • 354 citations

Differential binding of chemokines to glycosaminoglycan subpopulations

1994 • 351 citations

Genome Sequence of a Human Tumorigenic Poxvirus: Prediction of Specific Host Response-Evasion Genes

1996 • 329 citations

Encoding of a Homolog of the IFN-γ Receptor by Myxoma Virus

1992 • 303 citations

Interferon γ-Inducible Protein-10 (IP-10), a Member of the C-X-C Chemokine Family, Is an Inhibitor of Angiogenesis

1995 • 293 citations

Antagonists of monocyte chemoattractant protein 1 identified by modification of functionally critical NH2-terminal residues.

1995 • 288 citations

Involvement of heparan sulfate and related molecules in sequestration and growth promoting activity of fibroblast growth factor

1996 • 287 citations

Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells. Interacting effects involving suppression, synergistic suppression, and blocking of suppression.

1993 • 273 citations

Platelet factor 4 binds to interleukin 8 receptors and activates neutrophils when its N terminus is modified with Glu-Leu-Arg.

1993 • 262 citations

THE ROLE OF CXC CHEMOKINES AS REGULATORS OF ANGIOGENESIS

1995 • 240 citations

Control of Angiogenesis by Heparin and Other Sulfated Polysaccharides

1992 • 225 citations

Neutrophil attractant/activation protein‐1 (interleukin‐8) induces in vitro neutrophil migration by haptotactic mechanism

1993 • 215 citations

The T1/35kDa Family of Poxvirus-Secreted Proteins Bind Chemokines and Modulate Leukocyte Influx into Virus-Infected Tissues

1997 • 212 citations

Intervention of crescentic glomerulonephritis by antibodies to monocyte chemotactic and activating factor (MCAF/MCP‐1)

1996 • 205 citations

Fibroblast growth factors: at the heart of angiogenesis.

1995 • 190 citations

Crystal Structure of Recombinant Human Platelet Factor 4

1994 • 176 citations

The purified myxoma virus gamma interferon receptor homolog M-T7 interacts with the heparin-binding domains of chemokines

1997 • 173 citations

Chemokines and serpentines: the molecular biology of chemokine receptors

1993 • 167 citations

Regulation of adhesion of CD4+ T lymphocytes to intact or heparinase-treated subendothelial extracellular matrix by diffusible or anchored RANTES and MIP-1 beta.

1994 • 167 citations

Selectivity and antagonism of chemokine receptors

1996 • 159 citations

A Dominant Negative Inhibitor Indicates that Monocyte Chemoattractant Protein 1 Functions as a Dimer

1995 • 158 citations

Structure/activity analysis of human monocyte chemoattractant protein-1 (MCP-1) by mutagenesis. Identification of a mutated protein that inhibits MCP-1-mediated monocyte chemotaxis.

1994 • 158 citations

Heteronuclear (¹H,¹³C,¹⁵N) NMR Assignments and Solution Structure of the Monocyte Chemoattractant Protein-1 (MCP-1) Dimer^,

1996 • 150 citations

Chemokine Receptors and HIV-1: An Attractive Pair?

1996 • 146 citations

A potent inhibitor of endothelial cell proliferation is generated by proteolytic cleavage of the chemokine platelet factor 4.

1995 • 143 citations

Proton NMR Assignments and Solution Conformation of RANTES, a Chemokine of the C-C Type

1995 • 141 citations

Promiscuity of fibroblast growth factor receptors

1996 • 140 citations

Interleukin-8 antagonists generated by N-terminal modification.

1993 • 138 citations

Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors.

1991 • 135 citations

Chemokine receptors and HIV

1997 • 135 citations

Prevention of proteinuria by the administration of anti-interleukin 8 antibody in experimental acute immune complex-induced glomerulonephritis.

1994 • 134 citations

Three‐dimensional structures of α and β chemokines

1995 • 133 citations

Myxoma Virus M-T7, a Secreted Homolog of the Interferon-γ Receptor, Is a Critical Virulence Factor for the Development of Myxomatosis in European Rabbits

1996 • 128 citations

Tumor growth and angiogenesis induced by a secreted binding protein for fibroblast growth factors.

1994 • 125 citations

Chemokines: progress toward identifying molecular targets for therapeutic agents

1996 • 125 citations

The delayed-type hypersensitivity reaction is dependent on IL-8. Inhibition of a tuberculin skin reaction by an anti-IL-8 monoclonal antibody.

1995 • 119 citations

Interleukin 8 as a novel target for intervention therapy in acute inflammatory diseases

1996 • 116 citations

The Three-Dimensional Solution Structure of RANTES

1995 • 109 citations

Interaction of interleukin 7 (IL-7) with glycosaminoglycans and its biological relevance

1995 • 106 citations

Preferential self-association of basic fibroblast growth factor is stabilized by heparin during receptor dimerization and activation.

1996 • 103 citations

The Myxoma Virus-soluble Interferon- γ Receptor Homolog, M-T7, Inhibits Interferon- γ in a Species-specific Manner

1995 • 93 citations

Suramin is a Potent Inhibitor of Vascular Endothelial Growth Factor. A Contribution to the Molecular Basis of its Antiangiogenic Action

1996 • 88 citations

Chemokines as Mediators of Allergic Inflammation

1996 • 87 citations

New members of the chemokine receptor gene family

1996 • 86 citations

Interplay of T cells and cytokines in the context of enzymatically modified extracellular matrix

1996 • 80 citations

Uncoupling of stem cell inhibition from monocyte chemoattraction in MIP-1alpha by mutagenesis of the proteoglycan binding site.

1996 • 76 citations

Differential effect of cell-associated heparan sulfates on the binding of keratinocyte growth factor (KGF) and acidic fibroblast growth factor to the KGF receptor.

1994 • 75 citations

Late expression of a beta chemokine homolog by murine cytomegalovirus

1997 • 74 citations

Expression of recombinant rabbit IL-8 in Escherichia coli and establishment of the essential involvement of IL-8 in recruiting neutrophils into lipopolysaccharide-induced inflammatory site of rabbit skin

1993 • 72 citations

Uncoupling of stem cell inhibition from monocyte chemoattraction in MIP-1alpha by mutagenesis of the proteoglycan binding site.

1996 • 71 citations

Virus proteins that bind cytokines, chemokines or interferons

1996 • 71 citations

Receptor Recognition and Specificity of Interleukin-8 Is Determined by Residues That Cluster Near a Surface-accessible Hydrophobic Pocket

1996 • 67 citations

Human chemokines: enhancement of specific activity and effects in vitro on normal and leukemic progenitors and a factor-dependent cell line and in vivo in mice

1995 • 67 citations

Mutagenesis Studies of Interleukin-8

1996 • 64 citations

Synthetic hexa- and heptapeptides that inhibit IL-8 from binding to and activating human blood neutrophils.

1995 • 63 citations

Sulfate Moieties in the Subendothelial Extracellular Matrix Are Involved in Basic Fibroblast Growth Factor Sequestration, Dimerization, and Stimulation of Cell Proliferation

1996 • 54 citations

Molecular piracy of chemokine receptors by herpesviruses.

1994 • 52 citations

Mapping and investigation of the role in pathogenesis of the major unique secreted 35-kDa protein of rabbitpox virus

1995 • 48 citations

Cytokines and proteoglycans

1993 • 47 citations

Virus encoded cytokines and cytokine receptors

1997 • 44 citations

DNA sequence of the gene encoding a major secreted protein of vaccinia virus, strain Lister

1990 • 44 citations

Chemokines and their Role in Human Disease

1995 • 42 citations

The delayed type hypersensitivity reaction is dependent on IL-8

1994 • 42 citations

Signal Sequence Trap: Expression Cloning Method for Secreted Proteins and Type 1 Membrane Proteins

2003 • 35 citations

Inhibition of fibroblast growth factors

1996 • 28 citations

Regulation of Gene Expression of a Binding Protein for Fibroblast Growth Factors by Retinoic Acid

1996 • 27 citations

Chemokines: Molecular double agents

1996 • 23 citations

Interactions of Migrating T Lymphocytes, Inflammatory Mediators, and the Extracellular Matrix

1995 • 19 citations

Regulation of Leukocyte Recruitment by Proadhesive Cytokines Immobilized on Endothelial Proteoglycan

1993 • 10 citations