Acid-Base and Energy Metabolism of the Brain in Hypercapnia and Hypocapnia

Energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers

1968 • 2,371 citations

The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver

1967 • 1,821 citations

THE EFFECTS OF ALTERED ARTERIAL TENSIONS OF CARBON DIOXIDE AND OXYGEN ON CEREBRAL BLOOD FLOW AND CEREBRAL OXYGEN CONSUMPTION OF NORMAL YOUNG MEN 1

1948 • 1,810 citations

Handbook of Neurochemistry

1972 • 1,374 citations

Handbook of Neurochemistry

1969 • 940 citations

Biochemistry and the central nervous system

1986 • 794 citations

CALCULATION OF INTRACELLULAR pH FROM THE DISTRIBUTION OF 5,5-DIMETHYL-2,4-OXAZOLIDINEDIONE (DMO). APPLICATION TO SKELETAL MUSCLE OF THE DOG*

1959 • 686 citations

Wege des Wasserstoffs in der lebendigen Organisation

1958 • 635 citations

Biophysical Chemistry

1958 • 631 citations

Nature and Significance of Concentration Relations of Potassium and Sodium Ions in Skeletal Muscle

1957 • 406 citations

Intracellular pH.

1969 • 394 citations

Kinetic Evidence for Multiple Binding Sites on Phosphofructokinase

1966 • 336 citations

Studies on the respiratory response to disturbances of acid-base balance, with deductions concerning the ionic composition of cerebral interstitial fluid

1966 • 302 citations

Studies on the internal pH of large muscle and nerve fibres

1958 • 247 citations

Distribution of Blood (Fe ⁵⁹ ) and Plasma (I ¹³¹ ) Volumes of Rats Determined by Liquid Nitrogen Freezing

1956 • 233 citations

BIOCHEMICAL AND PHYSIOLOGICAL DIFFERENTIATION DURING MORPHOGENESIS—XXI

1957 • 211 citations

Blood and cerebrospinal fluid lactate during hyperventilation

1967 • 185 citations

Gradients of CO₂ Tension in the Brain

1966 • 166 citations

Carbon Dioxide Fixation in the Brain

1962 • 161 citations

Energy Transformations in Living Matter

1957 • 151 citations

QUANTITATIVE ASPECTS OF CO₂ FIXATION IN MAMMALIAN BRAIN IN VIVO*

1964 • 139 citations

Cerebral carbohydrate metabolism of man during respiratory and etabolic alkalosis.

1968 • 138 citations

Intracellular pH

1956 • 133 citations

Measurement of Intracellular pH of Skeletal Muscle with pH-sensitive Glass Microelectrodes*

1967 • 130 citations

THE ROLE OF CARBON DIOXIDE IN THE NERVOUS SYSTEM

1960 • 126 citations

The Effects of Hypercapnia and Hypocapnia upon the Cerebrospinal Fluid Lactate and Pyruvate Concentrations and upon the Lactate, Pyruvate, ATP, ADP, Phosphocreatine and Creatine Concentrations of Cat Brain Tissue

1969 • 125 citations

Extracellular space of rat cerebral cortex

1967 • 110 citations

Energy Transformations in Living Matter

1957 • 107 citations

THE DISTRIBUTION OF THE BICARBONATE ION IN MAMMALIAN MUSCLE

1942 • 103 citations

The Regulation of Extra‐ and Intracellular Acid‐Base Parameters in the Rat Brain during Hyper‐ and Hypocapnia

1969 • 101 citations

Biochemistry and the Central Nervous System

1966 • 98 citations

NEUROCHEMISTRY OF EPILEPSY

1961 • 94 citations

Effect of alkalosis on glycolysis in the isolated rat heart

1967 • 79 citations

The Solubility of Carbon Dioxide in Cerebral Cortical Tissue of Cats With a note on the solubility of carbon dioxide in water, 0.16 M NaCl and cerebrospinal fluid.

1962 • 72 citations

Neurochemistry of Epilepsy

1960 • 72 citations

Brain Function and Metabolic Disorders

1964 • 72 citations

BIOCHEMICAL AND PHYSIOLOGICAL DIFFERENTIATION DURING MORPHOGENESIS‐XXIII. FURTHER OBSERVATIONS RELATING TO THE SYNTHESIS OF AMINO ACIDS AND PROTEINS BY THE CEREBRAL CORTEX AND LIVER OF THE MOUSE*

1959 • 70 citations

Mean carbon dioxide tension in the brain after carbonic anhydrase inhibition

1967 • 69 citations

Ion Homeostasis of the Brain

1972 • 68 citations

Comparative Neurochemistry

1964 • 67 citations

A Method for the Determination of the Total Carbon Dioxide Content of Frozen Tissues

1964 • 64 citations

Comprehensive Biochemistry

1970 • 62 citations

Environmental CO2 Stimulation of Mitochondrial Adenosine Triphosphatase Activity

1963 • 58 citations

Effect of hyperbaric-hyperoxic hyperventilation on blood, brain, and CSF lactate

1968 • 56 citations

THE BICARBONATE/CARBONIC ACID BUFFER SYSTEM OF THE CEREBRAL CORTEX OF CATS, AS STUDIED IN TISSUE HOMOGENATES

2009 • 52 citations

Acid‐Base Changes in Rat Brain Tissue during Acute Respiratory Acidosis and Baseosis

1966 • 52 citations

The Intracellular pH‘ in the Brain in Acute and Sustained Hypercapnia

1971 • 52 citations

EFFECT OF HYDROGEN‐ION CONCENTRATION ON THE CARBOHYDRATE METABOLISM OF BRAIN TISSUE

1959 • 49 citations

Glucose Metabolism in Rat Brain In Vivo

1962 • 49 citations

Effect of pH, pCO2 and bicarbonate on metabolism of glucose by perfused rat heart

1966 • 48 citations

Advances in Clinical Chemistry

1969 • 46 citations

Lactate and Pyruvate in the Brain of Rats During Hyperventilation

1966 • 45 citations

The Effect of Combined Respiratory and Nonrespiratory Alkalosis on Energy Metabolites and Acid‐Base Parameters in the Rat Brain

1971 • 43 citations

The acid‐labile CO₂ in mammalian muscle and the pH of the muscle fibre

1944 • 43 citations

Quantification of pH Regulation in Hypercapnia and Hypocapnia

1971 • 42 citations

Regulation of the CSF pH in Acute and Sustained Respiratory Acidosis

1971 • 40 citations

EFFECTS OF ANESTHESIA ON METABOLISM AND CELLULAR FUNCTIONS. A WORKSHOP HELD UNDER THE COMMITTEE ON ANESTHESIA OF THE NATIONAL ACADEMY OF SCIENCES--NATIONAL RESEARCH COUNCIL.

1965 • 32 citations

The effect of hypercapnia on the blood-brain barrier to sucrose in the rabbit.

1969 • 31 citations

The Effect of Acute and Chronic Hypercapnia upon the Lactate, Pyruvate, α‐ketoglutarate, Glutamate and Phosphocreatine Contents of the Rat Brain

1971 • 30 citations

The bicarbonate/carbonic acid buffer system of the cerebral cortex of cats, as studied in tissue homogenates. 1. The amount of carbon dioxide bound at different carbon dioxide tensions. With a critique of the application of chloride space measurements to the study of the acid-base metabolism of the brain.

1962 • 29 citations

Lactate and Pyruvate in the Brain of Rats During Changes in Acid-Base Balance

1967 • 29 citations

EFFECT OF CARBON DIOXIDE ON BRAIN GLUCOSE, LACTATE, PYRUVATE AND PHOSPHATES

1949 • 26 citations

Effect of carbon dioxide-bicarbonate mixtures on rat liver mitochondrial oxidative phosphorylation

1966 • 25 citations

THE pK'1 OF CARBONIC ACID IN CONCENTRATED PROTEIN SOLUTIONS AND MUSCLE

1939 • 25 citations

A METHOD FOR DETERMINING TISSUE CARBON DIOXIDE

1939 • 24 citations

Intracellular pH based on the distribution of weak electrolytes.

1967 • 24 citations

Glucose Metabolism and α-Keto-acids in Rat Brain and Liver in vivo

1965 • 16 citations

Ein Verfahren zur Bestimmung der CO2-Leitf�higkeit und des CO2-Diffusionskoeffizienten im Gehirngewebe

1962 • 16 citations

Role of Hypoxia in Cerebral Circulatory and Metabolic Changes during Hypocarbia in Man: Studies in Hyperbaric Milieu

1968 • 16 citations

Regulation of Intracellular pH in the Rat Brain in Chronic Hypercapnia

1970 • 12 citations

ATP content in the central nervous system of rats exposed to chronic hypercapnea

1963 • 8 citations

Carbohydrate and Oxidative Metabolism in Neural Systems

1969 • 8 citations

CARBON DIOXIDE FIXATION IN VERTEBRATE AND INVERTEBRATE NERVOUS TISSUE

1964 • 5 citations