Receptors for Parathyroid Hormone and Parathyroid Hormone-Related Protein

G PROTEIN–COUPLED RECEPTOR KINASES

1998 • 1,335 citations

β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor

1996 • 1,329 citations

Turning off the signal: desensitization of β‐adrenergic receptor function

1990 • 1,241 citations

A G Protein-Linked Receptor for Parathyroid Hormone and Parathyroid Hormone-Related Peptide

1991 • 1,230 citations

Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors

2000 • 1,199 citations

β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

1990 • 1,162 citations

Requirement of Rigid-Body Motion of Transmembrane Helices for Light Activation of Rhodopsin

1996 • 1,159 citations

THE ROLE OF RECEPTOR KINASES AND ARRESTINS IN G PROTEIN–COUPLED RECEPTOR REGULATION

1998 • 1,074 citations

G Protein-coupled Receptors

1998 • 1,033 citations

Interaction of Tyrosine-Based Sorting Signals with Clathrin-Associated Proteins

1995 • 955 citations

A Constitutively Active Mutant PTH-PTHrP Receptor in Jansen-Type Metaphyseal Chondrodysplasia

1995 • 668 citations

β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family

1989 • 451 citations

Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F

1996 • 389 citations

The family of G‐protein‐coupled receptors

1995 • 369 citations

Rhodopsin and phototransduction: a model system for G protein‐linked receptors

1992 • 332 citations

Absence of functional receptors for parathyroid hormone and parathyroid hormone-related peptide in Blomstrand chondrodysplasia.

1998 • 315 citations

Constitutively Activated Receptors for Parathyroid Hormone and Parathyroid Hormone–Related Peptide in Jansen's Metaphyseal Chondrodysplasia

1996 • 293 citations

Receptors for secretin, calcitonin, parathyroid hormone (PTH)/PTH-related peptide, vasoactive intestinal peptide, glucagonlike peptide 1, growth hormone-releasing hormone, and glucagon belong to a newly discovered G-protein-linked receptor family

1993 • 291 citations

Receptors for PTH and PTHrP: their biological importance and functional properties

1999 • 228 citations

Parathyroid hormone receptor in intact embryonic chicken bone: characterization and cellular localization.

1982 • 209 citations

A new family of G-protein regulators — the RGS proteins

1997 • 201 citations

G‐protein coupled receptor kinases as modulators of G‐protein signalling

1999 • 188 citations

Inactivating Mutation in the Human Parathyroid Hormone Receptor Type 1 Gene in Blomstrand Chondrodysplasia

1998 • 180 citations

The G-Protein βγ Complex

1998 • 173 citations

Skeletal resistance to the calcemic action of parathyroid hormone in uremia: Role of 1,25(OH)2D3

1976 • 169 citations

A Homozygous Inactivating Mutation in the Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor Causing Blomstrand Chondrodysplasia

1998 • 166 citations

Endocytosis of Ligand-Human Parathyroid Hormone Receptor 1 Complexes Is Protein Kinase C-dependent and Involves β-Arrestin2

1999 • 144 citations

Receptors for VIP, PACAP, Secretin, GRF, Glucagon, GLP-1, and Other Members of Their New Family of G Protein-Linked Receptors: Structure-Function Relationship with Special Reference to the Human VIP-1 Receptora

2006 • 135 citations

Phosphorylation-independent inhibition of parathyroid hormone receptor signaling by G protein-coupled receptor kinases

1999 • 134 citations

The Cytoplasmic Tail of the G-protein-coupled Receptor for Parathyroid Hormone and Parathyroid Hormone-related Protein Contains Positive and Negative Signals for Endocytosis

1995 • 133 citations

Mutations in the Second Cytoplasmic Loop of the Rat Parathyroid Hormone (PTH)/PTH-related Protein Receptor Result in Selective Loss of PTH-stimulated Phospholipase C Activity

1997 • 132 citations

Structural basis of G protein-coupled receptor function

1999 • 119 citations

Distinct Saturable Pathways for the Endocytosis of Different Tyrosine Motifs

1998 • 118 citations

Renal adenylate cyclase and the interrelationship between parathyroid hormone and vitamin D in the regulation of urinary phosphate and adenosine cyclic 3',5'-monophosphate excretion.

1976 • 100 citations

Truncation of the Carboxyl-terminal Region of the Rat Parathyroid Hormone (PTH)/PTH-related Peptide Receptor Enhances PTH Stimulation of Adenylyl Cyclase but Not Phospholipase C

1995 • 100 citations

Characterization and Agonist-Induced Down-Regulation of Parathyroid Hormone Receptors in Clonal Rat Osteosarcoma Cells*

1988 • 99 citations

Identification of Phosphorylation Sites in the G Protein-Coupled Receptor for Parathyroid Hormone. Receptor Phosphorylation Is Not Required for Agonist-Induced Internalization

1998 • 98 citations

Endogenous Biologically Active Human Parathyroid Hormone: Measurement by a Guanyl Nucleotide-Amplified Renal Adenylate Cyclase Assay*

1981 • 98 citations

A Novel Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Mutation in Jansen’s Metaphyseal Chondrodysplasia¹

1999 • 96 citations

Regulation of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid by glucocorticoids and PTH in ROS 17/2.8 and OK cells.

1994 • 95 citations

Coupling of the PTH/PTHrP Receptor to Multiple G-Proteins: Direct Demonstration of Receptor Activation of G<sub>s</sub>, G<sub>q/11</sub>, and G<sub>i(1)</sub> by [α -<sup>32</sup>P]GTP-γ -Azidoanilide Photoaffinity Labeling

1998 • 93 citations

Clinical Implications of Genetic Defects in G Proteins

1999 • 93 citations

Transmembrane Residues of the Parathyroid Hormone (PTH)/PTH-related Peptide Receptor That Specifically Affect Binding and Signaling by Agonist Ligands

1996 • 92 citations

The N-terminal Region of the Third Intracellular Loop of the Parathyroid Hormone (PTH)/PTH-related Peptide Receptor Is Critical for Coupling to cAMP and Inositol Phosphate/Ca2+ Signal Transduction Pathways

1996 • 86 citations

Nephrogenous Cyclic AMP as a Parathyroid Function Test

1979 • 83 citations

A Novel Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Mutation in Jansen's Metaphyseal Chondrodysplasia

1999 • 75 citations

Inverse agonism of amino-terminally truncated parathyroid hormone (PTH) and PTH-related peptide (PTHrP) analogs revealed with constitutively active mutant PTH/PTHrP receptors.

1996 • 74 citations

Parathyroidectomy does not prevent the renal PTH/PTHrP receptor down-regulation in uremic rats

1995 • 71 citations

Mechanisms of Homologous and Heterologous Regulation of Parathyroid Hormone Receptors in the Rat Osteosarcoma Cell Line UMR-106*

1990 • 71 citations

Down-Regulation of Parathyroid Hormone (PTH) Receptors in Cultured Bone Cells Is Associated with Agonist-Specific Intracellular Processing of PTH-Receptor Complexes^*

1986 • 66 citations

Agonist-stimulated phosphorylation of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein.

1995 • 61 citations

Coupling of the Canine Renal Parathyroid Hormone Receptor to Adenylate Cyclase: Modulation by Guanyl Nucleotides and iV-Ethylmaleimide*

1982 • 58 citations

Regulation of the PTH-receptor-cyclase system of canine kidney: effects of calcium, magnesium, and guanine nucleotides

1981 • 58 citations

A C‐terminally truncated human parathyroid hormone receptor is functional and activates multiple G proteins

1994 • 58 citations

Visualizing Signal Transduction: Receptors, G-Proteins, and Adenylate Cyclases

1996 • 58 citations

Coordinate regulation of PTH/PTHrP receptors by PTH and calcitriol in UMR 106-01 osteoblast-like cells

1996 • 57 citations

Calcium metabolism in the jansen type of metaphyseal dysplasia

1993 • 55 citations

Canine renal receptors for parathyroid hormone. Down-regulation in vivo by exogenous parathyroid hormone.

1983 • 52 citations

The conformational switch in 7-transmembrane receptors: the muscarinic receptor paradigm

1999 • 50 citations

Phosphorylation of the cytoplasmic tail of the PTH/PTHrP receptor

1996 • 50 citations

The Jansen type of metaphyseal chondrodysplasia: Confirmation of dominant inheritance and review of radiographic manifestations in the newborn and adult

1984 • 47 citations

Receptors for parathyroid hormone and parathyroid hormone-related peptide: exploration of their biological importance

1999 • 46 citations

Mechanisms of desensitization to parathyroid hormone in human osteoblast-like SaOS-2 cells.

1992 • 46 citations

Mutations of neighboring polar residues on the second transmembrane helix disrupt signaling by the parathyroid hormone receptor.

1996 • 46 citations

Binding of Radioiodinated Bovine Parathyroid Hormone-(1–84) to Canine Renal Cortical Membranes*

1983 • 43 citations

Thrombin and Parathyroid Hormone Mobilize Intracellular Calcium in Rat Osteosarcoma Cells by Distinct Pathways^*

1991 • 42 citations

Reversible Resistance to the Renal Action of Parathyroid Hormone in Human Vitamin D Deficiency

1982 • 41 citations

Agonist-Dependent Phosphorylation of the Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor

1998 • 41 citations

Desensitization of parathyroid hormone receptors on cultured bone cells

1990 • 40 citations

Transforming growth factor-β1 regulates steady-state PTH/PTHrP receptor mRNA levels and PTHrP binding in ROS 17/2.8 osteosarcoma cells

1994 • 40 citations

Induction of metabolic changes and down regulation of bovine parathyroid hormone-responsive adenylate cyclase are dissociable in isolated osteoclastic and osteoblastic bone cells.

1979 • 38 citations

Conformational characterization of a peptide mimetic of the third cytoplasmic loop of the G-protein coupled parathyroid hormone/parathyroid hormone related protein receptor

1996 • 37 citations

Parathyroid hormone (PTH)/PTH-related protein receptor messenger ribonucleic acid expression and PTH response in a rat model of secondary hyperparathyroidism associated with vitamin D deficiency.

1995 • 36 citations

Rat Kidney Cells in Primary Culture: Hormone-Mediated Desensitization of the Adenosine 3′,5′-Monophosphate Response to Parathyroid Hormone and Calcitonin*

1982 • 34 citations

Parathyroid hormone-mediated refractoriness of rat kidney cyclic AMP system.

1979 • 32 citations

Down-regulation of the receptor for parathyroid hormone (PTH) and PTH-related peptide by PTH in primary fetal rat osteoblasts

1996 • 31 citations

Homologous Desensitization of Cultured Chick Kidney Cells to Parathyroid Hormone*

1983 • 29 citations

Rapid desensitization of parathyroid hormone dependent adenylate cyclase in perifused human osteosarcoma cells (SaOS-2)

1994 • 28 citations

Mutations of neighboring polar residues on the second transmembrane helix disrupt signaling by the parathyroid hormone receptor

1996 • 27 citations

β-Adrenergic Receptor Kinase-1 Acutely Regulates PTH/PTHrP Receptor Signalling in Human Osteoblastlike Cells

1997 • 27 citations

Hormonal and nonhormonal desensitization in isolated bone cells

1980 • 25 citations

Down-regulation of the receptor for parathyroid hormone (PTH) and PTH-related peptide by transforming growth factor-beta in primary fetal rat osteoblasts.

1995 • 24 citations

β-Adrenergic receptor kinase-like activity and β-arrestin are expressed in osteoblastic cells

1996 • 24 citations

Studies on the mechanism of desensitization of the parathyroid hormone-stimulated calcium signal in UMR-106 cells: Reversal of desensitization by alkaline phosphatase but not by protein kinase C downregulation

1994 • 23 citations

Mutational analysis of the cytoplasmic tail of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein: effects on receptor expression and signaling.

1995 • 20 citations

Transforming growth factor-beta: a down-regulator of the parathyroid hormone-related protein receptor in renal epithelial cells.

1994 • 19 citations

Regulation of the transcription of parathyroid-hormone/parathyroid-hormone-related peptide receptor mRNA by dexamethasone in ROS 17/2.8 osteosarcoma cells

1998 • 18 citations

Factors Regulating the Response of Cells Cultured from Human Giant Cell Tumors of Bone to Parathyroid Hormone*

1981 • 16 citations

STATES OF ACTIVATION OF CHICK KIDNEY ADENYLATE CYCLASE INDUCED BY PARATHYROID HORMONE AND GUANYL NUCLEOTIDES

1977 • 15 citations

Metaphyseal Dysostosis of Jansen

1969 • 15 citations

Evidence for interference of vitamin D with PTH/PTHrP receptor expression in opossum kidney cells

1998 • 11 citations

Human fat cell adenylate cyclase

1977 • 9 citations