Presynaptic Actions of Botulinum Toxin and β-Bungarotoxin

A study of supersensitivity in denervated mammalian skeletal muscle

1959 • 737 citations

The action of botulinum toxin on the neuro‐muscular junction

1949 • 618 citations

"Trophic" influences of nerve on muscle.

1968 • 596 citations

Multiple forms of acetylcholinesterase and their distribution in endplate and non‐endplate regions of rat diaphragm muscle

1973 • 505 citations

The acetylcholine sensitivity of frog muscle fibres after complete or partial devervation.

1960 • 502 citations

Chemistry and Pharmacology of Polypeptide Toxins in Snake Venoms

1972 • 479 citations

Acetylcholine Receptors in Muscle Fibres

1971 • 443 citations

Origin and blockade of the synaptic responses of curarized sympathetic ganglia

1961 • 427 citations

Choline uptake systems of rat brain synaptosomes

1973 • 387 citations

Isolation of neurotoxins from the venom of Bungarus multicinctus and their modes of neuromuscular blocking action

1965 • 379 citations

Synthesis, storage and release of [¹⁴C]acetylcholine in isolated rat diaphragm muscles

1970 • 353 citations

Supersensitivity of skeletal muscle produced by botulinum toxin

1960 • 319 citations

Binding of α-Bungarotoxin to Acetylcholine Receptors In Mammalian Muscle

1972 • 286 citations

Acetylcholine Receptors

1972 • 273 citations

Changes in motor innervation and cholinesterase localization induced by botulinum toxin in skeletal muscle of the mouse: differences between fast and slow muscles.

1970 • 230 citations

An electron microscopic study of the changes induced by botulinum toxin in the motor end-plates of slow and fast skeletal muscle fibres of the mouse

1971 • 225 citations

Chromatographic separation of the venom of Bungarus multicinctus and characterization of its components

1972 • 219 citations

An intracellular study of the action of repetitive nerve volleys and of botulinum toxin on miniature end‐plate potentials

1956 • 219 citations

Cholinergic Receptor Molecules and Cholinesterase Molecules at Mouse Skeletal Muscle Junctions

1971 • 212 citations

Studies of the presynaptic effect of -bungarotoxin on neuromuscular transmission.

1973 • 208 citations

The effect of type D botulinum toxin on frog neuromuscular junctions

1971 • 200 citations

Acetylcholine Receptors: Number and Distribution at Neuromuscular Junctions in Rat Diaphragm

1972 • 194 citations

Fluorescent staining of acetylcholine receptors in vertebrate skeletal muscle

1974 • 190 citations

A common subunit structure in Clostridium botulinum type A, B and E toxins

1972 • 184 citations

Impulse-flow regulation of high affinity choline uptake in brain cholinergic nerve terminals

1975 • 178 citations

Influence of nerve‐ending activity and of drugs on the rate of paralysis of rat diaphragm preparation by Cl. botulinum type A toxin

1962 • 165 citations

PROCEEDINGS OF THE PHYSIOLOGICAL SOCIETY

1960 • 159 citations

The cause of the vasodilatation accompanying activity in the submandibular salivary gland

1955 • 154 citations

Biosynthesis of acetylcholine in nervous tissue

1972 • 146 citations

Influence of Denervation on Localization of Neurotoxins from Clapid Venoms in Rat Diaphragm

1967 • 146 citations

Acetylcholine and choline acetyltransferase in the diaphragm of the rat

1964 • 129 citations

The peripheral action of Cl. botulinum toxin.

1949 • 121 citations

THE BINDING OF BOTULINUM TOXIN TO MEMBRANE LIPIDS: SPHINGOLIPIDS, STEROIDS AND FATTY ACIDS

1971 • 118 citations

The Purification and Crystallization of Clostridium botulinum Type A Toxin

1946 • 117 citations

BOTULISM. STUDIES ON THE MANNER IN WHICH THE TOXIN OF CLOSTRIDIUM BOTULINUM ACTS UPON THE BODY

1923 • 109 citations

The cholinergic nature of the cercal nerve‐giant fiber synapse in the sixth abdominal ganglion of the American cockroach, Periplaneta americana (L.)

1971 • 107 citations

Ganglioside inactivation of botulinum toxin

1971 • 104 citations

Biochemical and physiological properties of a purified snake venom neurotoxin which acts presynaptically

1974 • 100 citations

A further survey of the action of Clostridium botulinum toxin upon different types of autonomic nerve fibre

1951 • 97 citations

Effects of a Snake α-Neurotoxin on the Development of Innervated Skeletal Muscles in Chick Embryo

1973 • 97 citations

PHYSIOLOGY OF BOTULINUS TOXIN

1947 • 97 citations

Types and Locations of Cholinergic Receptor-like Molecules in Muscle Fibres

1973 • 95 citations

Antibody to bovine choline acetyltransferase and immunofluorescent localisation of the enzyme in neurones

1974 • 92 citations

Atrophy of Skeletal Muscle in Chick Embryos Treated with Botulinum Toxin

1964 • 91 citations

The peripheral action of Cl. botulinum toxin

1949 • 90 citations

Observations on the action of type A botulinum toxin on frog neuromuscular junctions

1974 • 86 citations

Nerve implants in botulinum poisoned mammalian muscle

1966 • 85 citations

Changes in the electron microscopic structure of slow and fast skeletal muscle fibres of the mouse after the local injection of botulinum toxin

1971 • 83 citations

Ultrastructural changes in the motor nerve terminals caused by β-bungarotoxin

1970 • 81 citations

Neurotrophic regulation of muscle cholinesterase: effects of botulinum toxin and denervation

1972 • 79 citations

Impairment of Sympathetic Transmission by Botulinum Toxin

1965 • 73 citations

Chromatographic fractionation of the crystalline toxin of Clostridiumbotulinum type a

1966 • 72 citations

Miniature End-plate Potentials at Mammalian Neuromuscular Junctions Poisoned by Botulinum Toxin

1972 • 70 citations

UNMASKING, AFTER CHOLINERGIC PARALYSIS BY BOTULINUM TOXIN, OF A REVERSED ACTION OF NICOTINE ON THE MAMMALIAN INTESTINE, REVEALING THE PROBABLE PRESENCE OF LOCAL INHIBITORY GANGLION CELLS IN THE ENTERIC PLEXUSES

1951 • 70 citations

THE PURIFICATION OF TOXIN FROM CLOSTRIDIUM BOTULINUM TYPE A

1946 • 67 citations

Neuropoisons: Their Pathophysiological Actions

2012 • 66 citations

Classification of intestinomotor drugs by means of type D botulinum toxin

1955 • 65 citations

A HISTOCHEMICAL PROCEDURE FOR THE LOCALIZATION OF CHOLINE ACETYLTRANSFERASE ACTIVITY

1970 • 61 citations

BOTULISM. STUDIES ON THE MANNER IN WHICH THE TOXIN OF CLOSTRIDIUM BOTULINUM ACTS UPON THE BODY

1923 • 60 citations

β‐NEUROTOXIN REDUCES NEUROTRANSMITTER STORAGE IN BRAIN SYNAPSES

1974 • 60 citations

Is Acetylcholine the Trophic Neuromuscular Transmitter?

1967 • 55 citations

N,O‐di andN,N,O‐tri [³H] acetyl α‐bungarotoxins as specific labelling agents of cholinergic receptors

1973 • 53 citations

Estimating the Firing Depth of Underground Explosions

1972 • 52 citations

Binding of d-tubocurarine and α-bungarotoxin in normal and denervated mouse muscles

1974 • 49 citations

EFFECT OF COOLING, LOCAL ANAESTHETIC COMPOUNDS AND BOTULINUM TOXIN ON THE RESPONSES OF AND THE ACETYLCHOLINE OUTPUT FROM THE ELECTRICALLY TRANSMURALLY STIMULATED ISOLATED GUINEA‐PIG ILEUM

1962 • 49 citations

-Bungarotoxin, a Phospholipase That Stimulates Transmitter Release

1976 • 49 citations

Botulinum Toxin as a Tool for Research on the Nervous System

1971 • 47 citations

Studies on the binding of botulinum toxin type a to the rat phrenic nerve-hemidiaphragm preparation

1974 • 38 citations

Hemagglutination by Botulinal Toxin

1948 • 37 citations

La science expérimentale

1878 • 37 citations

Comparison of the presynaptic actions of botulinum toxin and ?-bungarotoxin on neuromuscular transmission

1974 • 34 citations

Effects of the type A toxin fromClostridium botulinum on the development of skeletal muscles and of their innervation in chick embryo

1975 • 34 citations

The interaction between divalent cations and botulinum toxin type a in the paralysis of the rat phrenic nerve-hemidiaphragm preparation

1973 • 31 citations

Isolation and Characterization of a Toxic Moiety of Low Molecular Weight from Clostridium botulinum Type A

1965 • 30 citations

Ionic requirements for the neuromuscular blocking action of botulinum toxin: Implications with regard to synaptic transmission

1971 • 29 citations

Mutual Antagonism between Botulinum Toxin and β-Bungarotoxin

1973 • 26 citations

The role of acetylcholine receptors and acetylcholinesterase activity in the development of denervation supersensitivity.

1976 • 26 citations

The subcellular origin of the agetylcholine released at synapses

1975 • 26 citations

CONTRIBUTION TO THE PATHOLOGIC PHYSIOLOGY OF BOTULISM

1923 • 23 citations

Pharmacological studies on the bungarotoxins: separation of the fractions and their neuromuscular activity

1974 • 23 citations

Botulinum Toxin, Type A: Effects on Central Nervous System

1965 • 22 citations

Effect of Botulinum Toxin on Autonomic Nerves in a Dually Innervated Tissue

1967 • 20 citations

Action of botulinum toxin on transmission from sympathetic nerves to the vas deferens

1973 • 20 citations

Selective Block of Synaptic Transmission in Ciliary Ganglion by Type A Botulinus Toxin in Rabbits

1958 • 18 citations

On the mechanism of paralysis resulting from toxin of Clostridium botulinum; the action of the toxin on acetylcholine synthesis and on striated muscle.

1947 • 17 citations

ATROPHY IN SKELETAL MUSCLES POISONED WITH BOTULINUM TOXIN.

1964 • 17 citations

Mechanism of the local vascular actions or 1, 1‐dimethyl‐4‐phenylpiperazinium (DMPP), a potent ganglionic stimulant

1959 • 17 citations

CHARACTERIZATION OF BOTULINAL HEMAGGLUTINATION12

1953 • 17 citations

Amino Acid Analysis of the Isolated and Purified Components from Crystalline Toxin of Clostridium botulinum Type A

1970 • 15 citations

Homogeneity and Molecular Weight of Toxin of Clostridium botulinum Type B

1968 • 15 citations

Cholinesterase activity in skeletal muscle after botulinum toxin

1960 • 15 citations

The effect of botulinus toxin on the electromyogram.

1949 • 15 citations

Über das Botulinustoxin

1923 • 14 citations

POSTGANGLIONIC PARALYSIS OF THE GUINEA‐PIG HYPOGASTRIC NERVE‐VAS DEFERENS PREPARATION BY CLOSTRIDIUM BOTULINUM TYPE D TOXIN

1968 • 13 citations

Electrophysiological manifestations of experimental botulinal intoxication: Depression of cortical EEG

1967 • 13 citations

Failure to Inhibit In Vitro or In Vivo Acetycholinesterase with Botulinum Toxin Type A

1969 • 13 citations

The Use of Neuropoisons in the Study of Cholinergic Transmission

1974 • 12 citations

ON THE MECHANISM OF PARALYSIS RESULTING FROM TOXIN OF CLOSTRIDIUM BOTULINUM

1947 • 12 citations

In Vitro Acetylcholinesterase Inhibition by Type A Botulinum Toxin

1967 • 10 citations

Molecular Weight of Type A Botulinum Toxin

1970 • 9 citations

Pharmacological studies on the bungarotoxins: an analysis of the site of action of nicotinic agonists

1974 • 9 citations

Examination of the possible pathophysiology of the central nervous system during botulinal poisoning

1968 • 8 citations

Heterogeneity of Clostridium botulinum type A toxin

1968 • 7 citations

Failure of type A botulinum toxin to inhibit acetylcholinesterase

1968 • 7 citations

Mechanism of the respiratory paralysis in botulism, tetanus, and diphtheria

1964 • 1 citations

[Mechanism of action of botulin toxin on respiration].

1956 • 1 citations

THE SPECIFIC EFFECT OF BACTERIAL TOXINS ON THE NERVOUS REGULATION OF RESPIRATION.

1964 • 1 citations