Ionic requirements for the neuromuscular blocking action of botulinum toxin: Implications with regard to synaptic transmission

Spontaneous subthreshold activity at motor nerve endings

1952 • 1,820 citations

Stimulus‐secretion coupling: the concept and clues from chromaffin and other cells

1968 • 1,393 citations

The nature of the neuromuscular block produced by magnesium

1954 • 619 citations

Observations on the isolated phrenic nerve diaphragm preparation of the rat

1997 • 618 citations

The action of botulinum toxin on the neuro‐muscular junction

1949 • 618 citations

OBSERVATIONS ON THE ISOLATED PHRENIC NERVE DIAPHRAGM PREPARATION OF THE RAT

1946 • 581 citations

The effects of presynaptic polarization on the spontaneous activity at the mammalian neuromuscular junction

1956 • 381 citations

The effect of magnesium on the activity of motor nerve endings

1954 • 378 citations

Supersensitivity of skeletal muscle produced by botulinum toxin

1960 • 319 citations

An intracellular study of the action of repetitive nerve volleys and of botulinum toxin on miniature end‐plate potentials

1956 • 219 citations

Influence of nerve‐ending activity and of drugs on the rate of paralysis of rat diaphragm preparation by Cl. botulinum type A toxin

1962 • 165 citations

Statistical analysis of a rapid in vivo method for the titration of the toxin of Clostridium botulinum

1966 • 134 citations

The action of botulinum toxin on motor‐nerve filaments

1954 • 130 citations

The peripheral action of Cl. botulinum toxin.

1949 • 121 citations

The effects of osmotic pressure changes on the spontaneous activity at motor nerve endings

1956 • 112 citations

BOTULISM. STUDIES ON THE MANNER IN WHICH THE TOXIN OF CLOSTRIDIUM BOTULINUM ACTS UPON THE BODY

1923 • 109 citations

Competition between sodium and calcium ions in transmitter release at mammalian neuromuscular junction

1966 • 107 citations

Ganglioside inactivation of botulinum toxin

1971 • 104 citations

The pharmacological actions of magnesium ions with particular reference to the neuromuscular and the cardiovascular system.

1952 • 98 citations

A further survey of the action of Clostridium botulinum toxin upon different types of autonomic nerve fibre

1951 • 97 citations

PHYSIOLOGY OF BOTULINUS TOXIN

1947 • 97 citations

An investigation of the post‐tetanic potentiation of end‐plate potentials at a mammalian neuromuscular junction

1966 • 90 citations

The peripheral action of Cl. botulinum toxin

1949 • 90 citations

Dual Effect of Potassium on Transmitter Release

1965 • 76 citations

Neuropoisons: Their Pathophysiological Actions

2012 • 66 citations

The role of calcium in neurohumoral and neurohormonal extrusion processes

1968 • 66 citations

The botulinal, tetanal, and enterostaphylococcal toxins: A review

1967 • 61 citations

The drug-receptor complex

1966 • 61 citations

BOTULISM. STUDIES ON THE MANNER IN WHICH THE TOXIN OF CLOSTRIDIUM BOTULINUM ACTS UPON THE BODY

1923 • 60 citations

Presynaptic Effects of Potassium Ion on the Mammalian Neuromuscular Junction

1965 • 42 citations

Actions of calcium and magnesium on the rate of onset of botulinum toxin paralysis of the rat diaphragm

1967 • 36 citations

The Neuroparalytic and Hemagglutinating Activities of Botulinum Toxin

1971 • 28 citations

Studies of the Toxin of Clostridium botulinum. IV. Fluorescence of Clostridium botulinum Toxin and Its Relation to Toxicity

1959 • 20 citations

The effect of ascorbic acid on the cerebral and adrenal catecholamine content in the male rat

1968 • 20 citations

Influence of Sodium Ions on Transmitter Release

1965 • 16 citations

Failure to Inhibit In Vitro or In Vivo Acetycholinesterase with Botulinum Toxin Type A

1969 • 13 citations

The effect of botulinum toxin on uptake of calcium by synaptosomes

1969 • 10 citations

Effects of serotonin on the toxin of Clostridium botulinum.

1967 • 9 citations

Assay of Botulinum a Toxin with Goldfish.

1952 • 8 citations

Possible sites at which 5-hydroxytryptamine may antagonize in vivo neuromuscular paralysis

1970 • 4 citations

Mechanism of the antagonism by 5-hydroxytryptamine of the toxicity due to certain cholinergic blocking agents

1971 • 4 citations

Absence of binding by botulinum toxin to isolated synaptosomal membranes

1971 • 4 citations

Deleted Work

1955 • 0 citations