Secretion of Macrophage Enzymes in Relation to the Pathogenesis of Chronic Inflammation

LEUKOCYTE LOCOMOTION AND CHEMOTAXIS

1973 • 1,709 citations

Modulation of Inflammation and Immunity by Cyclic AMP

1974 • 923 citations

AN EXAMINATION OF THE CYTOTOXIC EFFECTS OF SILICA ON MACROPHAGES

1966 • 868 citations

AN ENZYMATIC FUNCTION ASSOCIATED WITH TRANSFORMATION OF FIBROBLASTS BY ONCOGENIC VIRUSES

1973 • 779 citations

POTENTIATION OF THE T-LYMPHOCYTE RESPONSE TO MITOGENS

1972 • 742 citations

SECRETION OF PLASMINOGEN ACTIVATOR BY STIMULATED MACROPHAGES

1974 • 719 citations

THE DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES

1965 • 704 citations

IN VITRO SYNTHESIS AND SECRETION OF LYSOZYME BY MONONUCLEAR PHAGOCYTES

1974 • 525 citations

ALTERATIONS OF MACROPHAGE FUNCTIONS BY MEDIATORS FROM LYMPHOCYTES

1971 • 507 citations

Human Monocytes: Distinct Receptor Sites for the Third Component of Complement and for Immunoglobulin G

1968 • 492 citations

PROPERTIES OF ANTIBODIES CYTOPHILIC FOR MACROPHAGES

1966 • 487 citations

Endotoxin and Double Stranded RNA render Macrophages Cytotoxic

1971 • 448 citations

MECHANISMS OF LYSOSOMAL ENZYME RELEASE FROM LEUKOCYTES EXPOSED TO IMMUNE COMPLEXES AND OTHER PARTICLES

1971 • 439 citations

THE PARTICULATE HYDROLASES OF MACROPHAGES

1963 • 422 citations

Effect of Cyclic AMP on Release of Lysosomal Enzymes from Phagocytes

1971 • 380 citations

Human Blood Monocytes: Stimulators of Granulocyte and Mononuclear Colony Formation in vitro

1972 • 374 citations

Role of Contractile Microfilaments in Macrophage Movement and Endocytosis

1971 • 353 citations

Mononuclear Phagocytes

2016 • 350 citations

MEMBRANE FUSION IN A MODEL SYSTEM

1973 • 343 citations

Human Granulocyte Collagenase

1968 • 335 citations

Respiratory Defense Mechanisms.

1978 • 330 citations

INDUCTION OF MACROPHAGE PLASMINOGEN ACTIVATOR BY ENDOTOXIN STIMULATION AND PHAGOCYTOSIS

1974 • 330 citations

Cooperation of Immune Lymphoid Cells with Macrophages in Tumour Immunity

1970 • 315 citations

Collagenase Production by Endotoxin-Activated Macrophages

1974 • 303 citations

Alternate-Day Prednisone

1974 • 298 citations

A Neutrophil Chemotactic Factor from Human C′5

1969 • 297 citations

Activity of a Macrophage Factor in Collagen Formation by Silica

1967 • 293 citations

The formation and properties of macrophage polykaryons (inflammatory giant cells)

1974 • 285 citations

The Structure and Function of Monocytes and Macrophages

1968 • 269 citations

Lymphocyte Cytotoxicity in vitro: Activation and Release of a Cytotoxic Factor

1968 • 266 citations

POLYMORPHONUCLEAR LEUKOCYTES IN IMMUNOLOGIC REACTIONS

1966 • 266 citations

Cellular hypersensitivity and immunity. Inhibition of macrophage migration and the lymphocyte mediators.

1972 • 260 citations

INTERACTION OF CELLS WITH IMMUNE COMPLEXES: ADHERENCE, RELEASE OF CONSTITUENTS, AND TISSUE INJURY

1971 • 255 citations

THE EFFECT OF GLUCOCORTICOSTEROIDS ON THE KINETICS OF MONONUCLEAR PHAGOCYTES

1970 • 252 citations

ASCORBIC ACID AND THE FORMATION OF COLLAGEN

1953 • 238 citations

GLUCOCORTICOID SUPPRESSION OF MACROPHAGE MIGRATION INHIBITORY FACTOR

1973 • 235 citations

CYTOSTATIC ELIMINATION OF SYNGENEIC RAT TUMOR CELLS IN VITRO BY NONSPECIFICALLY ACTIVATED MACROPHAGES

1973 • 233 citations

Control of Carcinogenesis: A Possible Role for the Activated Macrophage

1972 • 223 citations

DEMONSTRATION AND CHARACTERIZATION OF TWO DISTINCT HUMAN LEUKOCYTIC PYROGENS

1974 • 219 citations

Vascular Injury and Lysis of Basement Membrane in vitro by Neutral Protease of Human Leukocytes

1968 • 211 citations

CHEMOTAXIS OF MONONUCLEAR CELLS

1968 • 209 citations

Antibacterial and Enzymic Basic Proteins from Leukocyte Lysosomes: Separation and Identification

1963 • 207 citations

THE PATHOGENESIS OF CHRONIC INFLAMMATION IN EXPERIMENTAL ANTIGEN-INDUCED ARTHRITIS

1972 • 203 citations

The production by antigen-stimulated lymphocytes of a leukotactic factor distinct from migration inhibitory factor

1970 • 200 citations

Generation of C5-Derived Lysosomal Enzyme-Releasing Activity (C5a) by Lysates of Leukocyte Lysosomes

1974 • 197 citations

THE UPTAKE, STORAGE, AND INTRACELLULAR HYDROLYSIS OF CARBOHYDRATES BY MACROPHAGES

1969 • 193 citations

The production of granulomata by antigen‐antibody complexes

1969 • 184 citations

Formation of Prostaglandins during the Aggregation of Human Blood Platelets

1973 • 180 citations

Streptococci and Streptococcal Diseases. Recognition, Understanding, and Management.

1973 • 178 citations

IN VITRO INDUCTION OF LYSOSOMAL ENZYMES BY PHAGOCYTOSIS

1970 • 174 citations

Immune Complexes induce Selective Release of Lysosomal Hydrolases from Macrophages

1974 • 173 citations

Asbestos induces selective release of lysosomal enzymes from mononuclear phagocytes

1974 • 160 citations

Production by Stimulated Macrophages of Factors depressing Lymphocyte Transformation

1973 • 160 citations

Differentiation of human monocytes in bone marrow and blood. Sequential formation of two granule populations.

1973 • 158 citations

INFECTION AND TRANSFORMATION OF MOUSE PERITONEAL MACROPHAGES BY SIMIAN VIRUS 40

1971 • 155 citations

CHANGES IN CELLULAR ENZYME LEVELS AND EXTRACELLULAR RELEASE OF LYSOSOMAL ACID HYDROLASES IN MACROPHAGES EXPOSED TO GROUP A STREPTOCOCCAL CELL WALL SUBSTANCE

1974 • 155 citations

A neutrophil chemotatic factor derived from C'5 upon interaction of guinea pig serum with endotoxin.

1969 • 154 citations

An Inhibitor of Cell Proliferation Released by Cultures of Macrophages

1974 • 151 citations

The Role of Microfilaments and Microtubules in Cell Movement, Endocytosis and Exocytosis

1973 • 143 citations

THE REGULATION OF PINOCYTOSIS IN MOUSE MACROPHAGES

1966 • 141 citations

The Macrophage

1973 • 140 citations

THE FUNDAMENTAL PROPERTIES OF THE FIBROBLAST AND THE MACROPHAGE

1926 • 136 citations

THE EFFECT OF GLUCOCORTICOSTEROIDS ON THE PROLIFERATION AND KINETICS OF PROMONOCYTES AND MONOCYTES OF THE BONE MARROW

1973 • 136 citations

Macrophage turnover in inflamed connective tissue

1970 • 134 citations

Prostaglandins and lymphokines in arthritis

1974 • 132 citations

Future Trends in Inflammation

1975 • 132 citations

CYTOCHEMICAL OBSERVATIONS ON CHICKEN MONOCYTES MACROPHAGES AND GIANT CELLS IN TISSUE CULTURE

1953 • 130 citations

The origin of the mononuclear cells in inflammatory exudates induced by fibrinogen

1965 • 128 citations

THE CUTANEOUS REACTION TO SOLUBLE ANTIGEN-ANTIBODY COMPLEXES

1958 • 127 citations

Evidence for the role of lysosomes in the formation of prostaglandins during carrageenin induced inflammation in the rat

1971 • 122 citations

Cathepsins B1 and D. Action on human cartilage proteoglycans

1973 • 120 citations

A Chemotactic Factor for Mononuclear Leukocytes

1971 • 116 citations

MECHANISM OF ACTIVATION OF THE BONE MARROW-DERIVED LYMPHOCYTE

1973 • 111 citations

THE INTERACTION OF PARTICULATE HORSERADISH PEROXIDASE (HRP)-ANTI HRP IMMUNE COMPLEXES WITH MOUSE PERITONEAL MACROPHAGES IN VITRO

1972 • 110 citations

Breakdown of cartilage proteinpolysaccharide by lysosomes

1968 • 108 citations

Increased Vascular permeability produced by human platelet granule cationic extract

1970 • 106 citations

Lysosomes and the Toxicity of Particulate Pollutants

1971 • 103 citations

A Neutrophil Chemotactic Factor Derived from C′5 upon Interaction of Guinea Pig Serum with Endotoxin

1969 • 101 citations

IN VITRO PRODUCTION OF COLONY‐STIMULATING ACTIVITY. I. EXPOSURE OF MOUSE PERITONEAL CELLS TO ENDOTOXIN

1974 • 99 citations

Macrophage proteinase and inflammation: the production of chemotactic activity from the fifth complement by macrophage proteinase.

1972 • 98 citations

Mechanisms of Cell and Tissue Injury Induced by Group A Streptococci: Relation to Poststreptococcal Sequelae

1972 • 98 citations

Cyclic nucleotides and modulation of effector systems of inflammation

1974 • 95 citations

Enhancement of the Humoral Response of T Cell-Depleted Murine Spleens by a Factor Derived from Human Monocytes in Vitro

1974 • 94 citations

Erythrocyte Catabolism by Macrophages In Vitro THE EFFECT OF HYDROCORTISONE ON ERYTHROPHAGOCYTOSIS AND ON THE INDUCTION OF HEME OXYGENASE

1973 • 90 citations

Natural selection of long‐lived macrophages in experimental granulomata

1969 • 87 citations

CHOLESTEROL METABOLISM IN THE MACROPHAGE

1971 • 87 citations

METABOLIC AND FUNCTIONAL STUDIES ON ACTIVATED MOUSE MACROPHAGES

1973 • 85 citations

LYSOSOMAL PHOSPHOLIPASES A1 AND A2 OF NORMAL AND BACILLUS CALMETTE GUERIN-INDUCED ALVEOLAR MACROPHAGES

1973 • 82 citations

STUDIES ON THE MECHANISM OF ENDOGENOUS PYROGEN PRODUCTION

1974 • 79 citations

The origin of mononuclear cells in chronic inflammation and tuberculin reactions in the rat

1968 • 78 citations

Effects of dental plaque on the production and release of lysosomal hydrolases by macrophages in culture

1973 • 78 citations

Effects of anti-inflammatory and other compounds on the release of lysosomal enzymes from macrophages

1975 • 76 citations

Cytochalasin B Fails to Inhibit Pinocytosis by Macrophages

1972 • 69 citations

Macrophage Proteinase and Inflammation: The Production of Chemotactic Activity from the Fifth Component of Complement by Macrophage Proteinase

1972 • 67 citations

Macrophage and Neutrophil Specific Chemotactic Factors in Serum

1969 • 61 citations

Release of colony-stimulating factor from monocytes by endotoxin and polyinosinic-polycytidylic acid.

1974 • 59 citations

Biopolymer Membrane: A Model System for the Study of the Neutrophilic Leukocyte Response to Immune Complexes

1971 • 59 citations

CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY

1968 • 57 citations

The in-vitro effects of silica-treated hamster macrophages on collagen production by hamster fibroblasts

1973 • 57 citations

Effects of Endotoxin on Macrophages and Other Lymphoreticular Cells

1973 • 56 citations

Release of Lysosomal Enzymes by Alveolar Mononuclear Cells

1974 • 54 citations

THE CYTOTOXIC EFFECT OF MOUSE MACROPHAGES ON SYNGENEIC AND ALLOGENEIC ERYTHROCYTES

1973 • 54 citations

THE REGULATION OF PINOCYTOSIS IN MOUSE MACROPHAGES

1967 • 52 citations

Degradation of granuloma‐inducing micro‐organisms by macrophages

1970 • 51 citations

Leukocyte kininogenases and leukokinins from normal and malignant cells.

1972 • 50 citations

Regulation of DNA synthesis in mouse macrophages *1II. Studies on mechanisms of action of the macrophage growth factor

1971 • 48 citations

The in vitro effect of hydrocortisone on the uptake and intracellular digestion of particulate matter by macrophages in culture.

1972 • 45 citations

IDENTIFICATION OF A TOXIC CELLULAR COMPONENT OF GROUP A STREPTOCOCCI AS A COMPLEX OF GROUP-SPECIFIC C POLYSACCHARIDE AND A PROTEIN

1959 • 44 citations

Pathogenesis of the chronic inflammatory lesion induced by group A streptococcal cell walls.

1974 • 43 citations

Factors influencing chronicity in inflammation of rat skin

1968 • 40 citations

Cytotoxicity of immune guinea-pig cells. II. The mechanism of macrophage cytotoxicity.

1973 • 39 citations

Local Morphological Response Following a Single Subcutaneous Injection of Carrageenin in the Rat

1959 • 39 citations

INTRAPHAGOCYTIC ß-N-ACETYLGLUCOSAMINIDASE

1968 • 34 citations

Studies on leukokinins—II

1972 • 34 citations

Degradation of Immunoglobulin G by Lysosomal Acid Proteases

1970 • 31 citations

The Editor: Metro A. Ogryzlo.

1974 • 31 citations

HYALURONIDASE ACTIVITY OF ALVEOLAR MACROPHAGES

1968 • 28 citations

LYSOSOMAL ACID HYDROLASES AND HYPERREACTIVITY TO ENDOTOXIN IN MICE INFECTED WITH BCG

1965 • 27 citations

Differential Suppressive Effect of Hydrocortisone on Lymphocytes and Mononuclear Macrophages in Delayed Hypersensitivity of Guinea Pigs

1972 • 24 citations

The effect of neonatal and adult thymectomy on the inflammatory response

1972 • 23 citations

Polymorph migration stimulator. A new factor produced by hydrocortisone-treated monocytes.

1974 • 19 citations

The in vitro effect of hydrocortisone on cultures of peritoneal monocytes.

1969 • 19 citations

THE ROLE OF MYCOBACTERIA AND THE EFFECT OF PROTEOLYTIC DEGRADATION OF THYROGLOBULIN ON THE PRODUCTION OF AUTOIMMUNE THYROIDITIS

1969 • 18 citations

Normal macrophage migration inhibition in dexamethasone-treated guinea-pigs

1972 • 8 citations

Action on Collagen of Cathepsins B1 and D

1973 • 5 citations