Chapter 32 Transplantation of basal forebrain cholinergic neurons in the aged rat brain

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

1983 • 3,028 citations

Spatial localization does not require the presence of local cues

1981 • 2,665 citations

Neural grafting in the mammalian CNS

1985 • 536 citations

Spatial learning and motor deficits in aged rats

1984 • 509 citations

Spatial memory deficit in senescent rats.

1980 • 479 citations

Intracerebral Neural Implants: Neuronal Replacement and Reconstruction of Damaged Circuitries

1984 • 416 citations

Septal transplants restore maze learning in rats with fornix-fimbria lesions

1982 • 414 citations

Intracerebral grafting of neuronal cell suspensions. I. Introduction and general methods of preparation.

1983 • 403 citations

Regeneration of monoaminergic and cholinergic neurons in the mammalian central nervous system

1979 • 374 citations

Intrahippocampal Septal Grafts Ameliorate Learning Impairments in Aged Rats

1984 • 369 citations

Efferent synaptic connections of grafted dopaminergic neurons reinnervating the host neostriatum: a tyrosine hydroxylase immunocytochemical study

1985 • 339 citations

Function recovery following neural transplantation of embryonic septal nuclei in adult rats with septohippocampal lesions

1982 • 319 citations

Physiological compensation for loss of afferent synapses in rat hippocampal granule cells during senescence.

1980 • 285 citations

Reformation of the severed septohippocampal cholinergic pathway in the adult rat by transplanted septal neurons

1977 • 264 citations

Brain cholinergic dysfunction and memory in aged rats

1980 • 257 citations

Regional changes in brain glucose metabolism reflect cognitive impairments in aged rats

1984 • 246 citations

Transplantation of embryonic ventral forebrain neurons to the neocortex of rats with lesions of nucleus basalis magnocellularis—II. Sensorimotor and learning impairments

1985 • 242 citations

Age-related alterations in the rodent brain cholinergic system and behavior

1980 • 237 citations

Functional Activity of Substantia Nigra Grafts Reinnervating the Striatum: Neurotransmitter Metabolism and [¹⁴C]2‐Deoxy‐<scp>d</scp>‐glucose Autoradiography

1982 • 234 citations

Brain Acetylcholine Synthesis Declines with Senescence

1981 • 230 citations

Animal Models of Declining Memory in the Aged: Short-term and Spatial Memory in the Aged Rat

1980 • 227 citations

Cholinergic septal grafts into the hippocampal formation improve spatial learning and memory in aged rats by an atropine-sensitive mechanism

1986 • 224 citations

Patterns of Astroglial Hypertrophy and Neuronal Degeneration in the Hippocampus of Aged, Memory-deficient Rats

1977 • 219 citations

Age and neurochemical correlates of radial maze performance in rats

1981 • 217 citations

Intracerebral grafting of neuronal cell suspensions. III. Activity of intrastriatal nigral suspension implants as assessed by measurements of dopamine synthesis and metabolism.

1983 • 199 citations

Functional brain tissue transplantation: reversal of lesion-induced rotation by intraventricular substantia nigra and adrenal medulla grafts, with a note on intracranial retinal grafts.

1983 • 193 citations

Functional Development of Grafted Vasopressin Neurons

1980 • 193 citations

In vivo measurement of spontaneous release and metabolism of dopamine from intrastriatal nigral grafts using intracerebral dialysis

1986 • 192 citations

Cross-species neural grafting in a rat model of Parkinson's disease

1982 • 192 citations

Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease.

1985 • 190 citations

Cyclosporin A increases survival of cross-species intrastriatal grafts of embryonic dopamine-containing neurons

1985 • 186 citations

Intraocular Transplantation in Rodents: A Detailed Account of the Procedure and Examples of its Use in Neurobiology with Special Reference to Brain Tissue Grafting

1983 • 181 citations

Age-related alterations in neurotransmitter receptors: An electrophysiological and biochemical analysis

1981 • 167 citations

Aged Rats: Recovery of Motor Impairments by Intrastriatal Nigral Grafts

1983 • 162 citations

Lesion-induced synaptogenesis in the dentate gyrus of aged rats: I. Loss and reacquisition of normal synaptic density

1982 • 161 citations

Neural Transplants: Development and Function

1985 • 158 citations

Presynaptic cholinergic mechanisms in brain of aged rats with memory impairments

1981 • 139 citations

The peptidergic organization of the cat periaqueductal gray. I. The distribution of immunoreactive enkephalin-containing neurons and terminals

1983 • 131 citations

Loss of synapses in the dentate gyrus of the senescent rat

1976 • 130 citations

Hippocampal aging in rats: A morphometric study of multiple variables in semithin sections

1981 • 125 citations

Loss of place specificity in hippocampal complex spike cells of senescent rat

1983 • 119 citations

Formation of cholinergic synapses by intrahippocampal septal grafts as revealed by choline acetyltransferase immunocytochemistry

1986 • 118 citations

Electrophysiological properties of single units in dopamine-rich mesencephalic transplants in rat brain

1985 • 118 citations

Fetal raphe and hippocampal transplants into adult and aged C57BL/6N mice: A preliminary immunocytochemical study

1981 • 114 citations

Stability of numbers but not size of mouse forebrain cholinergic neurons to 53 months

1985 • 111 citations

Transplantation of embryonic ventral forebrain neurons to the neocortex of rats with lesions of nucleus basalis magnocellularis—I. Biochemical and anatomical observations

1985 • 85 citations

Transplanted septal neurons make viable cholinergic synapses with a host hippocampus

1985 • 81 citations

Intracerebral grafting of neuronal cell suspensions. VII. Recovery of choline acetyltransferase activity and acetylcholine synthesis in the denervated hippocampus reinnervated by septal suspension implants.

1983 • 80 citations

Intracerebral grafting of neuronal cell suspensions. VI. Survival and growth of intrahippocampal implants of septal cell suspensions.

1983 • 75 citations

Neurotransmitter characteristics of brain grafts: Striatal and septal tissues form the same laminated input to the hippocampus

1983 • 70 citations

Changes in neurotransmitter actions in the aged rat hippocampus

1982 • 70 citations

Loss of axosomatic synapses in the dentate gyrus of aged rats

1979 • 69 citations

Production of [¹⁴C]Acetylcholine and [¹⁴C]Carbon Dioxide from [U–¹⁴C]Glucose in Tissue Prisms from Aging Rat Brain

1982 • 63 citations

Intracerebral grafting of neuronal cell suspensions. VIII. Survival and growth of implants of nigral and septal cell suspensions in intact brains of aged rats.

1983 • 62 citations

Grafted septal neurons form cholinergic synaptic connections in the dentate gyrus of behaviorally impaired aged rats

1986 • 57 citations

Dopamine-rich transplants in experimental parkinsonism

1983 • 54 citations

Functional reactivation of the deafferented hippocampus by embryonic septal grafts as assessed by measurements of local glucose utilization

1985 • 52 citations

Prolonged survival of bovine adrenal chromaffin cells in rat cerebral ventricles.

1980 • 51 citations

Embryonic neural transplants across a major histocompatibility barrier: survival and specificity of innervation

1983 • 51 citations

Loss of axon terminals contacting neuronal somata in the dentate gyrus of aged rats

1981 • 29 citations

Cross-species transplants of cholinergic neurons and the recovery of function

1985 • 19 citations

Recovery of declined ovarian function in aged female rats by transplantation of newborn hypothalamic tissue.

1984 • 18 citations

Hypothalamic Grafts and Neuroendocrine Cascade Theories of Aging

1984 • 10 citations