Functional sites of neuroleptic drug action in the human brain: PET/FDG studies with and without haloperidol

THE [¹⁴C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT¹

1977 • 5,986 citations

Primate models of movement disorders of basal ganglia origin

1990 • 3,722 citations

Tomographic measurement of local cerebral glucose metabolic rate in humans with (F‐18)2‐fluoro‐2‐deoxy‐D‐glucose: Validation of method

1979 • 2,396 citations

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

1976 • 2,224 citations

Effect of Chlorpromazine or Haloperidol on Formation of 3‐Methoxytyramine and Normetanephrine in Mouse Brain

1963 • 2,148 citations

Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia

1986 • 2,026 citations

Rapid Automated Algorithm for Aligning and Reslicing PET Images

1992 • 1,958 citations

Comparing Functional (PET) Images: The Assessment of Significant Change

1991 • 1,647 citations

Neurotransmitters and neuromodulators in the basal ganglia

1990 • 1,578 citations

Positron Emission Tomography Reveals Elevated D ₂ Dopamine Receptors in Drug-Naive Schizophrenics

1986 • 935 citations

Basal Ganglia and Limbic System Pathology in Schizophrenia

1985 • 891 citations

Hypofrontality in Neuroleptic-Naive Patients and in Patients With Chronic Schizophrenia

1992 • 882 citations

Prenatal developmental disturbances in the limbic allocortex in schizophrenics

1986 • 879 citations

The Relationship between Global and Local Changes in PET Scans

1990 • 861 citations

Quantitative Analysis of D2 Dopamine Receptor Binding in the Living Human Brain by PET

1986 • 847 citations

Quantitative autoradiographic localization of the D1 and D2 subtypes of dopamine receptors in rat brain

1986 • 742 citations

Limbic System Abnormalities Identified in Schizophrenia Using Positron Emission Tomography With Fluorodeoxyglucose and Neocortical Alterations With Deficit Syndrome

1992 • 546 citations

Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia

1990 • 543 citations

Cell loss in the hippocampus of schizophrenics

1986 • 496 citations

Hippocampal Pathologic Findings in Schizophrenia

1989 • 437 citations

Increased GABAA receptor binding in superficial layers of cingulate cortex in schizophrenics

1992 • 371 citations

Localisation in PET Images: Direct Fitting of the Intercommissural (AC—PC) Line

1989 • 306 citations

Diagnosis and Drug Treatment of Psychiatric Disorders

1969 • 303 citations

An Analysis of the Arrangement of Neurons in the Cingulate Cortex of Schizophrenic Patients

1987 • 280 citations

Plastic Transformation of PET Images

1991 • 271 citations

Neuropathological Studies of Schizophrenia: A Selective Review

1983 • 211 citations

Effect of Neuroleptics on Altered Cerebral Glucose Metabolism in Schizophrenia

1988 • 188 citations

Positron emission tomography studies of basal ganglia and somatosensory cortex neuroleptic drug effects: Differences between normal controls and schizophrenic patients

1987 • 185 citations

Striatal Metabolic Rate and Clinical Response to Neuroleptics in Schizophrenia

1992 • 183 citations

Positron Emission Tomography in Schizophrenic Patients with and without Neuroleptic Medication

1985 • 177 citations

Brain metabolism in patients with schizophrenia before and after acute neuroleptic administration.

1986 • 128 citations

Distribution of effects of haloperidol on energy metabolism in the rat brain

1982 • 91 citations

Plasticity of [14C]2-deoxy-d-glucose incorporation into neostriatum and related structures in response to dopamine neuron damage and apomorphine replacement

1980 • 89 citations

Positron emission tomography and subcortical glucose metabolism in schizophrenia

1988 • 86 citations

Effects of antidromic stimulation of the ventral root on glucose utilization in the ventral horn of the spinal cord in the rat.

1987 • 83 citations

Importance of pharmacologic control in PET studies: Effects of thiothixene and haloperidol on cerebral glucose utilization in chronic schizophrenia

1991 • 69 citations

Effects of sulpiride and chlorpromazine on regional cerebral glucose metabolism in schizophrenic patients as determined by positron emission tomography

1989 • 65 citations

Characterization and localization of serotonin receptors in human brain postmortem

1986 • 61 citations

The effect of neuroleptics on dysfunction in a prefrontal substrate of sustained attention in schizophrenia

1988 • 55 citations

Acute versus chronic haloperidol: relationship between tolerance to catalepsy and striatal and accumbens dopamine, GABA and acetylcholine release

1994 • 53 citations

Changes in psychopathology and dyskinesia after neuroleptic withdrawal in a double-blind design

1993 • 40 citations

Reduced metabolic response of the rat brain to haloperidol after chronic treatment

1985 • 32 citations

Alterations in sleep polygraphy after neuroleptic withdrawal: A putative supersensitive dopaminergic mechanism

1989 • 29 citations

Apomorphine effects on brain metabolism in neuroleptic-naive schizophrenic patients

1991 • 28 citations

Low dose raclopride spares the extrapyramidal system in rat brain from metabolic effects

1993 • 19 citations

Effect of neuroleptic withdrawal on plasma prolactin: A possible marker of receptor adaptation

1989 • 15 citations

A Controlled Clinical Test of a New Psycholeptic Drug (Haloperidol)

1961 • 14 citations

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