A 22 kDa Calcium-Binding Protein, Sorcin, is Encoded by Amplified Genes in Multidrug-Resistant Cells

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1985 • 843 citations

Mechanism of multidrug resistance

1988 • 630 citations

Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.

1986 • 461 citations

Molecular Actions and Targets for Cancer Chemotherapeutic Agents

1981 • 361 citations

Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for calcium channel blockers.

1987 • 333 citations

Progesterone Interacts with P-Glycoprotein in Multidrug-resistant Cells and in the Endometrium of Gravid Uterus

1989 • 290 citations

Vinblastine photoaffinity labeling of a high molecular weight surface membrane glycoprotein specific for multidrug-resistant cells.

1986 • 290 citations

Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line.

1986 • 253 citations

MECHANISMS OF MULTIDRUG RESISTANCE AND IMPLICATIONS FOR THERAPY

1988 • 230 citations

Modulation of the expression of a multidrug resistance gene (mdr-1/P-glycoprotein) by differentiating agents

1989 • 222 citations

Phosphorylation of the Mr 170,000 to 180,000 glycoprotein specific to multidrug-resistant tumor cells: effects of verapamil, trifluoperazine, and phorbol esters.

1987 • 198 citations

Identification of members of the P-glycoprotein multigene family.

1989 • 195 citations

Localization of the human multiple drug resistance gene, MDR1, to 7q21.1

1987 • 179 citations

Genes amplified and overexpressed in human multidrug-resistant cell lines.

1988 • 170 citations

A 22-kd protein (sorcin/V19) encoded by an amplified gene in multidrug-resistant cells, is homologous to the calcium-binding light chain of calpain.

1986 • 137 citations

Phosphorylation of the multidrug resistance associated glycoprotein

1987 • 131 citations

Increased synthesis of a low molecular weight protein in vincristine-resistant cells

1981 • 121 citations

Differential amplification and disproportionate expression of five genes in three multidrug-resistant Chinese hamster lung cell lines.

1986 • 113 citations

Gene amplification-associated cytogenetic aberrations and protein changes in vincristine-resistant Chinese hamster, mouse, and human cells.

1985 • 100 citations

New Avenues in Developmental Cancer Chemotherapy

1987 • 93 citations

Sorcin (V19), a soluble acidic calcium-binding protein overproduced in multidrug-resistant cells

1987 • 60 citations

Mechanisms regulating cell resistance to adriamycin evidence that drug accumulation in resistant cells is modulated by phosphorylation of a plasma membrane glycoprotein

1985 • 59 citations

Purification of the Mr 22,000 calcium-binding protein (sorcin) associated with multidrug resistance and its detection with monoclonal antibodies.

1988 • 58 citations

Identification of a novel calcium‐binding protein (CP₂₂) in multidrug‐resistant murine and hamster cells

1986 • 53 citations

Drug resistance in mammalian cells

1989 • 53 citations

Chromosomal localization of three genes coamplified in the multidrug-resistant CHRC5 Chinese hamster ovary cell line.

1987 • 38 citations

Rational basis for chemotherapy

1984 • 35 citations

Mechanism of interaction between antineoplastic agents and natural differentiation factors in the induction of human leukemic cell maturation.

1986 • 29 citations

Protein phosphorylation in multidrug resistant Chinese hamster cells.

1989 • 18 citations

Immunocytochemical Identification and Localization of the Mr 22,000 Calcium‐binding Protein (Sorcin) in an Adriamycin‐resistant Myelogenous Leukemia Cell Line

1989 • 15 citations

Association of sorcin with drug resistance in L1210 cells

1989 • 12 citations

Expressions of resistance and cross-resistance in teniposide-resistant L1210 cells

1987 • 10 citations

Hyperproduction of a specific protein in cells resistant to colchicine and adriablastin

1983 • 6 citations