Intracellular Protein Turnover

Mammalian Protein Metabolism

1969 • 1,828 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells

1974 • 1,775 citations

Protein turnover in mammalian tissues and in the whole body

1978 • 1,237 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells: Part 2

1976 • 1,060 citations

Proteinases in mammalian cells and tissues

1978 • 981 citations

Control of Enzyme Levels in Animal Tissues

1970 • 680 citations

The Roles of Synthesis and Degradation in the Control of Rat Liver Tryptophan Pyrrolase

1965 • 592 citations

Studies on the Synthesis and Degradation of Proteins of the Endoplasmic Reticulum of Rat Liver

1969 • 538 citations

Advances in ENZYME REGULATION

2002 • 442 citations

The Importance of Both Synthesis and Degradation in the Control of Arginase Levels in Rat Liver

1964 • 396 citations

A new assay for cathepsin B1 and other thiol proteinases

1972 • 394 citations

Cathepsin L

1977 • 341 citations

Human cathepsin B1. Purification and some properties of the enzyme

1973 • 322 citations

Some aspects of the regulation of fuel supply in omnivorous animals

1972 • 246 citations

MEASUREMENT OF PROTEIN TURNOVER IN RAT LIVER

1958 • 211 citations

Direct evidence of importance of lysosomes in degradation of intracellular proteins

1975 • 209 citations

Regulation of Tyrosine α-Ketoglutarate Transaminase in Rat Liver

1967 • 199 citations

Intracellular protein degradation

1993 • 192 citations

Studies on the Correlation between Size and Relative Degradation Rate of Soluble Proteins

1973 • 165 citations

The specificity of cathepsin B. Hydrolysis of glucagon at the C-terminus by a peptidyldipeptidase mechanism

1978 • 159 citations

General characteristics of protein degradation in diabetes and starvation.

1978 • 125 citations

Purification and Properties of a New Cathepsin from Rat Liver1

1978 • 122 citations

Studies on the Induction and Repression of Enzymes in Rat Liver

1964 • 120 citations

Intracellular protein catabolism

1977 • 118 citations

Food and light as separate entrainment signals for rat liver enzymes

1973 • 89 citations

Cathepsin H: an endoaminopeptidase from rat liver lysosomes.

1977 • 84 citations

Relationship between Degradation Rates of Proteins in Vivo and Their Susceptibility to Lysosomal Proteases

1974 • 77 citations

Separation of a new alpha-N-benzoylarginine-beta-naphthylamide hydrolase from cathepsin B1. Purification, characterization, and properties of both enzymes from rabbit lung.

1978 • 73 citations

Lysosomal Enzymes as Agents of Turnover of Soluble Cytoplasmic Proteins

1975 • 69 citations

Purification and Properties of a Periplasmic Aminoendopeptidase from Escherichia coli

1975 • 65 citations

Concerning a possible mechanism for selective capture of cytoplasmic proteins by lysosomes

1975 • 64 citations

Über ein neues Kathepsin. Reinigung aus Rindermilz, Eigenschaften, sowie Vergleich mit Kathepsin B

1967 • 61 citations

Improved purification of cathepsin B1 and cathepsin B2

1975 • 54 citations

Identity and Activities of Lysosomal Enzymes in Parenchymal and Non‐Parenchymal Cells from Rat Liver

1975 • 51 citations

Zur Kenntnis des Kathepsins B′: Spezifität und Eigenschaften

1969 • 46 citations

Synthesis and turnover of lysosomal glycoproteins. Relation to the molecular heterogeneity of the lysosomal enzymes

1974 • 43 citations

Lactate dehydrogenase isoenzymes. Turnover in rat heart, skeletal muscle, and liver

1973 • 37 citations

Separation of a new protease from cathepsin B1 of rat liver lysosomes

1976 • 36 citations

Intrazellul�re Proteolyse

1968 • 34 citations

Pepstatin-insensitive proteolytic activity of rat liver lysosomes. Isolation and purification of a new pepstatin-insensitive proteolytic enzyme from rat liver lysosomes.

1977 • 29 citations

Fractionation of the rat liver enzymes that hydrolyze benzoyl-arginine-2-naphthylamide

1975 • 29 citations

LYSOSOMAL PROCESSING OF INTRACELLULAR PROTEIN IN RAT LIVER AND ITS GENERAL REGULATION BY AMINO ACIDS AND INSULIN

1978 • 28 citations

Crystallization and amino acid composition of cathepsin B from rat liver lysosomes

1978 • 25 citations

New intracellular proteases and their role in intracellular enzyme degradation

1977 • 24 citations

Präparative gewinnung hochgereinigter lysosomenenzyme aus rattenlebern

1969 • 19 citations

Rapid proteolytic removal of phosphopeptides and phosphorylatable sites from proteins in rat liver cell SAP

1978 • 16 citations

Conversion of proinsulin into insulin by cathepsins B and L from rat liver lysosomes

1977 • 16 citations

Isolation of Kupffer cell lysosomes, with observations on their chemical and enzymic composition

1974 • 13 citations

Intracellular protein catabolism. IX. Hydrophobicity of substrate proteins is a molecular basis of selectivity.

1977 • 12 citations

THE CHEMISTRY AND TURNOVER OF LYSOSOMAL ENZYMES**The unpublished work reported herein was supported in part by Grant 2-R01-CA-07489 from the National Cancer Institute, U.S. Public Health Service, and by Grants BMS-72-01955 and PCM 76-84268 from the National Science Foundation.

1978 • 9 citations

Protein degradation in rat liver cells

1977 • 6 citations

Primary Reaction of Intracellular Protein Catabolism

1977 • 6 citations

Cathepsin L and Cathepsin B3 from Rat Liver Lysosomes

1977 • 5 citations

Intracellular protein catabolism and new serine proteases

1977 • 4 citations

Life Span of Tissue Cells.

1963 • 4 citations

Attempts to relate enzyme inactivation to degradation in vivo.

1977 • 4 citations

Lactate Dehydrogenase, Isoenzymes

1974 • 4 citations

Increased Degradation Rates of Canavanine-Containing Proteins in Hepatoma Cells

1977 • 2 citations

INTRACELLULAR CYSTEINE PROTEASES FROM BOVINE LIVER

1976 • 1 citations

On the Specificity of Cathepsin B2

1977 • 1 citations

Cooperation of various subcellular fractions in protein degradation in vitro

1977 • 1 citations